Page last updated: 2024-09-05

enzastaurin and Glioma

enzastaurin has been researched along with Glioma in 10 studies

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's5 (50.00)29.6817
2010's5 (50.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Chen, X; Ma, W; Wang, J; Yan, C; Yang, Y1
Butowski, N; Cha, S; Chang, SM; Essock-Burns, E; Lupo, JM; Molinaro, AM; Nelson, SJ1
Butman, JA; Fine, HA; Fraum, TJ; Iwamoto, FM; Kreisl, TN; Li, A; Moustakas, A; Odia, Y; Salgado, CA; Sul, J1
Frank, B; Lemke, D; Maurer, G; Rieger, J; Tabatabai, G; Weiler, M; Weller, M; Wick, W1
Albert, PS; Duic, P; Fine, HA; Kim, L; Kotliarova, S; Kreisl, TN; Moore, K; Musib, L; Thornton, D; Walling, J1
Jane, EP; Pollack, IF2
Albert, PS; Butman, JA; Fine, HA; Kim, L; Kotliarova, S; Kreisl, TN; Musib, L; Thornton, D1
Stummer, W1
Christ, G; Frank, B; Heckl, S; Lemke, D; Obermüller, U; Tabatabai, G; von Kürthy, G; Weller, M; Wick, A; Wick, W1

Reviews

1 review(s) available for enzastaurin and Glioma

ArticleYear
Molecular biomarker-guided anti-angiogenic targeted therapy for malignant glioma.
    Journal of cellular and molecular medicine, 2019, Volume: 23, Issue:8

    Topics: Angiogenesis Inhibitors; Bevacizumab; Biomarkers, Tumor; Brain Neoplasms; Glioma; Humans; Indoles; Molecular Targeted Therapy; Prognosis; Snake Venoms

2019

Trials

3 trial(s) available for enzastaurin and Glioma

ArticleYear
A phase II trial of enzastaurin (LY317615) in combination with bevacizumab in adults with recurrent malignant gliomas.
    Journal of neuro-oncology, 2016, Volume: 127, Issue:1

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Brain Neoplasms; Female; Follow-Up Studies; Glioma; Glycogen Synthase Kinase 3; Humans; Indoles; Leukocytes, Mononuclear; Male; Middle Aged; Neoplasm Recurrence, Local; Neoplasm Staging; Prognosis; Quality of Life; Survival Rate

2016
A phase I trial of enzastaurin in patients with recurrent gliomas.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2009, May-15, Volume: 15, Issue:10

    Topics: Adult; Area Under Curve; Cross-Over Studies; Dose-Response Relationship, Drug; Glioma; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Indoles; Long QT Syndrome; Metabolic Clearance Rate; Neoplasm Recurrence, Local; Phosphoproteins; Protein Kinase C; Protein Kinase C beta; Survival Analysis; Thrombocytopenia

2009
A phase I/II trial of enzastaurin in patients with recurrent high-grade gliomas.
    Neuro-oncology, 2010, Volume: 12, Issue:2

    Topics: Anticonvulsants; Antineoplastic Agents; Brain Neoplasms; Glioma; Humans; Indoles; Kaplan-Meier Estimate; Neoplasm Recurrence, Local

2010

Other Studies

6 other study(ies) available for enzastaurin and Glioma

ArticleYear
The effects of anti-angiogenic therapy on the formation of radiation-induced microbleeds in normal brain tissue of patients with glioma.
    Neuro-oncology, 2016, Volume: 18, Issue:1

    Topics: Adult; Aged; Angiogenesis Inhibitors; Brain Neoplasms; Cerebral Hemorrhage; Female; Glioma; Humans; Indoles; Magnetic Resonance Imaging; Male; Middle Aged; Neovascularization, Pathologic; Radiotherapy; Treatment Outcome

2016
Enzastaurin-induced apoptosis in glioma cells is caspase-dependent and inhibited by BCL-XL.
    Journal of neurochemistry, 2008, Volume: 106, Issue:6

    Topics: Adult; Amino Acid Chloromethyl Ketones; Antineoplastic Agents; Apoptosis; bcl-X Protein; Brain Neoplasms; Caspases; Cell Line, Tumor; Cytochromes c; Drug Resistance, Neoplasm; Enzyme Inhibitors; Glioma; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Indoles; Mitochondria; Protein Kinase C; Proto-Oncogene Proteins c-akt; Receptors, TNF-Related Apoptosis-Inducing Ligand

2008
Enzastaurin induces H2AX phosphorylation to regulate apoptosis via MAPK signalling in malignant glioma cells.
    European journal of cancer (Oxford, England : 1990), 2010, Volume: 46, Issue:2

    Topics: Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Line, Tumor; Checkpoint Kinase 2; Dose-Response Relationship, Drug; Glioma; Histones; Humans; Indoles; Mitogen-Activated Protein Kinases; Phosphorylation; Protein Serine-Threonine Kinases; STAT1 Transcription Factor

2010
Perspectives in central nervous system malignancies.
    IDrugs : the investigational drugs journal, 2006, Volume: 9, Issue:6

    Topics: Antineoplastic Agents; Central Nervous System Neoplasms; Combined Modality Therapy; Drug Therapy, Combination; ErbB Receptors; Gefitinib; Glioma; Humans; Indoles; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Quinazolines; Randomized Controlled Trials as Topic; Sirolimus; TOR Serine-Threonine Kinases

2006
Synergistic antiglioma activity of radiotherapy and enzastaurin.
    Annals of neurology, 2007, Volume: 61, Issue:2

    Topics: Animals; Apoptosis; Brain Neoplasms; Combined Modality Therapy; Glioma; Indoles; Magnetic Resonance Imaging; Mice; Mice, Nude; Neoplasm Transplantation; Protein Kinase C; Protein Kinase C beta; Protein Kinase Inhibitors; Survival Analysis; Up-Regulation; Vascular Endothelial Growth Factor A

2007
The heat shock protein antagonist 17-AAG potentiates the activity of enzastaurin against malignant human glioma cells.
    Cancer letters, 2008, Sep-08, Volume: 268, Issue:1

    Topics: Apoptosis; Benzoquinones; Caspase 3; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cytochromes c; Down-Regulation; Drug Synergism; Glioma; HSP90 Heat-Shock Proteins; Humans; Indoles; Lactams, Macrocyclic; Oncogene Protein v-akt; Phosphorylation

2008