epiafzelechin and Edema

epiafzelechin has been researched along with Edema* in 1 studies

Other Studies

1 other study(ies) available for epiafzelechin and Edema

Article	Year
(-)-Epiafzelechin: cyclooxygenase-1 inhibitor and anti-inflammatory agent from aerial parts of Celastrus orbiculatus. Planta medica, 1999, Volume: 65, Issue:5 An inhibitor of cyclooxygenase (COX)-1 activity of prostaglandin H2 synthase was isolated from aerial parts of Celastrus orbiculatus Thunb. (Celastraceae), an oriental folk medicine for rheumatoid arthritis by activity-guided column chromatographic methods. The COX inhibitor was identified as (-)-epiafzelechin, a member of flavan-3-ols by the structural analysis with HR-EI-mass, 1H-NMR and 13C-NMR spectral data. The compound exhibited a dose-dependent inhibition on the COX activity with an IC50 value of 15 microM. (-)-Epiafzelechin exhibited about 3-fold weaker inhibitory potency on the enzyme activity than indomethacin as a positive control. (-)-Epiafzelechin exhibited significant anti-inflammatory activity on carrageenin-induced mouse paw edema when the compound (100 mg/kg) was orally administrated at 1 h before carrageenin treatment. Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Catechin; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Edema; Isoenzymes; Male; Medicine, Chinese Traditional; Membrane Proteins; Mice; Mice, Inbred ICR; Molecular Structure; Plant Extracts; Plants, Medicinal; Prostaglandin-Endoperoxide Synthases	1999

Article

Year

(-)-Epiafzelechin: cyclooxygenase-1 inhibitor and anti-inflammatory agent from aerial parts of Celastrus orbiculatus.

Planta medica, 1999, Volume: 65, Issue:5

An inhibitor of cyclooxygenase (COX)-1 activity of prostaglandin H2 synthase was isolated from aerial parts of Celastrus orbiculatus Thunb. (Celastraceae), an oriental folk medicine for rheumatoid arthritis by activity-guided column chromatographic methods. The COX inhibitor was identified as (-)-epiafzelechin, a member of flavan-3-ols by the structural analysis with HR-EI-mass, 1H-NMR and 13C-NMR spectral data. The compound exhibited a dose-dependent inhibition on the COX activity with an IC50 value of 15 microM. (-)-Epiafzelechin exhibited about 3-fold weaker inhibitory potency on the enzyme activity than indomethacin as a positive control. (-)-Epiafzelechin exhibited significant anti-inflammatory activity on carrageenin-induced mouse paw edema when the compound (100 mg/kg) was orally administrated at 1 h before carrageenin treatment.

Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Catechin; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Edema; Isoenzymes; Male; Medicine, Chinese Traditional; Membrane Proteins; Mice; Mice, Inbred ICR; Molecular Structure; Plant Extracts; Plants, Medicinal; Prostaglandin-Endoperoxide Synthases

1999