entinostat has been researched along with Leukemia in 11 studies
Leukemia: A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 7 (63.64) | 29.6817 |
| 2010's | 3 (27.27) | 24.3611 |
| 2020's | 1 (9.09) | 2.80 |
| Authors | Studies |
|---|---|
| Li, X | 1 |
| Zhang, Y | 1 |
| Jiang, Y | 1 |
| Wu, J | 1 |
| Inks, ES | 1 |
| Chou, CJ | 1 |
| Gao, S | 2 |
| Hou, J | 1 |
| Ding, Q | 1 |
| Li, J | 1 |
| Wang, X | 1 |
| Huang, Y | 1 |
| Xu, W | 1 |
| Alves Avelar, LA | 1 |
| Schrenk, C | 1 |
| Sönnichsen, M | 1 |
| Hamacher, A | 1 |
| Hansen, FK | 1 |
| Schliehe-Diecks, J | 1 |
| Borkhardt, A | 1 |
| Bhatia, S | 1 |
| Kassack, MU | 1 |
| Kurz, T | 1 |
| Kettyle, LM | 1 |
| Liberante, FG | 1 |
| Thompson, A | 1 |
| Noack, K | 1 |
| Mahendrarajah, N | 1 |
| Hennig, D | 1 |
| Schmidt, L | 1 |
| Grebien, F | 1 |
| Hildebrand, D | 1 |
| Christmann, M | 1 |
| Kaina, B | 1 |
| Sellmer, A | 1 |
| Mahboobi, S | 1 |
| Kubatzky, K | 1 |
| Heinzel, T | 1 |
| Krämer, OH | 1 |
| Vire, B | 1 |
| de Walque, S | 1 |
| Restouin, A | 1 |
| Olive, D | 1 |
| Van Lint, C | 1 |
| Collette, Y | 1 |
| Rosato, RR | 2 |
| Almenara, JA | 1 |
| Grant, S | 3 |
| Maggio, SC | 1 |
| Kramer, LB | 1 |
| Dai, Y | 2 |
| Rahmani, M | 2 |
| Paik, DS | 1 |
| Czarnik, AC | 1 |
| Payne, SG | 1 |
| Spiegel, S | 1 |
| Acharya, MR | 1 |
| Figg, WD | 2 |
| Dent, P | 1 |
| Gojo, I | 1 |
| Jiemjit, A | 1 |
| Trepel, JB | 1 |
| Sparreboom, A | 1 |
| Rollins, S | 1 |
| Tidwell, ML | 1 |
| Greer, J | 1 |
| Chung, EJ | 1 |
| Lee, MJ | 1 |
| Gore, SD | 1 |
| Sausville, EA | 1 |
| Zwiebel, J | 1 |
| Karp, JE | 1 |
| Mobley, A | 1 |
| Miller, C | 1 |
| Boklan, J | 1 |
| Chandra, J | 1 |
1 trial available for entinostat and Leukemia
| Article | Year |
|---|---|
Phase 1 and pharmacologic study of MS-275, a histone deacetylase inhibitor, in adults with refractory and relapsed acute leukemias.
Topics: Acetylation; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Benzamides; Enzyme Inhibitors; F | 2007 |
10 other studies available for entinostat and Leukemia
| Article | Year |
|---|---|
Selective HDAC inhibitors with potent oral activity against leukemia and colorectal cancer: Design, structure-activity relationship and anti-tumor activity study.
Topics: Animals; Antineoplastic Agents; Benzamides; Cell Proliferation; Colon; Colorectal Neoplasms; HCT116 | 2017 |
Synergistic induction of apoptosis in resistant head and neck carcinoma and leukemia by alkoxyamide-based histone deacetylase inhibitors.
Topics: Antineoplastic Agents; Apoptosis; Drug Synergism; Epigenomics; Head and Neck Neoplasms; Histone Deac | 2021 |
Rational drug repurposing using sscMap analysis in a HOX-TALE model of leukemia.
Topics: Animals; Antineoplastic Agents; Benzamides; Cell Line, Tumor; Databases, Genetic; Disease Models, An | 2014 |
Analysis of the interplay between all-trans retinoic acid and histone deacetylase inhibitors in leukemic cells.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Benzamides; CCAAT-Enhancer-Binding Protei | 2017 |
Anti-leukemia activity of MS-275 histone deacetylase inhibitor implicates 4-1BBL/4-1BB immunomodulatory functions.
Topics: 4-1BB Ligand; Antineoplastic Agents; Benzamides; Cell Proliferation; Gene Expression Regulation, Leu | 2009 |
The histone deacetylase inhibitor MS-275 promotes differentiation or apoptosis in human leukemia cells through a process regulated by generation of reactive oxygen species and induction of p21CIP1/WAF1 1.
Topics: Apoptosis; Benzamides; Cell Cycle; Cell Differentiation; Cell Division; Cyclin-Dependent Kinase Inhi | 2003 |
The histone deacetylase inhibitor MS-275 interacts synergistically with fludarabine to induce apoptosis in human leukemia cells.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Benzamides; Caspases; Cell Cycle; Cell Cy | 2004 |
Histone deacetylase inhibitor enhances the anti-leukemic activity of an established nucleoside analogue.
Topics: Antineoplastic Agents; Apoptosis; Benzamides; Cell Cycle; Cell Cycle Proteins; DNA (Cytosine-5-)-Met | 2004 |
Blockade of histone deacetylase inhibitor-induced RelA/p65 acetylation and NF-kappaB activation potentiates apoptosis in leukemia cells through a process mediated by oxidative damage, XIAP downregulation, and c-Jun N-terminal kinase 1 activation.
Topics: Acetylation; Apoptosis; Benzamides; Down-Regulation; Enzyme Activation; Enzyme Inhibitors; Gene Expr | 2005 |
Potentiation of reactive oxygen species is a marker for synergistic cytotoxicity of MS-275 and 5-azacytidine in leukemic cells.
Topics: Acetylation; Antimetabolites, Antineoplastic; Apoptosis; Azacitidine; Benzamides; Biomarkers; Caspas | 2008 |