entacapone and Disorders-of-Excessive-Somnolence

entacapone has been researched along with Disorders-of-Excessive-Somnolence* in 2 studies

Other Studies

2 other study(ies) available for entacapone and Disorders-of-Excessive-Somnolence

Article	Year
Excessive daytime sleepiness and 'sleep attacks' induced by entacapone. Fundamental & clinical pharmacology, 2003, Volume: 17, Issue:1 Three patients with advanced Parkinson's disease, all of whom developed excessive daytime sleepiness and 'sleep attacks' after the administration of entacapone, are described. This is another demonstration that inappropriate daytime sleep episodes are not exclusive to dopamine agonists. Topics: Aged; Antiparkinson Agents; Catechols; Disorders of Excessive Somnolence; Female; Humans; Male; Middle Aged; Nitriles; Parkinson Disease; Sleep Disorders, Circadian Rhythm	2003
Sleep attacks in Parkinson's disease induced by Entacapone, a COMT-inhibitor. Fundamental & clinical pharmacology, 2003, Volume: 17, Issue:1 We present a patient who suffered from sleep attacks after starting entacapone in addition to levodopa. Entacapone, a catechol-O-methyl transferase inhibitor, alters the pharmacokinetics of levodopa, leading to increase of levodopa concentration in plasma and brain. This mechanism is suspected to be involved in the pathophysiology of sleep attacks in this case. Topics: Aged; Antiparkinson Agents; Catechol O-Methyltransferase Inhibitors; Catechols; Disorders of Excessive Somnolence; Humans; Male; Nitriles; Parkinson Disease; Sleep Disorders, Circadian Rhythm	2003

Article

Year

Excessive daytime sleepiness and 'sleep attacks' induced by entacapone.

Fundamental & clinical pharmacology, 2003, Volume: 17, Issue:1

Three patients with advanced Parkinson's disease, all of whom developed excessive daytime sleepiness and 'sleep attacks' after the administration of entacapone, are described. This is another demonstration that inappropriate daytime sleep episodes are not exclusive to dopamine agonists.

Topics: Aged; Antiparkinson Agents; Catechols; Disorders of Excessive Somnolence; Female; Humans; Male; Middle Aged; Nitriles; Parkinson Disease; Sleep Disorders, Circadian Rhythm

2003

Sleep attacks in Parkinson's disease induced by Entacapone, a COMT-inhibitor.

Fundamental & clinical pharmacology, 2003, Volume: 17, Issue:1

We present a patient who suffered from sleep attacks after starting entacapone in addition to levodopa. Entacapone, a catechol-O-methyl transferase inhibitor, alters the pharmacokinetics of levodopa, leading to increase of levodopa concentration in plasma and brain. This mechanism is suspected to be involved in the pathophysiology of sleep attacks in this case.

Topics: Aged; Antiparkinson Agents; Catechol O-Methyltransferase Inhibitors; Catechols; Disorders of Excessive Somnolence; Humans; Male; Nitriles; Parkinson Disease; Sleep Disorders, Circadian Rhythm

2003