Page last updated: 2024-09-05

enzastaurin and Glioblastoma

enzastaurin has been researched along with Glioblastoma in 12 studies

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (16.67)29.6817
2010's10 (83.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Combs, SE; Hartmann, C; Moreau-Donnet, V; Platten, M; Shei, P; Steinbach, JP; Stoffregen, C; von Deimling, A; Wenz, F; Wick, W1
Cartron, PF; Cheray, M; Nadaradjane, A; Pacaud, R; Vallette, FM1
Butowski, N; Cha, S; Chang, S; Crane, J; Kadambi, AK; Li, Y; Molinaro, A; Nelson, SJ; Olson, M; Park, I; Roy, R1
Buckner, JC; Galanis, E1
Carpentier, AF; Chamberlain, MC; Cher, LM; Fine, HA; Hong, S; Liepa, AM; Mason, W; Musib, L; Puduvalli, VK; Thornton, DE; van den Bent, MJ; Weller, M; Wick, W1
Butowski, N; Chang, SM; Hristova-Kazmierski, M; Lamborn, KR; Musib, L; Nicol, SJ; Parvataneni, R; Polley, MY; Prados, MD; Thornton, DE1
Butowski, NA; Cha, S; Chang, SM; Essock-Burns, E; Lupo, JM; Nelson, SJ; Polley, MY1
Butowski, N; Chang, SM; Clarke, J; Costa, BM; Costello, JF; Hristova-Kazmierski, M; Hsieh, E; Lamborn, KR; Nicol, SJ; Nicole, A; Parvataneni, R; Pieper, R; Polley, MY; Prados, MD; Reis, RM; Sneed, PK; Thornton, DE; Vandenberg, S1
Decker, R; Gharib, M; Gorlia, T; Lacombe, D; Lai, C; Rampling, R; Sanson, M; Stoffregen, C; Taal, W; van den Bent, MJ1
Butowski, N; Cha, S; Chang, SM; Essock-Burns, E; Lupo, JM; Molinaro, AM; Nelson, SJ1
Bailey, SN; Banks, C; Brown, TJ; Campbell, RM; Capen, A; Geeganage, S; Goode, R; Graff, JR; Hanna, KR; Huss, KL; Iversen, PW; Konicek, BW; Lewis, JE; Lynch, RL; McNulty, AM; Musib, L; Neubauer, BL; Sams, L; Thornton, D1
Kondo, S; Kondo, Y1

Trials

5 trial(s) available for enzastaurin and Glioblastoma

ArticleYear
Enzastaurin before and concomitant with radiation therapy, followed by enzastaurin maintenance therapy, in patients with newly diagnosed glioblastoma without MGMT promoter hypermethylation.
    Neuro-oncology, 2013, Volume: 15, Issue:10

    Topics: Adult; Aged; Brain Neoplasms; Chemoradiotherapy; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Female; Follow-Up Studies; Glioblastoma; Humans; Indoles; Male; Middle Aged; Neoplasm Staging; Prognosis; Promoter Regions, Genetic; Survival Rate; Tumor Suppressor Proteins

2013
Phase III study of enzastaurin compared with lomustine in the treatment of recurrent intracranial glioblastoma.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2010, Mar-01, Volume: 28, Issue:7

    Topics: Adult; Aged; Brain Neoplasms; Female; Glioblastoma; Humans; Indoles; Lomustine; Male; Middle Aged; Neoplasm Recurrence, Local

2010
Enzastaurin plus temozolomide with radiation therapy in glioblastoma multiforme: a phase I study.
    Neuro-oncology, 2010, Volume: 12, Issue:6

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cohort Studies; Combined Modality Therapy; Dacarbazine; Female; Glioblastoma; Humans; Indoles; Male; Middle Aged; Temozolomide; Young Adult

2010
Phase II and pharmacogenomics study of enzastaurin plus temozolomide during and following radiation therapy in patients with newly diagnosed glioblastoma multiforme and gliosarcoma.
    Neuro-oncology, 2011, Volume: 13, Issue:12

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Brain; Brain Neoplasms; Case-Control Studies; Chemoradiotherapy; Chemotherapy, Adjuvant; Clinical Trials, Phase III as Topic; Dacarbazine; DNA Methylation; DNA, Neoplasm; Female; Follow-Up Studies; Glioblastoma; Gliosarcoma; Humans; Immunoenzyme Techniques; Indoles; Male; Middle Aged; Neoplasm Staging; Pharmacogenetics; Polymerase Chain Reaction; Prospective Studies; Survival Rate; Temozolomide; Treatment Outcome; Young Adult

2011
A phase I study of LY317615 (enzastaurin) and temozolomide in patients with gliomas (EORTC trial 26054).
    Neuro-oncology, 2012, Volume: 14, Issue:3

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Dacarbazine; Female; Glioblastoma; Humans; Indoles; Male; Maximum Tolerated Dose; Middle Aged; Temozolomide; Young Adult

2012

Other Studies

7 other study(ies) available for enzastaurin and Glioblastoma

ArticleYear
Histone H3 phosphorylation in GBM: a new rational to guide the use of kinase inhibitors in anti-GBM therapy.
    Theranostics, 2015, Volume: 5, Issue:1

    Topics: Adult; Aged; Antineoplastic Agents; Dacarbazine; Female; Glioblastoma; Histones; Humans; Indoles; Male; Middle Aged; Organophosphates; Phosphorylation; Prognosis; Protein Kinase Inhibitors; Protein Processing, Post-Translational; Pyrazoles; Pyrimidines; Quinazolines; Temozolomide

2015
Association of early changes in 1H MRSI parameters with survival for patients with newly diagnosed glioblastoma receiving a multimodality treatment regimen.
    Neuro-oncology, 2017, 03-01, Volume: 19, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Choline; Cohort Studies; Combined Modality Therapy; Creatine; Dacarbazine; Female; Follow-Up Studies; Glioblastoma; Humans; Image Processing, Computer-Assisted; Indoles; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Neoplasm Grading; Prognosis; Radiotherapy, Conformal; Survival Rate; Temozolomide; Tumor Burden

2017
Enzastaurin in the treatment of recurrent glioblastoma: a promise that did not materialize.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2010, Mar-01, Volume: 28, Issue:7

    Topics: Brain Neoplasms; Clinical Trials, Phase III as Topic; Glioblastoma; Humans; Indoles; Protein Kinase C; Protein Kinase C beta; Recurrence; Vascular Endothelial Growth Factor Receptor-2

2010
Assessment of perfusion MRI-derived parameters in evaluating and predicting response to antiangiogenic therapy in patients with newly diagnosed glioblastoma.
    Neuro-oncology, 2011, Volume: 13, Issue:1

    Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemotherapy, Adjuvant; Combined Modality Therapy; Dacarbazine; Disease Progression; Glioblastoma; Humans; Image Processing, Computer-Assisted; Indoles; Magnetic Resonance Imaging; Perfusion; Radiotherapy, Adjuvant; Survival Rate; Temozolomide; Treatment Outcome

2011
Using susceptibility-weighted imaging to determine response to combined anti-angiogenic, cytotoxic, and radiation therapy in patients with glioblastoma multiforme.
    Neuro-oncology, 2013, Volume: 15, Issue:4

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Chemoradiotherapy; Dacarbazine; Female; Follow-Up Studies; Glioblastoma; Humans; Image Processing, Computer-Assisted; Indoles; Magnetic Resonance Imaging; Male; Middle Aged; Neoplasm Staging; Prognosis; Survival Rate; Temozolomide

2013
The protein kinase Cbeta-selective inhibitor, Enzastaurin (LY317615.HCl), suppresses signaling through the AKT pathway, induces apoptosis, and suppresses growth of human colon cancer and glioblastoma xenografts.
    Cancer research, 2005, Aug-15, Volume: 65, Issue:16

    Topics: Animals; Apoptosis; Cell Growth Processes; Colonic Neoplasms; Female; Glioblastoma; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; HCT116 Cells; Humans; Indoles; Male; Mice; Mice, Nude; Phosphorylation; Prostatic Neoplasms; Protein Kinase C; Protein Kinase C beta; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Ribosomal Protein S6; Signal Transduction; Xenograft Model Antitumor Assays

2005
American Association for Cancer Research--97th annual meeting.
    IDrugs : the investigational drugs journal, 2006, Volume: 9, Issue:6

    Topics: Adenine; Animals; Antineoplastic Agents; Benzoquinones; Glioblastoma; HSP90 Heat-Shock Proteins; Humans; Indoles; Janus Kinase 2; Lactams, Macrocyclic; Neoplasms, Experimental; Organophosphonates; Protein Kinase C; Protein Kinase Inhibitors; Signal Transduction; Topotecan; Tyrphostins

2006