enzastaurin has been researched along with Brain Neoplasms in 16 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (12.50) | 29.6817 |
| 2010's | 14 (87.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, X; Ma, W; Wang, J; Yan, C; Yang, Y | 1 |
| Combs, SE; Hartmann, C; Moreau-Donnet, V; Platten, M; Shei, P; Steinbach, JP; Stoffregen, C; von Deimling, A; Wenz, F; Wick, W | 1 |
| Butowski, N; Cha, S; Chang, SM; Essock-Burns, E; Lupo, JM; Molinaro, AM; Nelson, SJ | 2 |
| Butman, JA; Fine, HA; Fraum, TJ; Iwamoto, FM; Kreisl, TN; Li, A; Moustakas, A; Odia, Y; Salgado, CA; Sul, J | 1 |
| Butowski, N; Cha, S; Chang, S; Crane, J; Kadambi, AK; Li, Y; Molinaro, A; Nelson, SJ; Olson, M; Park, I; Roy, R | 1 |
| Frank, B; Lemke, D; Maurer, G; Rieger, J; Tabatabai, G; Weiler, M; Weller, M; Wick, W | 1 |
| Buckner, JC; Galanis, E | 1 |
| Carpentier, AF; Chamberlain, MC; Cher, LM; Fine, HA; Hong, S; Liepa, AM; Mason, W; Musib, L; Puduvalli, VK; Thornton, DE; van den Bent, MJ; Weller, M; Wick, W | 1 |
| Albert, PS; Butman, JA; Fine, HA; Kim, L; Kotliarova, S; Kreisl, TN; Musib, L; Thornton, D | 1 |
| Butowski, N; Chang, SM; Hristova-Kazmierski, M; Lamborn, KR; Musib, L; Nicol, SJ; Parvataneni, R; Polley, MY; Prados, MD; Thornton, DE | 1 |
| Butowski, NA; Cha, S; Chang, SM; Essock-Burns, E; Lupo, JM; Nelson, SJ; Polley, MY | 1 |
| Butowski, N; Chang, SM; Clarke, J; Costa, BM; Costello, JF; Hristova-Kazmierski, M; Hsieh, E; Lamborn, KR; Nicol, SJ; Nicole, A; Parvataneni, R; Pieper, R; Polley, MY; Prados, MD; Reis, RM; Sneed, PK; Thornton, DE; Vandenberg, S | 1 |
| Decker, R; Gharib, M; Gorlia, T; Lacombe, D; Lai, C; Rampling, R; Sanson, M; Stoffregen, C; Taal, W; van den Bent, MJ | 1 |
| Abel, E; Ciuleanu, T; Fløtten, Ø; Grønberg, BH; Hahka-Kemppinen, M; Knuuttila, A; Krejcy, K; Langer, SW; Liepa, AM; Munoz, M; Sundstrøm, S | 1 |
| Christ, G; Frank, B; Heckl, S; Lemke, D; Obermüller, U; Tabatabai, G; von Kürthy, G; Weller, M; Wick, A; Wick, W | 1 |
1 review(s) available for enzastaurin and Brain Neoplasms
| Article | Year |
|---|---|
Molecular biomarker-guided anti-angiogenic targeted therapy for malignant glioma.
Topics: Angiogenesis Inhibitors; Bevacizumab; Biomarkers, Tumor; Brain Neoplasms; Glioma; Humans; Indoles; Molecular Targeted Therapy; Prognosis; Snake Venoms | 2019 |
8 trial(s) available for enzastaurin and Brain Neoplasms
| Article | Year |
|---|---|
Enzastaurin before and concomitant with radiation therapy, followed by enzastaurin maintenance therapy, in patients with newly diagnosed glioblastoma without MGMT promoter hypermethylation.
Topics: Adult; Aged; Brain Neoplasms; Chemoradiotherapy; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Female; Follow-Up Studies; Glioblastoma; Humans; Indoles; Male; Middle Aged; Neoplasm Staging; Prognosis; Promoter Regions, Genetic; Survival Rate; Tumor Suppressor Proteins | 2013 |
A phase II trial of enzastaurin (LY317615) in combination with bevacizumab in adults with recurrent malignant gliomas.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Brain Neoplasms; Female; Follow-Up Studies; Glioma; Glycogen Synthase Kinase 3; Humans; Indoles; Leukocytes, Mononuclear; Male; Middle Aged; Neoplasm Recurrence, Local; Neoplasm Staging; Prognosis; Quality of Life; Survival Rate | 2016 |
Phase III study of enzastaurin compared with lomustine in the treatment of recurrent intracranial glioblastoma.
Topics: Adult; Aged; Brain Neoplasms; Female; Glioblastoma; Humans; Indoles; Lomustine; Male; Middle Aged; Neoplasm Recurrence, Local | 2010 |
A phase I/II trial of enzastaurin in patients with recurrent high-grade gliomas.
Topics: Anticonvulsants; Antineoplastic Agents; Brain Neoplasms; Glioma; Humans; Indoles; Kaplan-Meier Estimate; Neoplasm Recurrence, Local | 2010 |
Enzastaurin plus temozolomide with radiation therapy in glioblastoma multiforme: a phase I study.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cohort Studies; Combined Modality Therapy; Dacarbazine; Female; Glioblastoma; Humans; Indoles; Male; Middle Aged; Temozolomide; Young Adult | 2010 |
Phase II and pharmacogenomics study of enzastaurin plus temozolomide during and following radiation therapy in patients with newly diagnosed glioblastoma multiforme and gliosarcoma.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Brain; Brain Neoplasms; Case-Control Studies; Chemoradiotherapy; Chemotherapy, Adjuvant; Clinical Trials, Phase III as Topic; Dacarbazine; DNA Methylation; DNA, Neoplasm; Female; Follow-Up Studies; Glioblastoma; Gliosarcoma; Humans; Immunoenzyme Techniques; Indoles; Male; Middle Aged; Neoplasm Staging; Pharmacogenetics; Polymerase Chain Reaction; Prospective Studies; Survival Rate; Temozolomide; Treatment Outcome; Young Adult | 2011 |
A phase I study of LY317615 (enzastaurin) and temozolomide in patients with gliomas (EORTC trial 26054).
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Dacarbazine; Female; Glioblastoma; Humans; Indoles; Male; Maximum Tolerated Dose; Middle Aged; Temozolomide; Young Adult | 2012 |
A placebo-controlled, randomized phase II study of maintenance enzastaurin following whole brain radiation therapy in the treatment of brain metastases from lung cancer.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Brain Neoplasms; Disease Progression; Female; Humans; Indoles; Lung Neoplasms; Maintenance Chemotherapy; Male; Middle Aged; Quality of Life; Treatment Outcome | 2012 |
7 other study(ies) available for enzastaurin and Brain Neoplasms
| Article | Year |
|---|---|
The effects of anti-angiogenic therapy on the formation of radiation-induced microbleeds in normal brain tissue of patients with glioma.
Topics: Adult; Aged; Angiogenesis Inhibitors; Brain Neoplasms; Cerebral Hemorrhage; Female; Glioma; Humans; Indoles; Magnetic Resonance Imaging; Male; Middle Aged; Neovascularization, Pathologic; Radiotherapy; Treatment Outcome | 2016 |
Association of early changes in 1H MRSI parameters with survival for patients with newly diagnosed glioblastoma receiving a multimodality treatment regimen.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Choline; Cohort Studies; Combined Modality Therapy; Creatine; Dacarbazine; Female; Follow-Up Studies; Glioblastoma; Humans; Image Processing, Computer-Assisted; Indoles; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Middle Aged; Neoplasm Grading; Prognosis; Radiotherapy, Conformal; Survival Rate; Temozolomide; Tumor Burden | 2017 |
Enzastaurin-induced apoptosis in glioma cells is caspase-dependent and inhibited by BCL-XL.
Topics: Adult; Amino Acid Chloromethyl Ketones; Antineoplastic Agents; Apoptosis; bcl-X Protein; Brain Neoplasms; Caspases; Cell Line, Tumor; Cytochromes c; Drug Resistance, Neoplasm; Enzyme Inhibitors; Glioma; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Indoles; Mitochondria; Protein Kinase C; Proto-Oncogene Proteins c-akt; Receptors, TNF-Related Apoptosis-Inducing Ligand | 2008 |
Enzastaurin in the treatment of recurrent glioblastoma: a promise that did not materialize.
Topics: Brain Neoplasms; Clinical Trials, Phase III as Topic; Glioblastoma; Humans; Indoles; Protein Kinase C; Protein Kinase C beta; Recurrence; Vascular Endothelial Growth Factor Receptor-2 | 2010 |
Assessment of perfusion MRI-derived parameters in evaluating and predicting response to antiangiogenic therapy in patients with newly diagnosed glioblastoma.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemotherapy, Adjuvant; Combined Modality Therapy; Dacarbazine; Disease Progression; Glioblastoma; Humans; Image Processing, Computer-Assisted; Indoles; Magnetic Resonance Imaging; Perfusion; Radiotherapy, Adjuvant; Survival Rate; Temozolomide; Treatment Outcome | 2011 |
Using susceptibility-weighted imaging to determine response to combined anti-angiogenic, cytotoxic, and radiation therapy in patients with glioblastoma multiforme.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Chemoradiotherapy; Dacarbazine; Female; Follow-Up Studies; Glioblastoma; Humans; Image Processing, Computer-Assisted; Indoles; Magnetic Resonance Imaging; Male; Middle Aged; Neoplasm Staging; Prognosis; Survival Rate; Temozolomide | 2013 |
Synergistic antiglioma activity of radiotherapy and enzastaurin.
Topics: Animals; Apoptosis; Brain Neoplasms; Combined Modality Therapy; Glioma; Indoles; Magnetic Resonance Imaging; Mice; Mice, Nude; Neoplasm Transplantation; Protein Kinase C; Protein Kinase C beta; Protein Kinase Inhibitors; Survival Analysis; Up-Regulation; Vascular Endothelial Growth Factor A | 2007 |