enkephalin-met--ala(2)- and Fever

enkephalin-met--ala(2)- has been researched along with Fever* in 1 studies

Other Studies

1 other study(ies) available for enkephalin-met--ala(2)- and Fever

Article	Year
The effect of intracerebroventricular infusion of morphine, methionine-enkephalin and D-Ala2-enkephalinamide on body temperature of rabbits. Archives internationales de physiologie et de biochimie, 1982, Volume: 90, Issue:1 The effect of intracerebroventricular infusions of two synthetically obtained peptides: Met-enkephalin hydrochloride and D-Ala2-Met-enkephalinamide hydrochloride, and of morphine hydrochloride on rectal temperature was investigated in conscious rabbits. Morphine hydrochloride in a dose of 240 micrograms and D-Ala2-Met-enkephalinamide hydrochloride in doses of 240 and 3000 micrograms produced a hyperthermia which was accompanied by ear vasoconstriction and shivering. No such effect ensued after Met-enkephalin, possibly due to rapid enzymatic degradation of this compound. The concept of opioid involvement in the central thermoregulatory mechanism is discussed. Topics: Animals; Body Temperature Regulation; Endorphins; Enkephalin, Methionine; Enkephalins; Female; Fever; Injections, Intraventricular; Male; Morphine; Rabbits; Shivering; Vasoconstriction	1982

Article

Year

The effect of intracerebroventricular infusion of morphine, methionine-enkephalin and D-Ala2-enkephalinamide on body temperature of rabbits.

Archives internationales de physiologie et de biochimie, 1982, Volume: 90, Issue:1

The effect of intracerebroventricular infusions of two synthetically obtained peptides: Met-enkephalin hydrochloride and D-Ala2-Met-enkephalinamide hydrochloride, and of morphine hydrochloride on rectal temperature was investigated in conscious rabbits. Morphine hydrochloride in a dose of 240 micrograms and D-Ala2-Met-enkephalinamide hydrochloride in doses of 240 and 3000 micrograms produced a hyperthermia which was accompanied by ear vasoconstriction and shivering. No such effect ensued after Met-enkephalin, possibly due to rapid enzymatic degradation of this compound. The concept of opioid involvement in the central thermoregulatory mechanism is discussed.

Topics: Animals; Body Temperature Regulation; Endorphins; Enkephalin, Methionine; Enkephalins; Female; Fever; Injections, Intraventricular; Male; Morphine; Rabbits; Shivering; Vasoconstriction

1982