entinostat has been researched along with Medulloblastoma in 5 studies
Medulloblastoma: A malignant neoplasm that may be classified either as a glioma or as a primitive neuroectodermal tumor of childhood (see NEUROECTODERMAL TUMOR, PRIMITIVE). The tumor occurs most frequently in the first decade of life with the most typical location being the cerebellar vermis. Histologic features include a high degree of cellularity, frequent mitotic figures, and a tendency for the cells to organize into sheets or form rosettes. Medulloblastoma have a high propensity to spread throughout the craniospinal intradural axis. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2060-1)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Entinostat treatment changed the expression of genes involved in 22 pathways, including downregulation of DNA damage response." | 1.91 | Class I HDAC inhibition reduces DNA damage repair capacity of MYC-amplified medulloblastoma cells. ( Ecker, J; Hielscher, T; Jamaladdin, N; Milde, T; Oehme, I; Peterziel, H; Ridinger, J; Valinciute, G; van Tilburg, CM; Vollmer, J; Witt, O, 2023) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 2 (40.00) | 2.80 |
| Authors | Studies |
|---|---|
| Valinciute, G | 2 |
| Ecker, J | 2 |
| Selt, F | 1 |
| Hielscher, T | 2 |
| Sigaud, R | 1 |
| Ridinger, J | 2 |
| Thatikonda, V | 1 |
| Gatzweiler, C | 1 |
| Robinson, S | 1 |
| Talbot, J | 1 |
| Bernardi, F | 1 |
| Picard, D | 1 |
| Blattner-Johnson, M | 1 |
| Schmid, S | 1 |
| Jones, DT | 1 |
| van Tilburg, CM | 2 |
| Capper, D | 1 |
| Kool, M | 1 |
| Remke, M | 1 |
| Oehme, I | 2 |
| Pfister, SM | 1 |
| Roussel, MF | 1 |
| Ayrault, O | 1 |
| Witt, O | 2 |
| Milde, T | 2 |
| Vollmer, J | 1 |
| Jamaladdin, N | 1 |
| Peterziel, H | 1 |
| Aguilera, DG | 1 |
| Das, CM | 1 |
| Sinnappah-Kang, ND | 1 |
| Joyce, C | 1 |
| Taylor, PH | 1 |
| Wen, S | 1 |
| Hasselblatt, M | 1 |
| Paulus, W | 1 |
| Fuller, G | 1 |
| Wolff, JE | 1 |
| Gopalakrishnan, V | 1 |
| Häcker, S | 1 |
| Dittrich, A | 1 |
| Mohr, A | 1 |
| Schweitzer, T | 1 |
| Rutkowski, S | 1 |
| Krauss, J | 1 |
| Debatin, KM | 1 |
| Fulda, S | 1 |
| Nesterenko, I | 1 |
| Wanningen, S | 1 |
| Bagci-Onder, T | 1 |
| Anderegg, M | 1 |
| Shah, K | 1 |
5 other studies available for entinostat and Medulloblastoma
| Article | Year |
|---|---|
Class I HDAC inhibitor entinostat synergizes with PLK1 inhibitors in MYC-amplified medulloblastoma cells.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cerebellar Neoplasms; Histone Deacetylase Inhibito | 2023 |
Class I HDAC inhibition reduces DNA damage repair capacity of MYC-amplified medulloblastoma cells.
Topics: Cell Line, Tumor; Cerebellar Neoplasms; Child; DNA Damage; Histone Deacetylase Inhibitors; Humans; M | 2023 |
Reactivation of death receptor 4 (DR4) expression sensitizes medulloblastoma cell lines to TRAIL.
Topics: Apoptosis; Benzamides; Blotting, Western; Caspase 8; Cell Line, Tumor; Cerebellar Neoplasms; Enzyme | 2009 |
Histone deacetylase inhibitors cooperate with IFN-gamma to restore caspase-8 expression and overcome TRAIL resistance in cancers with silencing of caspase-8.
Topics: Benzamides; Caspase 8; Cell Line, Tumor; Cell Survival; Cerebellar Neoplasms; Drug Combinations; Dru | 2009 |
Evaluating the effect of therapeutic stem cells on TRAIL resistant and sensitive medulloblastomas.
Topics: Animals; Apoptosis; Benzamides; Cerebellar Neoplasms; Drug Carriers; Drug Resistance, Neoplasm; Gene | 2012 |