enkephalin, leucine has been researched along with Nerve Pain in 28 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (3.57) | 18.2507 |
| 2000's | 6 (21.43) | 29.6817 |
| 2010's | 15 (53.57) | 24.3611 |
| 2020's | 6 (21.43) | 2.80 |
| Authors | Studies |
|---|---|
| Candeletti, S; Darcq, E; De Gregorio, D; Gobbi, G; He, Q; Kieffer, BL; Lopez-Canul, M; Luongo, L; Pearl-Dowler, L; Posa, L; Romualdi, P; Rullo, L | 1 |
| Grace, PM; Heijnen, CJ; Junigan, JM; Kavelaars, A; Trinh, R; Zhang, J | 1 |
| Mika, J; Piotrowska, A; Przewłocka, B; Przewłocki, R; Rojewska, E; Starnowska-Sokół, J; Wawrzczak-Bargieła, A; Ziółkowska, B | 1 |
| Ma, G; Pan, M; Xie, P; Yang, J; Zhang, L | 1 |
| Antoniazzi, MM; Giardini, AC; Jared, SGS; Kimura, LF; Mattaraia, VGM; Pagano, RL; Picolo, G; Sant'Anna, MB; Zambelli, VO | 1 |
| Calligaro, H; Cheng, K; Goel, V; Ibrahim, MM; Khanna, R; Kranz, T; Largent-Milnes, TM; Martin, LF; Moutal, A; Patwardhan, A; Washington, SM | 1 |
| Li, H; Long, R; Sun, Q; Sun, Y; Zhang, D | 1 |
| Makuch, W; Mika, J; Piotrowska, A; Popiolek-Barczyk, K | 1 |
| Ali, R; Klein, AH; Mohammad, HK; Peper, B; Raja, SN; Ringkamp, M; Sweitzer, S; Wilson, SP | 1 |
| Candeletti, S; Caputi, FF; Mercatelli, D; Palmisano, M; Romualdi, P | 1 |
| Benyhe, S; Mika, J; Przewlocka, B; Przewlocki, R; Rojewska, E; Starnowska, J; Szucs, E; Wawrzczak-Bargiela, A | 1 |
| Dimitrov, E; Paretkar, T | 1 |
| Baños, JE; Bilecki, W; Dickenson, AH; Gonçalves, L; Lara-Mayorga, IM; Maldonado, R; Martínez-Navarro, M; Negrete, R; Przewłocki, R; Wawrzczak-Bargieła, A | 1 |
| Chou, AH; Day, YJ; Lee, CM; Lee, HC; Liao, CC; Lin, YC; Liou, JT; Mao, CC | 1 |
| Bonnard, E; Dangé, E; Fournié-Zaluski, MC; Poras, H; Roques, BP | 1 |
| Alique, M; Herrero, JF; Schröder, W | 1 |
| Cai, Z; Cheng, X; Guo, Q; Hu, C; Lu, Y; Wu, Z; Zhang, Q | 1 |
| Bernard, C; Bernard, R; Claude, FZ; Elisabeth, B; Sophie, D; Thibault, K | 1 |
| Guo, QL; He, ZH; Wang, E; Yang, Y; Zou, WY | 1 |
| Korostynski, M; Luvisetto, S; Makuch, W; Marinelli, S; Mika, J; Pavone, F; Przewlocka, B; Rojewska, E | 1 |
| Cabral, L; Lima, D; Martins, I; Pinto, A; Tavares, I; Wilson, SP | 1 |
| Guo, Q; Huang, C; Pan, Y; Yan, J; Yang, Y; Zou, W | 1 |
| Attri, P; Dhanda, S; Khaket, TP; Singh, J | 1 |
| Gardell, LR; Gardell, SE; Lai, J; Ossipov, MH; Porreca, F; Vanderah, TW; Wang, R | 1 |
| Caron, MG; Chavkin, C; Czyzyk, TA; Lefkowitz, RJ; McLaughlin, JP; Petraschka, M; Pintar, JE; Terman, GW; Westenbroek, RE; Xu, M | 1 |
| An, K; Gao, F; Jin, XG; Tian, XB; Tian, YK; Wang, P; Wang, XY; Xu, Y; Yang, H | 1 |
| Basbaum, AI; Fields, HL; Skinner, K | 1 |
| Cheng, HY; Crackower, M; Goncalves, J; Ikura, M; Joza, NA; Kockeritz, LK; Laviolette, SR; Oliveira-dos-Santos, AJ; Penninger, JM; Pitcher, GM; Salter, MW; Sarosi, I; Tong, KI; van der Kooy, D; Wada, T; Whishaw, IQ; Woodgett, JR | 1 |
1 review(s) available for enkephalin, leucine and Nerve Pain
| Article | Year |
|---|---|
Enkephalin degrading enzymes: metalloproteases with high potential for drug development.
Topics: Aminopeptidases; Animals; Antineoplastic Agents; Drug Design; Enkephalins; Humans; Neoplasms; Neuralgia | 2012 |
27 other study(ies) available for enkephalin, leucine and Nerve Pain
| Article | Year |
|---|---|
Supraspinal melatonin MT
Topics: Analgesics, Opioid; Animals; Enkephalins; Melatonin; Mice; Naloxone; Narcotic Antagonists; Neuralgia; Rats; Receptors, Opioid, delta; Receptors, Opioid, mu | 2022 |
HDAC6 Inhibition Reverses Cisplatin-Induced Mechanical Hypersensitivity via Tonic Delta Opioid Receptor Signaling.
Topics: Analgesics, Opioid; Animals; Antibodies, Neutralizing; Antineoplastic Agents; Cisplatin; Enkephalin, Methionine; Enkephalins; Female; Histone Deacetylase 6; Histone Deacetylase Inhibitors; Hyperalgesia; Ligands; Male; Mice; Mice, Inbred C57BL; Narcotic Antagonists; Neuralgia; Niacinamide; Receptors, Opioid, delta | 2022 |
Neuropathic Pain Dysregulates Gene Expression of the Forebrain Opioid and Dopamine Systems.
Topics: Animals; Corpus Striatum; Enkephalins; Gene Expression; Male; Mice; Neuralgia; Pain Measurement; Prosencephalon; Protein Precursors; Receptors, Dopamine; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2020 |
Transplantation of Mesenchymal Stromal Cells Expressing the Human Preproenkephalin Gene Can Relieve Pain in a Rat Model of Neuropathic Pain.
Topics: Animals; Cell Engineering; Enkephalins; Gene Transfer Techniques; Genetic Therapy; Humans; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Neuralgia; Protein Precursors; Rats, Sprague-Dawley; Sciatic Nerve; Sciatic Neuropathy | 2020 |
Early exposure to environmental enrichment protects male rats against neuropathic pain development after nerve injury.
Topics: Animals; Cell Survival; Constriction, Pathologic; Endorphins; Enkephalins; Environment; Hyperalgesia; Male; Nerve Fibers; Neuralgia; Peripheral Nerve Injuries; Rats; Rats, Wistar; Receptors, Glucocorticoid; Sciatic Nerve; Spinal Cord; Weight-Bearing | 2020 |
Green Light Antinociceptive and Reversal of Thermal and Mechanical Hypersensitivity Effects Rely on Endogenous Opioid System Stimulation.
Topics: Animals; beta-Endorphin; Disease Models, Animal; Enkephalins; Male; Neuralgia; Phototherapy; Protein Precursors; Rats; Spinal Cord | 2021 |
Intrathecal administration of human bone marrow mesenchymal stem cells genetically modified with human proenkephalin gene decrease nociceptive pain in neuropathic rats.
Topics: Animals; Enkephalins; Humans; Injections, Spinal; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Neuralgia; Nociceptive Pain; Pain Threshold; Protein Precursors; Rats, Sprague-Dawley; Spinal Cord | 2017 |
Biphalin, a Dimeric Enkephalin, Alleviates LPS-Induced Activation in Rat Primary Microglial Cultures in Opioid Receptor-Dependent and Receptor-Independent Manners.
Topics: Animals; Cell Survival; Cells, Cultured; Enkephalins; Inflammation; Inflammation Mediators; Lipopolysaccharides; Male; Microglia; Neuralgia; Nitric Oxide; Nociception; Rats, Wistar; Receptors, Opioid | 2017 |
Overexpression of µ-Opioid Receptors in Peripheral Afferents, but Not in Combination with Enkephalin, Decreases Neuropathic Pain Behavior and Enhances Opioid Analgesia in Mouse.
Topics: Analgesia; Analgesics, Opioid; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Enkephalins; Female; Herpesvirus 1, Human; Male; Mice; Morphine; Neuralgia; Neurons, Afferent; Proto-Oncogene Proteins c-fos; Receptors, Opioid, mu | 2018 |
Dynorphinergic system alterations in the corticostriatal circuitry of neuropathic mice support its role in the negative affective component of pain.
Topics: Animals; Brain-Derived Neurotrophic Factor; Cerebral Cortex; Enkephalins; Male; Mice; Neuralgia; Nucleus Accumbens; Protein Precursors; Receptors, Opioid, kappa; RNA, Messenger | 2019 |
Alterations in the Activity of Spinal and Thalamic Opioid Systems in a Mice Neuropathic Pain Model.
Topics: Animals; Enkephalins; Guanosine 5'-O-(3-Thiotriphosphate); Male; Mice; Neuralgia; Pain Threshold; Protein Precursors; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; RNA, Messenger; Sciatic Nerve; Spinal Cord; Thalamus | 2018 |
Activation of enkephalinergic (Enk) interneurons in the central amygdala (CeA) buffers the behavioral effects of persistent pain.
Topics: Animals; Anxiety; Central Amygdaloid Nucleus; Chronic Pain; Enkephalins; Interneurons; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neuralgia | 2019 |
Influence of behavioral traits in the inter-individual variability of nociceptive, emotional and cognitive manifestations of neuropathic pain.
Topics: Animals; Behavior, Animal; Cell Cycle Proteins; Central Amygdaloid Nucleus; Cognition; Emotions; Enkephalins; Gene Expression; Individuality; Interleukin-6; Male; Mice; Neuralgia; Nociceptive Pain; Protein Precursors; Social Behavior | 2019 |
Lack of interleukin-17 leads to a modulated micro-environment and amelioration of mechanical hypersensitivity after peripheral nerve injury in mice.
Topics: Animals; Behavior, Animal; beta-Endorphin; Central Nervous System Sensitization; Cytokines; Disease Models, Animal; Dynorphins; Enkephalins; Hyperalgesia; Inflammation; Interleukin-10; Interleukin-13; Interleukin-17; Interleukin-1beta; Interleukin-2; Interleukin-6; Macrophages; Mice; Mice, Inbred C57BL; Mice, Knockout; Neuralgia; Neutrophils; Nociception; Peripheral Nerve Injuries; Peroxidase; Sciatic Nerve; T-Lymphocytes; Tumor Necrosis Factor-alpha | 2014 |
New orally active dual enkephalinase inhibitors (DENKIs) for central and peripheral pain treatment.
Topics: Administration, Oral; Analgesics; Animals; CD13 Antigens; Disulfides; Enkephalins; Humans; Male; Mice; Neprilysin; Neuralgia; Phenylpropionates; Prodrugs; Propylamines; Protease Inhibitors; Rats | 2014 |
Effects of the mas-related gene (Mrg) C receptor agonist BAM6-22 on nociceptive reflex activity in naive, monoarthritic and mononeuropathic rats after intraplantar and intrathecal administration.
Topics: Animals; Arthritis; Enkephalins; Injections, Spinal; Male; Neuralgia; Nociception; Peptide Fragments; Rats; Rats, Wistar; Receptors, G-Protein-Coupled; Reflex | 2016 |
Nonviral vector plasmid DNA encoding human proenkephalin gene attenuates inflammatory and neuropathic pain-related behaviors in mice.
Topics: Adjuvants, Immunologic; Animals; Behavior, Animal; DNA; Enkephalins; Freund's Adjuvant; Genetic Therapy; Genetic Vectors; Humans; Hyperalgesia; Inflammation; Injections, Intramuscular; Injections, Spinal; Neuralgia; Pain; Pain Management; Plasmids; Protein Precursors; Sciatic Nerve | 2016 |
Antinociceptive and anti-allodynic effects of oral PL37, a complete inhibitor of enkephalin-catabolizing enzymes, in a rat model of peripheral neuropathic pain induced by vincristine.
Topics: Administration, Oral; Analgesics; Animals; Antineoplastic Agents, Phytogenic; Disease Models, Animal; Disulfides; Dose-Response Relationship, Drug; Enkephalins; Enzyme Inhibitors; Injections, Intraperitoneal; Male; Neuralgia; Pain Measurement; Propylamines; Rats; Rats, Sprague-Dawley; Temperature; Vincristine | 2008 |
[Analgesic effect of intrathecal injection of Herpes simplex virus type I amplicon vector-mediated human preproenkephalin gene on chronic neuropathic pain: experiment with rats].
Topics: Analgesia; Animals; DNA, Viral; Enkephalins; Genetic Therapy; Genetic Vectors; Herpesvirus 1, Human; Humans; Injections, Spinal; Male; Neuralgia; Pain Measurement; Protein Precursors; Random Allocation; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Sciatic Nerve; Spinal Cord; Treatment Outcome | 2008 |
The effect of botulinum neurotoxin A on sciatic nerve injury-induced neuroimmunological changes in rat dorsal root ganglia and spinal cord.
Topics: Animals; Botulinum Toxins, Type A; Disease Models, Animal; Down-Regulation; Enkephalins; Ganglia, Spinal; Male; Neuralgia; Neuroimmunomodulation; Neurotoxins; Posterior Horn Cells; Protein Precursors; Rats; Rats, Wistar; Sciatic Neuropathy; Up-Regulation | 2011 |
Reversal of inflammatory pain by HSV-1-mediated overexpression of enkephalin in the caudal ventrolateral medulla.
Topics: Animals; Enkephalins; Gene Expression Regulation, Viral; Genetic Therapy; Genetic Vectors; Herpesvirus 1, Human; Inflammation; Male; Medulla Oblongata; Neuralgia; Neuritis; Pain Management; Rats; Rats, Wistar | 2011 |
Microinjection of HSV-1 amplicon vector-mediated human proenkephalin into the periaqueductal grey attenuates neuropathic pain in rats.
Topics: Animals; Constriction, Pathologic; Enkephalin, Leucine; Enkephalins; Gene Transfer Techniques; Genetic Therapy; Genetic Vectors; Herpesvirus 1, Human; Humans; Hyperalgesia; Male; Microinjections; Naloxone; Narcotic Antagonists; Neuralgia; Pain Measurement; Pain Threshold; Periaqueductal Gray; Protein Precursors; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Recombination, Genetic | 2012 |
Enhanced evoked excitatory transmitter release in experimental neuropathy requires descending facilitation.
Topics: Afferent Pathways; Analgesics, Opioid; Animals; Calcitonin Gene-Related Peptide; Capsaicin; Disease Models, Animal; Dynorphins; Enkephalins; Hyperesthesia; Ligation; Lumbosacral Region; Male; Medulla Oblongata; Microinjections; N-Glycosyl Hydrolases; Nerve Compression Syndromes; Neuralgia; Neuronal Plasticity; Neurotransmitter Agents; Oligopeptides; Opioid Peptides; Pain Measurement; Protein Precursors; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Recombinant Fusion Proteins; Ribosome Inactivating Proteins, Type 1; Saporins; Sensory Thresholds; Spinal Cord; Spinal Nerves | 2003 |
Neuropathic pain activates the endogenous kappa opioid system in mouse spinal cord and induces opioid receptor tolerance.
Topics: Animals; Astrocytes; Disease Models, Animal; Disease Progression; Drug Tolerance; Dynorphins; Enkephalins; G-Protein-Coupled Receptor Kinase 3; Hyperalgesia; Lumbosacral Region; Mice; Mice, Inbred C57BL; Mice, Knockout; Narcotic Antagonists; Narcotics; Neuralgia; Neurons; Protein Precursors; Protein Serine-Threonine Kinases; Receptors, Opioid; Receptors, Opioid, kappa; Sciatic Neuropathy; Spinal Cord | 2004 |
[Analgesic effect of intrathecal transplant of immortalized rat astrocyte strain genetically modified by human preproenkephalin gene on rat chronic neuropathic pain].
Topics: Animals; Astrocytes; Cells, Cultured; Chronic Pain; Disease Models, Animal; Enkephalins; Genetic Therapy; Humans; Male; Neuralgia; Protein Precursors; Rats; Rats, Sprague-Dawley | 2005 |
Cholecystokinin and enkephalin in brain stem pain modulating circuits.
Topics: Animals; Brain Stem; Cholecystokinin; Enkephalins; Immunohistochemistry; Male; Nerve Endings; Neuralgia; Rats; Rats, Sprague-Dawley | 1997 |
DREAM is a critical transcriptional repressor for pain modulation.
Topics: Animals; Base Sequence; Behavior, Animal; Calcium-Binding Proteins; Cells, Cultured; Consensus Sequence; Down-Regulation; Enkephalins; Heart; Hyperalgesia; Inflammation; Kv Channel-Interacting Proteins; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Neuralgia; Neurons; Physical Stimulation; Presenilin-1; Presenilin-2; Protein Precursors; Proto-Oncogene Proteins c-fos; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, kappa; Repressor Proteins; Spinal Cord; Stimulation, Chemical; Transcription, Genetic | 2002 |