enkephalin-leu--ala(2)-arg(6)- has been researched along with Reperfusion-Injury* in 1 studies
1 other study(ies) available for enkephalin-leu--ala(2)-arg(6)- and Reperfusion-Injury
| Article | Year |
|---|---|
Effect of opiate peptide dalargin and des-Tyr-dalargin on cardiac pump function during ischemia-reperfusion.
Experiments on isolated perfused rat heart showed that nonselective micro- and delta-opiate receptor agonist dalargin decreased contractility of the intact heart, but had no effect on pump function of the ischemic myocardium. Dalargin analogue des-Tyr-dalargin not binding to opiate receptors decreased contractility of intact myocardium and isolated heart exposed to 45-min total ischemia. We hypothesize that the influence of dalargin is related to activation of cardiac delta-opiate receptors, while the inotropic effect of des-Tyr-dalargin is mediated by other receptors. Topics: Animals; Enkephalin, Leucine-2-Alanine; Heart; In Vitro Techniques; Myocardial Contraction; Rats; Reperfusion Injury; Ventricular Pressure | 2004 |