enprostil has been researched along with Achlorhydria* in 1 studies
1 trial(s) available for enprostil and Achlorhydria
| Article | Year |
|---|---|
Effect of a single oral dose of enprostil on gastric secretion and gastrin release. Studies in healthy volunteers and patients with pernicious anemia.
In healthy human volunteers, a single oral dose of enprostil (35 micrograms) inhibited basal gastric acid output by a mean of 71 percent, pentagastrin-stimulated output by 46 percent, sham-meal-stimulated output by 48 percent, and histamine-stimulated output by 16 percent. In each case, there was a reduction in both the volume and acidity of the gastric juice. Pepsin output was unchanged. Although enprostil increased the gastric pH, it did not induce basal or post-prandial hypergastrinemia. In patients with hypergastrinemia secondary to achlorhydria, enprostil lowered the basal gastrin level and reduced or abolished the post-prandial gastrin rise in a dose-related fashion. Enprostil reduces basal and stimulated gastric acid secretion and inhibits gastrin release. Topics: Achlorhydria; Adult; Anemia, Pernicious; Enprostil; Gastric Acid; Gastric Juice; Gastrins; Histamine; Humans; Hydrogen-Ion Concentration; Male; Pentagastrin; Pepsin A; Prostaglandins E, Synthetic | 1986 |