Page last updated: 2024-09-05

enzastaurin and Metastase

enzastaurin has been researched along with Metastase in 9 studies

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's5 (55.56)29.6817
2010's4 (44.44)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Birkmann, J; Hanauske, A; Lahn, M; Ohnmacht, U; Smetak, M; Weigang-Koehler, K; Wilhelm, M1
Cui, J; Gao, D; Guo, K; Kang, X; Li, Y; Liu, Y; Sun, L1
Hristova-Kazmierski, M; Isakoff, SJ; Johnson, C; Krop, I; Miller, KD; Mina, L; Schneider, CJ; Shonukan, OO; Sledge, GW; Vaughn, LG; Wang, Y; Yu, M; Zon, RT1
Gonelli, A; Guerrini, R; Mischiati, C; Salvadori, S; Voltan, R; Zauli, G1
Asmar, L; Becerra, C; Boehm, KA; Gersh, RH; Gill, JF; Hozak, RR; Kuefler, PR; Mullaney, BP; Myrand, SP; Nicol, SJ; Obasaju, CK; Richards, DA; Wilfong, LS; Zhan, F; Zhao, L1
Dreicer, R; Garcia, J; Hussain, M; Kania, M; Raghavan, D; Rini, B; Somer, B; Srinivas, S; Vogelzang, N; Zhao, YD1
Allgayer, H; Körner, A; Manegold, C; Mudduluru, G1
Di Bartolomeo, M; Fuchs, M; Heinemann, V; Hossain, AM; Nicol, S; Stoffregen, C; Wolff, RA1
Beerepoot, LV; Beijnen, JH; Enas, N; Mehra, N; Musib, L; Radema, SA; Rademaker-Lakhai, JM; Schellens, JH; van Hal, G; van Maanen, R; Vermaat, JS; Visseren-Grul, CM; Voest, EE; Witteveen, EO1

Reviews

1 review(s) available for enzastaurin and Metastase

ArticleYear
Perspectives of protein kinase C (PKC) inhibitors as anti-cancer agents.
    Mini reviews in medicinal chemistry, 2009, Volume: 9, Issue:4

    Topics: Animals; Antineoplastic Agents; Apoptosis; Bryostatins; Cell Cycle; Cell Transformation, Neoplastic; Clinical Trials as Topic; Humans; Indoles; Neoplasm Metastasis; Neovascularization, Pathologic; Plant Extracts; Protein Kinase C-delta; Protein Kinase C-epsilon; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-mdm2; Tumor Suppressor Protein p53

2009

Trials

5 trial(s) available for enzastaurin and Metastase

ArticleYear
A phase II study of oral enzastaurin in patients with metastatic breast cancer previously treated with an anthracycline and a taxane containing regimen.
    Investigational new drugs, 2009, Volume: 27, Issue:6

    Topics: Administration, Oral; Adult; Aged; Anthracyclines; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Bridged-Ring Compounds; Female; Humans; Indoles; Middle Aged; Neoplasm Metastasis; Taxoids; Treatment Outcome

2009
Gemcitabine plus enzastaurin or single-agent gemcitabine in locally advanced or metastatic pancreatic cancer: results of a phase II, randomized, noncomparative study.
    Investigational new drugs, 2011, Volume: 29, Issue:1

    Topics: Aged; Aged, 80 and over; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Deoxycytidine; Disease-Free Survival; Female; Gemcitabine; Humans; Immunohistochemistry; Indoles; Male; Middle Aged; Neoplasm Metastasis; Neoplasm Staging; Pancreatic Neoplasms; Quality of Life; Treatment Outcome

2011
Oral enzastaurin in prostate cancer: a two-cohort phase II trial in patients with PSA progression in the non-metastatic castrate state and following docetaxel-based chemotherapy for castrate metastatic disease.
    Investigational new drugs, 2011, Volume: 29, Issue:6

    Topics: Administration, Oral; Aged; Aged, 80 and over; Antineoplastic Agents; Cohort Studies; Disease-Free Survival; Humans; Indoles; Male; Middle Aged; Neoplasm Metastasis; Prostate-Specific Antigen; Prostatic Neoplasms; Treatment Outcome

2011
A double-blind, randomized, placebo-controlled, phase 2 study of maintenance enzastaurin with 5-fluorouracil/leucovorin plus bevacizumab after first-line therapy for metastatic colorectal cancer.
    Cancer, 2012, Sep-01, Volume: 118, Issue:17

    Topics: Adult; Aged; Aged, 80 and over; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Colorectal Neoplasms; Disease-Free Survival; Double-Blind Method; Female; Fluorouracil; Humans; Indoles; Leucovorin; Maintenance Chemotherapy; Male; Middle Aged; Neoplasm Metastasis; Placebos; Retreatment

2012
Phase I pharmacokinetic and pharmacodynamic study of the oral protein kinase C beta-inhibitor enzastaurin in combination with gemcitabine and cisplatin in patients with advanced cancer.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2007, Aug-01, Volume: 13, Issue:15 Pt 1

    Topics: AC133 Antigen; Adult; Aged; Antigens, CD; Antineoplastic Combined Chemotherapy Protocols; CD146 Antigen; Cisplatin; Deoxycytidine; Endothelium, Vascular; Female; Gemcitabine; Glycoproteins; Humans; Indoles; Male; Maximum Tolerated Dose; Middle Aged; Neoplasm Metastasis; Neoplasm Recurrence, Local; Neoplasms; Peptides; Prognosis; Protein Kinase C; Protein Kinase C beta; RNA, Messenger; Survival Rate

2007

Other Studies

3 other study(ies) available for enzastaurin and Metastase

ArticleYear
Reduction of HLA-DR+ lymphocytes after treatment with enzastaurin in patients with metastatic thyroid cancer.
    Chemotherapy, 2008, Volume: 54, Issue:4

    Topics: Antineoplastic Agents; HLA-DR Antigens; Humans; Immunophenotyping; Indoles; Lymphocyte Count; Lymphocytes; Neoplasm Metastasis; Thyroid Neoplasms

2008
Role of PKCbeta in hepatocellular carcinoma cells migration and invasion in vitro: a potential therapeutic target.
    Clinical & experimental metastasis, 2009, Volume: 26, Issue:3

    Topics: Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movement; Humans; Indoles; Liver Neoplasms; Neoplasm Invasiveness; Neoplasm Metastasis; Oligonucleotide Array Sequence Analysis; Protein Kinase C; Protein Kinase C beta; RNA Interference; Tetradecanoylphorbol Acetate

2009
Enzastaurin inhibits invasion and metastasis in lung cancer by diverse molecules.
    British journal of cancer, 2010, Sep-07, Volume: 103, Issue:6

    Topics: Blotting, Western; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Electrophoretic Mobility Shift Assay; Enzyme-Linked Immunosorbent Assay; Gene Knockdown Techniques; Humans; Indoles; Lung Neoplasms; Neoplasm Invasiveness; Neoplasm Metastasis; Nucleic Acid Hybridization; Reverse Transcriptase Polymerase Chain Reaction

2010