enoxacin has been researched along with Seizures in 18 studies
Enoxacin: A broad-spectrum 6-fluoronaphthyridinone antibacterial agent that is structurally related to NALIDIXIC ACID.
enoxacin : A 1,8-naphthyridine derivative that is 1,4-dihydro-1,8-naphthyridine with an ethyl group at the 1 position, a carboxy group at the 3-position, an oxo sustituent at the 4-position, a fluoro substituent at the 5-position and a piperazin-1-yl group at the 7 position. An antibacterial, it is used in the treatment of urinary-tract infections and gonorrhoea.
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| ", doses of individual drugs) that induced seizure-like events, and identified diphenhydramine, enoxacin, strychnine and theophylline as "seizure-inducing" drugs, which have indeed been reported to induce seizures in clinical situations." | 4.98 | [Machine Learning-based Prediction of Seizure-inducing Action as an Adverse Drug Effect]. ( Gao, M; Ikegaya, Y; Sato, M, 2018) |
| " Nicardipine remarkably inhibited epileptic seizures induced by combined treatment with enoxacin (p." | 3.69 | Epileptogenic activity induced by combined treatment with antiinflammatory drugs and enoxacin and its inhibition by a calcium antagonist, nicardipine. ( Kamei, C; Kitazumi, K; Ohishi, H; Okumura, Y; Sugimoto, Y, 1996) |
| "The clinical risk of convulsion for each combination was estimated using a pharmacodynamic model based on receptor occupancy using the in vitro data set obtained and pharmacokinetic parameters in humans collected from the literature." | 1.35 | Quantitative comparison of the convulsive activity of combinations of twelve fluoroquinolones with five nonsteroidal antiinflammatory agents. ( Kim, J; Ohtani, H; Sawada, Y; Tsujimoto, M, 2009) |
| "Convulsant activity of pazufloxacin mesilate (PZFX mesilate), a new quinolone antibacterial agent for intravenous use, in combination with nonsteroidal anti-inflammatory drug (NSAID) was investigated in mice after intravenous or intracerebroventricular administration." | 1.31 | [Drug interactions between nonsteroidal anti-inflammatory drug and pazufloxacin mesilate, a new quinolone antibacterial agent for intravenous use: convulsions in mice after intravenous or intracerebroventricular administration]. ( Fukuda, H; Kawamura, Y, 2002) |
| "We experienced a case of convulsion following the combination of single oral administration of enoxacine before an emergency operation and single postoperative intravenous administration of flurbiprofen axetil." | 1.31 | [Convulsion following the combination of single preoperative oral administration of enoxacine and single postoperative intravenous administration of flurbiprofen axetil]. ( Kaneko, A; Machida, K; Mizuno, J; Sugimoto, S; Tsutsui, T; Zushi, N, 2001) |
| "CSF concentration of ENX at the time of convulsion in clinical situation approximated the IC50 of ENX for the GABA response." | 1.30 | Inhibitory effect of new quinolones on GABA(A) receptor-mediated response and its potentiation with felbinac in Xenopus oocytes injected with mouse-brain mRNA: correlation with convulsive potency in vivo. ( Asanuma, A; Iga, T; Kawakami, J; Sawada, Y; Yamamoto, K; Yanagisawa, K, 1997) |
| "1." | 1.30 | Role of nitric oxide in the convulsive seizures induced by fluoroquinolones coadministered with 4-biphenyl acetic acid. ( Fujimura, H; Kohno, K; Niwa, M; Nozaki, M; Uematsu, T, 1997) |
| "The suppression of the convulsions by 7-nitroindazole was not reversed by the pretreatment of L-arginine." | 1.30 | Role of nitric oxide in the convulsions following the coadministration of enoxacin with fenbufen in mice. ( Masukawa, T; Nakanishi, K; Natsuki, R, 1998) |
| "The effects of drugs on the convulsions induced by the combination of a new quinolone antimicrobial, enoxacin, and a nonsteroidal anti-inflammatory drug, fenbufen, were studied in mice." | 1.28 | [Effects of drugs on the convulsions induced by the combination of a new quinolone antimicrobial, enoxacin, and a nonsteroidal anti-inflammatory drug, fenbufen, in mice]. ( Ally, A; Hara, Y; Murayama, S; Suzuki, T, 1992) |
| "Mice were observed for convulsions for 90 minutes after the administration of temafloxacin HCl (100 mg/kg orally [p." | 1.28 | Assessment of temafloxacin neurotoxicity in rodents. ( Giardina, WJ, 1991) |
| "Concomitant use of the bronchodilator theophylline and the antibacterial agent enoxacin has been associated with significant neurologic and other adverse effects." | 1.28 | Effect of enoxacin on theophylline neurotoxicity. ( Hoffman, A; Levy, G, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (16.67) | 18.7374 |
| 1990's | 10 (55.56) | 18.2507 |
| 2000's | 3 (16.67) | 29.6817 |
| 2010's | 2 (11.11) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gao, M | 2 |
| Sato, M | 1 |
| Ikegaya, Y | 2 |
| Igata, H | 1 |
| Takeuchi, A | 1 |
| Sato, K | 1 |
| Kim, J | 1 |
| Ohtani, H | 1 |
| Tsujimoto, M | 1 |
| Sawada, Y | 2 |
| Fukuda, H | 2 |
| Kawamura, Y | 1 |
| Taniguchi, Y | 1 |
| Deguchi, Y | 1 |
| Noda, K | 1 |
| Kamei, C | 1 |
| Sugimoto, Y | 1 |
| Ohishi, H | 1 |
| Okumura, Y | 1 |
| Kitazumi, K | 1 |
| Masukawa, T | 2 |
| Nakanishi, K | 2 |
| Kawakami, J | 1 |
| Yamamoto, K | 1 |
| Asanuma, A | 1 |
| Yanagisawa, K | 1 |
| Iga, T | 1 |
| Kohno, K | 1 |
| Niwa, M | 2 |
| Nozaki, M | 1 |
| Uematsu, T | 1 |
| Fujimura, H | 1 |
| Natsuki, R | 1 |
| Ito, Y | 1 |
| Ishige, K | 1 |
| Aizawa, M | 1 |
| Mizuno, J | 1 |
| Sugimoto, S | 1 |
| Kaneko, A | 1 |
| Tsutsui, T | 2 |
| Zushi, N | 1 |
| Machida, K | 1 |
| Hara, Y | 1 |
| Ally, A | 1 |
| Suzuki, T | 1 |
| Murayama, S | 1 |
| Motomura, M | 1 |
| Kataoka, Y | 1 |
| Takeo, G | 1 |
| Shibayama, K | 1 |
| Ohishi, K | 1 |
| Nakamura, T | 1 |
| Tsujihata, M | 1 |
| Nagataki, S | 1 |
| Giardina, WJ | 1 |
| Hoffman, A | 1 |
| Levy, G | 1 |
| Simpson, KJ | 1 |
| Brodie, MJ | 1 |
| Morita, H | 1 |
| Maemura, K | 1 |
| Sakai, Y | 1 |
| Kaneda, Y | 1 |
1 review available for enoxacin and Seizures
| Article | Year |
|---|---|
[Machine Learning-based Prediction of Seizure-inducing Action as an Adverse Drug Effect].
Topics: Animals; Diphenhydramine; Drug Discovery; Drug Evaluation, Preclinical; Drug-Related Side Effects an | 2018 |
17 other studies available for enoxacin and Seizures
| Article | Year |
|---|---|
Machine learning-based prediction of adverse drug effects: An example of seizure-inducing compounds.
Topics: Animals; CA1 Region, Hippocampal; Diphenhydramine; Enoxacin; In Vitro Techniques; Male; Mice; Mice, | 2017 |
Quantitative comparison of the convulsive activity of combinations of twelve fluoroquinolones with five nonsteroidal antiinflammatory agents.
Topics: Animals; Anti-Bacterial Agents; Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Cipr | 2009 |
[Drug interactions between nonsteroidal anti-inflammatory drug and pazufloxacin mesilate, a new quinolone antibacterial agent for intravenous use: convulsions in mice after intravenous or intracerebroventricular administration].
Topics: Administration, Oral; Animals; Anti-Bacterial Agents; Anti-Infective Agents; Anti-Inflammatory Agent | 2002 |
Interaction between enoxacin, a new antimicrobial, and nimesulide, a new non-steroidal anti-inflammatory agent in mice.
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Drug Interactions; Enoxacin | 1996 |
Epileptogenic activity induced by combined treatment with antiinflammatory drugs and enoxacin and its inhibition by a calcium antagonist, nicardipine.
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; A | 1996 |
Circadian variation in enoxacin-induced convulsions in mice coadministered with fenbufen.
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Brain; Circadian Rhythm; Dr | 1997 |
Inhibitory effect of new quinolones on GABA(A) receptor-mediated response and its potentiation with felbinac in Xenopus oocytes injected with mouse-brain mRNA: correlation with convulsive potency in vivo.
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Bicuculline; Brain Chemistr | 1997 |
Role of nitric oxide in the convulsive seizures induced by fluoroquinolones coadministered with 4-biphenyl acetic acid.
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Ciprofloxacin; Convulsants; | 1997 |
Role of nitric oxide in the convulsions following the coadministration of enoxacin with fenbufen in mice.
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Brain; Enoxacin; Enzyme Inh | 1998 |
Characterization of quinolone antibacterial-induced convulsions and increases in nuclear AP-1 DNA- and CRE-binding activities in mouse brain.
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Brain; Cyclic AMP Receptor | 1999 |
[Convulsion following the combination of single preoperative oral administration of enoxacine and single postoperative intravenous administration of flurbiprofen axetil].
Topics: Administration, Oral; Aged; Analgesics; Anti-Infective Agents; Enoxacin; Female; Flurbiprofen; Human | 2001 |
[Effects of drugs on the convulsions induced by the combination of a new quinolone antimicrobial, enoxacin, and a nonsteroidal anti-inflammatory drug, fenbufen, in mice].
Topics: Amino Acids; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Diazepam; Dizocilpin | 1992 |
Hippocampus and frontal cortex are the potential mediatory sites for convulsions induced by new quinolones and non-steroidal anti-inflammatory drugs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cerebral Cortex; Drug Combinations; Enoxacin; Hipp | 1991 |
Assessment of temafloxacin neurotoxicity in rodents.
Topics: Animals; Anti-Infective Agents; Central Nervous System; Ciprofloxacin; Enoxacin; Fluoroquinolones; M | 1991 |
Effect of enoxacin on theophylline neurotoxicity.
Topics: Animals; Body Temperature; Body Weight; Chromatography, High Pressure Liquid; Drug Interactions; Eno | 1989 |
Convulsions related to enoxacin.
Topics: Adolescent; Anti-Infective Agents; Enoxacin; Humans; Male; Naphthyridines; Seizures | 1985 |
[A case of convulsion, loss of consciousness and subsequent acute renal failure caused by enoxacin and fenbufen].
Topics: Acute Kidney Injury; Adult; Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Consciou | 1988 |