entinostat has been researched along with Brain Ischemia in 2 studies
Brain Ischemia: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We used the mouse model of transient middle cerebral artery occlusion (MCAO) and primary cortical neurons exposed to oxygen glucose deprivation (OGD)." | 1.39 | Targeted acetylation of NF-kappaB/RelA and histones by epigenetic drugs reduces post-ischemic brain injury in mice with an extended therapeutic window. ( Annunziato, L; Benarese, M; Branca, C; Cuomo, O; Lanzillotta, A; Pignataro, G; Pizzi, M; Sarnico, I; Spano, P, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Murphy, SP | 1 |
| Lee, RJ | 1 |
| McClean, ME | 1 |
| Pemberton, HE | 1 |
| Uo, T | 1 |
| Morrison, RS | 1 |
| Bastian, C | 1 |
| Baltan, S | 1 |
| Lanzillotta, A | 1 |
| Pignataro, G | 1 |
| Branca, C | 1 |
| Cuomo, O | 1 |
| Sarnico, I | 1 |
| Benarese, M | 1 |
| Annunziato, L | 1 |
| Spano, P | 1 |
| Pizzi, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Clinical, Neurophysiological and Genetical Predictors of Consciousness Recovery and Functional Outcomes After Severe Acquired Brain Injuries[NCT04495192] | 520 participants (Anticipated) | Observational [Patient Registry] | 2020-06-09 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 other studies available for entinostat and Brain Ischemia
| Article | Year |
|---|---|
MS-275, a class I histone deacetylase inhibitor, protects the p53-deficient mouse against ischemic injury.
Topics: Action Potentials; Animals; Benzamides; Blotting, Western; Brain Ischemia; Disease Models, Animal; H | 2014 |
Targeted acetylation of NF-kappaB/RelA and histones by epigenetic drugs reduces post-ischemic brain injury in mice with an extended therapeutic window.
Topics: Acetylation; Animals; Benzamides; Brain; Brain Ischemia; Cell Hypoxia; Disease Models, Animal; Epige | 2013 |