ent-dextilidine and Body-Weight

Topics: Body Weight; Child; Child, Preschool; Humans; Infant; Tilidine

The carcinogenic potential of tilidine fumarate, a synthetic analgesic, was studied for 80 and 104 weeks in mice and rats, respectively. Groups of 50 albino CF1 mice and 65 albino Wistar rats of each sex received tilidine fumarate-lactose blend (1:1) at doses of 100, 40 and 16 mg/kg. The control groups consisted of 100 mice and 115 rats of each sex and received the lactose vehicle only. Treatment-related non-neoplastic changes consisted of reversible, increased cytoplasmic eosinophilia of hepatocytes in high and mid dose rats corresponding to areas of proliferating smooth endoplasmic reticulum; and an increased incidence in high dose rats of proliferative or cystic lesions of the biliary epithelium. Adequate survival rates allowed stringent statistical analysis of neoplasia. Tilidine did not evoke increased tumor incidences or changes in the average latency or onset of tumors in either species. The most frequent tumors represented spontaneous neoplasia characteristic of historical background incidence in these strains. In mice, the only statistically significant (P less than 0.01) variation in tumor incidence was an increased rate of lung alveologenic adenocarcinomas in females at 100 mg/kg (24%), compared with the concurrent untreated controls (10%), but without a statistically significant difference from historical control data (27%). Female rats given 100 mg/kg showed statistically significant (P less than 0.01) decreased incidences of mammary fibroadenoma and pituitary adenoma. From these data, it was concluded that the synthetic analgesic tilidine does not possess tumorigenic potential in rodents.

Topics: Administration, Oral; Animals; Body Weight; Carcinogens; Cyclohexanecarboxylic Acids; Drug Evaluation, Preclinical; Female; Kidney; Liver; Male; Mice; Neoplasms, Experimental; Organ Size; Rats; Rats, Inbred Strains; Sex Factors; Species Specificity; Tilidine

Topics: Animals; Body Weight; Cyclohexanecarboxylic Acids; Drinking; Drug Interactions; Drug Tolerance; Female; Male; Morphine; Rats; Reaction Time; Tilidine; Time Factors