enkephalin, leucine has been researched along with Neuroblastoma in 216 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 114 (52.78) | 18.7374 |
| 1990's | 93 (43.06) | 18.2507 |
| 2000's | 6 (2.78) | 29.6817 |
| 2010's | 3 (1.39) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Abagyan, A; Funkelstein, L; Hook, V; Mosier, C; Toneff, T; Ziegler, M | 1 |
| Asahi, T; Sawamura, N; Wada, T | 1 |
| Ammer, H; Eisinger, DA; Heiss, A | 1 |
| Candeletti, S; D'Addario, C; Ekström, TJ; Johansson, S; Ögren, SO; Romualdi, P; Terenius, L | 1 |
| Koob, GF; Lipkin, WI; Solbrig, MV | 1 |
| Campos, D; Carrión, AM; Jiménez-Díaz, L | 1 |
| Lentzen, H; Linke, J; Reinsch, I | 1 |
| Dawson, G; McLawhon, RW; Miller, RJ; West, RE | 2 |
| Berry-Kravis, E; Dawson, G | 3 |
| Herken, H | 1 |
| Brandt, M; Buchen, C; Hamprecht, B | 1 |
| Chang, KJ; Cuatrecasas, P; Hazum, E | 5 |
| Law, PY; Loh, HH; Nicksic, TD | 1 |
| Hamprecht, B; Propst, F | 1 |
| Kimura, S; Lewis, RV; Rossier, J; Stein, S; Stern, AS; Udenfriend, S | 1 |
| Ferrara, P; Hammonds, RG; Li, CH | 2 |
| Hullihan, J; Jones, BN; Kilpatrick, DL; Kimura, S; Shively, JE; Stein, S; Stern, AS; Taniguchi, T; Udenfriend, S | 1 |
| Brandt, M; Hamprecht, B; Löffler, F; Propst, F; van Calker, D | 1 |
| Glaser, T; Hamprecht, B; Hübner, K | 3 |
| Chang, KJ; Cuatrecasas, P; Hazum, E; Killian, A | 1 |
| Blume, AJ; Fantozzi, R; Mullikin-Kilpatrick, D | 1 |
| Gilbert, JA; Knodel, EL; Richelson, E; Stenstrom, SD | 1 |
| Dawson, G; McLawhon, RW; Schoon, GS | 1 |
| de Castiglione, R; Glaser, T; Hamprecht, B; Hübner, K | 1 |
| Blanchard, SG; Chang, KJ; Eckel, RW | 1 |
| Costa, T; English, ML; Shimohigashi, Y; Stammer, CH | 1 |
| Dornay, M; Simantov, R | 1 |
| Koehler, JE; Law, PY; Loh, HH | 1 |
| Costa, T; Krumins, SA; Munson, PJ; Rodbard, D; Shimohigashi, Y | 1 |
| Baram, D; Simantov, R | 1 |
| Costa, T; Krumins, SA; Rodbard, D | 1 |
| Baram, D; Levy, R; Simantov, R | 1 |
| Blume, AJ; Larsen, NE; Mullikin-Kilpatrick, D | 1 |
| Costa, T; Gramsch, C; Wüster, M | 1 |
| Akiyama, K; Burks, TF; Galligan, JJ; Gee, K; Hruby, VJ; Hurst, R; Mosberg, HI; Yamamura, HI | 1 |
| Blanchard, SG; Chang, KJ; Cuatrecasas, P | 2 |
| Dawson, G; Lockney, MW; Scheideler, MA | 1 |
| Knodel, EL; Richelson, E | 1 |
| Deslauriers, R; Griffith, DW; Jarrell, HC; McGregor, WH; Smith, IC | 1 |
| Dawson, G; McLawhon, R; Miller, RJ | 2 |
| Medzihradsky, F; Yabaluri, N | 1 |
| Chang, KJ; Chung, NN; Lee, PH; Nguyen, TM; Schiller, PW | 1 |
| Chakrabarti, S; Law, PY; Loh, HH | 2 |
| Fukuda, K; Higashida, H; Kato, S; Mori, K; Morikawa, H | 1 |
| Kushner, L; Tamir, M | 1 |
| Cruciani, RA; Dvorkin, B; Klinger, HP; Makman, MH | 1 |
| Nahorski, SR; Traynor, JR | 1 |
| Elliott, J; Lambert, DG; Smart, D; Traynor, JR | 2 |
| Friederich, P; Hescheler, J; Nürnberg, B; Schultz, G | 1 |
| Jauzac, P; Polastron, J | 1 |
| Bakalkin, G; Terenius, L; Yakovleva, T | 1 |
| Law, PY; Prather, PL; Tsai, AW | 1 |
| Cox, BM; Kiang, JG; Tang, T | 1 |
| Garty, M; Keren, O; Sarne, Y | 1 |
| Graeser, D; Neubig, RR | 1 |
| Carter, BD; Medzihradsky, F | 2 |
| Atcheson, R; Lambert, DG; Rowbotham, DJ | 1 |
| Lambert, DG; Smart, D; Smith, G | 1 |
| Balsam, LB; Chu, HM; Comb, MJ; Kobierski, LA; Tan, Y | 1 |
| Jin, W; Lee, NM; Loh, HH; Thayer, SA | 2 |
| Ammer, H; Schulz, R | 1 |
| Kondo, Y; Okajima, F; Tomura, H | 2 |
| Laugwitz, KL; Offermanns, S; Schultz, G; Spicher, K | 1 |
| Crain, SM; Fan, SF; Shen, KF | 1 |
| Agarwal, D; Glasel, JA | 1 |
| Baumhaker, Y; Goldstein, MN; Sarne, Y; Wollman, Y | 1 |
| Han, JS; Ren, MF; Shun, XJ; Wang, JF; Yang, HF | 1 |
| Baumhaker, Y; Gafni, M; Keren, O; Sarne, Y | 1 |
| Monstein, HJ | 1 |
| Hirst, RA; Lambert, DG | 1 |
| Cai, Y; Pei, G; Wu, Y; Zhang, Y | 1 |
| Lambert, DG; Smart, D | 1 |
| Amoroso, D; Catozzi, L; Ceppi, E; Groppetti, A; Guglielmetti, F; Palazzi, E | 1 |
| Campbell, DJ; Lambert, DG; Rowbotham, DJ | 1 |
| Bamberger, AM; Cool, DR; Loh, YP; Pu, LP | 1 |
| Chueh, SH; Liu, TY | 1 |
| Burks, TF; Hruby, VJ; Roerig, SC; Rosenfeld, GC; Williams, CL | 1 |
| Casulari, LA; Maggi, R; Martini, L; Pimpinelli, F; Piva, F | 1 |
| Feigenbaum, JJ; Simantov, R | 1 |
| Chien, CC; Pasternak, GW; Ryan-Moro, J; Standifer, KM | 1 |
| Fields, A; Gafni, M; Keren, O; Sarne, Y | 1 |
| Fujimoto, J; Ho, BY; Holmes, BB; Zhao, J | 1 |
| Cai, YC; Cheng, ZJ; Fan, GH; Jiang, LZ; Ma, L; Pei, G | 1 |
| Taglietti, V; Toselli, M; Tosetti, P | 1 |
| Breivogel, CS; Childers, SR; Selley, DE | 1 |
| Cai, YC; Fan, GH; Jiang, LZ; Ma, L; Pei, G; Zhao, J | 1 |
| Carabelli, V; Carbone, E; Lovallo, M; Magnelli, V; Zucker, H | 1 |
| Lou, LG; Pei, G | 1 |
| Fields, A; Sarne, Y | 1 |
| Elliott, J; Guo, L; Traynor, JR | 1 |
| Beacham, DW; Bunzow, JR; Cook, SP; Grandy, DK; Nah, SY; Unteutsch, A | 1 |
| Szekeres, PG; Traynor, JR | 1 |
| Antunes Bras, JM; Bourgoin, S; Cesselin, F; Epstein, AL; Hamon, M; Pohl, M | 1 |
| Fan, GH; Jing, Q; Lou, LG; Ma, L; Pei, G; Wu, YL; Zhang, Z; Zhao, J | 1 |
| Fields, A; Gafni, M; Rubovitch, V; Sarne, Y | 1 |
| Harrison, LM; Kastin, AJ; Zadina, JE | 1 |
| Carrión, AM; Mellström, B; Naranjo, JR | 1 |
| Imanishi, Y; Kimura, S; Yano, K | 1 |
| Kramer, HK; Simon, EJ | 2 |
| Allen, RG; Fujimoto, KI; Nelson, CS; Pellegrino, MJ; Sirianni, MJ | 1 |
| Murphy, J; Schulz, K; Schulz, R; Wehmeyer, A | 1 |
| Allouche, S; Jauzac, P; Marie, N; Roussel, M | 1 |
| Clark, MJ; Emmerson, PJ; Medzihradsky, F; Remmers, AE | 1 |
| Allouche, S; Hasbi, A; Homburger, V; Jauzac, P; Polastron, J | 1 |
| Gomes, I; Gupta, A; Sharma, SK; Singh, SP | 1 |
| Ma, L; Pei, G; Wu, GX; Xin, SM; Zhang, WB; Zhang, Z | 1 |
| Carrión, AM; Ledo, F; Link, WA; Mellström, B; Naranjo, JR | 1 |
| Brandt, M; Glaser, T; Hamprecht, B; Klebensberger, W; Traber, J | 1 |
| Blume, AJ | 1 |
| Gerber, LD; Rubinstein, M; Stein, S; Udenfriend, S; Wideman, J | 1 |
| Chang, KJ; Cuatrecasas, P; Miller, RJ | 1 |
| Blume, AJ; Boone, G; Lichtshtein, D | 1 |
| Chang, KJ; Cooper, BR; Cuatrecasas, P; Hazum, E | 1 |
| Fox, CF; Lee, TT; Williams, RE | 1 |
| Law, PY; Loh, HH; Roerig, SC | 1 |
| Anthony, E; Beardsley, PM; Chandrakumar, NS; Drury, B; Lopez, OT; Reichman, M; Savage, MA; Stapelfeld, A; Williamson, LN | 1 |
| Hawkins, PT; Jackson, TR; Poyner, DR | 1 |
| Costa, EM; Hoffman, BB; Loew, GH | 1 |
| Crain, SM; Fan, SF; Scheideler, MA; Shen, KF | 1 |
| Gnegy, ME; Mangels, LA | 1 |
| Han, JS; Ren, MF; Sun, XJ; Wang, JF; Yang, HF | 1 |
| Kasai, H | 1 |
| Cone, RI; Lameh, J; Sadée, W | 1 |
| Bleasdale, JE; Denlinger, LC; Fisher, SK; Mostafapour, SP; Thompson, AK | 1 |
| Duan, DS; Eiger, S; Lameh, J; Sadée, W; Yu, VC | 1 |
| Folkesson, R; Geijer, T; Monstein, HJ | 1 |
| Adams, M; Boarder, MR; Marriott, D | 1 |
| McLaughlin, PJ; Zagon, IS | 2 |
| Bykov, V; George, C; Jacobson, AE; Kim, CH; Klee, WA; Long, JB; Mattson, MV; Rice, KC; Rothman, RB; Streaty, RA | 1 |
| Folkesson, R; Geijer, T; Monstein, HJ; Terenius, L | 1 |
| Bidlack, JM; Selley, DE | 1 |
| Krumins, SA | 1 |
| Bidlack, JM; O'Malley, WE; Schulz, R | 1 |
| Goodman, SR; McLaughlin, PJ; Zagon, IS | 1 |
| Delay-Goyet, P; Foucaud, B; Rigaudy, P; Roques, BP; Zajac, JM | 1 |
| Akiyama, K; Gee, KW; Hruby, VJ; Mosberg, HI; Yamamura, HI | 1 |
| Kurose, H; Ui, M | 1 |
| Richards, ML; Sadée, W; Yu, VC | 1 |
| Kazmi, SM; Mishra, RK | 2 |
| Brown, SR; Cote, TE; Cox, BM; Puttfarcken, P; Werling, LL | 1 |
| Sabol, SL; Yoshikawa, K | 1 |
| Joniau, M; Leclercq, G; Willems, J | 1 |
| Folkesson, R; Geijer, T; Monstein, HJ; Nilsson, K; Påhlman, S; Terenius, L | 1 |
| Schwartz, JP | 1 |
| Fukuda, T; Hirota, M; Hitomi, J; Hoshi, N; Kusakabe, T; Suzuki, T | 1 |
| Aktories, K; Costa, T; Jakobs, KH; Wüster, M | 1 |
| Barg, J; Levy, R; Simantov, R | 1 |
| Murphy, MG; Rao, BG | 1 |
| Griffin, MT; Law, PY; Loh, HH | 1 |
| Costa, T; Wüster, M | 1 |
| Dawson, G; Louie, AK | 1 |
| Braas, KM; Childers, SR; U'Prichard, DC | 1 |
| Moses, MA; Snell, CR | 2 |
| Hom, DS; Law, PY; Loh, HH | 2 |
| Brandt, U; Lentzen, H; Palenker, J | 1 |
| Blount, M; DeLellis, RA; Lee, AK; Tischler, AS; Wolfe, HJ | 1 |
| Cote, T; Cox, BM; Kiang, JG; Tang, T | 1 |
| Chueh, SH; Liu, TY; Song, SL | 1 |
| Côté, TE; Cox, BM; Kiang, JG; Tang, T | 1 |
| Belardetti, F; Gutowski, S; Sternweis, PC; Wilk-Blaszczak, MA | 1 |
| Dragatsis, I; Georgoussi, Z; Konidakis, G; Megaritis, G; Merkouris, M; Milligan, G; Zioudrou, C | 1 |
| Buzas, B; Cox, BM; Rosenberger, J | 1 |
| Campana, G; Di Toro, R; Murari, G; Sciarretta, V; Spampinato, S | 1 |
| Gafni, M; Keren, O; Sarne, Y | 1 |
| Chen, ZW; Han, JS; Wang, Y; Yang, K | 1 |
| McKenzie, FR; Milligan, G | 1 |
| Dawson, G; Scheideler, MA | 1 |
| Narahashi, T; Tsunoo, A; Yoshii, M | 1 |
| Berry-Kravis, E; Dawson, G; Derechin, V; Kazmierczak, BI | 1 |
| Hescheler, J; Rosenthal, W; Schultz, G; Tang, M; Trautwein, W; Wulfern, M; Yajima, M | 1 |
| Costa, T; Lang, J | 1 |
| Costa, T; Herz, A; Ott, S | 1 |
| Brown, DA; Docherty, RJ; McFadzean, I | 1 |
| Costa, T; Herz, A | 1 |
| Costa, T; Klinz, FJ | 1 |
| Costa, T; Herz, A; Vachon, L | 2 |
| Moak, CM; Murphy, MG; Rao, BG | 1 |
| Chuang, DM; Zhu, XZ | 1 |
| Law, PY; Loh, HH; Louie, AK; Zhan, JN | 1 |
| McLaughlin, P; Zagon, IS | 1 |
| Magee, AI; Milligan, G; Mullaney, I; Unson, CG | 1 |
| Ishii, S; Satoh, M; Yokosawa, H | 1 |
| Krumins, SA; Rodbard, D | 1 |
| Burke, TR; Costa, T; Cruciani, RA; Jacobson, AE; Krumins, SA; Lutz, RA; Rice, KC; Rodbard, D | 1 |
| Costa, T; Gramsch, C; Herz, A; Wüster, M | 1 |
| Ard, MD; Goldstein, MN; Gottlieb, DI; Nash, DR | 1 |
| Grandt, R; Greiner, C; Jakobs, KH; Zubin, P | 1 |
| Charness, ME; Diamond, I; Querimit, LA | 1 |
| Klein, C; Levy, R; Simantov, R | 1 |
| Coscia, CJ; Devane, WA; Howlett, AC; Spain, JW | 1 |
| Hochhaus, G; Sadée, W; Yu, VC | 1 |
| Greenspan, DL; Musacchio, JM | 1 |
| Dawson, G; Francel, PC | 1 |
5 review(s) available for enkephalin, leucine and Neuroblastoma
| Article | Year |
|---|---|
[Nerve cell clonal lines in culture--models for studying the molecular basis of neuropharmacological actions].
Topics: Astrocytoma; Catecholamines; Cell Differentiation; Cell Line; Chromatography, High Pressure Liquid; Clone Cells; Cyclic AMP; Enkephalins; gamma-Aminobutyric Acid; Humans; Models, Biological; Neuroblastoma; Neurons; Oligodendroglioma; Pheochromocytoma; Phosphorylation; Prostaglandins; Substance P; Tyrosine 3-Monooxygenase | 1983 |
Glycolipids and opiate action.
Topics: Animals; Cell Line; Cyclic AMP; Enkephalins; Glycolipids; Levorphanol; Mice; Models, Biological; Morphine; Neoplasms, Experimental; Neuroblastoma; Receptors, Opioid | 1981 |
Involvement of sulfhydryl groups in the functional integrity of the opiate receptors of neuroblastoma x glioma hybrid NG108-15.
Topics: Animals; Enkephalins; Ethylmaleimide; Glioma; Hybrid Cells; Kinetics; Mice; Neoplasms, Experimental; Neuroblastoma; Rats; Receptors, Opioid; Sulfhydryl Compounds | 1983 |
Stimulatory effects of opioids on transmitter release and possible cellular mechanisms: overview and original results.
Topics: Adenylyl Cyclases; Animals; Cell Line; Enkephalins; GTP-Binding Proteins; Humans; Membrane Potentials; Narcotics; Neuroblastoma; Neurons; Neurotransmitter Agents; Signal Transduction; Tumor Cells, Cultured | 1996 |
The opioid-induced desensitization (tolerance) in neuroblastoma x glioma NG 108-15 hybrid cells: results from receptor uncoupling.
Topics: Animals; Bacterial Toxins; Carbachol; Cell Membrane; Cyclic AMP; Drug Tolerance; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Glioma; Hybrid Cells; Mice; Naloxone; Narcotics; Neuroblastoma; Norepinephrine; Prostaglandins E; Rats; Receptors, Opioid; Virulence Factors, Bordetella | 1984 |
211 other study(ies) available for enkephalin, leucine and Neuroblastoma
| Article | Year |
|---|---|
Beta-amyloid peptides undergo regulated co-secretion with neuropeptide and catecholamine neurotransmitters.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Catecholamines; Cattle; Cells, Cultured; Chromaffin Cells; Colforsin; Cyclic AMP; Dopamine; Enkephalins; Epinephrine; Galanin; Ganglionic Stimulants; Humans; Neuroblastoma; Neurons; Neuropeptide Y; Neuropeptides; Neurotransmitter Agents; Nicotine; Norepinephrine; Peptide Fragments; Secretory Vesicles | 2013 |
Nuclear cereblon modulates transcriptional activity of Ikaros and regulates its downstream target, enkephalin, in human neuroblastoma cells.
Topics: Adaptor Proteins, Signal Transducing; Cell Line, Tumor; Enkephalins; Humans; Ikaros Transcription Factor; Neuroblastoma; Peptide Hydrolases; Promoter Regions, Genetic; Transcription, Genetic; Ubiquitin-Protein Ligases | 2016 |
delta-Opioid receptor-stimulated Akt signaling in neuroblastoma x glioma (NG108-15) hybrid cells involves receptor tyrosine kinase-mediated PI3K activation.
Topics: Cell Line, Tumor; Cell Survival; Cytoprotection; Enkephalins; Enzyme Activation; Etorphine; Glioma; Glycogen Synthase Kinase 3; GTP-Binding Protein alpha Subunits, Gi-Go; GTP-Binding Protein beta Subunits; GTP-Binding Protein gamma Subunits; Humans; Hybrid Cells; Insulin-Like Growth Factor I; Neuroblastoma; Nuclear Envelope; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Transport; Proto-Oncogene Proteins c-akt; Receptor Protein-Tyrosine Kinases; Receptors, Nerve Growth Factor; Receptors, Opioid, delta; Signal Transduction; Transcriptional Activation | 2009 |
Ethanol and acetaldehyde exposure induces specific epigenetic modifications in the prodynorphin gene promoter in a human neuroblastoma cell line.
Topics: Acetaldehyde; Cell Line, Tumor; Central Nervous System Depressants; Chromatin; DNA Methylation; Enkephalins; Epigenomics; Ethanol; Gene Expression Regulation; Humans; Neuroblastoma; Promoter Regions, Genetic; Protein Precursors | 2011 |
Key role for enkephalinergic tone in cortico-striatal-thalamic function.
Topics: Animals; Astrocytes; Borna Disease; Borna disease virus; Cells, Cultured; Dynorphins; Enkephalins; Gene Expression; Genes, fos; Humans; Male; Neuroblastoma; Protein Precursors; Putamen; Rats; Rats, Inbred Lew; Receptors, Dopamine D2; Tumor Cells, Cultured | 2002 |
Ca(2+)-dependent prodynorphin transcriptional derepression in neuroblastoma cells is exerted through DREAM protein activity in a kinase-independent manner.
Topics: Animals; Caffeine; Calcium; Calcium Signaling; Calcium-Binding Proteins; Central Nervous System; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enkephalins; Enzyme Inhibitors; Gene Expression Regulation; Genes, Regulator; Humans; Kv Channel-Interacting Proteins; Mutation; Neuroblastoma; Neurons; Protein Biosynthesis; Protein Precursors; Repressor Proteins; RNA, Messenger; Tumor Cells, Cultured | 2003 |
Angiotensin-converting enzyme, enkephalinase A and aminopeptidases in the breakdown of enkephalin--studies in cell cultures.
Topics: Aminopeptidases; Animals; Astrocytes; Carboxypeptidases; Cell Membrane; Chick Embryo; Clone Cells; Endopeptidases; Enkephalins; Neprilysin; Neuroblastoma; Neuroglia; Neurons; Peptidyl-Dipeptidase A | 1984 |
Distinct high-affinity binding sites for benzomorphan drugs and enkephalin in a neuroblastoma--brain hybrid cell line.
Topics: Analgesics, Opioid; Animals; Benzomorphans; Binding Sites; Binding, Competitive; Brain; Cell Line; Cyclazocine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Hybrid Cells; Kinetics; Morphinans; Neuroblastoma; Phenazocine; Rats; Receptors, Opioid | 1981 |
Modulation of an adenylate cyclase-linked serotonin (5-HT) receptor system in a neuroblastoma x brain explant hybrid cell line (NCB-20) by opiates, prostaglandins, and alpha 2-adrenergic agonists.
Topics: Adenylyl Cyclases; Adrenergic alpha-Agonists; Animals; Ascorbic Acid; Brain; Cations; Cell Line; Cell Membrane; Cricetinae; Cricetulus; Enkephalins; Hybrid Cells; Mice; Narcotics; Neuroblastoma; Prostaglandins; Receptors, Serotonin | 1983 |
Relationship between the actions of calcium ions, opiods, and prostaglandin E1 on the level of cyclic AMP in neuroblastoma x glioma hybrid cells.
Topics: Animals; Calcium; Cell Line; Cholera Toxin; Cyclic AMP; Dose-Response Relationship, Drug; Egtazic Acid; Endorphins; Enkephalins; Glioma; Hybrid Cells; Kinetics; Mice; Neuroblastoma; Prostaglandins E | 1980 |
Cluster formation of opiate (enkephalin) receptors in neuroblastoma cells: differences between agonists and antagonists and possible relationships to biological functions.
Topics: Adenylyl Cyclases; Animals; Cells, Cultured; Enkephalins; Enzyme Activation; Membrane Fluidity; Morphine; Naloxone; Neoplasms, Experimental; Neuroblastoma; Prostaglandins E; Receptors, Opioid; Sulfhydryl Reagents | 1980 |
Enkephalin inhibition of adenylate cyclase activity in neuroblastoma N18TG2 cells: effect of sulfatide incorporation.
Topics: Adenylyl Cyclase Inhibitors; Animals; Cells, Cultured; Cyclic AMP; Drug Synergism; Endorphins; Enkephalins; Membranes; Neoplasm Proteins; Neoplasms, Experimental; Neuroblastoma; Rats; Sulfoglycosphingolipids; Time Factors | 1980 |
Possible role of distinct morphine and enkephalin receptors in mediating actins of benzomorphan drugs (putative kappa and sigma agonists).
Topics: Animals; Benzomorphans; Brain; Cyclazocine; Diprenorphine; Endorphins; Enkephalins; Ethylketocyclazocine; Guanosine Triphosphate; Morphinans; Morphine; Naloxone; Neuroblastoma; Rats; Receptors, Opioid; Sodium; Synaptic Membranes | 1980 |
Opioids, noradrenaline and GTP analogs inhibit cholera toxin activated adenylate cyclase in neuroblastoma x glioma hybrid cells.
Topics: Adenylyl Cyclases; Animals; Cell Line; Cholera Toxin; Clone Cells; Diphosphonates; Endorphins; Enkephalin, Methionine; Enkephalins; Glioma; Guanosine Monophosphate; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Hybrid Cells; Kinetics; Mice; Morphine; Neuroblastoma; Norepinephrine; Rats | 1981 |
Opioid hexapeptides and heptapeptides in adrenal medulla and brain possible implications on the biosynthesis of enkephalins.
Topics: Adrenal Medulla; Amino Acids; Animals; Brain Chemistry; Cattle; Cell Line; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Glioma; Hybrid Cells; Neuroblastoma; Receptors, Opioid | 1980 |
beta-Endorphin: characteristics of binding sites in a neuroblastoma--glioma hybrid cell.
Topics: Animals; Cell Line; Endorphins; Enkephalins; Glioma; Kinetics; Ligands; Neoplasms, Experimental; Neuroblastoma; Phospholipids; Rats; Receptors, Opioid; Structure-Activity Relationship | 1981 |
A highly potent 3200-dalton adrenal opioid peptide that contains both a [Met]- and [Leu]enkephalin sequence.
Topics: Adrenal Medulla; Amino Acid Sequence; Animals; Biological Assay; Cattle; Cell Line; Chromaffin Granules; Chromaffin System; Endorphins; Enkephalins; Glioma; Guinea Pigs; Ileum; Mice; Molecular Weight; Muscle Contraction; Neuroblastoma; Receptors, Opioid | 1981 |
Regulation by neurohormones of cyclic AMP concentration in cells derived from the nervous system.
Topics: Acetylcholine; Animals; Brain; Calcium; Cations; Cell Line; Cells, Cultured; Cyclic AMP; Enkephalin, Leucine; Enkephalins; Glioma; Guanine Nucleotides; Hybrid Cells; Mice; Narcotics; Neuroblastoma; Norepinephrine; Rats; Sodium | 1981 |
Glucocorticoids elevate the level of enkephalin-like peptides in neuroblastoma x glioma hybrid cells.
Topics: Alprostadil; Animals; Chromatography, High Pressure Liquid; Cyclic AMP; Dexamethasone; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Glioma; Glucocorticoids; Hybrid Cells; Naloxone; Neuroblastoma; Prostaglandins E | 1981 |
Interactions of ligands with morphine and enkephalin receptors are differentially affected by guanine nucleotide.
Topics: Animals; Brain; Cells, Cultured; Diprenorphine; Endorphins; Enkephalins; Guanosine Triphosphate; In Vitro Techniques; Magnesium; Naloxone; Neoplasms, Experimental; Neuroblastoma; Rats; Receptors, Opioid; Sodium | 1981 |
Irreversible inactivation of the opiate receptors in the neuroblastoma x glioma hybrid NG108-15 by chlornaltrexamine.
Topics: Animals; Cyclic AMP; Enkephalin, Methionine; Enkephalins; Glioma; Hybrid Cells; Mice; Naloxone; Naltrexone; Neoplasms, Experimental; Neuroblastoma; Nitrogen Mustard Compounds; Prostaglandins E, Synthetic; Rats; Receptors, Opioid | 1981 |
Function and regulation of methionine5-enkephalin and its receptors in murine neuroblastoma cells.
Topics: Alprostadil; Animals; Cell Division; Cell Line; Chromatography, High Pressure Liquid; Cyclic AMP; Endorphins; Enkephalin, Methionine; Enkephalins; Kinetics; Mice; Naloxone; Neoplasms, Experimental; Neuroblastoma; Prostaglandins E; Receptors, Opioid | 1982 |
Dermorphins, opioid peptides from amphibian skin, act on opioid receptors of mouse neuroblastoma x rat glioma hybrid cells.
Topics: Amphibians; Animals; Binding, Competitive; Cell Line; Enkephalin, Leucine; Enkephalins; Glioma; Hybrid Cells; Kinetics; Mice; Neuroblastoma; Oligopeptides; Opioid Peptides; Rats; Receptors, Opioid; Structure-Activity Relationship | 1981 |
Opioid peptides induce reduction of enkephalin receptors in cultured neuroblastoma cells.
Topics: Animals; Cell Membrane; Cells, Cultured; Dose-Response Relationship, Drug; Endorphins; Enkephalins; Kinetics; Mice; Naloxone; Narcotics; Neuroblastoma; Neurons; Rats; Receptors, Opioid; Structure-Activity Relationship | 1982 |
Dehydro-enkephalins. IV. Discriminative recognition of delta and mu opiate receptors by enkephalin analogs.
Topics: Animals; Brain; Cell Membrane; Endorphins; Enkephalins; Kinetics; Neoplasms, Experimental; Neuroblastoma; Rats; Receptors, Opioid; Structure-Activity Relationship | 1982 |
Opiate receptors from different tissue sources: solubilization and characterization.
Topics: Animals; Brain; Cell Line; Cerebral Cortex; Enkephalin, Methionine; Enkephalins; Glioma; Hybridomas; Hypothalamus; Male; Mice; Neuroblastoma; Rats; Rats, Inbred Strains; Receptors, Opioid; Solubility; Thalamus | 1982 |
Neuroblastoma X glioma hybrid cells synthesize enkephalin-like opioid peptides.
Topics: Alprostadil; Animals; Cell Line; Cyclic AMP; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Glioma; Hybrid Cells; Mice; Naloxone; Neuroblastoma; Oxidation-Reduction; Prostaglandins E; Rats | 1982 |
Comparison of opiate inhibition of adenylate cyclase activity in neuroblastoma N18tG2 and neuroblastoma x glioma NG108-15 hybrid cell lines.
Topics: Adenylyl Cyclase Inhibitors; Animals; Cell Line; Cyclic AMP; Enkephalins; Glioma; Guanosine Triphosphate; Hybrid Cells; Kinetics; Mice; Narcotics; Neoplasms, Experimental; Neuroblastoma; Rats; Receptors, Opioid | 1982 |
Differential effects of GTP and cations on binding of labeled dimeric and monomeric enkephalins to neuroblastoma-glioma cell delta opiate receptors.
Topics: Animals; Binding, Competitive; Cell Line; Enkephalins; Glioma; Guanosine Triphosphate; Hybrid Cells; Kinetics; Macromolecular Substances; Manganese; Mice; Neuroblastoma; Rats; Receptors, Opioid; Receptors, Opioid, delta; Sodium | 1982 |
Enkephalins and opiate antagonists control calmodulin distribution in neuroblastoma-glioma cells.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Calcium-Binding Proteins; Calmodulin; Cell Line; Enkephalins; Glioma; Hybrid Cells; Kinetics; Mice; Narcotic Antagonists; Neuroblastoma; Rats; Receptors, Opioid; Subcellular Fractions | 1983 |
Enkephalin dimers: regulation of cyclic AMP levels in NG108-15 cells.
Topics: Alprostadil; Animals; Cyclic AMP; Enkephalins; Glioma; Hybrid Cells; Kinetics; Mice; Neuroblastoma; Prostaglandins E; Rats; Structure-Activity Relationship | 1983 |
Down regulation of enkephalin (delta) receptors. Demonstration in membrane-bound and solubilized receptors.
Topics: Alkaloids; Animals; Drug Tolerance; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Etorphine; Glioma; Hybrid Cells; In Vitro Techniques; Morphine; Neuroblastoma; Rats; Receptors, Opioid; Solubility | 1982 |
Uncoupling of receptors is essential for opiate-induced desensitization (tolerance) in neuroblastoma x glioma hybrid cells NG 108-15.
Topics: Animals; Cell Line; Enkephalins; Glioma; Hybrid Cells; Kinetics; Mice; Narcotics; Neuroblastoma; Norepinephrine; Rats; Receptors, Opioid | 1983 |
Cyclic penicillamine containing enkephalin analogs display profound delta receptor selectivities.
Topics: Animals; Brain; Cell Line; Cell Membrane; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Glioma; Guinea Pigs; Hybrid Cells; Ileum; Male; Mice; Muscle Contraction; Neuroblastoma; Rats; Receptors, Opioid; Receptors, Opioid, delta; Structure-Activity Relationship; Vas Deferens | 1983 |
Visualization of enkephalin receptors by image-intensified fluorescence microscopy.
Topics: Animals; Cell Line; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Fluorescent Dyes; Iodine Radioisotopes; Mice; Microscopy, Fluorescence; Neuroblastoma; Receptors, Opioid; Xanthenes | 1983 |
Cell-cycle dependence of a ganglioside glycosyltransferase activity and its inhibition by enkephalin in a neurotumor cell line.
Topics: Animals; Cell Cycle; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; G(M2) Ganglioside; G(M3) Ganglioside; Galactosyltransferases; Gangliosides; Glioma; Hybrid Cells; Kinetics; Mice; N-Acetylgalactosaminyltransferases; Neuroblastoma; Rats | 1984 |
Methionine-enkephalin immunoreactivity in fetal rat brain cells in aggregating culture and in mouse neuroblastoma cells.
Topics: Animals; Brain; Clone Cells; Endorphins; Enkephalins; Fluorescent Antibody Technique; Mice; Neoplasms, Experimental; Neuroblastoma; Neurons; Rats | 1980 |
Production and regulation of enkephalin-like peptides in neuroblastoma x glioma cells.
Topics: Cells, Cultured; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Glioma; Humans; Hybrid Cells; Neoplasms, Experimental; Neuroblastoma; Steroids | 1982 |
Degradation of enkephalin and enkephalinamide by neuroblastoma x glioma hybrid cells as studied by 13C n.m.r.
Topics: Cell Membrane; Chromatography, Thin Layer; Endorphins; Enkephalin, Methionine; Enkephalins; Glioma; Humans; Hybrid Cells; Magnetic Resonance Spectroscopy; Neuroblastoma; Puromycin; Trypsin | 1980 |
Inhibition of sialoglycosphingolipid (ganglioside) biosynthesis in mouse clonal lines N4TG1 and NG108-15 by beta-endorphin, enkephalins, and opiates.
Topics: Animals; Cell Line; Endorphins; Enkephalins; Galactosamine; Galactose; Gangliosides; Glioma; Glucosamine; Glycosphingolipids; Hybrid Cells; Kinetics; Mice; Morphine; Naloxone; Narcotics; Neuroblastoma | 1980 |
Reversible modulation of opioid receptor binding in intact neural cells by endogenous guanosine triphosphate.
Topics: Adenylyl Cyclases; Amino Acid Sequence; Analgesics; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; GTP-Binding Proteins; Guanosine Triphosphate; Humans; Kinetics; Molecular Sequence Data; Mycophenolic Acid; Naltrexone; Narcotic Antagonists; Neuroblastoma; Neurons; Receptors, Opioid, mu; Tritium; Tumor Cells, Cultured | 1995 |
Tyrosine-iodination converts the delta-opioid peptide antagonist TIPP to an agonist.
Topics: Amino Acid Sequence; Analgesics; Animals; Brain Neoplasms; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Humans; Iodine; Mice; Molecular Sequence Data; Molecular Weight; Narcotic Antagonists; Neuroblastoma; Oligopeptides; Receptors, Opioid, delta; Spectrometry, Mass, Fast Atom Bombardment; Tetrahydroisoquinolines; Tumor Cells, Cultured; Tyrosine | 1995 |
Neuroblastoma Neuro2A cells stably expressing a cloned mu-opioid receptor: a specific cellular model to study acute and chronic effects of morphine.
Topics: Analgesics; Animals; Binding, Competitive; Cell Line; Colforsin; Dose-Response Relationship, Drug; Down-Regulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Mice; Models, Biological; Morphine; Neuroblastoma; Receptors, Opioid, mu; Time Factors | 1995 |
Coupling of the cloned mu-opioid receptor with the omega-conotoxin-sensitive Ca2+ current in NG108-15 cells.
Topics: Animals; Calcium Channels; Cloning, Molecular; DNA, Complementary; Electric Conductivity; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Gene Expression; Glioma; GTP-Binding Proteins; Hybrid Cells; Neuroblastoma; omega-Conotoxin GVIA; Peptides; Pertussis Toxin; Rats; Receptors, Opioid, mu; Transfection; Tumor Cells, Cultured; Virulence Factors, Bordetella | 1995 |
Expression of functional delta opioid receptors in Xenopus oocytes.
Topics: Adenylyl Cyclases; Analgesics; Analysis of Variance; Animals; Cyclic AMP; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Female; Glioma; Hybrid Cells; Isoproterenol; Mice; Naltrexone; Neuroblastoma; Oocytes; Poly A; Rats; Receptors, Opioid, delta; RNA; RNA, Messenger; Xenopus laevis | 1993 |
Presence in neuroblastoma cells of a mu 3 receptor with selectivity for opiate alkaloids but without affinity for opioid peptides.
Topics: Animals; Binding, Competitive; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Male; Mice; Morphine; NAD; Neuroblastoma; Opioid Peptides; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Tumor Cells, Cultured | 1994 |
Modulation by mu-opioid agonists of guanosine-5'-O-(3-[35S]thio)triphosphate binding to membranes from human neuroblastoma SH-SY5Y cells.
Topics: Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Fentanyl; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Humans; Narcotics; Neuroblastoma; Receptors, Opioid, mu; Tumor Cells, Cultured | 1995 |
Characterisation of mu-opioid receptors on SH-SY5Y cells using naloxonazine and beta-funaltrexamine.
Topics: Amino Acid Sequence; Animals; Brain Neoplasms; Cerebral Cortex; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Humans; Ligands; Molecular Sequence Data; Naloxone; Naltrexone; Neuroblastoma; Rats; Receptors, Opioid, mu; Somatostatin; Tumor Cells, Cultured | 1994 |
Inversion of Ca2+ current modulation during recovery of neuroblastoma cells from pertussis toxin pretreatment.
Topics: Calcium; Cell Differentiation; Dopamine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Humans; Membrane Potentials; Neuroblastoma; Pertussis Toxin; Somatostatin; Tretinoin; Tumor Cells, Cultured; Virulence Factors, Bordetella | 1993 |
Different subtypes of opioid receptors have different affinities for G-proteins.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adenylyl Cyclases; Amino Acid Sequence; Animals; Binding, Competitive; Cerebellum; Colforsin; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Etorphine; GTP-Binding Proteins; Guinea Pigs; Humans; Hybrid Cells; Molecular Sequence Data; Morphine; Naloxone; Neoplasm Proteins; Nerve Tissue Proteins; Neuroblastoma; Oligopeptides; Pyrrolidines; Rabbits; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Tumor Cells, Cultured | 1994 |
Prodynorphin gene expression relates to NF-kappa B factors.
Topics: Animals; Base Sequence; Binding Sites; Cell Line; Choriocarcinoma; Enkephalins; Gene Expression; Humans; Lung Neoplasms; Molecular Sequence Data; Neuroblastoma; NF-kappa B; Oligodeoxyribonucleotides; Oligonucleotide Probes; Protein Precursors; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-rel; Rats; Sequence Homology, Nucleic Acid; Swine; Tumor Cells, Cultured | 1994 |
Mu and delta opioid receptor desensitization in undifferentiated human neuroblastoma SHSY5Y cells.
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Analgesics; Cell Differentiation; Colforsin; Cyclic AMP; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Humans; Neuroblastoma; Neurons; Receptors, Opioid, delta; Receptors, Opioid, mu; Sensitivity and Specificity; Signal Transduction; Stimulation, Chemical; Tumor Cells, Cultured | 1994 |
Opioids acting through delta receptors elicit a transient increase in the intracellular free calcium concentration in dorsal root ganglion-neuroblastoma hybrid ND8-47 cells.
Topics: Analgesics; Aniline Compounds; Animals; Binding Sites; Calcium; Cell Membrane; Enkephalins; Flow Cytometry; Fluorescence; Fura-2; Ganglia, Spinal; Hybrid Cells; Intracellular Fluid; Kinetics; Lasers; Mice; Narcotics; Neuroblastoma; Neurons, Afferent; Rats; Receptors, Opioid, delta; Tumor Cells, Cultured; Xanthenes | 1994 |
Dual regulation by opioids of 3H-norepinephrine release in the human neuroblastoma cell-line SK-N-SH.
Topics: Cell Line; Dextrorphan; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Humans; Kinetics; Levorphanol; Morphine; Naloxone; Narcotics; Neuroblastoma; Norepinephrine; Receptors, Opioid; Tritium; Tumor Cells, Cultured | 1994 |
Compartmentation of receptors and guanine nucleotide-binding proteins in NG108-15 cells: lack of cross-talk in agonist binding among the alpha 2-adrenergic, muscarinic, and opiate receptors.
Topics: Adrenergic alpha-Agonists; Animals; Binding Sites; Cell Compartmentation; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Glioma; GTP-Binding Proteins; Mathematics; Neuroblastoma; Oxotremorine; Parasympathomimetics; Receptors, Adrenergic, alpha; Receptors, Muscarinic; Receptors, Opioid; Signal Transduction | 1993 |
Go mediates the coupling of the mu opioid receptor to adenylyl cyclase in cloned neural cells and brain.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclases; Analgesics; Animals; Antibodies; Cell Membrane; Clone Cells; Corpus Striatum; Cyclic AMP; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; GTP-Binding Proteins; Humans; Kinetics; Membrane Proteins; Neuroblastoma; Pertussis Toxin; Rats; Receptors, Opioid, mu; Somatostatin; Tumor Cells, Cultured; Virulence Factors, Bordetella | 1993 |
Fentanyl inhibits the release of [3H]noradrenaline from SH-SY5Y human neuroblastoma cells.
Topics: Atropine; Carbachol; Cell Differentiation; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Fentanyl; Humans; Morphine; Neuroblastoma; Norepinephrine; Potassium; Receptors, Muscarinic; Tumor Cells, Cultured | 1994 |
mu-Opioid receptor stimulation of inositol (1,4,5)trisphosphate formation via a pertussis toxin-sensitive G protein.
Topics: Calcium; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Fentanyl; GTP-Binding Proteins; Humans; Inositol 1,4,5-Trisphosphate; Morphine; Narcotic Antagonists; Neuroblastoma; Pertussis Toxin; Receptors, Opioid, mu; Tumor Cells, Cultured; Virulence Factors, Bordetella | 1994 |
Characterization of the mu-opioid receptors on SH-SY5Y cells using beta-funaltrexamine (beta-FNA) and naloxonazine.
Topics: Analgesics; Cell Line; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Humans; Kinetics; Naloxone; Naltrexone; Narcotic Antagonists; Neuroblastoma; Receptors, Opioid, mu; Tumor Cells, Cultured | 1993 |
Activating transcription factor-3 stimulates 3',5'-cyclic adenosine monophosphate-dependent gene expression.
Topics: Activating Transcription Factor 3; Base Sequence; beta-Galactosidase; Binding Sites; Cyclic AMP; DNA; Drug Synergism; Enkephalins; Gene Expression; Humans; Leucine Zippers; Macromolecular Substances; Molecular Sequence Data; Neuroblastoma; Phosphorylation; Protein Precursors; Proto-Oncogene Proteins c-jun; Recombinant Fusion Proteins; Signal Transduction; Transcription Factors; Transfection; Tumor Cells, Cultured | 1994 |
Opioids mobilize calcium from inositol 1,4,5-trisphosphate-sensitive stores in NG108-15 cells.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Calcium; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Fluorescent Dyes; Fura-2; Glioma; Hybrid Cells; Inositol 1,4,5-Trisphosphate; Kinetics; Mice; Microscopy, Fluorescence; Naloxone; Narcotics; Neuroblastoma; Pyrrolidines; Rats; Tumor Cells, Cultured | 1994 |
Alterations in the expression of G-proteins and regulation of adenylate cyclase in human neuroblastoma SH-SY5Y cells chronically exposed to low-efficacy mu-opioids.
Topics: Adenylyl Cyclases; Amino Acid Sequence; Analgesics; Cell Differentiation; Cell Membrane; Cycloheximide; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; GTP-Binding Proteins; Humans; Molecular Sequence Data; Morphine; Narcotics; Neuroblastoma; Time Factors; Tumor Cells, Cultured; Up-Regulation | 1993 |
Enkephalin activates the phospholipase C/Ca2+ system through cross-talk between opioid receptors and P2-purinergic or bradykinin receptors in NG 108-15 cells. A permissive role for pertussis toxin-sensitive G-proteins.
Topics: Adenosine Triphosphate; Bradykinin; Calcium; Enkephalin, Leucine; Enkephalins; Enzyme Activation; Glioma; GTP-Binding Proteins; Hybrid Cells; Inositol 1,4,5-Trisphosphate; Naloxone; Neuroblastoma; Pertussis Toxin; Receptors, Bradykinin; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Purinergic; Terpenes; Thapsigargin; Tumor Cells, Cultured; Type C Phospholipases; Virulence Factors, Bordetella | 1993 |
mu and delta opioid receptors differentially couple to G protein subtypes in membranes of human neuroblastoma SH-SY5Y cells.
Topics: Affinity Labels; Azides; Cell Membrane; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; GTP-Binding Proteins; Guanosine Triphosphate; Humans; Immunosorbent Techniques; Neuroblastoma; Pertussis Toxin; Photochemistry; Receptors, Opioid, delta; Receptors, Opioid, mu; Tumor Cells, Cultured; Virulence Factors, Bordetella | 1993 |
Receptor mechanisms of opioid tolerance in SH-SY5Y human neural cells.
Topics: Adenylyl Cyclase Inhibitors; Amino Acid Sequence; Cyclic AMP; Down-Regulation; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; GTP Phosphohydrolases; Humans; Levorphanol; Molecular Sequence Data; Naltrexone; Narcotics; Neuroblastoma; Neurons; Receptors, Opioid; Signal Transduction; Tumor Cells, Cultured | 1993 |
mu and delta opioid agonists at low concentrations decrease voltage-dependent K+ currents in F11 neuroblastoma x DRG neuron hybrid cells via cholera toxin-sensitive receptors.
Topics: Animals; Cholera Toxin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ganglia, Spinal; Hybrid Cells; Membrane Potentials; Neuroblastoma; Neurons; Pertussis Toxin; Potassium Channels; Rats; Receptors, Opioid, delta; Receptors, Opioid, mu; Virulence Factors, Bordetella | 1993 |
Co-localization of mu and delta opioid receptors on SK-N-SH cells detected by fluorescence microscopy using labeled anti-idiotypic antibodies.
Topics: Antibodies, Anti-Idiotypic; Binding, Competitive; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Humans; Microscopy, Fluorescence; Neuroblastoma; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Tumor Cells, Cultured | 1993 |
Evidence for mu-, delta-, and kappa-opioid receptors in a human neuroblastoma cell line.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Binding, Competitive; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Humans; Kinetics; Neuroblastoma; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sensitivity and Specificity; Tritium; Tumor Cells, Cultured | 1993 |
Suppression by [D-Pen2, D-Pen5]enkephalin on cyclic AMP dependent protein kinase-induced, but not protein kinase C-induced increment of intracellular free calcium in NG108-15 cells.
Topics: Analgesics; Animals; Bucladesine; Calcium; Calcium Channels; Colforsin; Depression, Chemical; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Glioma; Hybrid Cells; Intracellular Fluid; Mice; Neuroblastoma; Potassium Chloride; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Rats; Receptors, Opioid, delta; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1993 |
Selective and interactive down-regulation of mu- and delta-opioid receptors in human neuroblastoma SK-N-SH cells.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Down-Regulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Humans; Morphine; Naltrexone; Neuroblastoma; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, mu; Tumor Cells, Cultured | 1993 |
Identification of an AP-1 transcription factor binding site within the human cholecystokinin (CCK) promoter.
Topics: Actins; Animals; Base Sequence; Binding Sites; Cholecystokinin; Enkephalins; Gene Expression; Genes, fos; Genes, jun; Humans; Molecular Sequence Data; Mutagenesis, Site-Directed; Neuroblastoma; Oligonucleotide Probes; Promoter Regions, Genetic; Protein Precursors; Proto-Oncogene Proteins c-jun; Rats; Tumor Cells, Cultured | 1993 |
Do SH-SY5Y human neuroblastoma cells express cannabinoid receptors?
Topics: Adenylyl Cyclase Inhibitors; Cannabinoids; Colforsin; Cyclic AMP; Dronabinol; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Humans; Neuroblastoma; Potassium; Receptors, Cannabinoid; Receptors, Drug; Receptors, Opioid; Tumor Cells, Cultured | 1995 |
delta Opioid receptor in neuronal cells undergoes acute and homologous desensitization.
Topics: 1-Methyl-3-isobutylxanthine; Analgesics; Animals; Cerebral Cortex; Cyclic AMP; Dose-Response Relationship, Drug; Embryo, Mammalian; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Glioma; Hybrid Cells; Kinetics; Mice; Neuroblastoma; Neurons; Rats; Receptors, Opioid, delta; Time Factors; Tumor Cells, Cultured | 1996 |
delta-Opioids stimulate inositol 1,4,5-trisphosphate formation, and so mobilize Ca2+ from intracellular stores, in undifferentiated NG108-15 cells.
Topics: Analgesics; Animals; Calcium; Calcium Channel Blockers; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Glioma; Inositol 1,4,5-Trisphosphate; Neuroblastoma; Nickel; Nifedipine; Pertussis Toxin; Receptors, Opioid, delta; Tumor Cells, Cultured; Type C Phospholipases; Virulence Factors, Bordetella | 1996 |
Biochemical evidence of functional interaction between mu- and delta-opioid receptors in SK-N-BE neuroblastoma cell line.
Topics: Adenylyl Cyclases; Analgesics; Binding, Competitive; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Humans; Membrane Proteins; Neuroblastoma; Receptors, Opioid, delta; Receptors, Opioid, mu; Time Factors; Tumor Cells, Cultured | 1996 |
Do nitrous oxide and halothane influence opioid receptor binding in SH-SY5Y human neuroblastoma cells?
Topics: Analgesics; Anesthetics, Inhalation; Diprenorphine; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Halothane; Humans; Neuroblastoma; Nitrous Oxide; Receptors, Opioid; Tumor Cells, Cultured | 1995 |
The Neuro-2a neuroblastoma cell line expresses [Met]-enkephalin and vasopressin mRNA and peptide.
Topics: Animals; Arginine Vasopressin; Chromatography, High Pressure Liquid; Enkephalin, Methionine; Enkephalins; Gene Expression; Immunohistochemistry; In Situ Hybridization; Mice; Neuroblastoma; Polymerase Chain Reaction; Proprotein Convertase 2; Protein Precursors; RNA-Directed DNA Polymerase; RNA, Messenger; Subtilisins; Tumor Cells, Cultured; Vasopressins | 1995 |
Carbachol but not bradykinin blocks the enkephalin-induced calcium transient in human neuroblastoma SK-N-SH cells.
Topics: Bradykinin; Calcium; Carbachol; Cells, Cultured; Enkephalins; Humans; Inositol 1,4,5-Trisphosphate; Neuroblastoma | 1995 |
Inhibition of adenylyl cyclase activity by the cholecystokinin analog SNF 9007 in neuroblastoma x glioma NG108-15 hybrid cells.
Topics: Adenylyl Cyclase Inhibitors; Amino Acid Sequence; Analgesics; Cholecystokinin; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Enzyme Inhibitors; Glioma; Hybrid Cells; Molecular Sequence Data; Neuroblastoma; Oligopeptides; Pain; Peptide Fragments; Receptors, Opioid, delta | 1996 |
Antiprogestins inhibit the binding of opioids to mu-opioid receptors in nervous membrane preparations.
Topics: Analgesics; Animals; Dihydromorphine; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Female; Gonanes; Hormone Antagonists; Humans; In Vitro Techniques; Male; Membranes; Mice; Mifepristone; Narcotic Antagonists; Narcotics; Nerve Tissue; Nervous System Neoplasms; Neuroblastoma; Progestins; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Sodium; Tumor Cells, Cultured | 1996 |
Lack of effect of gamma-hydroxybutyrate on mu, delta and kappa opioid receptor binding.
Topics: Adjuvants, Anesthesia; Analgesics; Animals; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Etorphine; Glioma; Guinea Pigs; Naloxone; Narcotic Antagonists; Narcotics; Neuroblastoma; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sodium Oxybate; Tritium; Tumor Cells, Cultured | 1996 |
Sigma binding in a human neuroblastoma cell line.
Topics: Adenylyl Cyclases; Analgesics; Analysis of Variance; Animals; Binding, Competitive; Brain; Carbachol; Cell Line; Colforsin; Cyclic AMP; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guanylyl Imidodiphosphate; Guinea Pigs; Haloperidol; Humans; Kinetics; Morphine; Naloxone; Neuroblastoma; Pentazocine; Phosphatidylinositols; Receptors, Opioid; Receptors, sigma; Trypsin; Tumor Cells, Cultured | 1996 |
Determination of delta-opioid in NG108-15 cells.
Topics: Animals; Benzylidene Compounds; Cyclic AMP; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Glioma; Mice; Naltrexone; Neuroblastoma; Rats; Receptors, Opioid, delta; Tumor Cells, Cultured | 1997 |
Functional expression, activation and desensitization of opioid receptor-like receptor ORL1 in neuroblastoma x glioma NG108-15 hybrid cells.
Topics: Colforsin; Cyclic AMP; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Glioma; GTP-Binding Proteins; Hybrid Cells; Naltrexone; Narcotic Antagonists; Neuroblastoma; Nociceptin; Nociceptin Receptor; Opioid Peptides; Pertussis Toxin; Receptors, Opioid; Receptors, Opioid, delta; Virulence Factors, Bordetella | 1997 |
Mu and delta opioid receptor activation inhibits omega-conotoxin-sensitive calcium channels in a voltage- and time-dependent mode in the human neuroblastoma cell line SH-SY5Y.
Topics: Barium; Calcium Channels; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Neuroblastoma; Receptors, Opioid, delta; Receptors, Opioid, mu; Tumor Cells, Cultured | 1997 |
Acute and chronic effects of opioids on delta and mu receptor activation of G proteins in NG108-15 and SK-N-SH cell membranes.
Topics: Analgesics; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Glioma; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Hybrid Cells; Membrane Proteins; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Neuroblastoma; Protein Binding; Rats; Receptors, Opioid, delta; Receptors, Opioid, mu; Signal Transduction; Sulfur Radioisotopes; Time Factors | 1997 |
Activation of N-methyl-D-aspartate receptor attenuates acute responsiveness of delta-opioid receptors.
Topics: Analgesics; Animals; CHO Cells; Cricetinae; Cyclic AMP-Dependent Protein Kinases; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Glioma; Ketamine; Mice; N-Methylaspartate; Neuroblastoma; Neurons; Phosphorylation; Protein Kinase C; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, delta; Signal Transduction | 1997 |
Voltage-dependent modulation of single N-Type Ca2+ channel kinetics by receptor agonists in IMR32 cells.
Topics: Barium; Calcium Channel Agonists; Calcium Channels; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Humans; Ion Channel Gating; Kinetics; Membrane Potentials; Models, Chemical; Neuroblastoma; Norepinephrine; Patch-Clamp Techniques; Tumor Cells, Cultured | 1996 |
Modulation of protein kinase C and cAMP-dependent protein kinase by delta-opioid.
Topics: Calcium; Cyclic AMP-Dependent Protein Kinases; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Enzyme Activation; Glioma; Hybrid Cells; Kinetics; Neuroblastoma; Pertussis Toxin; Protein Kinase C; Receptors, Opioid, delta; Tumor Cells, Cultured; Virulence Factors, Bordetella | 1997 |
The stimulatory effect of opioids on cyclic AMP production in SK-N-SH cells is mediated by calcium ions.
Topics: Calcium; Calcium Channel Blockers; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Cell Line; Cyclic AMP; Egtazic Acid; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Humans; Naloxone; Narcotic Antagonists; Neuroblastoma; Opioid Peptides; Sulfonamides | 1997 |
Tolerance to mu-opioid agonists in human neuroblastoma SH-SY5Y cells as determined by changes in guanosine-5'-O-(3-[35S]-thio)triphosphate binding.
Topics: Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Morphine; Neuroblastoma; Receptors, Opioid, mu; Tumor Cells, Cultured | 1997 |
Mu and delta opioids but not kappa opioid inhibit voltage-activated Ba2+ currents in neuronal F-11 cell.
Topics: Analgesics; Analgesics, Opioid; Animals; Barium; Calcium; Calcium Channel Blockers; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ethylmaleimide; Gene Expression Regulation; Hybrid Cells; Ion Channel Gating; Mice; Neuroblastoma; omega-Conotoxin GVIA; Patch-Clamp Techniques; Peptides; Pertussis Toxin; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; RNA, Messenger; Sulfhydryl Reagents; Virulence Factors, Bordetella | 1997 |
Delta opioid modulation of the binding of guanosine-5'-O-(3-[35S]thio)triphosphate to NG108-15 cell membranes: characterization of agonist and inverse agonist effects.
Topics: Animals; Benzylidene Compounds; CHO Cells; Cricetinae; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Guanosine 5'-O-(3-Thiotriphosphate); Mice; Naltrexone; Neuroblastoma; Rats; Receptors, Opioid, delta; Sodium | 1997 |
Herpes simplex virus 1-mediated transfer of preproenkephalin A in rat dorsal root ganglia.
Topics: Animals; beta-Galactosidase; Enkephalins; Ganglia, Spinal; Gene Expression Regulation, Viral; Gene Transfer Techniques; Genes, Reporter; Herpesvirus 1, Human; Humans; Male; Neuroblastoma; Pain; Promoter Regions, Genetic; Protein Precursors; Rats; Rats, Sprague-Dawley; Recombinant Proteins; RNA, Messenger; Tumor Cells, Cultured | 1998 |
N-Methyl-D-aspartate attenuates opioid receptor-mediated G protein activation and this process involves protein kinase C.
Topics: Animals; Cells, Cultured; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Enzyme Activation; GTP-Binding Proteins; Humans; Mice; Mutagenesis, Site-Directed; N-Methylaspartate; Neuroblastoma; Neurons; Phosphorylation; Protein Kinase C; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Tetradecanoylphorbol Acetate; Transfection; Tumor Cells, Cultured | 1998 |
Dissociation between the inhibitory and stimulatory effects of opioid peptides on cAMP formation in SK-N-SH neuroblastoma cells.
Topics: Calcium; Cyclic AMP; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; GTP-Binding Proteins; Humans; Kinetics; Neuroblastoma; Opioid Peptides; Receptors, Opioid, delta; Receptors, Opioid, mu; Tumor Cells, Cultured; Virulence Factors, Bordetella | 1998 |
Differential effects of endomorphin-1, endomorphin-2, and Tyr-W-MIF-1 on activation of G-proteins in SH-SY5Y human neuroblastoma membranes.
Topics: Cell Membrane; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; MSH Release-Inhibiting Hormone; Narcotic Antagonists; Neuroblastoma; Oligopeptides; Receptors, Opioid; Tumor Cells, Cultured | 1998 |
Distinct differences between morphine- and [D-Ala2,N-MePhe4,Gly-ol5]-enkephalin-mu-opioid receptor complexes demonstrated by cyclic AMP-dependent protein kinase phosphorylation.
Topics: Analgesics, Opioid; Antibody Specificity; Carbazoles; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Enzyme Inhibitors; Indoles; Morphine; Neuroblastoma; Neurons; Phosphorylation; Precipitin Tests; Pyrroles; Receptors, Opioid, mu; Tumor Cells, Cultured | 1998 |
Protein kinase A-dependent derepression of the human prodynorphin gene via differential binding to an intragenic silencer element.
Topics: 5' Untranslated Regions; Cyclic AMP-Dependent Protein Kinases; DNA-Binding Proteins; Enkephalins; Enzyme Activation; Gene Expression Regulation; Genes, Regulator; Humans; Mutagenesis, Site-Directed; Neuroblastoma; Nuclear Proteins; Promoter Regions, Genetic; Protein Precursors; Transcription, Genetic; Tumor Cells, Cultured | 1998 |
Simultaneous activation of two different receptor systems by enkephalin/neurotensin conjugates having spacer chains of various lengths.
Topics: Animals; Cattle; Circular Dichroism; Cyclic GMP; Enkephalins; Neuroblastoma; Neurotensin; Protein Conformation; Receptors, Neurotensin; Receptors, Opioid; Recombinant Fusion Proteins; Structure-Activity Relationship; Tumor Cells, Cultured | 1998 |
Role of protein kinase C (PKC) in agonist-induced mu-opioid receptor down-regulation: II. Activation and involvement of the alpha, epsilon, and zeta isoforms of PKC.
Topics: Analgesics; Analgesics, Opioid; Biological Transport; Carcinogens; Diprenorphine; Down-Regulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Enzyme Activation; Humans; Immunoblotting; Isoenzymes; Narcotic Antagonists; Neuroblastoma; Phorbol 12,13-Dibutyrate; Phorbol Esters; Protein Kinase C; Protein Kinase C-alpha; Protein Kinase C-epsilon; Receptors, Opioid, mu; Second Messenger Systems; Tritium; Tumor Cells, Cultured | 1999 |
Role of protein kinase C (PKC) in agonist-induced mu-opioid receptor down-regulation: I. PKC translocation to the membrane of SH-SY5Y neuroblastoma cells is induced by mu-opioid agonists.
Topics: Analgesics; Analgesics, Opioid; Binding, Competitive; Biological Transport; Carcinogens; Diprenorphine; Down-Regulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Humans; Kinetics; Membrane Proteins; Morphine; Naloxone; Narcotic Antagonists; Neuroblastoma; Phorbol 12,13-Dibutyrate; Protein Kinase C; Receptors, Opioid, mu; Second Messenger Systems; Time Factors; Tritium; Tumor Cells, Cultured | 1999 |
Cyclic AMP analogs induce synthesis, processing, and secretion of prepro nociceptin/orphanin FQ-derived peptides by NS20Y neuroblastoma cells.
Topics: Animals; Cell Size; Chromatography, High Pressure Liquid; Colforsin; Cyclic AMP; Dexamethasone; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Mice; Narcotics; Neurites; Neuroblastoma; Neurons; Nociceptin; Opioid Peptides; Peptide Fragments; Radioimmunoassay; Receptors, Opioid, delta; RNA, Messenger; Signal Transduction; Thionucleotides; Time Factors; Tumor Cells, Cultured | 1999 |
Effect of phosducin on opioid receptor function.
Topics: Cyclic AMP; DNA; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Eye Proteins; Flow Cytometry; Glioma; Green Fluorescent Proteins; GTP Phosphohydrolases; GTP-Binding Protein Regulators; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Hybrid Cells; Luminescent Proteins; Microscopy, Confocal; Nerve Tissue Proteins; Neuroblastoma; Phosphoproteins; Radioligand Assay; Receptors, Opioid; Recombinant Fusion Proteins; Transfection; Tumor Cells, Cultured | 1999 |
Differential desensitization of human delta-opioid receptors by peptide and alkaloid agonists.
Topics: Adenylyl Cyclase Inhibitors; Alkaloids; Analgesics; Analgesics, Opioid; Cyclic AMP; Drug Interactions; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Etorphine; Humans; Naloxone; Neuroblastoma; Oligopeptides; Peptides; Receptors, Opioid, delta; Tumor Cells, Cultured | 1999 |
Membrane microviscosity modulates mu-opioid receptor conformational transitions and agonist efficacy.
Topics: Animals; Cell Line; Cell Membrane; Cholesterol Esters; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Glioma; Guanosine 5'-O-(3-Thiotriphosphate); Membrane Fluidity; Nalbuphine; Naltrexone; Narcotic Antagonists; Narcotics; Neuroblastoma; Protein Conformation; Rats; Receptors, Opioid, mu; Sodium Chloride; Sufentanil; Tumor Cells, Cultured; Viscosity | 1999 |
Differential G-protein activation by alkaloid and peptide opioid agonists in the human neuroblastoma cell line SK-N-BE.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Alkaloids; Animals; Azides; Cell Membrane; Colforsin; Cyclic AMP; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Etorphine; GTP-Binding Proteins; Guanosine Triphosphate; Humans; Isoelectric Point; Neuroblastoma; Neurons; Oligodeoxyribonucleotides, Antisense; Oligopeptides; Peptides; Pertussis Toxin; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Tumor Cells, Cultured; Virulence Factors, Bordetella | 1999 |
Monoclonal antibody to the delta opioid receptor acts as an agonist in dual regulation of adenylate cyclase in NG108-15 cells.
Topics: Adenylyl Cyclases; Alprostadil; Amino Acid Sequence; Animals; Antibodies, Monoclonal; Blotting, Western; Cyclic AMP; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Epitopes; Fluorescent Antibody Technique; Glioma; Molecular Sequence Data; Neuroblastoma; Precipitin Tests; Receptors, Opioid, delta; Tumor Cells, Cultured | 1999 |
Endogenous delta-opioid and ORL1 receptors couple to phosphorylation and activation of p38 MAPK in NG108-15 cells and this is regulated by protein kinase A and protein kinase C.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cyclic AMP-Dependent Protein Kinases; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Enzyme Activation; Enzyme Inhibitors; Glioma; Hybrid Cells; Imidazoles; Kinetics; Mitogen-Activated Protein Kinases; Neuroblastoma; Nociceptin Receptor; p38 Mitogen-Activated Protein Kinases; Pertussis Toxin; Phosphorylation; Protein Kinase C; Pyridines; Receptors, Opioid; Receptors, Opioid, delta; Recombinant Proteins; Transfection; Virulence Factors, Bordetella | 1999 |
DREAM-alphaCREM interaction via leucine-charged domains derepresses downstream regulatory element-dependent transcription.
Topics: Amino Acid Motifs; Amino Acid Sequence; Calcium; Calcium-Binding Proteins; Cell Line; Colforsin; Cyclic AMP Response Element Modulator; Cyclic AMP Response Element-Binding Protein; Cyclic AMP-Dependent Protein Kinases; DNA-Binding Proteins; Enkephalins; Gene Expression Regulation; Genes, Regulator; Genes, Reporter; Humans; Kv Channel-Interacting Proteins; Molecular Sequence Data; Mutation; Neuroblastoma; Phosphorylation; Protein Precursors; Recombinant Proteins; Repressor Proteins; RNA, Messenger; Sequence Alignment; Transfection; Tumor Cells, Cultured | 2000 |
Different receptors for somatostatin and opioids in neuroblastoma X glioma hybrid cells.
Topics: Animals; Binding, Competitive; Cyclic AMP; Enkephalins; Etorphine; Glioma; Hybrid Cells; Naloxone; Neuroblastoma; Neurons; Prostaglandins E; Rats; Receptors, Cell Surface; Receptors, Opioid; Somatostatin | 1977 |
Opiate binding to membrane preparations of neuroblastoma x glioma hybrid cells NG108-15: effects of ions and nucleotides.
Topics: Cell Membrane; Cells, Cultured; Enkephalins; Etorphine; Glioma; Guanylyl Imidodiphosphate; Hybrid Cells; Magnesium; Manganese; Naloxone; Neuroblastoma; Nucleotides; Receptors, Opioid; Sodium | 1978 |
Binding assay for opioid peptides with neuroblastoma x glioma hybrid cells: specificity of the receptor site.
Topics: Animals; beta-Lipotropin; Binding, Competitive; Cell Line; Endorphins; Enkephalins; Glioma; Mice; Neoplasms, Experimental; Neuroblastoma; Radioligand Assay; Receptors, Opioid | 1978 |
Interaction of enkephalin with opiate receptors in intact cultured cells.
Topics: Binding, Competitive; Brain; Cations; Cell Line; Endorphins; Enkephalins; Glioma; Hydrolases; Kinetics; Narcotic Antagonists; Narcotics; Neuroblastoma; Receptors, Opioid | 1978 |
Rapid degradation of [3H]leucine-enkephalin by intact neuroblastoma cells.
Topics: Cells, Cultured; Endorphins; Enkephalins; Kinetics; Narcotics; Neuroblastoma; Receptors, Opioid | 1979 |
Opiates and enkephalins inhibit synthesis of gangliosides and membrane glycoproteins in mouse neuroblastoma cell line N4TG1.
Topics: Animals; Cell Line; Endorphins; Enkephalins; Gangliosides; Glycoproteins; Glycosphingolipids; Membrane Proteins; Mice; Narcotics; Nerve Tissue Proteins; Neuroblastoma; Neurons; Proteoglycans; Receptors, Opioid | 1979 |
Regulation of the neuroblastoma x glioma hybrid opiate receptors by Na+ and guanine nucleotides.
Topics: Animals; Binding, Competitive; Cell Line; Enkephalins; Glioma; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Hybrid Cells; Kinetics; Neuroblastoma; Receptors, Opioid; Sodium | 1979 |
Multiple opiate receptors: different regional distribution in the brain and differential binding of opiates and opioid peptides.
Topics: Animals; Brain; Endorphins; Enkephalins; In Vitro Techniques; Manganese; Morphine; Narcotics; Neuroblastoma; Rats; Receptors, Opioid | 1979 |
Opiate (Enkephalin) receptors of neuroblastoma cells: occurrence in clusters on the cell surface.
Topics: Animals; Cell Line; Endorphins; Enkephalins; Mice; Microscopy, Fluorescence; Neoplasms, Experimental; Neuroblastoma; Receptors, Opioid; Synaptic Membranes | 1979 |
Photoaffinity inactivation of the enkephalin receptor.
Topics: Affinity Labels; Animals; Cell Line; Cell Membrane; Endorphins; Enkephalins; Glioma; Hybrid Cells; Kinetics; Mice; Neuroblastoma; Photolysis; Rats; Receptors, Opioid; Spectrophotometry, Ultraviolet | 1979 |
Role of disulphide and sulphydryl groups in clustering of enkephalin receptors in neuroblastoma cells.
Topics: Animals; Cell Line; Cell Membrane; Disulfides; Endorphins; Enkephalins; Membrane Fluidity; Microscopy, Fluorescence; Neuroblastoma; Neurons; Oxidation-Reduction; Rats; Receptors, Opioid; Sulfhydryl Compounds; Sulfhydryl Reagents | 1979 |
Identification of three separate guanine nucleotide-binding proteins that interact with the delta-opioid receptor in NG108-15 neuroblastoma x glioma hybrid cells.
Topics: Adenosine Diphosphate Ribose; Adenylate Cyclase Toxin; Analgesics; Animals; Autoradiography; Cell Line; Cell Membrane; Cholera Toxin; Electrophoresis, Polyacrylamide Gel; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Glioma; GTP-Binding Proteins; Hybrid Cells; Kinetics; Mice; Molecular Weight; Neuroblastoma; Pertussis Toxin; Phosphorus Radioisotopes; Rats; Receptors, Opioid; Receptors, Opioid, delta; Virulence Factors, Bordetella | 1992 |
Analogs of the delta opioid receptor selective cyclic peptide [2-D-penicillamine,5-D-penicillamine]-enkephalin: 2',6'-dimethyltyrosine and Gly3-Phe4 amide bond isostere substitutions.
Topics: Amides; Amino Acid Sequence; Analgesics; Animals; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Glycine; Male; Mice; Molecular Sequence Data; Muscle Contraction; Neuroblastoma; Peptides, Cyclic; Phenylalanine; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Structure-Activity Relationship; Substrate Specificity; Tumor Cells, Cultured; Tyrosine; Vas Deferens | 1992 |
Stimulation of phosphatidylinositol-3-kinase by insulin-like growth factor 1 and other agonists.
Topics: Animals; Bradykinin; Cell Line; Enkephalins; Enzyme Activation; Glioma; Insulin-Like Growth Factor I; Interleukin-1; Kinetics; Nerve Growth Factors; Neuroblastoma; Phosphatidylinositol 3-Kinases; Phosphotransferases; Transforming Growth Factor beta; Vasopressins | 1992 |
Assessment of delta-opioid receptor activation by a series of peptides in cultured cells.
Topics: Amino Acid Sequence; Binding, Competitive; Cell Membrane; Cyclic AMP; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Glioma; GTP Phosphohydrolases; Hybrid Cells; Molecular Sequence Data; Neuroblastoma; Protein Conformation; Receptors, Opioid, delta; Structure-Activity Relationship; Tumor Cells, Cultured | 1992 |
F11 neuroblastoma x DRG neuron hybrid cells express inhibitory mu- and delta-opioid receptors which increase voltage-dependent K+ currents upon activation.
Topics: Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Hybrid Cells; Mice; Neuroblastoma; Neurons; Potassium Channels; Radioligand Assay; Rats; Receptors, Opioid, delta; Receptors, Opioid, mu; Spinal Cord | 1992 |
Dual excitatory and inhibitory effects of opioids on intracellular calcium in neuroblastoma x glioma hybrid NG108-15 cells.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Bucladesine; Calcium; Calcium Channels; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Glioma; Hybrid Cells; Ion Channel Gating; Narcotics; Neuroblastoma; Phorbol 12,13-Dibutyrate; Pyrrolidines; Receptors, Opioid, delta; Tumor Cells, Cultured | 1992 |
Enkephalin induces Ca2+ mobilization in single cells of bradykinin-sensitized differentiated neuroblastoma hybridoma (NG108-15) cells.
Topics: Animals; Bradykinin; Bucladesine; Calcium; Cell Differentiation; Egtazic Acid; Enkephalins; Fura-2; Glioma; Hybrid Cells; Kinetics; Mice; Microscopy, Fluorescence; Neuroblastoma; Pertussis Toxin; Rats; Time Factors; Video Recording; Virulence Factors, Bordetella | 1992 |
Cyclic AMP accumulation alters calmodulin localization in SK-N-SH human neuroblastoma cells.
Topics: Adenylyl Cyclases; Adrenergic alpha-Agonists; Alprostadil; Analgesics; Brimonidine Tartrate; Bucladesine; Calcium; Calmodulin; Carbachol; Cell Line; Colforsin; Cyclic AMP; Cytosol; Edetic Acid; Egtazic Acid; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Humans; Kinetics; Neuroblastoma; Quinoxalines; Tumor Cells, Cultured; Vasoactive Intestinal Peptide | 1992 |
Mobilization of calcium from intracellular store as a possible mechanism underlying the anti-opioid effect of angiotensin II.
Topics: Angiotensin II; Calcium; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Naloxone; Neuroblastoma; Potassium Chloride; Saralasin; Tumor Cells, Cultured | 1992 |
Tonic inhibition and rebound facilitation of a neuronal calcium channel by a GTP-binding protein.
Topics: Animals; Calcium Channels; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Ethylmaleimide; GTP-Binding Proteins; In Vitro Techniques; Membrane Potentials; Mollusk Venoms; Neuroblastoma; Neurons; Peptides, Cyclic; Pertussis Toxin; Rats; Tumor Cells, Cultured; Virulence Factors, Bordetella | 1991 |
Rapid agonist-induced loss of 125I-beta-endorphin opioid receptor sites in NG108-15, but not SK-N-SH neuroblastoma cells.
Topics: Analgesics; Animals; beta-Endorphin; Binding Sites; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Humans; Mice; Neuroblastoma; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Tumor Cells, Cultured | 1991 |
The aminosteroid U-73122 inhibits muscarinic receptor sequestration and phosphoinositide hydrolysis in SK-N-SH neuroblastoma cells. A role for Gp in receptor compartmentation.
Topics: Alprostadil; Cell Line; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Down-Regulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Estrenes; GTP-Binding Proteins; Humans; Inositol; Kinetics; Neuroblastoma; Oxotremorine; Phosphatidylinositols; Pyrrolidinones; Receptors, Muscarinic; Scopolamine; Type C Phospholipases | 1991 |
Regulation of cyclic AMP by the mu-opioid receptor in human neuroblastoma SH-SY5Y cells.
Topics: 1-Methyl-3-isobutylxanthine; Alprostadil; Cell Line; Colforsin; Cyclic AMP; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Humans; Kinetics; Morphine; Neuroblastoma; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Theophylline; Vasoactive Intestinal Peptide | 1990 |
Procholecystokinin and proenkephalin A mRNA expression is modulated by cyclic AMP and noradrenaline.
Topics: Bucladesine; Cholecystokinin; Cyclic AMP; Enkephalins; Gene Expression; Humans; Isoproterenol; Neuroblastoma; Norepinephrine; Nucleic Acid Hybridization; Protein Precursors; RNA Probes; RNA, Messenger; Tumor Cells, Cultured | 1990 |
Met-enkephalyl-Arg6-Phe7 immunoreactivity in a human neuroblastoma cell line: effect of dibutyryl 3':5'-cyclic AMP and reserpine.
Topics: 1-Methyl-3-isobutylxanthine; Alprostadil; Bucladesine; Cell Line; Cyclic AMP; Enkephalin, Methionine; Enkephalins; Humans; Neuroblastoma; Peptide Fragments; Protein Precursors; Reserpine | 1986 |
Opioid antagonist modulation of murine neuroblastoma: a profile of cell proliferation and opioid peptides and receptors.
Topics: Animals; Cell Division; Cell Line; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Male; Mice; Naltrexone; Neoplasms, Experimental; Neuroblastoma; Receptors, Opioid | 1989 |
Probes for narcotic receptor mediated phenomena. 15. (3S,4S)-(+)-trans-3-methylfentanyl isothiocyanate, a potent site-directed acylating agent for the delta opioid receptors in vitro.
Topics: Acylation; Adenylyl Cyclase Inhibitors; Analgesia; Animals; Brain; Cell Membrane; Chemical Phenomena; Chemistry; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Fentanyl; Glioma; Hybrid Cells; Indicators and Reagents; Ligands; Male; Molecular Structure; Neuroblastoma; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Stereoisomerism; Structure-Activity Relationship; Tumor Cells, Cultured | 1989 |
Modulation of proenkephalin A gene expression by cyclic AMP.
Topics: Cyclic AMP; Dexamethasone; Enkephalins; Gene Expression Regulation; Humans; Neuroblastoma; Norepinephrine; Protein Precursors; Receptors, Adrenergic, beta; RNA, Messenger; Tumor Cells, Cultured | 1989 |
Guanine nucleotide regulation of [125I]beta-endorphin binding to NG108-15 and SK-N-SH cell membranes: specific cation requirements.
Topics: beta-Endorphin; Cations; Cell Membrane; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Glioma; Guanine Nucleotides; Guanosine Diphosphate; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Humans; Hybrid Cells; Neuroblastoma; Oligopeptides; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Sodium Chloride; Tumor Cells, Cultured | 1989 |
The effects of long-term treatment of NG108-15 cells with penta- and tetrapeptide enkephalin dimers on opioid receptor binding and cyclic AMP (cAMP) levels.
Topics: Alprostadil; Animals; Cell Line; Cyclic AMP; Enkephalins; Glioma; Hybrid Cells; Kinetics; Mice; Neuroblastoma; Rats; Receptors, Opioid; Structure-Activity Relationship | 1987 |
Comparison of [125I]beta-endorphin binding to rat brain and NG108-15 cells using a monoclonal antibody directed against the opioid receptor.
Topics: Animals; Antibodies, Monoclonal; beta-Endorphin; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Glioma; Immunoglobulin M; In Vitro Techniques; Iodine Radioisotopes; Male; Molecular Weight; Neuroblastoma; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Tumor Cells, Cultured | 1988 |
Characterization of opioid binding sites in murine neuroblastoma.
Topics: Analgesics, Opioid; Animals; Binding, Competitive; Cell Line; Clone Cells; Cyclazocine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Kinetics; Ligands; Mice; Neuroblastoma; Receptors, Opioid | 1988 |
Comparative binding properties of linear and cyclic delta-selective enkephalin analogues: [3H]-[D-Thr2, Leu5] enkephalyl-Thr6 and [3H]-[D-Pen2, D-Pen5] enkephalin.
Topics: Animals; Brain; Cell Line; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Glioma; Guinea Pigs; Isomerism; Kinetics; Neuroblastoma; Oligopeptides; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta | 1985 |
Characterization of [3H][2-D-penicillamine, 5-D-penicillamine]-enkephalin binding to delta opiate receptors in the rat brain and neuroblastoma--glioma hybrid cell line (NG 108-15).
Topics: Animals; Brain; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Glioma; Hybrid Cells; Kinetics; Membranes; Mice; Neuroblastoma; Rats; Receptors, Opioid; Receptors, Opioid, delta | 1985 |
Dual pathways of receptor-mediated cyclic GMP generation in NG108-15 cells as differentiated by susceptibility to islet-activating protein, pertussis toxin.
Topics: Adenylate Cyclase Toxin; Animals; Bacterial Toxins; Calcimycin; Cyclic AMP; Cyclic GMP; Dinoprost; Enkephalins; Glioma; Hybrid Cells; Melitten; Mice; Neuroblastoma; Pertussis Toxin; Phospholipids; Prostaglandins F; Rats; Receptors, Cell Surface; Virulence Factors, Bordetella | 1985 |
A human neuroblastoma cell line expresses mu and delta opioid receptor sites.
Topics: Bone Neoplasms; Cell Line; Child, Preschool; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Etorphine; Female; Guanylyl Imidodiphosphate; Humans; Kinetics; Naloxone; Neuroblastoma; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Sodium Chloride | 1986 |
Opioid receptors in human neuroblastoma SH-SY5Y cells: evidence for distinct morphine (mu) and enkephalin (delta) binding sites.
Topics: Animals; Binding, Competitive; Cell Line; Enkephalins; Humans; Ligands; Mice; Morphine; Neuroblastoma; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1986 |
Sodium regulation of agonist binding at opioid receptors. I. Effects of sodium replacement on binding at mu- and delta-type receptors in 7315c and NG108-15 cells and cell membranes.
Topics: Adenylyl Cyclase Inhibitors; Animals; Cell Line; Cell Membrane; Cyclazocine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Etorphine; Glioma; Guinea Pigs; Monensin; Naloxone; Neuroblastoma; Pituitary Neoplasms; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Sodium | 1986 |
Glucocorticoids and cyclic AMP synergistically regulate the abundance of preproenkephalin messenger RNA in neuroblastoma-glioma hybrid cells.
Topics: Base Sequence; Cells, Cultured; Colforsin; Cyclic AMP; Drug Synergism; Enkephalin, Methionine; Enkephalins; Gene Expression Regulation; Glioma; Glucocorticoids; Hybrid Cells; Neuroblastoma; Protein Precursors; RNA, Messenger | 1986 |
Comparative pharmacological properties and functional coupling of mu and delta opioid receptor sites in human neuroblastoma SH-SY5Y cells.
Topics: Binding, Competitive; Cell Line; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Humans; Kinetics; Narcotics; Neuroblastoma; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1987 |
Enhanced oxygen metabolism of peritoneal macrophages in the presence of murine neuroblastoma cells is partly caused by enkephalins.
Topics: Animals; Antigenic Variation; Enkephalins; Female; Macrophages; Male; Mice; Mice, Inbred Strains; Neuroblastoma; Oxygen Consumption; Peritoneal Cavity; Tissue Extracts; Tumor Cells, Cultured | 1988 |
Expression of the proenkephalin gene in human neuroblastoma cell lines.
Topics: Adrenal Gland Neoplasms; Cell Line; Enkephalins; Genes; Humans; Neuroblastoma; Nucleic Acid Hybridization; Pheochromocytoma; Protein Biosynthesis; Protein Precursors; RNA, Messenger; Transcription, Genetic | 1988 |
Chronic exposure to opiate agonists increases proenkephalin biosynthesis in NG108 cells.
Topics: Animals; Cell Line; Colforsin; Enkephalin, Methionine; Enkephalins; Etorphine; Genes; Glioma; Hybrid Cells; Morphinans; Morphine; Naloxone; Neuroblastoma; Protein Precursors; RNA, Messenger; Transcription, Genetic | 1988 |
Distinct morphological and immunohistochemical features and different growth rates among four human neuroblastomas heterotransplanted into nude mice.
Topics: Animals; Calcitonin Gene-Related Peptide; Child; Child, Preschool; Enkephalin, Leucine; Enkephalin, Methionine; Female; Galanin; Humans; Infant; Male; Mice; Mice, Nude; Neoplasm Transplantation; Neuroblastoma; Neuropeptide Y; Secretory Vesicles; Serotonin; Transplantation, Heterologous; Tyrosine 3-Monooxygenase; Vasoactive Intestinal Peptide | 2008 |
Sodium regulation of opioid agonist binding is potentiated by pertussis toxin.
Topics: Animals; Bacterial Toxins; Cell Line; Diprenorphine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Glioma; Guanine Nucleotides; Hybrid Cells; Mice; Morphinans; Neuroblastoma; Pertussis Toxin; Rats; Receptors, Opioid; Sodium; Virulence Factors, Bordetella | 1984 |
Up-regulation of opiate receptors by opiate antagonists in neuroblastoma-glioma cell culture: the possibility of interaction with guanosine triphosphate-binding proteins.
Topics: Animals; Cells, Cultured; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Glioma; GTP-Binding Proteins; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Naloxone; Neuroblastoma; Rats; Receptors, Opioid; Receptors, Opioid, delta | 1984 |
Beta-endorphin. Binding activity of synthetic analogs with various chain lengths in neuroblastoma x glioma NG108-15 cell membranes.
Topics: Animals; beta-Endorphin; Cell Membrane; Endorphins; Enkephalin, Leucine; Glioma; In Vitro Techniques; Kinetics; Neuroblastoma; Rats; Receptors, Opioid; Structure-Activity Relationship | 1984 |
Opiate peptide receptors on intact NIE-115 neuroblastoma: radioligand binding properties, intracellular response, and effects of increasing membrane cholesterol.
Topics: Animals; Cholesterol; Clone Cells; Enkephalin, Leucine; Enkephalin, Methionine; Membrane Lipids; Mice; Morphine; Naloxone; Neuroblastoma; Receptors, Opioid | 1984 |
Mechanisms of multiple cellular adaptation processes in clonal cell lines during chronic opiate treatment.
Topics: Adaptation, Physiological; Adenylyl Cyclases; Animals; Cell Line; Clone Cells; Cytosol; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Etorphine; Glioma; Guanylyl Imidodiphosphate; Lanthanum; Mice; Naloxone; Narcotics; Neuroblastoma; Rats; Receptors, Opioid; Sodium; Time Factors | 1984 |
Gangliosides as modulators of the coupling of neurotransmitters to adenylate cyclase.
Topics: Adenylyl Cyclases; Animals; Brain; Cell Line; Clonidine; Cricetinae; Cricetulus; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Gangliosides; Hybrid Cells; Kinetics; Mice; Neuroblastoma; Neurons; Neurotransmitter Agents; Receptors, Serotonin | 1984 |
Effects of opiate and alpha 2-adrenergic agonists in a neuroblastoma x brain explant hybrid cell line (NCB-20).
Topics: Adrenergic alpha-Agonists; Alprostadil; Animals; Brain; Cell Line; Clonidine; Cricetinae; Cricetulus; Cyclic AMP; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Hybrid Cells; Mice; Narcotics; Neuroblastoma; Neurons; Prostaglandins E | 1984 |
Induction of differentiation increases Met5-enkephalin and Leu5-enkephalin content in NG108-15 hybrid cells: an immunocytochemical and biochemical analysis.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Bucladesine; Cell Differentiation; Culture Media; Cyclic AMP; Enkephalin, Leucine; Enkephalin, Methionine; Glioma; Hybrid Cells; Immunochemistry; Neuroblastoma; Staining and Labeling | 1983 |
Characterization of the association of tritiated enkephalin with neuroblastoma cells under conditions optimal for receptor down regulation.
Topics: 2,4-Dinitrophenol; Animals; Cell Line; Dinitrophenols; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Mice; Neuroblastoma; Receptors, Opioid; Temperature | 1983 |
The regulation of delta-opiate receptor density on 108CC15 neuroblastoma X glioma hybrid cells.
Topics: Animals; Bucladesine; Cell Differentiation; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Glioma; Hybrid Cells; Mice; Morphine; Neuroblastoma; Rats; Receptors, Opioid; Receptors, Opioid, delta | 1984 |
Down-regulation of opiate receptor in neuroblastoma x glioma NG108-15 hybrid cells. Chloroquine promotes accumulation of tritiated enkephalin in the lysosomes.
Topics: Animals; Cell Line; Chloroquine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Glioma; Hybrid Cells; Kinetics; Lysosomes; Mice; Neuroblastoma; Rats; Receptors, Opioid | 1984 |
Down regulation of opiate receptors on 108CC15 hybrid cells is inhibited by receptor occupancy.
Topics: Animals; Cell Line; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Glioma; Hybrid Cells; Kinetics; Mice; Neuroblastoma; Rats; Receptors, Opioid; Receptors, Opioid, delta | 1983 |
Enkephalin degradation by enkephalinergic neuroblastoma cells. Involvement of angiotensin-converting-enzyme.
Topics: Aminopeptidases; Angiotensin-Converting Enzyme Inhibitors; Animals; Captopril; Cell Line; Cell Membrane; Cells, Cultured; Enkephalin, Leucine; Hydrolysis; Leucine; Mice; Neuroblastoma; Peptidyl-Dipeptidase A; Thiorphan; Tiopronin | 1984 |
Leu-enkephalin-like immunoreactivity in proliferative lesions of the human adrenal medulla and extra-adrenal paraganglia.
Topics: Adrenal Gland Neoplasms; Adrenal Medulla; Enkephalin, Leucine; Ganglioneuroma; Histocytochemistry; Humans; Hyperplasia; Immunoenzyme Techniques; Neuroblastoma; Pheochromocytoma | 1983 |
[3H]ethylketocyclazocine binding to NCB-20 hybrid neurotumor cells.
Topics: Animals; Binding, Competitive; Brain; Cricetinae; Cricetulus; Cyclazocine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylketocyclazocine; Hybrid Cells; Kinetics; Neuroblastoma; Trypsin | 1983 |
Opioid-induced increase in [Ca2+]i in ND8-47 neuroblastoma x dorsal root ganglion hybrid cells is mediated through G protein-coupled delta-opioid receptors and desensitized by chronic exposure to opioid.
Topics: Calcium; Calcium Channels; Cholera Toxin; Dihydropyridines; Enkephalin, Leucine; Ganglia, Spinal; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Hybrid Cells; Intracellular Membranes; Narcotics; Neuroblastoma; Osmolar Concentration; Pertussis Toxin; Receptors, Opioid; Receptors, Opioid, delta; Time Factors; Tumor Cells, Cultured; Virulence Factors, Bordetella | 1995 |
Heterologous desensitization of opioid-stimulated Ca2+ increase by bradykinin or ATP in NG108-15 cells.
Topics: Adenosine Triphosphate; Bradykinin; Calcium; Cyclic AMP; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Glioma; Inositol 1,4,5-Trisphosphate; Neuroblastoma; Receptors, Opioid, delta; Tumor Cells, Cultured | 1995 |
Antisense oligodeoxynucleotide to the Gi2 protein alpha subunit sequence inhibits an opioid-induced increase in the intracellular free calcium concentration in ND8-47 neuroblastoma x dorsal root ganglion hybrid cells.
Topics: Analgesics; Base Sequence; Calcium; Calcium Channels; Cells, Cultured; Enkephalin, Leucine; Ganglia, Spinal; GTP-Binding Proteins; Hybrid Cells; Molecular Sequence Data; Neuroblastoma; Oligonucleotides, Antisense; Receptors, Opioid, delta | 1995 |
Bradykinin modulates potassium and calcium currents in neuroblastoma hybrid cells via different pertussis toxin-insensitive pathways.
Topics: Animals; Bradykinin; Calcium Channels; Electrophysiology; Enkephalin, Leucine; Glioma; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Hybrid Cells; Kinetics; Models, Biological; Neuroblastoma; Pertussis Toxin; Phosphatidylinositol Diacylglycerol-Lyase; Phosphoinositide Phospholipase C; Phosphoric Diester Hydrolases; Potassium Channels; Tetrodotoxin; Tumor Cells, Cultured; Virulence Factors, Bordetella | 1994 |
Identification of the critical domains of the delta-opioid receptor involved in G protein coupling using site-specific synthetic peptides.
Topics: Amino Acid Sequence; Analgesics; Animals; Binding Sites; Enkephalin, Leucine; Fibroblasts; Glioma; GTP Phosphohydrolases; GTP-Binding Proteins; Hybrid Cells; Kinetics; Mice; Molecular Sequence Data; Neuroblastoma; Peptide Fragments; Protein Structure, Tertiary; Rats; Receptors, Opioid, delta; Structure-Activity Relationship; Substrate Specificity; Transfection; Tritium; Tumor Cells, Cultured | 1996 |
Regulation of delta-opioid receptor mRNA levels by receptor-mediated and direct activation of the adenylyl cyclase-protein kinase A pathway.
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Analgesics; Animals; Binding Sites; Bucladesine; Calcium Channels; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Diprenorphine; Enkephalin, Leucine; Gene Expression Regulation, Enzymologic; Mice; Neuroblastoma; Protein Synthesis Inhibitors; Receptors, Opioid, delta; RNA, Messenger; Tritium; Tumor Cells, Cultured | 1997 |
Regulation of delta opioid receptors by delta9-tetrahydrocannabinol in NG108-15 hybrid cells.
Topics: Animals; Colforsin; Dose-Response Relationship, Drug; Dronabinol; Enkephalin, Leucine; Glioma; Mice; Neuroblastoma; Piperidines; Pyrazoles; Rats; Receptors, Opioid, delta; Rimonabant; RNA, Messenger; Tumor Cells, Cultured | 1998 |
Potentiation of transmitter release from NMB human neuroblastoma cells by kappa-opioids is mediated by N-type voltage-dependent calcium channels.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Calcium Channel Blockers; Calcium Channels, N-Type; Dopamine; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Humans; Neuroblastoma; omega-Conotoxins; Pertussis Toxin; Potassium Cyanide; Receptors, Opioid, kappa; Tumor Cells, Cultured; Virulence Factors, Bordetella | 1999 |
The metabolic evidence of synergistic effect between ohmefentanyl and [D-Pen2, D-Pen5] enkephalin on differentiated SH-SY5Y cells in humans.
Topics: Acids; Analgesics; Analgesics, Opioid; Animals; Cell Differentiation; CHO Cells; Cricetinae; Drug Synergism; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Extracellular Space; Fentanyl; Humans; Naloxone; Narcotic Antagonists; Neuroblastoma; Neurons; Tumor Cells, Cultured | 2001 |
Delta-opioid-receptor-mediated inhibition of adenylate cyclase is transduced specifically by the guanine-nucleotide-binding protein Gi2.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclase Inhibitors; Amino Acid Sequence; Animals; Base Sequence; Cell Line; DNA, Neoplasm; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Glioma; GTP Phosphohydrolases; GTP-Binding Proteins; Guanylyl Imidodiphosphate; Hybrid Cells; Immune Sera; Kinetics; Mice; Molecular Sequence Data; NAD; Neuroblastoma; Oligonucleotide Probes; Pertussis Toxin; Rats; Receptors, Opioid; Receptors, Opioid, delta; RNA, Neoplasm; Signal Transduction; Virulence Factors, Bordetella | 1990 |
Direct demonstration of the activation of UDP-N-acetylgalactosamine: [GM3]N-acetylgalactosaminyltransferase by cyclic AMP.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Brain; Cell Line; Cyclic AMP; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enzyme Activation; Galactosyltransferases; Glioma; Kinetics; Mice; Microsomes; N-Acetylgalactosaminyltransferases; Neuroblastoma; Phosphoproteins; Phosphorylation; Polypeptide N-acetylgalactosaminyltransferase; Protein Kinases; Rats | 1986 |
Block of calcium channels by enkephalin and somatostatin in neuroblastoma-glioma hybrid NG108-15 cells.
Topics: Animals; Calcium; Calcium Channel Blockers; Cell Line; Dose-Response Relationship, Drug; Electric Conductivity; Enkephalin, Leucine; Glioma; Ion Channels; Naloxone; Neuroblastoma; Rats; Somatostatin | 1986 |
Neuromodulator-mediated phosphorylation of specific proteins in a neurotumor hybrid cell line (NCB-20).
Topics: 1-Methyl-3-isobutylxanthine; 2-Chloroadenosine; Adenosine; Alprostadil; Animals; Brain; Calcimycin; Colforsin; Cricetinae; Cyclic AMP; Electrophoresis, Polyacrylamide Gel; Embryo, Mammalian; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Hybrid Cells; Immunoassay; Mice; Nerve Tissue Proteins; Neuroblastoma; Neurotransmitter Agents; Phosphoproteins; Phosphorylation; Protein Kinases; Serotonin; Tumor Cells, Cultured; Tyrosine 3-Monooxygenase | 1988 |
Involvement of the guanine nucleotide-binding protein, No, in the inhibitory regulation of neuronal calcium channels.
Topics: Animals; Calcium; Cell Line; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Glioma; GTP-Binding Proteins; Homeostasis; Hybrid Cells; Ion Channels; Neuroblastoma; Neurons | 1988 |
Chronic exposure of NG 108-15 cells to opiate agonists does not alter the amount of the guanine nucleotide-binding proteins Gi and Go.
Topics: Adenosine Diphosphate Ribose; Electrophoresis, Polyacrylamide Gel; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Glioma; GTP-Binding Proteins; Hybrid Cells; Immunoblotting; Morphine; NAD; Neuroblastoma; Pertussis Toxin; Time Factors; Tumor Cells, Cultured; Virulence Factors, Bordetella | 1989 |
Opioid receptors of neuroblastoma cells are in two domains of the plasma membrane that differ in content of G proteins.
Topics: Adenosine Diphosphate Ribose; Adenylate Cyclase Toxin; Adenylyl Cyclases; Cell Fractionation; Cell Membrane; Centrifugation; Diprenorphine; Electrophoresis, Polyacrylamide Gel; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; GTP Phosphohydrolases; GTP-Binding Proteins; Guanosine Triphosphate; Neuroblastoma; Pertussis Toxin; Receptors, Opioid; Tumor Cells, Cultured; Virulence Factors, Bordetella | 1989 |
Calcium channels in vertebrate neurons. Experiments on a neuroblastoma hybrid model.
Topics: Acetylcholine; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Cadmium; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Electric Conductivity; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Gadolinium; GTP-Binding Proteins; Neuroblastoma; Neurons; Norepinephrine; Tumor Cells, Cultured | 1989 |
Antagonists with negative intrinsic activity at delta opioid receptors coupled to GTP-binding proteins.
Topics: Animals; Benzomorphans; Cell Line; Cell Membrane; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylmaleimide; Glioma; GTP Phosphohydrolases; GTP-Binding Proteins; Kinetics; Narcotic Antagonists; Neuroblastoma; Pertussis Toxin; Receptors, Opioid; Receptors, Opioid, delta; Virulence Factors, Bordetella | 1989 |
Cholera toxin ADP-ribosylates the receptor-coupled form of pertussis toxin-sensitive G-proteins.
Topics: Adenosine Diphosphate Ribose; Animals; Cell Line; Cell Membrane; Cholera Toxin; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Glioma; GTP Phosphohydrolases; GTP-Binding Proteins; Hybrid Cells; NAD; Neuroblastoma; Pertussis Toxin; Receptors, Opioid; Virulence Factors, Bordetella | 1989 |
Opioid receptor desensitization in NG 108-15 cells. Differential effects of a full and a partial agonist on the opioid-dependent GTPase.
Topics: Adenylyl Cyclase Inhibitors; Cell Line; Cell Membrane; Drug Tolerance; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Glioma; GTP Phosphohydrolases; Hybrid Cells; Morphine; Neuroblastoma; Phosphoric Monoester Hydrolases; Receptors, Opioid | 1987 |
Effects of membrane polyunsaturated fatty acids on opiate peptide inhibition of basal and prostaglandin E1-stimulated cyclic AMP formation in intact N1E-115 neuroblastoma cells.
Topics: Adenylyl Cyclase Inhibitors; Alprostadil; Cell Division; Cell Membrane; Cyclic AMP; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Fatty Acids, Unsaturated; Fluorescence Polarization; Kinetics; Linoleic Acid; Linoleic Acids; Naloxone; Neuroblastoma; Receptors, Opioid; Tumor Cells, Cultured | 1987 |
Differential regulation by butyrate and dibutyryl cyclic AMP of delta-opioid, alpha 2-adrenergic, and muscarinic cholinergic receptors in NCB-20 cells.
Topics: Alprostadil; Animals; Binding, Competitive; Brain; Bucladesine; Butyrates; Butyric Acid; Carbachol; Clonidine; Cyclic AMP; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Hybrid Cells; Kinetics; Mice; Neuroblastoma; Phosphatidylinositols; Quinuclidinyl Benzilate; Receptors, Adrenergic, alpha; Receptors, Muscarinic; Receptors, Opioid; Receptors, Opioid, delta; Tumor Cells, Cultured | 1988 |
Modification of opioid receptor activity by acid phosphatase in neuroblastoma x glioma NG108-15 hybrid cells.
Topics: Acid Phosphatase; Animals; Chromatography, High Pressure Liquid; Cyclic AMP; Diprenorphine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Etorphine; Glioma; Guanfacine; Guanidines; Hybrid Cells; Neuroblastoma; Phenylacetates; Receptors, Opioid | 1988 |
Endogenous opioids and the growth regulation of a neural tumor.
Topics: Animals; Antineoplastic Agents; Enkephalin, Leucine; Enkephalin, Methionine; Male; Mice; Naloxone; Neoplasm Transplantation; Neuroblastoma; Receptors, Opioid | 1988 |
Differential regulation of amounts of the guanine-nucleotide-binding proteins Gi and Go in neuroblastoma x glioma hybrid cells in response to dibutyryl cyclic AMP.
Topics: Bucladesine; Cell Differentiation; Cell Membrane; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Glioma; GTP-Binding Proteins; Hybrid Cells; Neuroblastoma; Time Factors | 1988 |
Degradation of dynorphin-(1-13) and dynorphin-(1-17) by the neuroblastoma cell membrane. Evidence for the involvement of a cysteine protease.
Topics: Amino Acids; Captopril; Cell Line; Cysteine Endopeptidases; Dynorphins; Endopeptidases; Enkephalin, Leucine; Ethylmaleimide; Neuroblastoma; Peptide Fragments | 1986 |
Multiple affinity states of opiate receptor in neuroblastoma x glioma NG108-15 hybrid cells. Opiate agonist association rate is a function of receptor occupancy.
Topics: Animals; Binding, Competitive; Cell Line; Diprenorphine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Glioma; Guanylyl Imidodiphosphate; Hybrid Cells; Kinetics; Magnesium; Neuroblastoma; Receptors, Opioid; Sodium | 1985 |
Comparative studies of the binding of dimeric and monomeric enkephalins to neuroblastoma-glioma NG108-15 cells.
Topics: Animals; Cell Line; Cell Membrane; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Glioma; Neuroblastoma; Receptors, Opioid; Tritium | 1985 |
Increased affinity of dimeric enkephalins is not dependent on receptor density.
Topics: Animals; Cell Line; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Glioma; Kinetics; Models, Neurological; Neuroblastoma; Receptors, Opioid; Receptors, Opioid, delta | 1985 |
Desensitization of opioid-stimulated GTPase in neuroblastoma x glioma hybrid cells.
Topics: Animals; Drug Resistance; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; GTP Phosphohydrolases; Hybrid Cells; Kinetics; Magnesium; Membranes; Neuroblastoma; Neuroglia; Phosphoric Monoester Hydrolases; Rats; Sodium | 1985 |
Multiple states of opioid receptors may modulate adenylate cyclase in intact neuroblastoma X glioma hybrid cells.
Topics: Adenylyl Cyclases; Animals; Cell Line; Cyclic AMP; Diprenorphine; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Etorphine; Glioma; Hybrid Cells; Kinetics; Ligands; Morphine; Naloxone; Neuroblastoma; Neurons; Receptors, Opioid; Receptors, Opioid, delta | 1985 |
Evidence for [D-Ala2,D-Leu5]enkephalin-induced supersensitivity to 5-hydroxytryptamine in a neurotumor x brain hybrid cell line (NCB-20).
Topics: Adenylyl Cyclases; Alprostadil; Animals; Brain; Brain Chemistry; Cell Line; Cholera Toxin; Clonidine; Cricetinae; Cricetulus; Cyclic AMP; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Hybrid Cells; Mice; Neuroblastoma; Receptors, Serotonin; Serotonin | 1985 |
NMB: a human neuroblastoma cell line with specific opiate binding sites.
Topics: Binding Sites; Cell Line; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Humans; Neuroblastoma; Receptors, Opioid; Receptors, Opioid, delta; Sodium; Tritium | 1985 |
Bradykinin stimulates GTP hydrolysis in NG108-15 membranes by a high-affinity, pertussis toxin-insensitive GTPase.
Topics: Bradykinin; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Glioma; GTP Phosphohydrolases; GTP-Binding Proteins; Guanosine Triphosphate; Hybrid Cells; Hydrolysis; Membranes; Neuroblastoma; Pertussis Toxin; Phosphatidylinositols; Phosphoric Monoester Hydrolases; Virulence Factors, Bordetella | 1986 |
Ethanol increases the expression of functional delta-opioid receptors in neuroblastoma x glioma NG108-15 hybrid cells.
Topics: Cell Line; Cyclic AMP; Cycloheximide; Dactinomycin; Diprenorphine; DNA; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethanol; Etorphine; Glioma; Hybridomas; Naloxone; Neuroblastoma; Phenylisopropyladenosine; Receptors, Opioid; Receptors, Opioid, delta; Sodium; Transcription, Genetic | 1986 |
Subcellular compartmentation of opioid receptors: modulation by enkephalin and alkaloids.
Topics: Animals; Cell Line; Cell Membrane; Centrifugation, Density Gradient; Chloroquine; Diprenorphine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Etorphine; Glioma; Golgi Apparatus; Kinetics; Lysosomes; Microsomes; Neuroblastoma; Receptors, Opioid | 1986 |
An assessment of the role of opioid receptors in the response to cannabimimetic drugs.
Topics: Adenylyl Cyclase Inhibitors; Animals; Cannabinoids; Cell Line; Dronabinol; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Etorphine; Morphine; Naltrexone; Neuroblastoma; Neurons; Receptors, Opioid; Receptors, Opioid, delta | 1986 |
Delta opioid receptors in human neuroblastoma cell lines.
Topics: Binding, Competitive; Cell Line; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Humans; Kinetics; Neuroblastoma; Receptors, Opioid; Receptors, Opioid, delta | 1986 |
The adenylate cyclase rebound response to naloxone in the NG108-15 cells. Effects of etorphine and other opiates.
Topics: Adenylyl Cyclases; Alprostadil; Cell Line; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Etorphine; Glioma; Morphinans; Morphine; Naloxone; Neuroblastoma; Receptors, Opioid | 1986 |
Modulation of human neuroblastoma transplanted into nude mice by endogenous opioid systems.
Topics: Animals; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Naltrexone; Neoplasm Transplantation; Neuroblastoma; Receptors, Opioid; Transplantation, Heterologous | 1987 |
Bradykinin induces a rapid release of inositol trisphosphate from a neuroblastoma hybrid cell line NCB-20 that is not antagonized by enkephalin.
Topics: Animals; Bradykinin; Brain; Cell Line; Clone Cells; Cricetinae; Cricetulus; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Hybrid Cells; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Mice; Neuroblastoma; Neurons; Sugar Phosphates | 1986 |