enkephalin, leucine has been researched along with Muscle Contraction in 310 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 220 (70.97) | 18.7374 |
| 1990's | 75 (24.19) | 18.2507 |
| 2000's | 14 (4.52) | 29.6817 |
| 2010's | 1 (0.32) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cooney, MG; Goodman, M; Osapay, G; Polinsky, A; Toy-Palmer, A | 1 |
| Lemieux, C; Maziak, LA; Nguyen, TM; Schiller, PW | 1 |
| Schiller, PW; St-Hilaire, J | 1 |
| Burke, TR; Konicki, PE; Pert, CB; Quirion, R; Rice, KC | 1 |
| Berezowska, I; Chung, NN; Falcone-Hindley, ML; Hirschmann, R; Iwama, S; Lemieux, C; Liu, J; Nguyen, TM; Schiller, PW; Schmidt, R; Smith, AB; Yao, W | 1 |
| Chung, NN; Lemieux, C; Lu, Y; Schiller, PW; Weltrowska, G | 1 |
| Ambo, A; Hirabuki, M; Ouchi, H; Sasaki, Y; Yamamoto, Y | 1 |
| Cassel, JA; Chung, NN; Daubert, JD; DeHaven, RN; Goodman, M; Schiller, PW; Schlechtingen, G; Taulane, JP | 1 |
| Bassirirad, NM; Davis, P; Deekonda, S; Hruby, VJ; Kulkarni, V; Lai, J; Largent-Milnes, TM; Porreca, F; Rankin, D; Vanderah, TW; Wang, Y; Wugalter, L | 1 |
| Cassel, JA; Chung, NN; DeHaven, RN; Goodman, M; Malkmus, S; Rew, Y; Schiller, PW; Svensson, C; Taulane, JP; Yaksh, TL | 1 |
| Milanov, P; Naydenova, E; Pajpanova, T; Pencheva, N; Vezenkov, L | 1 |
| Chancellor, MB; de Miguel, F; Kim, JH; Kim, Y; Kwon, D; Minnery, B; Yoshimura, N | 1 |
| Berezowska, I; Chung, NN; Lemieux, C; Schiller, PW; Wilkes, BC | 1 |
| Davis, P; Guardiani, G; Hruby, VJ; Lai, J; Ma, SW; Mannina, L; Mollica, A; Porreca, F; Sobolev, AP | 1 |
| Davis, P; Hruby, VJ; Lai, J; Lee, YS; Ma, SW; Park, CK; Petrov, R; Porreca, F; Vardanyan, R | 1 |
| Bain, J; Chandler, DL; Granger, JP; Grubbs, L; LaMarca, BD; McLemore, GR; Ryan, MJ | 1 |
| Chaillet, P; Costentin, J; Coulaud, A; Fournie-Zaluski, MC; Roques, BP; Zajac, JM | 1 |
| Itzhak, Y; Simon, EJ | 1 |
| Hirobe, M; Konno, F; Shibata, R; Takayanagi, I | 1 |
| Corbett, AD; Gillan, MG; Kosterlitz, HW; McKnight, AT; Paterson, SJ; Robson, LE | 2 |
| Dray, A; Metsch, R | 1 |
| Chernysheva, ON; Kachalov, IuP; Nozdrachev, AD | 1 |
| Aoki, K; Inoue, H; Kajiwara, M; Oka, T; Shinozaki, K; Ueki, M | 1 |
| Kosterlitz, HW; Lord, JA; Paterson, SJ; Waterfield, AA | 1 |
| Elliott, J; Jhamandas, K | 1 |
| Kitabgi, P; Monier, S | 1 |
| Bajusz, S; Berzétei, IP; Rónai, AZ; Székely, JI | 1 |
| Dickinson, SL; Slater, P | 1 |
| Bitar, KN; Makhlouf, GM; Saffouri, B | 1 |
| Bitar, KN; Makhlouf, GM | 2 |
| Ikeda, Y; Imura, H; Nakao, K; Numa, S; Sakamoto, M; Suda, M; Yanaihara, N; Yoshimasa, T | 1 |
| Herman, ZS; Kowalski, J | 1 |
| Donnerer, J; Holzer, P; Lembeck, F | 1 |
| Brodin, E; Håkanson, R; Holmin, T; Leander, S; Malmfors, G; Sundler, F | 1 |
| Håkanson, R; Leander, S; Sundler, F | 1 |
| Antonaccio, MJ; Greenberg, R; O'Keefe, EH | 1 |
| Huidobro-Toro, JP; Way, EL | 1 |
| Chang, KJ; Cuatrecasas, P; Hazum, E; Leighton, HJ; Lever, OW | 1 |
| Fujiwara, M; Hayashi, H; Muramatsu, I; Ueda, N | 1 |
| Holmgren, S | 1 |
| Gumulka, WS; Lipkowski, AW; Osipiak, B | 1 |
| Fahrenkrug, J; Ottesen, B; Söndergaard, F | 1 |
| Herz, A; Krenss, H; Schulz, R; Wüster, M | 1 |
| Audigier, Y; Cros, J; Gout, R; Mazarguil, H | 1 |
| Hayes, RJ; Summers, MC | 1 |
| Herz, A; Illes, P; Zieglgänsberger, W | 1 |
| Bajusz, S; Berzétei, I; Rónai, AZ; Soós, J | 1 |
| Balasubramanian, TM; Cicero, TJ; Gorin, FA; Marshall, GR; Schwietzer, J | 1 |
| Fondacaro, JD; Pawlik, WW; Walus, KM | 1 |
| Huidobro, F; Huidobro-Toro, JP; Miranda, H | 2 |
| Dalith, M; Keren, O; Sarne, Y; Weissman, BA | 1 |
| Handa, BK; Land, AC; Lord, JA; Morgan, BA; Rance, MJ; Smith, CF | 1 |
| Chavkin, C; Goldstein, A | 1 |
| Gillan, MG; Kosterlitz, HW; Kriwaczek, VM; Paterson, SJ; Schwyzer, R | 1 |
| Hullihan, J; Jones, BN; Kilpatrick, DL; Kimura, S; Shively, JE; Stein, S; Stern, AS; Taniguchi, T; Udenfriend, S | 1 |
| Hall, ME; Hsi, LH; Stewart, JM; Vavrek, RJ; York, EJ | 1 |
| Dzoljic, MR; van der Poel-Heisterkamp, AL | 1 |
| Do, KQ; Fauchère, JL; Gillan, MG; Kosterlitz, HW; Paterson, SJ; Robson, LE; Schwyzer, R | 1 |
| Cohen, ML; Geary, LE; Scott, WL; Wiley, KS | 1 |
| Baker, RJ; McCallum, JA; Sullivan, SN; Wells, G; Worobetz, LJ | 1 |
| Ishizuka, Y; Kajiwara, M; Matsumiya, T; Negishi, K; Oka, T; Watanabe, Y | 1 |
| Bajusz, S; Berzétei, IP; Hársing, LG; Rónai, AZ; Vizi, ES | 1 |
| Burks, TF; Galligan, JJ; Gee, K; Hruby, VJ; Hurst, R; Mosberg, HI; Yamamura, HI | 3 |
| Asmuko, AA; Bespalova, JD; Chetverina, EV; Chichenkov, ON; Korobov, NV; Mestechkina, NM; Miheeva, LM; Rjazhsky, GG; Rogozhin, SV; Zaslavsky, BY | 1 |
| Di Gléria, K; Friedmann, T; Kerecsen, L; Knoll, J; Kovács, A; Medzihradszky, K; Szécsi, JH | 1 |
| Kamikawa, Y; Shimo, Y | 2 |
| Costa, T; Krumins, S; Rodbard, D; Shimohigashi, Y | 1 |
| Egawa, M; Imura, H; Katsumaru, Y; Mochizuki, T; Numa, S; Tobe, A; Yamamoto, Y; Yanaihara, C; Yanaihara, N | 1 |
| Berman, JM; Goodman, M; Nguyen, TM; Schiller, PW | 1 |
| Day, AR; Freer, RJ; Liao, CS; Muthukumaraswamy, N; Pinon, D | 1 |
| Höllt, V; Rezvani, A; Way, EL | 1 |
| Ikeda, Y; Imura, H; Nakao, K; Numa, S; Sakamoto, M; Suda, M; Yanaihara, C; Yanaihara, N; Yoshimasa, T | 1 |
| Akiyama, K; Burks, TF; Galligan, JJ; Gee, K; Hruby, VJ; Hurst, R; Mosberg, HI; Yamamura, HI | 1 |
| Cui, RL; Kosterlitz, HW; Paterson, S; Stewart, JM; Vavrek, RJ; York, EJ | 1 |
| Burks, TF; Galligan, JJ; Hruby, VJ; Hurst, R; Mosberg, HI | 1 |
| Amano, H; Kaneko, S; Morimoto, Y; Takagi, H | 1 |
| Davis, TP; Dray, A; Porreca, F | 1 |
| Imura, H; Morii, N; Nakao, K; Numa, S; Sakamoto, M; Suda, M; Yanaihara, N; Yoshimasa, T | 1 |
| Elliott, J; Jhamandas, K; Notman, H; Sutak, M | 1 |
| Alpermann, HG; Bickel, M; Geiger, R; Teetz, V | 1 |
| Belton, P; Cotton, R; Giles, MB; Gormley, JJ; Miller, L; Shaw, JS; Timms, D; Wilkinson, A | 1 |
| Puig, MM; Vargas, ML | 1 |
| Garzón, J; Lee, NM; Sánchez-Blázquez, P | 3 |
| Behar, J; Biancani, P | 1 |
| Alumets, J; Håkanson, R; Sundler, F; Uddman, R; Walles, B | 1 |
| Huidobro-Toro, P; Li, CH; Nádasdi, L; Yamashiro, D | 1 |
| Kalikhevich, VN; Missiul', BV; Usubakunov, EU | 1 |
| Biasini, I; Carenzi, A; Della Bella, D; Frigeni, V | 1 |
| Petkov, V; Radomirov, R | 1 |
| Fauchère, JL | 1 |
| Kromer, W; Shearman, GT; Steigemann, N | 1 |
| Konecka, AM; Lipkowski, AW; Sadowski, B | 1 |
| Baranowski, RL; Currie, BL; Krstenansky, JL | 1 |
| Chapman, DB; Hu, J; Way, EL | 1 |
| Salvadori, S; Sarto, GP; Tomatis, R | 1 |
| Bajusz, S; Berzétei, IP; Kurgyis, J; Miglécz, E; Rónai, AZ; Székely, JI | 1 |
| Chipkin, RE; English, MG; Morris, DH; Rosamond, JD; Stammer, CH; Stewart, JM; York, EJ | 1 |
| Coy, DH; Kastin, AJ | 1 |
| Akita, T; Kiso, Y; Moritoki, H; Nakamura, H; Takei, M; Yamaguchi, M | 1 |
| Goldenberg, E; Jhamandas, K; Nakatsu, K; Penning, D | 1 |
| Aleixandre, A; Garcia de Jalón, P; Martin, I | 1 |
| Gothilf, Y; Sarne, Y; Weissman, BA | 1 |
| Dembiński, A; Konturek, SJ; Król, R; Schally, AV; Thor, P | 1 |
| Ku, PY; Lee, HK; Yen, MH | 1 |
| Abraham, GJ; Dhume, VG; Diniz, RS; Pereira, JS | 1 |
| Corbett, AD; Kosterlitz, HW; McKnight, AT; Sosa, RP | 1 |
| Furukawa, K; Nomoto, T; Tonoue, T | 1 |
| Kangawa, K; Matsuo, H; Minamino, N; Mizuno, K | 1 |
| Adachi, T; Ambo, A; Sasaki, Y | 1 |
| Collins, JG; Harada, Y; Kitahata, LM; Nakatani, K; Nishioka, K | 1 |
| Collins, JG; Harada, Y; Kishikawa, K; Kitahata, LM; Nishioka, K | 1 |
| Alsasua, A; Martín, MI; Parra, L; Pérez-Vizcaíno, F; Tamargo, J | 1 |
| Bocheva, A; Dimitrov, E; Ivancheva, C; Pencheva, N; Radomirov, R | 2 |
| Nicosia, F; Rehder, K; Rocchi, D; Song, P; Zappi, L | 1 |
| Galligan, JJ | 1 |
| Alfaro, MJ; Goicoechea, C; Lopez, F; Martin, MI; Ormazabal, MJ | 1 |
| Moriguchi, S; Sasaki, R; Takahashi, M; Yoshikawa, M | 1 |
| Angel, F; Baumann, R; Chamouard, P; Meyer, C; Rohr, S | 1 |
| Heyl, DL; Kroona, H; Lomize, AL; Ma, W; Mosberg, HI; Mousigian, C; Porreca, F; Sobczyk-Kojiro, K; Wang, C | 1 |
| Davis, P; Heyl, DL; Lomize, A; Mosberg, HI; Mousigian, C; Nordan, I; Omnaas, JR; Porreca, F | 1 |
| Lazova, L; Pencheva, N; Radomirov, R; Stoyneva, I | 1 |
| Adamo, EB; Di Giovanni, G; Marini, R; Mulè, F; Postorino, A; Serio, R | 1 |
| Christinck, F; Cipris, S; Daniel, EE; Fox-Threlkeld, JE; Hruby, VJ; Woskowska, Z | 1 |
| Amodeo, P; Bianchi, C; Guerrini, R; Lazarus, LH; Picone, D; Salvadori, S; Tancredi, T; Temussi, PA; Tomatis, R | 1 |
| Bartosz-Bechowski, H; Davis, P; Hruby, VJ; Porreca, F; Slaninova, J; Yamamura, HI; Zalewska, T | 1 |
| Bültmann, R; Driessen, B; Starke, K; von Kügelgen, I | 1 |
| Alfaro, MJ; Colado, MI; Goicoechea, C; Martín, MI | 1 |
| Hiranuma, T; Iwao, K; Liu, XF; Matsumiya, T; Ohgiya, N; Oka, T | 1 |
| Capasso, A; Di Giannuario, A; Loizzo, A; Pieretti, S; Sagratella, S; Sorrentino, L | 1 |
| Davis, P; DeLeon, IA; Hruby, VJ; Li, G; Lou, BS; Lung, FD; Meyer, JP; Porreca, F; Xiang, L; Yamamura, HI | 1 |
| Alfaro, MJ; Goicoechea, C; Martin, MI; Ormazabal, MJ | 1 |
| Bailey, EC; Bruce, DS; Hellgren, EC; Horton, ND; Jacobson, D; Oeltgen, PR; Setran, DP; Tramell, MS | 1 |
| Demedts, MG; Dupont, LJ; Pype, JL; Verleden, GM | 1 |
| Becketts, K; Bilsky, EJ; Calderon, SN; Davis, P; Flippen-Anderson, JL; Horvath, R; Kayakiri, H; Porreca, F; Rice, KC; Rothman, RB; Smith, LE; Xu, H | 1 |
| Davis, P; Horvath, R; Hruby, VJ; Lipkowski, AW; Misicka, A; Porreca, F; Yamamura, HI | 1 |
| Khan, S; Smith, ME | 1 |
| Kurahashi, K; Moriguchi, S; Sasaki, R; Shiota, A; Suganuma, H; Takahashi, M; Tani, F; Usui, H; Yoshikawa, M | 1 |
| Nicosia, F; Nicosia, S; Rehder, K; Song, P; Zappi, L | 1 |
| Cavagnero, S; Davis, P; Horvath, R; Hruby, VJ; Misicka, A; Porreca, F; Yamamura, HI | 1 |
| Balboni, G; Caliendo, G; Capasso, A; Guerrini, R; Lazarus, LH; Marastoni, M; Salvadori, S; Santagada, V; Sorrentino, L; Tomatis, R | 1 |
| Balboni, G; Bianchi, C; Bryant, SD; Cooper, PS; Guerrini, R; Lazarus, LH; Salvadori, S; Tomatis, R | 1 |
| Davis, P; Haaseth, RC; Hruby, VJ; Porreca, F; Yamamura, HI; Zalewska, T | 1 |
| Capasso, A; Pinto, A; Sorrentino, L | 1 |
| Bhandari, RN; Clarke, RW; Ogilvie, J | 1 |
| Balestra, B; Brecha, NC; Bunnett, NW; Grady, EF; McConalogue, K; Minnis, J; Sternini, C; Tonini, M | 1 |
| Ananthan, S; Bilsky, EJ; Carter, RL; Davis, P; Dersch, CM; Kezar, HS; Porreca, F; Rice, KC; Rothman, RB; Saini, SK; Wells, JL; Xu, H | 1 |
| Borsodi, A; Makó, E; Medzihradszky, K; Orosz, G; Rónai, AZ; Szatmári, I | 1 |
| Otsuka, M; Takahashi, T | 1 |
| Henderson, G; Hughes, J; Kosterlitz, HW; Smokcum, RW; Waterfield, AA | 1 |
| Chau-Pham, TT | 1 |
| Crooks, PA; Deeks, T; Waigh, RD | 2 |
| Duncalf, D; Fishman, J; Foldes, FF; Hahn, EF; Nagashima, H; Shiwaku, Y | 1 |
| Beddell, CR; Chang, KJ; Clark, RB; Cuatrecasas, P; Lowe, LA; Miller, R; Wilkinson, S | 1 |
| Hughes, J; Kosterlitz, HW | 1 |
| Chang, KJ; Cuatrecasas, P; Leighton, J; Miller, RJ | 1 |
| Murakami, H; Ogawa, H; Segawa, T; Yajima, H | 1 |
| Cuatrecasas, P; Miller, RJ | 1 |
| Britton, DR; Coy, DH; Fertel, R; Kastin, AJ | 1 |
| Buckett, WR | 1 |
| Fournie-Zaluski, MC; Gacel, G; Lecomte, JM; Roques, BP; Senault, B | 1 |
| Burnstock, G; Cocks, T | 1 |
| den Hertog, A; Huizinga, JD | 1 |
| Fellion, E; Fournié-Zaluski, MC; Gacel, G; Lecomte, JM; Malfroy, B; Roques, BP; Schwartz, JC; Senault, B; Swerts, JP | 1 |
| Szerb, JC; Vohra, MM | 1 |
| Moore, AF | 1 |
| Kosterlitz, HW; Leslie, FM; Ling, N; Lord, JA; Waterfield, AA | 1 |
| Zetler, G | 1 |
| Bajusz, S; Berzétei, I; Miglécz, E; Rónai, AZ; Székely, JI | 1 |
| Hart, SL; Kitchen, I; Waddell, PR | 1 |
| Jaques, R | 1 |
| Hughes, J; Kosterlitz, HW; Lord, JA; Waterfield, AA | 1 |
| Berti, F; Bruno, F; Iuliano, E; Longiave, D; Mandelli, V; Racagni, G | 1 |
| Shaw, JS; Turnbull, MJ | 1 |
| Carney, JM; Day, AR; Dewey, WL; Freer, RJ; Rosecrans, JA | 1 |
| Takemori, AE; Vaught, JL | 1 |
| Lemaire, S; Magnan, J; Regoli, D | 1 |
| Berti, F; Bruno, F; Omini, C; Racagni, G | 1 |
| Coy, DH; Kastin, AJ; Meyers, CA; Schally, AV | 1 |
| Chipkin, RE; Morris, DH; Stewart, JM | 1 |
| Arrigo-Reina, R; Ferri, S; Santagostino, A; Scoto, GM; Spadaro, C | 1 |
| Berggren, A; Rubenson, A; Sillén, U | 1 |
| Barnes, PJ; Belvisi, MG; Miura, M; Stretton, CD; Yacoub, MH | 1 |
| Haaseth, RC; Hammond, DL; Hansen, DW; Mosberg, HI; Reichman, M; Savage, MA; Stapelfeld, A | 1 |
| Gu, ZF; Jensen, RT; Maton, PN; Pradhan, T; Zhang, L | 1 |
| Anthony, E; Beardsley, PM; Chandrakumar, NS; Drury, B; Lopez, OT; Reichman, M; Savage, MA; Stapelfeld, A; Williamson, LN | 1 |
| Burks, TF; Ceusters, M; Couder, J; Davis, P; Knapp, R; Kramer, TH; Leysen, JE; Meert, D; Tourwé, D; Yamamura, HI | 1 |
| Abisova, NA; Argintaev, ES; Bobrova, IV; Pavlenko, VS; Shil'nikov, MG; Zoloev, GK | 1 |
| Kastin, AJ; Kersh, D; Wyatt, A; Zadina, JE | 1 |
| Costa, M; Tonini, M; Waterman, SA | 1 |
| Matsuyama, S; Nakayama, S; Sano, I; Takeda, K; Tanaka, C; Taniyama, K; Yoshihara, C | 1 |
| Burks, TF; Davis, P; Delaet, N; Kramer, TH; Tourwe, D | 1 |
| Grider, JR; Makhlouf, GM | 1 |
| Fox, AJ; Morton, IK | 1 |
| Khokhlov, AP; Yarygin, KN | 1 |
| Burks, TF; Davis, P; Davis, TP; Hoyer, GL | 1 |
| Burks, TF; Davis, P; Hruby, VJ; Knapp, R; Kramer, TH; Lui, G; Toth, G; Yamamura, HI | 1 |
| Baba, A; Doi, M; Inoue, M; Ishida, T; Iwata, H; Katagawa, Y; Kitamura, K; Sadatome, T; Yara, H; Yasuda, M | 1 |
| Dissanayake, VU; Hill, RG; Hughes, J; Hunter, JC | 1 |
| Ayres, EA; Burks, TF; Davis, P | 1 |
| Hill, JM; Kaufman, MP | 1 |
| Leek, BF; Maas, CL | 1 |
| Barnes, PJ; Frossard, N | 1 |
| Arnbjörnsson, E; Ekblad, E; Ekman, R; Håkanson, R; Sundler, F | 1 |
| Barra, D; Corsi, R; Erspamer, V; Falconieri-Erspamer, G; Kreil, G; Melchiorri, P; Negri, L; Severini, C; Simmaco, M | 1 |
| Kaiser, ET; Taylor, JW | 1 |
| Kaneto, H; Kawasaki, K; Maeda, M; Takahashi, M; Watanabe, J | 1 |
| Nunan, L; Porreca, F; Sheldon, RJ | 2 |
| Follenfant, RL; Hardy, GW; Lowe, LA; Mills, G; Sang, PY; Shankley, C; Simpkin, DS; Smith, TW | 1 |
| Gintzler, AR; Jacobson, AR; Sayre, LM | 1 |
| Goodman, M; Lucietto, P; Mierke, DF; Schiller, PW | 1 |
| Porreca, F; Tortella, FC | 1 |
| Dougall, IG; Leff, P | 1 |
| Daugé, V; Delay-Goyet, P; Gacel, G; Roques, BP; Zajac, JM | 1 |
| Lovett, JA; Portoghese, PS | 1 |
| Hill, RG; Hughes, J; Johnson, MA | 1 |
| Costa, M; Humphreys, CM; Johnson, SM; Shearman, R | 1 |
| Hayes, AG; Sheehan, MJ; Tyers, MB | 1 |
| Casy, AF | 1 |
| Dray, A | 1 |
| Dray, A; Nunan, L; Wire, W | 4 |
| Corbett, AD; Kosterlitz, HW; Marcoli, M; McKnight, AT | 1 |
| Kaneto, H; Kawasaki, K; Maeda, M; Tsuji, T; Watanabe, J | 1 |
| Edwards, JV; Lemieux, C; Schiller, PW; Spatola, AF | 1 |
| Gusel', VA; Illarionova, NG; Kozhevnikova, NIu; Pavlov, VN; Vlasov, GP | 1 |
| Buéno, L; Fioramonti, J | 1 |
| Izumiya, N; Kato, T; Koshizaka, T; Kurono, M; Ogasawara, T; Shimohigashi, Y; Waki, M; Yagi, K | 1 |
| Carraway, RE; Ferris, CF; Mitra, SP; Singer, EA | 1 |
| Follenfant, RL; Hardy, GW; Lowe, LA; Sang, PY; Simpkin, DS; Smith, TW; Wilkinson, S | 1 |
| Corbett, AD; Kosterlitz, HW; McKnight, AT | 1 |
| García-Antón, JM; Reig, F; Rodríguez, RE; Torres, JL; Valencia, G | 1 |
| Dray, A; Nunan, L | 1 |
| Culling-Berglund, AJ; Davis, TP; Gillespie, TJ; Papietro, HM; Porreca, F; Shook, JE | 1 |
| Funakoshi, S; Kaneko, S; Kosuga, N; Kubota, M; Li, W; Satoh, M; Takagi, H; Tamura, S; Xu, JP; Yajima, H | 1 |
| Horvat, S; Lemieux, C; Schiller, PW; Varga, L | 1 |
| Mizutani, M; Nakayama, S; Neya, T; Takaki, M; Yamasato, T | 1 |
| Daniel, EE; Fox, JE | 1 |
| Bailey, C; Kitchen, I | 1 |
| Ambo, A; Ariizumi, T; Igari, Y; Kohara, H; Niizuma, H; Sasaki, A; Sasaki, Y; Sato, K | 1 |
| Akahori, K; Arai, Y; Jin, XL; Kobayashi, H; Kosaka, K; Oka, T; Yoshikawa, M | 1 |
| Bakalkin, GIa; Bespalova, ZhD; Iakovleva, TV; Korobov, KP; Vinogradov, VA | 1 |
| Beleslin, DB; Mićić, D; Samardzić, R; Terzić, B | 1 |
| Huidobro-Toro, JP; Lee, NM; Loh, HH; Way, EL; Yoshimura, K | 1 |
| Chavkin, C; Cox, BM | 1 |
| Fischli, W; Goldstein, A; James, IF | 1 |
| Rezvani, A; Way, EL | 1 |
| Dünzen, RG; Wienbeck, M | 1 |
| Klee, WA; Loukas, S; Nicolaou, N; Streaty, RA; Varoucha, D; Zioudrou, C | 1 |
| Laorden, ML; Miralles, F; Olaso, MJ; Puig, MM | 1 |
| Gintzler, AR; Hyde, D | 1 |
| Cotton, R; Giles, MG; Miller, L; Shaw, JS; Timms, D | 1 |
| Bellini, C; Biondi, L; Filippi, B; Filira, F; Rocchi, R; Sarto, G | 1 |
| Elhilali, MM; Galeano, C; Jubelin, B; Ladouceur, D; Lemaire, S | 1 |
| Kimura, H; Ren-Lin, C; Shimohigashi, Y; Stammer, CH; Stewart, J | 1 |
| Akita, T; Inai, M; Kiso, Y; Kitagawa, K; Moritoki, H | 1 |
| Biondi, L; Filippi, B; Filira, F; Rocchi, R | 1 |
| Cohen, S; Ouyang, A; Reynolds, JC | 1 |
| Contreras, E; Gaete, S; Juica, S; Tamayo, L | 1 |
| Coupar, IM; Hancock, DL | 1 |
| Kishioka, S; Masuda, Y; Miyamoto, Y; Ozaki, M; Yamamoto, H | 1 |
| Lin, SX; Ma, D; Qin, BZ; Yuan, SL; Yuan, XP | 1 |
| Futaki, S; Hama, T; Hibi, T; Kitagawa, K; Konishi, R; Mizobuchi, N | 1 |
| Decker, B; Golenhofen, K; Kutschenreuter, U; Mandrek, K; McGregor, GP; Vadokas, B; Voigt, K | 1 |
| Brown, DR; Poonyachoti, S; Portoghese, PS | 1 |
| Khugaeva, VK | 2 |
| Kaneto, H; Kawasaki, K; Kobayashi, Y; Maeda, M; Shimokawa, K; Taguchi, T; Takahashi, M; Tokuyama, S; Watanabe, J; Yamamoto, Y | 1 |
| Bilotta, JM; Brackeen, MF; Feldman, PL; James, MK; Leighton, HJ; Schuster, SV | 1 |
| Bunnett, NW; Gu, ZF; Maton, PN; Menozzi, D | 1 |
| Chorev, M; Gilon, C; Laufer, R; Roques, BP; Roubini, E; Selinger, Z | 1 |
| Dixon, DM; Traynor, JR | 1 |
| Pencheva, N; Radomirov, R; Venkova, K | 2 |
| Butsugan, Y; Fukuta, N; Ito, N; Kagami, T; Kawai, M; Kudo, Y; Maruyama, M | 1 |
| Goromaru, N; Kanematsu, K; Koike, K; Konno, F; Mori, T; Takayanagi, I; Yoshida, M | 1 |
| Callahan, SM; Creed, KE | 1 |
| Borson, DB; Djokic, TD; Nadel, JA; Sekizawa, K | 1 |
| Booth, AM; de Groat, WC; Kawatani, M; Whitney, T | 1 |
| Alexiev, V; Mancheva, I; Minchev, S; Petkov, D; Petkov, VD; Petkov, VV; Radomirov, R; Stoev, S; Stoyneva, I; Venkova, K | 1 |
| Petkov, VD; Radomirov, R; Venkova, K | 2 |
| Kennedy, C; Krier, J | 1 |
| Horvat, J; Horvat, S; Lemieux, C; Schiller, PW | 1 |
| Bertiger, G; Cohen, S; Ouyang, A; Reynolds, JC | 1 |
| Grider, JR; Makhlouf, GM; Severi, C | 1 |
| Russell, JA; Simons, EJ | 1 |
| Abissova, NA; Bobrova, IV; Chipens, GI; Nikiforovich, GV; Rozental', GF | 1 |
| Rezvani, A; Rhoads, DL; Stokes, KB; Way, EL | 1 |
| Bertelli, G; Borea, PA; Marastoni, M; Salvadori, S; Tomatis, R | 1 |
| Kasakov, L; Papasova, M; Velkova, V | 1 |
| Faermark, IF; Shvarts, GIa | 1 |
| Charakchieva, S; Chernaeva, L | 1 |
| Fan, JZ; Li, JL; Lin, SX | 1 |
| Giles, TD; Given, MB; Sander, GE | 1 |
| Klarskov, P | 1 |
| Anwer, MK; Bettag, AL; Browne, B; Edwards, JV; Lahti, R; Rowell, P; Saneii, H; Spatola, AF; Von Voigtlander, P | 1 |
| Shishkina, IuA; Smirnova, AP; Zavalishina, NA; Zverev, MD | 1 |
7 review(s) available for enkephalin, leucine and Muscle Contraction
| Article | Year |
|---|---|
On the enzymatic degradation of enkephalins: pharmacological implications.
Topics: Animals; Biotransformation; Drug Interactions; Electric Stimulation; Endorphins; Enkephalins; In Vitro Techniques; Muscle Contraction; Pain; Protease Inhibitors | 1980 |
[Enkephalin-inactivating enzymes].
Topics: Aminopeptidases; Animals; Electric Stimulation; Enkephalin, Methionine; Enkephalins; Guinea Pigs; Hydrolysis; Ileum; In Vitro Techniques; Male; Mice; Muscle Contraction; Neprilysin; Peptidyl-Dipeptidase A; Protease Inhibitors; Rats; Receptors, Opioid; Vas Deferens | 1993 |
Putative peptide neurotransmitters.
Topics: Angiotensin II; Animals; Anura; Carnosine; Cats; Cattle; Enkephalins; Muscle Contraction; Muscle, Smooth; Neurons; Neurotransmitter Agents; Oligopeptides; Peptides; Pituitary Gland; Pituitary Hormone-Releasing Hormones; Rats; Spinal Cord; Structure-Activity Relationship; Substance P | 1977 |
The opiate receptors and the discovery of opioid-like peptides.
Topics: Amino Acids; Analgesics; Animals; Behavior, Animal; Endorphins; Enkephalins; Guinea Pigs; Humans; Hydrogen-Ion Concentration; Ions; Lipids; Mice; Morphine Dependence; Muscle Contraction; Neurotransmitter Agents; Peptide Hydrolases; Peptides; Rats; Receptors, Opioid; Temperature | 1978 |
Opiate receptors and endogenous opioid peptides in tolerance and dependence.
Topics: Adenylyl Cyclases; Animals; Cells, Cultured; Drug Tolerance; Endorphins; Enkephalins; Guinea Pigs; Humans; In Vitro Techniques; Muscle Contraction; Prostaglandins E; Receptors, Opioid; Substance-Related Disorders; Time Factors | 1977 |
The enkephalins. Peptides with morphine-like activity.
Topics: Animals; Brain; Brain Chemistry; Endorphins; Enkephalins; Hypophysectomy; Intestinal Mucosa; Male; Muscle Contraction; Organ Specificity; Rats; Receptors, Opioid; Species Specificity; Structure-Activity Relationship; Vas Deferens | 1978 |
Enkephalins, other endogenous opioids and colonic motility in dog and man.
Topics: Animals; Central Nervous System; Colon; Dogs; Endorphins; Enkephalins; Gastrointestinal Motility; Humans; In Vitro Techniques; Morphine; Muscle Contraction; Naloxone; Receptors, Opioid; Species Specificity; Thiorphan; Tiopronin | 1987 |
303 other study(ies) available for enkephalin, leucine and Muscle Contraction
| Article | Year |
|---|---|
Synthesis and conformational properties of the lanthionine-bridged opioid peptide [D-AlaL2,AlaL5]enkephalin as determined by NMR and computer simulations.
Topics: Amino Acid Sequence; Analgesics; Animals; Computer Simulation; Enkephalins; Guinea Pigs; In Vitro Techniques; Magnetic Resonance Spectroscopy; Male; Mice; Molecular Sequence Data; Muscle Contraction; Muscle, Smooth; Protein Conformation; Rats; Thermodynamics | 1992 |
Synthesis and activity profiles of novel cyclic opioid peptide monomers and dimers.
Topics: Amino Acid Sequence; Animals; Biological Assay; Brain; Chemical Phenomena; Chemistry; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Guinea Pigs; Ileum; Macromolecular Substances; Male; Mice; Muscle Contraction; Oligopeptides; Peptides, Cyclic; Protein Conformation; Rats; Receptors, Opioid; Structure-Activity Relationship; Vas Deferens | 1985 |
Synthesis, in vitro opiate activity, and intramolecular tyrosine--tryptophan distances of [4-tryptophan]enkephalin analogues. A reassessment of conformational models of enkephalin in solution.
Topics: Animals; Chemical Phenomena; Chemistry; Endorphins; Enkephalins; Guinea Pigs; In Vitro Techniques; Molecular Conformation; Muscle Contraction; Muscle, Smooth; Receptors, Opioid; Solutions; Spectrometry, Fluorescence; Structure-Activity Relationship; Thermodynamics; Tryptophan; Tyrosine | 1980 |
Synthesis and pharmacological characterization of (+/-)-5,9 alpha-dimethyl-2-[2-(4-fluorophenyl)ethyl]-2'-hydroxy-6,7-benzomorphan (fluorophen), a ligand suitable for visualization of opiate receptors in vivo.
Topics: Animals; Benzomorphans; Biological Assay; Brain; Guinea Pigs; Ileum; Indicators and Reagents; Male; Morphinans; Muscle Contraction; Rats; Rats, Inbred Strains; Receptors, Opioid | 1983 |
Novel ligands lacking a positive charge for the delta- and mu-opioid receptors.
Topics: Animals; Binding, Competitive; Brain; Guinea Pigs; Ileum; In Vitro Techniques; Ligands; Male; Mice; Muscle Contraction; Muscle, Smooth; Narcotic Antagonists; Neurokinin-1 Receptor Antagonists; Oligopeptides; Peptides, Cyclic; Radioligand Assay; Rats; Receptors, Neurokinin-1; Receptors, Opioid, mu; Structure-Activity Relationship; Vas Deferens | 2000 |
Stereospecific synthesis of (2S)-2-methyl-3-(2',6'-dimethyl-4'-hydroxyphenyl)-propionic acid (Mdp) and its incorporation into an opioid peptide.
Topics: Animals; Brain; Enkephalins; Guinea Pigs; Ileum; Inhibitory Concentration 50; Male; Membranes; Mice; Muscle Contraction; Opioid Peptides; Phenols; Propionates; Protein Binding; Rats; Receptors, Opioid, delta; Receptors, Opioid, mu; Stereoisomerism; Structure-Activity Relationship; Vas Deferens | 2001 |
Enkephalin analogues with 2',6'-dimethylphenylalanine replacing phenylalanine in position 4.
Topics: Animals; Binding, Competitive; Brain; Enkephalin, Leucine; Ileum; Inhibitory Concentration 50; Male; Muscle Contraction; Phenylalanine; Protein Binding; Rats; Receptors, Opioid, delta; Receptors, Opioid, mu; Structure-Activity Relationship; Synaptosomes; Vas Deferens | 2001 |
Structure-activity relationships of dynorphin a analogues modified in the address sequence.
Topics: Analgesics, Opioid; Animals; CHO Cells; Cricetinae; Dynorphins; Guanosine 5'-O-(3-Thiotriphosphate); Guinea Pigs; Ileum; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Oligopeptides; Radioligand Assay; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Structure-Activity Relationship | 2003 |
Design and synthesis of novel bivalent ligands (MOR and DOR) by conjugation of enkephalin analogues with 4-anilidopiperidine derivatives.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Drug Design; Enkephalins; Guinea Pigs; Ligands; Mice; Molecular Conformation; Muscle Contraction; Pain Measurement; Pain Threshold; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Structure-Activity Relationship | 2015 |
Synthesis and biological activities of cyclic lanthionine enkephalin analogues: delta-opioid receptor selective ligands.
Topics: Alanine; Analgesics; Animals; CHO Cells; Cricetinae; Enkephalins; Escape Reaction; Humans; Ileum; In Vitro Techniques; Injections, Spinal; Male; Mice; Muscle Contraction; Muscle, Smooth; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sulfides; Swine; Vas Deferens | 2002 |
Opioid profiles of Cys2-containing enkephalin analogues.
Topics: Animals; Cysteine; Dose-Response Relationship, Drug; Enkephalins; Guinea Pigs; Ileum; In Vitro Techniques; Kinetics; Male; Mice; Muscle Contraction; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Structure-Activity Relationship; Vas Deferens | 2004 |
Neurologic recovery and improved detrusor contractility using muscle-derived cells in rat model of unilateral pelvic nerve transection.
Topics: Animals; Denervation; Disease Models, Animal; Electric Stimulation; Enkephalins; Female; Hypogastric Plexus; Immunohistochemistry; Muscle Cells; Muscle Contraction; Muscle, Skeletal; Nerve Regeneration; Rats; Rats, Sprague-Dawley; Urinary Bladder; Urinary Bladder, Neurogenic | 2005 |
Dicarba analogues of the cyclic enkephalin peptides H-Tyr-c[D-Cys-Gly-Phe-D(or L)-Cys]NH(2) retain high opioid activity.
Topics: Allyl Compounds; Animals; Brain; Enkephalins; Guinea Pigs; Ileum; In Vitro Techniques; Male; Models, Molecular; Molecular Conformation; Muscle Contraction; Muscle, Smooth; Peptides, Cyclic; Radioligand Assay; Rats; Receptors, Opioid, delta; Receptors, Opioid, mu; Stereoisomerism; Structure-Activity Relationship; Vas Deferens | 2007 |
Synthesis of stable and potent delta/mu opioid peptides: analogues of H-Tyr-c[D-Cys-Gly-Phe-D-Cys]-OH by ring-closing metathesis.
Topics: Allyl Compounds; Animals; Enkephalins; Guinea Pigs; Ileum; In Vitro Techniques; Male; Mice; Mice, Inbred ICR; Muscle Contraction; Muscle, Smooth; Myenteric Plexus; Peptides, Cyclic; Radioligand Assay; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Structure-Activity Relationship; Vas Deferens | 2007 |
Development of novel enkephalin analogues that have enhanced opioid activities at both mu and delta opioid receptors.
Topics: Animals; Binding, Competitive; Cell Line; Cricetinae; Cricetulus; Enkephalins; Guinea Pigs; Humans; Ileum; In Vitro Techniques; Male; Mice; Muscle Contraction; Muscle, Smooth; Radioligand Assay; Rats; Receptors, Opioid, delta; Receptors, Opioid, mu; Structure-Activity Relationship; Vas Deferens | 2007 |
Role of sex steroids in modulating tumor necrosis factor alpha-induced changes in vascular function and blood pressure.
Topics: Acetylcholine; Animals; Blood Pressure; Enkephalins; Estradiol; Estrogens; Female; Gonadal Steroid Hormones; Hypertension; In Vitro Techniques; Kidney; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Nitroprusside; Ovariectomy; Progesterone; Protein Precursors; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha; Vascular Diseases; Vasodilator Agents | 2007 |
The mu rather than the delta subtype of opioid receptors appears to be involved in enkephalin-induced analgesia.
Topics: Analgesics; Animals; Enkephalin, Leucine; Enkephalins; Guinea Pigs; In Vitro Techniques; Leucine; Male; Mice; Morphine; Muscle Contraction; Muscle, Smooth; Nalorphine; Naloxone; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Thiorphan; Tiopronin | 1984 |
A novel phencyclidine analog interacts selectively with mu opioid receptors.
Topics: Analgesia; Animals; Benzomorphans; Binding, Competitive; Cerebellum; Dihydromorphine; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Guinea Pigs; Ileum; Male; Mice; Muscle Contraction; Naloxone; Phencyclidine; Rats; Receptors, Opioid; Receptors, Opioid, mu; Vas Deferens | 1984 |
Interaction of morphine-epoxide with multiple opiate receptors.
Topics: Analgesics; Animals; Brain; Dihydromorphine; Enkephalins; Guinea Pigs; In Vitro Techniques; Male; Mice; Morphine; Morphine Derivatives; Muscle Contraction; Naloxone; Rats; Rats, Inbred Strains; Receptors, Opioid | 1984 |
Selectivities of opioid peptide analogues as agonists and antagonists at the delta-receptor.
Topics: Animals; Brain; Electric Stimulation; Enkephalins; Guinea Pigs; In Vitro Techniques; Male; Mice; Muscle Contraction; Muscle, Smooth; Myenteric Plexus; Rabbits; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Species Specificity; Vas Deferens | 1984 |
Opioid receptor subtypes involved in the central inhibition of urinary bladder motility.
Topics: Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Female; In Vitro Techniques; Injections, Intravenous; Injections, Intraventricular; Morphine; Muscle Contraction; Naloxone; Narcotics; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Urinary Bladder | 1984 |
[Action of enkephalins on synaptic processes in the metasympathetic nervous system].
Topics: Animals; Electric Stimulation; Enkephalins; Evoked Potentials; Guinea Pigs; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Naloxone; Neuromuscular Junction; Receptors, Opioid; Sympathetic Nervous System; Sympatholytics; Synapses; Tetrodotoxin | 1984 |
Radioligands for probing opioid receptors.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzomorphans; Binding Sites; Brain; Cyclazocine; Diprenorphine; Enkephalin, Leucine; Enkephalins; Ethylketocyclazocine; Guinea Pigs; Ileum; In Vitro Techniques; Male; Mice; Muscle Contraction; Muscle, Smooth; Myenteric Plexus; Naloxone; Pro-Opiomelanocortin; Protein Precursors; Pyrrolidines; Radioligand Assay; Rats; Receptors, Opioid; Vas Deferens | 1984 |
Two new opioid delta-receptor ligands: a highly selective agonist and a potent selective antagonist in in vitro isolated preparations.
Topics: Animals; Benzomorphans; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Guinea Pigs; Ileum; In Vitro Techniques; Kinetics; Ligands; Male; Mice; Mice, Inbred ICR; Muscle Contraction; Muscle, Smooth; Naloxone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, delta; Vas Deferens | 1984 |
Effects of changes in the structure of enkephalins and of narcotic analgesic drugs on their interactions with mu- and delta-receptors.
Topics: Analgesics, Opioid; Animals; Binding, Competitive; Brain; Endorphins; Enkephalins; Guinea Pigs; Ligands; Male; Mice; Mice, Inbred C57BL; Muscle Contraction; Naltrexone; Receptors, Opioid; Structure-Activity Relationship | 1980 |
Comparative effects of somatostatin and enkephalins on the guinea pig ileum and the rat vas deferens.
Topics: Animals; Endorphins; Enkephalins; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Naloxone; Narcotics; Rats; Somatostatin; Time Factors; Vas Deferens | 1980 |
Effects of beta-endorphin, met-enkephalin and somatostatin on the neurotensin-induced neurogenic contraction in the guinea-pig ileum.
Topics: Animals; Atropine; beta-Endorphin; Endorphins; Enkephalin, Methionine; Enkephalins; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Naloxone; Neurotensin; Somatostatin | 1981 |
The in vitro pharmacology of D-Met2,Pro5-enkephalinamide.
Topics: Animals; Endorphins; Enkephalin, Methionine; Enkephalins; In Vitro Techniques; Kinetics; Male; Muscle Contraction; Muscle, Smooth; Naltrexone; Narcotics; Nictitating Membrane; Rats; Receptors, Opioid; Vas Deferens | 1981 |
Opiate receptor antagonism by L-prolyl-L-leucyl-glycinamide, MIF-I.
Topics: Animals; Cyclazocine; Enkephalin, Leucine; Enkephalins; Ethylketocyclazocine; Female; Ileum; In Vitro Techniques; Male; Mice; Morphine; Motor Activity; MSH Release-Inhibiting Hormone; Muscle Contraction; Pain; Rats; Rats, Inbred Strains; Receptors, Opioid; Vas Deferens | 1980 |
Cholinergic and peptidergic receptors on isolated human antral smooth muscle cells.
Topics: Cholecystokinin; Enkephalin, Methionine; Enkephalins; Humans; Muscle Contraction; Muscle, Smooth; Neurotransmitter Agents; Peptide Fragments; Pyloric Antrum; Receptors, Cell Surface; Receptors, Cholinergic; Receptors, Muscarinic; Sincalide; Vasoactive Intestinal Peptide | 1982 |
Specific opiate receptors on isolated mammalian gastric smooth muscle cells.
Topics: Animals; Dose-Response Relationship, Drug; Dynorphins; Endorphins; Enkephalins; Gastric Mucosa; Guinea Pigs; Kinetics; Muscle Contraction; Muscle, Smooth; Naloxone; Neurotransmitter Agents; Receptors, Opioid | 1982 |
A novel opioid peptide, leumorphin, acts as an agonist at the kappa opiate receptor.
Topics: Animals; Dynorphins; Endorphins; Enkephalins; Guinea Pigs; Ileum; Male; Muscle Contraction; Naloxone; Neuromuscular Junction; Protein Precursors; Receptors, Opioid; Receptors, Opioid, kappa; Structure-Activity Relationship; Swine; Vas Deferens | 1983 |
The effect of a single temazepam administration on enkephalin content in the striatum and hypothalamus of the rat.
Topics: Animals; Anti-Anxiety Agents; Corpus Striatum; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Hypothalamus; In Vitro Techniques; Male; Mice; Muscle Contraction; Muscle, Smooth; Rats; Rats, Inbred Strains; Temazepam; Time Factors | 1983 |
Caerulein, substance P, serotonin and cholinomimetics induce rhythmic contractions of the intestinal circular muscle.
Topics: Animals; Bethanechol Compounds; Bombesin; Ceruletide; Desensitization, Immunologic; Dimethylphenylpiperazinium Iodide; Enkephalins; Female; Gastrointestinal Motility; Guinea Pigs; Hexamethonium Compounds; Ileum; In Vitro Techniques; Male; Muscle Contraction; Norepinephrine; Parasympathomimetics; Peristalsis; Serotonin; Substance P; Tetrodotoxin; Tropicamide | 1980 |
Peptide-containing neurons intrinsic to the gut wall. An experimental study in the pig.
Topics: Animals; Enkephalins; Jejunum; Muscle Contraction; Muscle, Smooth; Nerve Fibers; Peptides; Somatostatin; Substance P; Swine; Vasoactive Intestinal Peptide | 1981 |
Nerves containing substance P, vasoactive intestinal polypeptide, enkephalin or somatostatin in the guinea-pig taenia coli. Distribution, ultrastructure and possible functions.
Topics: Animals; Colon; Endorphins; Enkephalins; Gastrointestinal Hormones; Guinea Pigs; Male; Muscle Contraction; Muscle, Smooth; Myenteric Plexus; Nerve Fibers; Somatostatin; Substance P; Vasoactive Intestinal Peptide | 1981 |
The effect of captopril and ascorbic acid on nonenzymatic methionine enkephalin inactivation in the guinea-pig ileum.
Topics: Animals; Ascorbic Acid; Captopril; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Guinea Pigs; Ileum; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Proline; Puromycin; Sodium Hypochlorite; Teprotide | 1981 |
Contractile effect of morphine and related opioid alkaloids, beta-endorphin and methionine enkephalin on the isolated colon from Long Evans rats.
Topics: Animals; beta-Endorphin; Calcium; Colon; Dose-Response Relationship, Drug; Drug Tolerance; Endorphins; Enkephalin, Methionine; Enkephalins; Hexamethonium Compounds; Histamine Release; Humans; In Vitro Techniques; Male; Morphine; Muscle Contraction; Naloxone; Narcotics; Opioid-Related Disorders; Rats; Rats, Inbred Strains; Tetrodotoxin | 1981 |
Increased biological activity of dimers of oxymorphone and enkephalin: possible role of receptor crosslinking.
Topics: Animals; Binding, Competitive; Biological Assay; Brain; Cell Membrane; Chemical Phenomena; Chemistry; Endorphins; Enkephalins; Guinea Pigs; Hydromorphone; Ileum; Kinetics; Muscle Contraction; Oxymorphone; Receptors, Opioid; Structure-Activity Relationship | 1982 |
Trigeminal nerve: the possible origin of substance p-nergic response in isolated rabbit iris sphincter muscle.
Topics: Animals; Bradykinin; Capsaicin; Carbachol; Electric Stimulation; Enkephalins; Female; In Vitro Techniques; Iris; Male; Muscle Contraction; Muscles; Rabbits; Somatostatin; Substance P; Trigeminal Nerve; Vasoactive Intestinal Peptide | 1982 |
The effects of putative non-adrenergic, non-cholinergic autonomic transmitters on isolated strips from the stomach of the rainbow trout. Salmo gairdneri.
Topics: Adenosine; Adenosine Triphosphate; Animals; Bombesin; Enkephalins; Muscle Contraction; Muscle, Smooth; Neurotensin; Neurotransmitter Agents; Serotonin; Somatostatin; Stomach; Structure-Activity Relationship; Substance P; Trout; Vasoactive Intestinal Peptide | 1983 |
An approach to the self regulatory mechanism of substance P actions: II. Biological activity of new synthetic peptide analogs related both to enkephalin and substance P.
Topics: Animals; Biological Assay; Enkephalins; Guinea Pigs; Ileum; Male; Mice; Muscle Contraction; Rats; Structure-Activity Relationship; Substance P; Vas Deferens | 1983 |
Neuropeptides in the regulation of female genital smooth muscle contractility.
Topics: Adult; Aged; Enkephalins; Female; Genitalia, Female; Humans; Middle Aged; Muscle Contraction; Muscle, Smooth; Nerve Tissue Proteins; Somatostatin; Substance P; Vasoactive Intestinal Peptide | 1983 |
Selective development of tolerance without dependence in multiple opiate receptors of mouse vas deferens.
Topics: Animals; Dose-Response Relationship, Drug; Drug Tolerance; Electric Stimulation; Endorphins; Enkephalin, Leucine-2-Alanine; Enkephalins; Fentanyl; Humans; Male; Mice; Muscle Contraction; Muscle, Smooth; Receptors, Opioid; Substance-Related Disorders; Sufentanil; Vas Deferens | 1980 |
Structure-activity relationships of enkephalin analogs at opiate and enkephalin receptors: correlation with analgesia.
Topics: Amino Acid Sequence; Analgesics; Animals; Endorphins; Enkephalins; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Rats; Receptors, Opioid; Structure-Activity Relationship; Vas Deferens | 1980 |
Acetaldehyde-enkephalins: pronounced changes in the opiate activity of methionine-enkephalin and leucine-enkephalin on reaction with acetaldehyde.
Topics: Animals; Brain; Electric Stimulation; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Guinea Pigs; Ileum; Male; Mice; Morphine; Muscle Contraction; Rats; Receptors, Opioid; Vas Deferens | 1980 |
Lack of cross-tolerance between morphine and Leu-enkephalin in the mouse vas deferens.
Topics: Animals; Drug Tolerance; Electric Stimulation; Endorphins; Enkephalins; Male; Mice; Morphine; Muscle Contraction; Muscle, Smooth; Naloxone; Neuromuscular Junction; Receptors, Opioid; Vas Deferens | 1980 |
Correlation between circular dichroism data and biological activities of 2,5 substituted enkephalin analogues.
Topics: Animals; Chemical Phenomena; Chemistry; Circular Dichroism; Endorphins; Enkephalins; Guinea Pigs; Ileum; In Vitro Techniques; Male; Mice; Muscle Contraction; Muscle, Smooth; Receptors, Opioid; Structure-Activity Relationship; Vas Deferens | 1980 |
Novel analogues of enkephalin: indentification of functional groups required for biological activity.
Topics: Animals; Bacitracin; Binding, Competitive; Brain; Chromatography, High Pressure Liquid; Endorphins; Enkephalins; Guinea Pigs; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Naloxone; Rats; Receptors, Opioid; Structure-Activity Relationship | 1980 |
Effects of methionine-enkephalin on intestinal circulation and oxygen consumption.
Topics: Animals; Depression, Chemical; Dogs; Dose-Response Relationship, Drug; Endorphins; Enkephalins; Female; Ileum; Male; Muscle Contraction; Muscle, Smooth; Naloxone; Oxygen Consumption; Receptors, Opioid; Regional Blood Flow | 1980 |
Interactions between morphine and the opioid-like peptides in the rat vas deferens.
Topics: Animals; Binding Sites; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Endorphins; Enkephalins; In Vitro Techniques; Male; Morphine; Muscle Contraction; Rats; Receptors, Opioid; Vas Deferens | 1980 |
Heterogeneity of endogeneous opiates: H-endorphin is not correlated with enkephalin or with beta-endorphin.
Topics: Animals; beta-Endorphin; Brain Chemistry; Endorphins; Enkephalin, Leucine; Enkephalins; Guinea Pigs; In Vitro Techniques; Male; Mice; Muscle Contraction; Muscle, Smooth; Rats | 1980 |
Analogues of beta-LPH61-64 possessing selective agonist activity at mu-opiate receptors.
Topics: Animals; Behavior, Animal; beta-Lipotropin; Binding, Competitive; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Guinea Pigs; Ileum; Male; Mice; Muscle Contraction; Naloxone; Pain; Peptide Fragments; Radioligand Assay; Receptors, Opioid; Structure-Activity Relationship; Vas Deferens | 1981 |
Demonstration of a specific dynorphin receptor in guinea pig ileum myenteric plexus.
Topics: Animals; Binding, Competitive; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalins; Guinea Pigs; Ileum; Kinetics; Muscle Contraction; Myenteric Plexus; Naltrexone; Narcotic Antagonists; Narcotics; Nitrogen Mustard Compounds; Peptide Fragments; Receptors, Opioid | 1981 |
Tobacco mosaic virus-enkephalin conjugates: potentiation of opioid activity.
Topics: Animals; Binding, Competitive; Biological Assay; Dihydromorphine; Drug Synergism; Endorphins; Enkephalins; Guinea Pigs; Ileum; Male; Mice; Muscle Contraction; Myenteric Plexus; Receptors, Opioid; Structure-Activity Relationship; Tobacco Mosaic Virus; Vas Deferens | 1981 |
A highly potent 3200-dalton adrenal opioid peptide that contains both a [Met]- and [Leu]enkephalin sequence.
Topics: Adrenal Medulla; Amino Acid Sequence; Animals; Biological Assay; Cattle; Cell Line; Chromaffin Granules; Chromaffin System; Endorphins; Enkephalins; Glioma; Guinea Pigs; Ileum; Mice; Molecular Weight; Muscle Contraction; Neuroblastoma; Receptors, Opioid | 1981 |
Minimum structure opioids-dipeptide and tripeptide analogs of the enkephalins.
Topics: Animals; Chemical Phenomena; Chemistry, Physical; Dipeptides; Endorphins; Enkephalins; Female; Guinea Pigs; Ileum; In Vitro Techniques; Male; Mice; Muscle Contraction; Muscle, Smooth; Oligopeptides; Reaction Time; Receptors, Opioid; Structure-Activity Relationship | 1981 |
Delta opiate receptors are involved in the endopioid-induced myoclonic contractions.
Topics: Analgesics; Animals; Benzomorphans; Endorphins; Enkephalins; Female; Male; Morphine; Muscle Contraction; Myoclonus; Rats; Rats, Inbred Strains; Receptors, Opioid | 1982 |
Interaction of p-nitrophenylalanine enkephalins with mu-, delta- and kappa-subtypes of the opiate receptor.
Topics: Animals; Binding, Competitive; Brain Chemistry; Endorphins; Enkephalins; Guinea Pigs; In Vitro Techniques; Male; Mice; Muscle Contraction; Muscle, Smooth; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Structure-Activity Relationship | 1982 |
Degradation of exogenous enkephalin in the guinea-pig ileum: relative importance of aminopeptidase, enkephalinase and angiotensin converting enzyme activity.
Topics: Aminopeptidases; Angiotensin I; Animals; Bradykinin; Endopeptidases; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Neprilysin; Peptidyl-Dipeptidase A; Thiorphan; Tiopronin | 1982 |
The effect of naloxone, morphine, and an enkephalin analogue on cholecystokinin octapeptide-stimulated gallbladder emptying.
Topics: Adult; Cholecystokinin; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Endorphins; Enkephalins; Gallbladder; Humans; Male; Morphine; Muscle Contraction; Naloxone; Peptide Fragments; Sincalide; Stimulation, Chemical; Ultrasonics | 1982 |
The choice of opiate receptor subtype by neo-endorphins.
Topics: Animals; Benzomorphans; beta-Endorphin; Cyclazocine; Drug Interactions; Endorphins; Enkephalins; Ethylketocyclazocine; Guinea Pigs; Ileum; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Naloxone; Protein Precursors; Rabbits; Receptors, Opioid | 1982 |
[Met5]enkephalin-Arg-Phe ACTS on vascular opiate receptors.
Topics: Animals; Cyclazocine; Electric Stimulation; Endorphins; Enkephalin, Methionine; Enkephalins; Ethylketocyclazocine; In Vitro Techniques; Muscle Contraction; Muscle, Smooth, Vascular; Rabbits; Receptors, Opioid | 1982 |
[D-Pen2, L-Cys5]enkephalinamide and[D-Pen2, D-Cys5] enkephalinamide, conformationally constrained cyclic enkephalinamide analogs with delta receptor specificity.
Topics: Animals; Biological Assay; Brain; Endorphins; Enkephalins; Female; Guinea Pigs; Ileum; Male; Mice; Morphine Derivatives; Muscle Contraction; Rats; Rats, Inbred Strains; Receptors, Opioid; Structure-Activity Relationship; Vas Deferens | 1982 |
Correlation of hydrophobic character of opioid peptides with their biological activity measured in various bioassay systems.
Topics: Animals; Chemical Phenomena; Chemistry, Physical; Enkephalins; Guinea Pigs; In Vitro Techniques; Male; Mice; Mice, Inbred Strains; Morphine; Muscle Contraction; Muscle, Smooth; Naloxone; Rats; Rats, Inbred Strains; Receptors, Opioid; Solubility; Structure-Activity Relationship | 1982 |
Comparison of biological activities of enkephalin analogues in isolated organs.
Topics: Amino Acid Sequence; Animals; Cats; Enkephalins; Female; Guinea Pigs; Ileum; In Vitro Techniques; Male; Mice; Muscle Contraction; Muscle, Smooth; Nictitating Membrane; Organ Specificity; Receptors, Opioid; Spleen; Structure-Activity Relationship; Vas Deferens | 1982 |
Pharmacological characterization of the opioid receptor in the submucous plexus of the guinea-pig oesophagus.
Topics: Acetylcholine; Animals; Electric Stimulation; Endorphins; Enkephalins; Esophagus; Guinea Pigs; In Vitro Techniques; Male; Morphine; Mucous Membrane; Muscle Contraction; Muscle, Smooth; Naloxone; Receptors, Opioid | 1983 |
Dimeric pentapeptide and tetrapeptide enkephalins: new tools for the study of delta opioid receptors.
Topics: Animals; Cyclic AMP; Enkephalins; Guanosine Triphosphate; In Vitro Techniques; Kinetics; Male; Mice; Muscle Contraction; Muscle, Smooth; Naloxone; Rats; Receptors, Opioid; Receptors, Opioid, delta | 1983 |
Conformationally constrained cyclic enkephalin analogs with pronounced delta opioid receptor agonist selectivity.
Topics: Animals; Biological Assay; Brain; Enkephalins; Guinea Pigs; Ileum; Male; Mice; Muscle Contraction; Protein Conformation; Rats; Receptors, Opioid; Structure-Activity Relationship; Vas Deferens | 1983 |
Synthesis of porcine leumorphin and some of its biological activities.
Topics: Analgesia; Animals; beta-Endorphin; Biological Assay; Dynorphins; Electric Stimulation; Endorphins; Enkephalins; Guinea Pigs; Ileum; Indicators and Reagents; Mice; Muscle Contraction; Naloxone; Narcotics; Peptide Fragments; Protein Precursors; Swine | 1983 |
Bis-penicillamine enkephalins possess highly improved specificity toward delta opioid receptors.
Topics: Animals; Binding, Competitive; Biological Assay; Brain; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Isomerism; Kinetics; Muscle Contraction; Naloxone; Oligopeptides; Rats; Receptors, Opioid; Receptors, Opioid, delta; Structure-Activity Relationship | 1983 |
Cyclic and acyclic partial retro-inverso enkephalinamides: Mu receptor selective enzyme resistant analogs.
Topics: Amino Acid Sequence; Animals; Biological Assay; Brain; Cell Membrane; Enkephalins; Guinea Pigs; Ileum; Kinetics; Muscle Contraction; Rats; Receptors, Opioid; Receptors, Opioid, mu; Structure-Activity Relationship | 1983 |
Selective ligands for opioid receptors. beta-Cyclopropylalanyl containing analogs of enkephalin.
Topics: Amino Acid Sequence; Animals; Biological Assay; Enkephalins; Guinea Pigs; Ileum; Indicators and Reagents; Ligands; Male; Muscle Contraction; Rats; Receptors, Opioid; Structure-Activity Relationship; Vas Deferens | 1983 |
K receptor activities of the three opioid peptide families.
Topics: Animals; Enkephalins; Male; Muscle Contraction; Pituitary Hormones, Anterior; Pro-Opiomelanocortin; Protein Precursors; Rabbits; Receptors, Opioid; Receptors, Opioid, kappa; Structure-Activity Relationship; Vas Deferens | 1983 |
Comparison of the action of putative endogenous kappa-agonists, leumorphin and rimorphin in vitro.
Topics: Animals; Biological Assay; Dynorphins; Electric Stimulation; Endorphins; Enkephalin, Leucine; Enkephalins; Guinea Pigs; Ileum; Male; Muscle Contraction; Muscle, Smooth; Naloxone; Protein Precursors; Rabbits; Receptors, Opioid; Receptors, Opioid, kappa; Vas Deferens | 1983 |
Cyclic penicillamine containing enkephalin analogs display profound delta receptor selectivities.
Topics: Animals; Brain; Cell Line; Cell Membrane; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Glioma; Guinea Pigs; Hybrid Cells; Ileum; Male; Mice; Muscle Contraction; Neuroblastoma; Rats; Receptors, Opioid; Receptors, Opioid, delta; Structure-Activity Relationship; Vas Deferens | 1983 |
Lysine substitution increases mu-selectivity of potent di- and tri-peptide enkephalin analogs.
Topics: Animals; Brain; Enkephalins; Guinea Pigs; Ileum; Male; Mice; Muscle Contraction; Receptors, Opioid; Receptors, Opioid, mu; Structure-Activity Relationship; Vas Deferens | 1983 |
Cerebral delta opioid receptors mediate analgesia but not the intestinal motility effects of intracerebroventricularly administered opioids.
Topics: Analgesia; Animals; Biological Assay; Brain; Enkephalins; Gastrointestinal Motility; Hot Temperature; Injections, Intraventricular; Male; Mice; Muscle Contraction; Narcotics; Receptors, Opioid; Vas Deferens | 1984 |
Opioid activity of enkephalin analogues containing the kyotorphin-related structure in the N-terminus.
Topics: Analgesics; Animals; Brain; Cell Membrane; Endorphins; Enkephalins; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Protease Inhibitors; Rats; Rats, Inbred Strains; Receptors, Opioid; Thiorphan; Tiopronin; Vas Deferens | 1984 |
The pro-enkephalin A derivative, peptide E, is centrally processed to active fragments.
Topics: Animals; Brain; Enkephalins; Female; Gastrointestinal Motility; In Vitro Techniques; Male; Mice; Mice, Inbred ICR; Muscle Contraction; Peptides; Rats; Rats, Inbred Strains; Urinary Bladder | 1984 |
Leumorphin is a novel endogenous opioid peptide in man.
Topics: Adult; Animals; Brain Chemistry; Chromatography, Gel; Chromatography, High Pressure Liquid; Enkephalins; Guinea Pigs; Humans; Ileum; Muscle Contraction; Protein Precursors; Radioimmunoassay | 1984 |
Antagonism of enkephalin action on acetylcholine release by methylxanthines: lack of a purine link.
Topics: Acetylcholine; Adenosine; Animals; Caffeine; Cerebral Cortex; Enkephalins; Guinea Pigs; In Vitro Techniques; Morphine; Muscle Contraction; Muscle, Smooth; Myenteric Plexus; Rats; Theophylline; Xanthines | 1983 |
Central and peripheral action of enkephalin analogues.
Topics: Animals; Dogs; Enkephalins; Gastrointestinal Motility; Guinea Pigs; Ileum; Indicators and Reagents; Male; Muscle Contraction; Pain; Rats; Rats, Inbred Strains; Structure-Activity Relationship; Vocalization, Animal | 1983 |
Divergent structure activity relationships in series of enkephalin agonists and cognate antagonists.
Topics: Animals; Biological Assay; Enkephalins; Guinea Pigs; Ileum; Male; Mice; Molecular Conformation; Muscle Contraction; Structure-Activity Relationship; Vas Deferens | 1983 |
[Effect of opiates on the rat vas deferens].
Topics: Animals; Cyclazocine; Enkephalins; Male; Morphine; Muscle Contraction; Naloxone; Narcotics; Rats; Rats, Inbred Strains; Vas Deferens | 1983 |
Opioid peptides derived from pre-proenkephalin B sequence: biological evaluation in guinea pig ileum and mouse vas deferens.
Topics: Animals; Electric Stimulation; Endorphins; Enkephalin, Leucine; Enkephalins; Guinea Pigs; Ileum; In Vitro Techniques; Male; Mice; Mice, Inbred ICR; Muscle Contraction; Muscle, Smooth; Protein Precursors; Vas Deferens | 1983 |
Neural control of the sphincter of Oddi. Physiologic role of enkephalins on the regulation of basal sphincter of Oddi motor activity in the cat.
Topics: Ampulla of Vater; Animals; Atropine; Autonomic Nerve Block; Cats; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Female; Male; Muscle Contraction; Reserpine; Serotonin; Serotonin Antagonists; Sphincter of Oddi; Tetrodotoxin | 1984 |
Peptidergic (enkephalin) innervation of the mammalian esophagus.
Topics: Adrenergic Fibers; Animals; Autonomic Agents; Cats; Cholinergic Fibers; Endorphins; Enkephalins; Esophagus; Fetus; Guinea Pigs; Haplorhini; Humans; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Naloxone; Opossums; Swine; Tetrodotoxin | 1980 |
Enkephalin analogs: synthesis and properties of analogs with lipophilic or extended carboxyl-terminus. Quantitative structure-activity relationship of analogs modified in residue position 5.
Topics: Analgesics; Animals; Enkephalins; Guinea Pigs; Ileum; In Vitro Techniques; Mice; Muscle Contraction; Structure-Activity Relationship | 1983 |
[Interaction of gastrointestinal peptides and the autonomic nervous system in the contractile function of the gallbladder].
Topics: Angiotensin II; Animals; Autonomic Nervous System; Cholecystokinin; Dogs; Enkephalins; Gallbladder; Gastric Mucosa; Gastrins; Gastrointestinal Hormones; Muscle Contraction; Neurotensin; Pentagastrin; Sympathectomy; Time Factors; Vagotomy | 1983 |
Met-enkephalin as a modulator of smooth-muscle mechanical activity.
Topics: Animals; Cats; Endorphins; Enkephalin, Methionine; Enkephalins; Guinea Pigs; Muscle Contraction; Muscle Tonus; Muscle, Smooth; Rats; Rats, Inbred Strains | 1982 |
A quantitative structure-activity relationship study of the inhibitory action of a series of enkephalin-like peptides in the guinea pig ileum and mouse vas deferens bioassays.
Topics: Animals; Enkephalins; Guinea Pigs; Ileum; In Vitro Techniques; Male; Mice; Muscle Contraction; Muscle, Smooth; Protein Conformation; Structure-Activity Relationship; Vas Deferens | 1982 |
Differential effects of SKF 10,047 (N-allyl-normetazocine) on peristalsis and longitudinal muscle contractions of the isolated guinea-pig ileum.
Topics: Animals; Electric Stimulation; Enkephalins; Gastrointestinal Motility; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Peristalsis; Phenazocine | 1982 |
Double enkephalins.
Topics: Animals; Binding Sites; Enkephalins; Guinea Pigs; Ileum; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Structure-Activity Relationship | 1982 |
A new approach to conformationally restricted peptide analogs: rigid beta-bends. 1. Enkephalin as an example.
Topics: Animals; Biological Assay; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Guinea Pigs; Ileum; Models, Molecular; Muscle Contraction; Protein Conformation; Structure-Activity Relationship | 1982 |
Methionine-enkephalin antagonism and endorphin potentiation of narcotic-induced analgesia.
Topics: Animals; Drug Interactions; Drug Tolerance; Endorphins; Enkephalin, Methionine; Enkephalins; Guinea Pigs; Humans; In Vitro Techniques; Male; Mice; Mice, Inbred ICR; Morphine; Morphine Dependence; Muscle Contraction; Muscle, Smooth; Reaction Time | 1980 |
Synthesis and pharmacological activity of modified leu-enkephalin derivatives. III.
Topics: Animals; Endorphins; Enkephalin, Leucine; Enkephalins; Guinea Pigs; In Vitro Techniques; Male; Mice; Muscle Contraction; Muscle, Smooth | 1980 |
Enkephalin-like character and analgesia.
Topics: Analgesics; Animals; Endorphins; Enkephalins; Guinea Pigs; Ileum; In Vitro Techniques; Injections, Intravenous; Injections, Intraventricular; Male; Mice; Muscle Contraction; Muscle, Smooth; Rats; Reaction Time; Structure-Activity Relationship | 1981 |
Potent tetrapeptide enkephalins.
Topics: Animals; Behavior, Animal; Biological Assay; Endorphins; Enkephalins; Guinea Pigs; Ileum; Kinetics; Male; Mice; Muscle Contraction; Oligopeptides; Structure-Activity Relationship | 1981 |
Tyrosine-modified analogs of methionine-enkephalin and their effects on the mouse vas deferens.
Topics: Animals; Endorphins; Enkephalin, Methionine; Enkephalins; Male; Mice; Muscle Contraction; Structure-Activity Relationship; Vas Deferens | 1980 |
Super-active enkephalin analogues. Simple tripeptide hydroxyalkylamides exhibit surprisingly high and long-lasting opioid activities.
Topics: Animals; Behavior, Animal; Biological Assay; Endorphins; Enkephalins; Female; Guinea Pigs; Ileum; Mice; Muscle Contraction; Oligopeptides; Structure-Activity Relationship | 1981 |
Enkephalin-induced inhibition of the isolated rat ileum is not blocked by naloxone.
Topics: Animals; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Male; Morphine; Muscle Contraction; Muscle, Smooth; Naloxone; Rats; Rats, Inbred Strains | 1981 |
Effect of enkephalins in the presence of the antibiotic bacitracin in the longitudinal muscle strip preparation from guinea-pig ileum.
Topics: Animals; Bacitracin; Endorphins; Enkephalin, Methionine; Enkephalins; Guinea Pigs; Ileum; Muscle Contraction; Muscle, Smooth | 1981 |
Long-term interactions between endogenous and exogenous opiates.
Topics: Animals; Drug Interactions; Endorphins; Enkephalins; Guinea Pigs; In Vitro Techniques; Morphine; Muscle Contraction; Muscle, Smooth; Narcotics; Time Factors | 1980 |
Influence of methionine-enkephalin and morphine on myoelectric activity of small bowel.
Topics: Action Potentials; Animals; Dogs; Dose-Response Relationship, Drug; Duodenum; Endorphins; Enkephalins; Gastrointestinal Motility; Ileum; Intestine, Small; Jejunum; Membrane Potentials; Morphine; Muscle Contraction; Muscle, Smooth | 1980 |
The effect of (D-Ala2)-Met-enkephalin on the contraction of nictitating membrane in cats.
Topics: Animals; Cats; Cocaine; Dose-Response Relationship, Drug; Drug Synergism; Electric Stimulation; Endorphins; Enkephalin, Methionine; Enkephalins; Female; Male; Morphine; Muscle Contraction; Naloxone; Nictitating Membrane; Norepinephrine; Sympathetic Nervous System | 1980 |
Effect of met-enkephalin on the responses of rat fundus and colon and chick rectum to PGE2 and its release from rat aortic strip.
Topics: Animals; Aorta; Blood Vessels; Chickens; Colon; Drug Interactions; Endorphins; Enkephalin, Methionine; Enkephalins; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Prostaglandins E; Rats; Rectum; Stomach | 1980 |
Effects of electrical stimulation on the enkephalins in guinea-pig small intestine.
Topics: Animals; Cycloheximide; Electric Stimulation; Endorphins; Enkephalins; Guinea Pigs; In Vitro Techniques; Intestine, Small; Male; Muscle Contraction; Myenteric Plexus; Time Factors | 1980 |
Myogenic receptivity for Met-enkephalin in the rat duodenum: comparison with the guinea-pig duodenum.
Topics: Animals; Drug Interactions; Duodenum; Endorphins; Enkephalin, Methionine; Enkephalins; Guinea Pigs; In Vitro Techniques; Male; Morphine; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Rats; Species Specificity; Tetrodotoxin | 1980 |
A new endogenous opioid peptide from bovine adrenal medulla: isolation and amino acid sequence of a dodecapeptide (BAM-12P).
Topics: Adrenal Medulla; Amino Acid Sequence; Amino Acids; Animals; Cattle; Endorphins; Enkephalin, Methionine; Enkephalins; Guinea Pigs; Hydrolysis; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Protein Precursors; Radioimmunoassay; Trypsin | 1980 |
Synthesis and opioid activities of [D-Leu-8]Dynorphin(1-8) analogs containing a reduced peptide bond, psi(CH2-NH).
Topics: Amino Acid Sequence; Analgesics; Animals; Binding, Competitive; Cerebellum; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Guanylyl Imidodiphosphate; Guinea Pigs; Ileum; In Vitro Techniques; Male; Molecular Sequence Data; Muscle Contraction; Muscle, Smooth; Opioid Peptides; Receptors, Opioid | 1995 |
Contrasting actions of intrathecal U50,488H, morphine, or [D-Pen2, D-Pen5] enkephalin or intravenous U50,488H on the visceromotor response to colorectal distension in the rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Colon; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intravenous; Injections, Spinal; Male; Morphine; Muscle Contraction; Pain; Pyrrolidines; Rats; Rats, Sprague-Dawley; Rectum | 1995 |
Visceral antinociceptive effects of spinal clonidine combined with morphine, [D-Pen2, D-Pen5] enkephalin, or U50,488H.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Clonidine; Colon; Drug Synergism; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Spinal; Male; Morphine; Muscle Contraction; Pain; Pyrrolidines; Rats; Rats, Sprague-Dawley; Rectum | 1995 |
mu- and delta-opioid receptor-mediated contractile effects on rat aortic vascular smooth muscle.
Topics: Amino Acid Sequence; Analgesics; Analysis of Variance; Animals; Aorta; Benzomorphans; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Molecular Sequence Data; Morphine; Muscle Contraction; Muscle, Smooth, Vascular; Naltrexone; Norepinephrine; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, mu | 1995 |
Dalargin and [Cys-(O2NH2)]2 analogues of enkephalins and their selectivity for mu opioid receptors.
Topics: Amino Acid Sequence; Animals; Electric Stimulation; Enkephalin, Leucine-2-Alanine; Enkephalins; Guinea Pigs; Ileum; In Vitro Techniques; Male; Molecular Sequence Data; Muscle Contraction; Muscle, Smooth; Naloxone; Receptors, Opioid, mu; Sympatholytics; Tetrodotoxin | 1995 |
Opioid agonists modulate release of neurotransmitters in bovine trachealis muscle.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetylcholine; Analgesics; Animals; Cattle; Dose-Response Relationship, Drug; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; In Vitro Techniques; Muscle Contraction; Neurotransmitter Agents; Pyrrolidines; Receptors, Opioid; Trachea | 1995 |
Differential inhibition of cholinergic and noncholinergic neurogenic contractions by mu opioid and alpha-2 adrenergic agonists in guinea pig ileum.
Topics: Acetylcholine; Adrenergic alpha-Agonists; Animals; Brimonidine Tartrate; Choline; Clonidine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Guinea Pigs; Ileum; In Vitro Techniques; Male; Morphine; Motor Neurons; Muscle Contraction; Muscle, Smooth; Neuromuscular Junction; Neurotransmitter Uptake Inhibitors; Quinoxalines; Receptors, Adrenergic, alpha; Receptors, Opioid, mu; Substance P; Synaptic Transmission | 1993 |
Analgesic effect of two calcitonins and in vitro interaction with opioids.
Topics: Analgesics; Animals; Benzomorphans; Calcitonin; Dose-Response Relationship, Drug; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guinea Pigs; In Vitro Techniques; Male; Mice; Morphine; Muscle Contraction; Muscle, Smooth; Narcotics; Pain Measurement; Pain Threshold; Rabbits; Rats; Rats, Wistar | 1995 |
Isolation and characterization of oryzatensin: a novel bioactive peptide with ileum-contracting and immunomodulating activities derived from rice albumin.
Topics: Adjuvants, Immunologic; Adult; Albumins; Amino Acid Sequence; Animals; Atropine; Brain; Cell Membrane; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Guinea Pigs; Humans; Ileum; In Vitro Techniques; Molecular Sequence Data; Muscle Contraction; Muscle, Smooth; Neutrophils; Oligopeptides; Oryza; Peptide Fragments; Phagocytosis; Plant Proteins; Radioligand Assay; Rats; Receptors, Opioid, mu; Sequence Homology, Amino Acid; Superoxides; Tetrodotoxin; Trypsin | 1994 |
Delta-opioid receptor agonists inhibit neuromuscular transmission in human colon.
Topics: Analgesics; Analgesics, Opioid; Colon; Dynorphins; Electric Stimulation; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Gastrointestinal Motility; Humans; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Naltrexone; Narcotic Antagonists; Neuromuscular Junction; Peptide Fragments; Receptors, Opioid, delta; Synaptic Transmission | 1994 |
Development of a model for the delta opioid receptor pharmacophore. 1. Conformationally restricted Tyr1 replacements in the cyclic delta receptor selective tetrapeptide Tyr-c[D-Cys-Phe-D-Pen]OH (JOM-13).
Topics: Amino Acid Sequence; Animals; Binding, Competitive; Cyclization; Enkephalins; Guinea Pigs; Ileum; Male; Mice; Mice, Inbred ICR; Models, Molecular; Molecular Sequence Data; Muscle Contraction; Protein Conformation; Receptors, Opioid, delta; Receptors, Opioid, mu; Structure-Activity Relationship; Thermodynamics; Tyrosine; Vas Deferens | 1994 |
Development of a model for the delta opioid receptor pharmacophore. 2. Conformationally restricted Phe3 replacements in the cyclic delta receptor selective tetrapeptide Tyr-c[D-Cys-Phe-D-Pen]OH (JOM-13).
Topics: Amino Acid Sequence; Aminobutyrates; Animals; Cyclization; Enkephalins; Guinea Pigs; Ileum; Male; Mice; Molecular Sequence Data; Muscle Contraction; Phenylalanine; Protein Conformation; Receptors, Opioid, delta; Stereoisomerism; Structure-Activity Relationship; Thermodynamics; Vas Deferens | 1994 |
Opioid effects of short enkephalin fragments containing the Gly-Phe sequence on contractile responses of guinea pig ileum.
Topics: Acetylcholine; Amino Acid Sequence; Animals; Electric Stimulation; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Guinea Pigs; Ileum; In Vitro Techniques; Male; Molecular Sequence Data; Morphine; Muscle Contraction; Muscle, Smooth; Peptide Fragments | 1994 |
Modulation of non-adrenergic non-cholinergic inhibitory transmission in rat duodenum: role of opiates and 5-hydroxytryptamine.
Topics: Analgesics; Animals; Atropine; Autonomic Nervous System; Duodenum; Dynorphins; Electric Stimulation; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Gastrointestinal Motility; Guanethidine; In Vitro Techniques; Male; Muscle Contraction; Naloxone; Rats; Rats, Wistar; Serotonin; Synaptic Transmission; Tetrodotoxin | 1993 |
Identification of mechanisms and sites of actions of mu and delta opioid receptor activation in the canine intestine.
Topics: Amino Acid Sequence; Animals; Dogs; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Ileum; In Vitro Techniques; Male; Molecular Sequence Data; Muscle Contraction; Nitric Oxide; Peptide Fragments; Peptides; Receptors, Opioid, delta; Receptors, Opioid, mu; Somatostatin; Vasoactive Intestinal Peptide | 1994 |
Selective opioid dipeptides.
Topics: Amino Acid Sequence; Animals; Binding, Competitive; Brain; Cell Membrane; Dipeptides; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guinea Pigs; Ileum; In Vitro Techniques; Isoquinolines; Kinetics; Models, Molecular; Molecular Sequence Data; Muscle Contraction; Muscle, Smooth; Narcotics; Oligopeptides; Protein Conformation; Radioligand Assay; Rats; Receptors, Opioid, delta; Receptors, Opioid, mu; Stereoisomerism; Structure-Activity Relationship; Synaptosomes; Tetrahydroisoquinolines | 1994 |
Cyclic enkephalin analogs with exceptional potency at peripheral delta opioid receptors.
Topics: Amino Acid Sequence; Animals; Blood-Brain Barrier; Cell Membrane; Cerebellum; Chemical Phenomena; Chemistry, Physical; Cyclization; Enkephalins; Guinea Pigs; Ileum; Lipid Metabolism; Male; Mice; Molecular Sequence Data; Muscle Contraction; Peptides, Cyclic; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Structure-Activity Relationship; Vas Deferens | 1994 |
Effect of opioid receptor subtype-selective agonists on purinergic and adrenergic components of neurogenic contractions of mouse vas deferens.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Mice; Mice, Inbred Strains; Muscle Contraction; Muscle, Smooth; Pyrrolidines; Receptors, Adrenergic; Receptors, Opioid; Receptors, Purinergic; Sympathetic Nervous System; Vas Deferens | 1993 |
In vitro study of the interaction of salmon calcitonin with mu, delta and kappa opioid agonists.
Topics: Animals; Benzomorphans; Calcitonin; Drug Interactions; Electric Stimulation; Enkephalins; Guinea Pigs; Ileum; In Vitro Techniques; Male; Mice; Muscle Contraction; Muscle, Smooth; Rabbits; Receptors, Opioid; Vas Deferens | 1993 |
Dexamethasone selective inhibition of acute opioid physical dependence in isolated tissues.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Cycloheximide; Dexamethasone; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Guinea Pigs; In Vitro Techniques; Male; Mifepristone; Muscle Contraction; Naloxone; Opioid-Related Disorders; Pyrrolidines; Rabbits; Substance Withdrawal Syndrome | 1996 |
Effects of modifications of residues in position 3 of dynorphin A(1-11)-NH2 on kappa receptor selectivity and potency.
Topics: Amino Acid Sequence; Analgesics; Animals; Benzeneacetamides; Brain; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Guinea Pigs; Ileum; Molecular Sequence Data; Muscle Contraction; Muscle, Smooth; Peptide Fragments; Protein Binding; Protein Conformation; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Structure-Activity Relationship | 1996 |
Effect of the intraperitoneal administration of salmon-calcitonin on the "in vitro" actions of opioid agonists.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Calcitonin; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Guinea Pigs; Ileum; In Vitro Techniques; Male; Mice; Muscle Contraction; Narcotics; Pyrrolidines; Rabbits; Receptors, Opioid, delta; Receptors, Opioid, kappa; Vas Deferens | 1995 |
Circannual variations in bear plasma albumin and its opioid-like effects on guinea pig ileum.
Topics: Analgesics; Animals; Dynorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guinea Pigs; Hibernation; Ileum; In Vitro Techniques; Male; Morphine; Muscle Contraction; Muscle, Smooth; Naloxone; Narcotic Antagonists; Narcotics; Receptors, Opioid; Seasons; Serum Albumin; Ursidae | 1996 |
[Cys(O2NH2)2]enkephalin analogues and dalargin: selectivity for delta-opioid receptors.
Topics: Adenosine Triphosphate; Animals; Dose-Response Relationship, Drug; Electric Stimulation; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Guinea Pigs; Ileum; In Vitro Techniques; Male; Mice; Muscle Contraction; Muscle, Smooth; Norepinephrine; Receptors, Opioid, delta; Receptors, Opioid, kappa; Structure-Activity Relationship; Vas Deferens | 1996 |
Opioids modulate the cholinergic contraction but not the nonadrenergic relaxation in guinea-pig airways in vitro.
Topics: Animals; Benzeneacetamides; Cholinergic Fibers; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Trachea | 1996 |
Probes for narcotic receptor mediated phenomena. 23. Synthesis, opioid receptor binding, and bioassay of the highly selective delta agonist (+)-4-[(alpha R)-alpha-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]- N,N-diethylbenzamide (SNC 80)
Topics: Animals; Benzamides; Binding, Competitive; Brain; Crystallography, X-Ray; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Guinea Pigs; Ileum; Magnetic Resonance Spectroscopy; Male; Mice; Molecular Conformation; Molecular Structure; Muscle Contraction; Piperazines; Radioligand Assay; Rats; Receptors, Opioid, delta; Receptors, Opioid, mu; Stereoisomerism; Vas Deferens | 1997 |
Structure-activity relationship of biphalin. The synthesis and biological activities of new analogues with modifications in positions 3 and 4.
Topics: Analgesics; Animals; Brain; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guinea Pigs; Ileum; Male; Mice; Mice, Inbred ICR; Muscle Contraction; Muscle, Smooth; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu; Somatostatin; Structure-Activity Relationship; Vas Deferens | 1997 |
Actions of beta-endorphin peptides on the contractions of mouse diaphragm muscle.
Topics: Animals; Benzylidene Compounds; beta-Endorphin; Diaphragm; Dipeptides; Electric Stimulation; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Mice; Mice, Inbred C57BL; Muscle Contraction; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Neostigmine; Oligopeptides; Peptide Fragments | 1997 |
Identification of casoxin C, an ileum-contracting peptide derived from bovine kappa-casein, as an agonist for C3a receptors.
Topics: Amino Acid Sequence; Animals; Caseins; Cattle; Complement C3a; Dinoprostone; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Guinea Pigs; Humans; Ileum; Membrane Proteins; Muscle Contraction; Muscle, Smooth; Oligopeptides; Peptide Fragments; Phagocytosis; Protein Binding; Pyrilamine; Receptors, Complement; Receptors, Opioid, mu; Sequence Homology, Amino Acid; Structure-Activity Relationship | 1997 |
Inhibition of airway constriction by opioids is different down the isolated bovine airway.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetylcholine; Analgesics; Animals; Bronchi; Bronchoconstriction; Cattle; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Narcotics; Pyrrolidines; Receptors, Opioid; Trachea | 1997 |
Synthesis and biological properties of beta-MePhe3 analogues of deltorphin I and dermenkephalin: influence of biased chi 1 Phe3 residues on peptide recognition for delta-opioid receptors.
Topics: Aminobutyrates; Analgesics, Opioid; Animals; Binding, Competitive; Brain; Electric Stimulation; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Mice; Mice, Inbred ICR; Muscle Contraction; Oligopeptides; Protein Binding; Protein Conformation; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Stereoisomerism | 1997 |
Synthesis and pharmacological activity of deltorphin and dermorphin-related glycopeptides.
Topics: Amino Acid Sequence; Analgesics, Opioid; Animals; Binding, Competitive; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Glycopeptides; Guinea Pigs; Ileum; In Vitro Techniques; Indicators and Reagents; Jejunum; Kinetics; Male; Mice; Muscle Contraction; Muscle, Smooth; Oligopeptides; Opioid Peptides; Pain; Rabbits; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Structure-Activity Relationship; Synaptosomes | 1997 |
Evolution of the Dmt-Tic pharmacophore: N-terminal methylated derivatives with extraordinary delta opioid antagonist activity.
Topics: Animals; Binding, Competitive; Cell Membrane; Dipeptides; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guinea Pigs; Ileum; In Vitro Techniques; Indicators and Reagents; Isoquinolines; Kinetics; Male; Methylation; Mice; Muscle Contraction; Muscle, Smooth; Narcotic Antagonists; Radioligand Assay; Receptors, Opioid, delta; Receptors, Opioid, mu; Stereoisomerism; Structure-Activity Relationship; Vas Deferens | 1997 |
Para-substituted phenylalanine-4 analogues of [L-Ala3]DPDPE: highly selective delta opioid receptor ligands.
Topics: Animals; Binding, Competitive; Brain; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guinea Pigs; Ileum; Male; Mass Spectrometry; Mice; Muscle Contraction; Muscle, Smooth; Phenylalanine; Rats; Receptors, Opioid, delta; Vas Deferens | 1997 |
The role of nitric oxide in the development of opioid withdrawal induced by naloxone after acute treatment with mu- and kappa-opioid receptor agonists.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetylcholine; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Enzyme Inhibitors; Guinea Pigs; Ileum; In Vitro Techniques; Male; Morphine; Muscle Contraction; Naloxone; Narcotic Antagonists; Narcotics; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroglycerin; Receptors, Opioid, kappa; Receptors, Opioid, mu; Substance Withdrawal Syndrome; Vasodilator Agents | 1998 |
Differences in opioidergic inhibition of spinal reflexes and Fos expression evoked by mechanical and chemical noxious stimuli in the decerebrated rabbit.
Topics: Animals; Colchicine; Decerebrate State; Electric Stimulation; Enkephalins; Female; Gene Expression Regulation; Genes, fos; Image Processing, Computer-Assisted; Irritants; Male; Motor Neurons; Muscle Contraction; Muscle, Skeletal; Mustard Plant; Naloxone; Narcotic Antagonists; Nerve Crush; Nerve Tissue Proteins; Nociceptors; Plant Extracts; Plant Oils; Proto-Oncogene Proteins c-fos; Rabbits; Receptors, Opioid; Reflex; Stress, Mechanical; Toes | 1999 |
Activation and internalization of the mu-opioid receptor by the newly discovered endogenous agonists, endomorphin-1 and endomorphin-2.
Topics: Analgesics, Opioid; Animals; Cell Line; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Flow Cytometry; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Myenteric Plexus; Neurons; Oligopeptides; Rats; Receptors, Opioid, mu; Tissue Distribution | 1999 |
Synthesis, opioid receptor binding, and biological activities of naltrexone-derived pyrido- and pyrimidomorphinans.
Topics: Analgesics; Animals; Binding, Competitive; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Guinea Pigs; Ileum; Male; Mice; Mice, Inbred Strains; Morphinans; Morphine; Muscle Contraction; Naltrexone; Protein Binding; Rats; Receptors, Opioid; Vas Deferens | 1999 |
New opioid affinity labels containing maleoyl moiety.
Topics: Affinity Labels; Amino Acid Substitution; Animals; Brain; Enkephalins; Guinea Pigs; In Vitro Techniques; Ligands; Male; Maleates; Membranes; Mice; Muscle Contraction; Muscle, Smooth; Opioid Peptides; Radioligand Assay; Rats; Rats, Wistar; Receptors, Opioid | 1999 |
In vitro pharmacology of the opioid peptides, enkephalins and endorphins.
Topics: Animals; beta-Lipotropin; Brain; Depression, Chemical; Electric Stimulation; Endorphins; Enkephalins; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Naloxone; Neurotransmitter Agents; Oligopeptides; Peptide Fragments; Peptides; Synaptic Transmission; Time Factors; Vas Deferens | 1977 |
The synthesis and in vitro pharmacological evaluation of some novel enkephalin analogues [proceedings].
Topics: Animals; Endorphins; Enkephalins; Guinea Pigs; In Vitro Techniques; Muscle Contraction; Muscle, Smooth | 1979 |
The agonist and antagonist properties of N-allylenkephalins.
Topics: Allyl Compounds; Animals; Endorphins; Enkephalins; Guinea Pigs; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Naloxone; Receptors, Opioid; Tachyphylaxis | 1977 |
A conformational analysis for leucine-enkephalin using activity and binding data of synthetic analogues.
Topics: Animals; Brain; Electric Stimulation; Endorphins; Enkephalins; Hydrogen Bonding; In Vitro Techniques; Male; Mice; Molecular Conformation; Muscle Contraction; Rats; Receptors, Opioid; Vas Deferens | 1977 |
Interaction of iodinated enkephalin analogues with opiate receptors.
Topics: Animals; Brain; Cells, Cultured; Endorphins; Enkephalins; Guinea Pigs; In Vitro Techniques; Iodine Radioisotopes; Isotope Labeling; Manganese; Mice; Muscle Contraction; Protein Binding; Rats; Receptors, Opioid; Sodium | 1978 |
Effect of enkephalin and substance P on sympathetic nerve transmission in mouse vas deferens.
Topics: Animals; Electric Stimulation; Endorphins; Enkephalins; In Vitro Techniques; Male; Mice; Muscle Contraction; Muscle, Smooth; Norepinephrine; Potassium; Substance P; Sympathetic Nervous System; Synaptic Transmission; Vas Deferens | 1978 |
Effect of enkephalin and endorphin analogs on receptors in the mouse vas deferens.
Topics: Animals; Drug Stability; Electric Stimulation; Endorphins; Enkephalins; In Vitro Techniques; Male; Mice; Muscle Contraction; Muscle, Smooth; Receptors, Opioid; Vas Deferens | 1978 |
Evidence for morphine and morphine-like alkaloid responses resistant to naloxone blockade in the rat vas deferens.
Topics: Animals; Drug Tolerance; Electric Stimulation; Enkephalins; In Vitro Techniques; Leucine; Male; Morphine; Morphine Derivatives; Muscle Contraction; Naloxone; Narcotics; Placebos; Rats; Receptors, Opioid; Vas Deferens | 1979 |
The actions of enkephalins are not modified by the "kininase-II" inhibitor captopril.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Captopril; Drug Interactions; Electric Stimulation; Endorphins; Enkephalins; Guinea Pigs; In Vitro Techniques; Muscle Contraction; Proline; Reaction Time | 1979 |
Demonstration of the crucial role of the phenylalanine moiety in enkephalin analogues for differential recognition of the mu- and delta-receptors.
Topics: Animals; Endorphins; Enkephalins; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Phenylalanine; Receptors, Opioid; Vas Deferens | 1979 |
Effects of neuronal polypeptides on intestinal smooth muscle; a comparison with non-adrenergic, non-cholinergic nerve stimulation and ATP.
Topics: Adenosine Triphosphate; Animals; Electric Stimulation; Enkephalins; Female; Guinea Pigs; In Vitro Techniques; Indomethacin; Intestines; Male; Muscle Contraction; Muscle, Smooth; Neurotensin; Peptides; Somatostatin; Substance P; Vasoactive Intestinal Peptide | 1979 |
The effect of enkephalins on the intramural inhibitory non-adrenergic nerve responses of smooth muscle.
Topics: Animals; Colon; Endorphins; Enkephalins; Female; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Naloxone; Neural Inhibition; Stomach | 1979 |
Conformation and biological activities of hexapeptides related to enkephalins: respective roles of the ammonium and hydroxyl groups of tyrosine.
Topics: Animals; Endorphins; Enkephalins; Guinea Pigs; Ileum; In Vitro Techniques; Male; Mice; Molecular Conformation; Muscle Contraction; Muscle, Smooth; Oligopeptides; Quaternary Ammonium Compounds; Structure-Activity Relationship; Tyrosine; Vas Deferens | 1979 |
Potencies of normorphine and met-enkephalin in the vas deferens of different strains of mice.
Topics: Animals; Endorphins; Enkephalins; Male; Mice; Mice, Inbred Strains; Morphine Derivatives; Muscle Contraction; Species Specificity; Vas Deferens | 1979 |
The interaction of enkephalins with substance P on vascular smooth muscle.
Topics: Animals; Aorta; Drug Interactions; Endorphins; Enkephalins; Female; In Vitro Techniques; Morphine; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Norepinephrine; Rabbits; Substance P | 1979 |
Opioid activities of fragments of beta-endorphin and of its leucine65-analogue. Comparison of the binding properties of methionine- and leucine-enkephalin.
Topics: Animals; beta-Lipotropin; Brain; Brain Chemistry; Endorphins; Enkephalins; Guinea Pigs; In Vitro Techniques; Leucine; Ligands; Methionine; Mice; Muscle Contraction; Swine | 1979 |
Antagonism of cholecystokinin-like peptides by opioid peptides, morphine or tetrodotoxin.
Topics: Animals; Cholecystokinin; Electric Stimulation; Endorphins; Enkephalins; Guinea Pigs; Ileum; In Vitro Techniques; Male; Mice; Morphine; Muscle Contraction; Muscle, Smooth; Peptides; Tetrodotoxin; Vas Deferens | 1979 |
Tetrapeptide-amide analogues of enkephalin: the role of C-terminus in determining the character of opioid activity.
Topics: Animals; Behavior, Animal; Biological Assay; Electric Stimulation; Endorphins; Enkephalins; Ileum; Male; Mice; Muscle Contraction; Rats; Structure-Activity Relationship; Vas Deferens | 1979 |
Different effects of current strength on inhibitory responses of the mouse vas deferens to methionine- and leucine-enkephalin.
Topics: Animals; Electric Stimulation; Endorphins; Enkephalins; Ileum; In Vitro Techniques; Male; Mice; Muscle Contraction; Muscle, Smooth; Vas Deferens | 1979 |
Inhibitory effect of enkephalins on contractions of the guinea-pig ileum elicited by PGE1.
Topics: Animals; Endorphins; Enkephalins; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Naloxone; Prostaglandins E | 1977 |
Differences in the inhibitory effects of normorphine and opioid peptides on the responses of the vasa deferentia of two strains of mice.
Topics: Animals; Depression, Chemical; Endorphins; Enkephalins; In Vitro Techniques; Male; Mice; Mice, Inbred C57BL; Morphine Derivatives; Muscle Contraction; Muscle, Smooth; Species Specificity | 1978 |
Comparative in vitro and in vivo studies between morphine and methionine-enkephalin: genotype dependent response in two different strains of mice.
Topics: Adenylyl Cyclases; Analgesics; Animals; Corpus Striatum; Endorphins; Enkephalins; Genotype; In Vitro Techniques; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Morphine; Motor Activity; Muscle Contraction; Muscle, Smooth; Reaction Time; Species Specificity; Vas Deferens | 1978 |
In vitro profile of some opioid pentapeptide analogues.
Topics: Animals; Endorphins; Enkephalins; Guinea Pigs; Ileum; In Vitro Techniques; Male; Mice; Muscle Contraction; Muscle, Smooth; Naloxone; Vas Deferens | 1978 |
Synthesis of two enzyme resistant enkephalin analogs possessing enhanced analgesic activity.
Topics: Analgesics; Animals; Drug Tolerance; Endorphins; Enkephalins; Guinea Pigs; In Vitro Techniques; Mice; Morphine; Muscle Contraction; Muscle, Smooth; Naloxone; Rats; Reaction Time; Time Factors | 1978 |
Characterization of leucine and methionine enkephalin and their interaction with morphine on the guinea pig ileal longitudinal muscle.
Topics: Animals; Drug Interactions; Drug Tolerance; Electric Stimulation; Endorphins; Enkephalins; Guinea Pigs; Ileum; In Vitro Techniques; Male; Morphine; Muscle Contraction; Muscle, Smooth; Nalorphine | 1978 |
Rat vas deferens: a specific bioassay for endogenous opioid peptides.
Topics: Animals; Cats; Electric Stimulation; Endorphins; Enkephalins; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Rabbits; Rats; Vas Deferens | 1978 |
Genotype dependent response of morphine and methionine-enkephalin on the electrically induced contractions of the mouse vas deferens.
Topics: Animals; Electric Stimulation; Endorphins; Enkephalins; Genotype; In Vitro Techniques; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Morphine; Muscle Contraction; Muscle, Smooth; Naltrexone; Vas Deferens | 1978 |
Antagonistic effect of compound 48/80 on the inhibitory actions of morphine and methionine-enkephalin on electrically-induced contractions of the guinea-pig ileum.
Topics: Adenine Nucleotides; Animals; Electric Stimulation; Endorphins; Enkephalins; Epinephrine; Guinea Pigs; Ileum; In Vitro Techniques; Male; Morphine; Muscle Contraction; Muscle, Smooth; Norepinephrine; p-Methoxy-N-methylphenethylamine | 1978 |
Activity of VIP, somatostatin and other peptides in the mouse vas deferens assay.
Topics: Animals; Enkephalins; Gastrointestinal Hormones; Male; Mice; Muscle Contraction; Muscle, Smooth; Naloxone; Peptides; Somatostatin; Vas Deferens; Vasoactive Intestinal Peptide | 1978 |
Substance P and opioid interaction on stimulated and non-stimulated guinea pig ileum.
Topics: Animals; Atropine; Drug Interactions; Electric Stimulation; Enkephalins; Guinea Pigs; Ileum; In Vitro Techniques; Male; Morphine; Muscle Contraction; Muscle, Smooth; Naloxone; Narcotics; Substance P | 1978 |
[Pharmacological characterization of a pituitary extract with a morphine-like effect].
Topics: Animals; Endorphins; Enkephalins; Female; Guinea Pigs; Ileum; Morphinans; Muscle Contraction; Muscle, Smooth; Pituitary Gland; Rats; Tissue Extracts | 1977 |
Involvement of opioid mechanisms in peripheral motor control of detrusor muscle.
Topics: Animals; Electric Stimulation; Enkephalins; Ganglionic Blockers; Hexamethonium; Hexamethonium Compounds; Humans; Indoles; Male; Morphinans; Morphine; Muscle Contraction; Muscles; Naloxone; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu; Substance P; Sympatholytics | 1992 |
Role of K+ channels in the modulation of cholinergic neural responses in guinea-pig and human airways.
Topics: Adolescent; Adult; Animals; Benzopyrans; Charybdotoxin; Cholinergic Fibers; Clonidine; Cromakalim; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Guinea Pigs; Humans; Male; Muscle Contraction; Neuropeptide Y; Potassium Channels; Pyrroles; Scorpion Venoms; Synaptic Transmission; Trachea | 1992 |
Systemic analgesic activity and delta-opioid selectivity in [2,6-dimethyl-Tyr1,D-Pen2,D-Pen5]enkephalin.
Topics: Analgesia; Analgesics; Animals; Brain; Cell Membrane; Electric Stimulation; Enkephalins; Male; Mice; Mice, Inbred ICR; Muscle Contraction; Pain Measurement; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Structure-Activity Relationship; Vas Deferens | 1992 |
Characterization of opioid receptors on smooth muscle cells from guinea pig stomach.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Benzeneacetamides; Binding, Competitive; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Gastric Mucosa; Guinea Pigs; In Vitro Techniques; Kinetics; Male; Muscle Contraction; Muscle, Smooth; Naloxone; Narcotic Antagonists; Pyrrolidines; Receptors, Opioid; Stomach | 1992 |
Analogs of the delta opioid receptor selective cyclic peptide [2-D-penicillamine,5-D-penicillamine]-enkephalin: 2',6'-dimethyltyrosine and Gly3-Phe4 amide bond isostere substitutions.
Topics: Amides; Amino Acid Sequence; Analgesics; Animals; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Glycine; Male; Mice; Molecular Sequence Data; Muscle Contraction; Neuroblastoma; Peptides, Cyclic; Phenylalanine; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Structure-Activity Relationship; Substrate Specificity; Tumor Cells, Cultured; Tyrosine; Vas Deferens | 1992 |
Synthesis and biological activities of linear and cyclic enkephalin analogues containing a psi (E,CH = CH) or psi (CH2CH2) isosteric replacement.
Topics: Amino Acid Sequence; Animals; Enkephalins; Guinea Pigs; In Vitro Techniques; Magnetic Resonance Spectroscopy; Male; Mice; Molecular Sequence Data; Molecular Structure; Muscle Contraction; Peptides, Cyclic; Rats; Receptors, Opioid; Structure-Activity Relationship | 1992 |
[The significance of the mu- and delta-opiate receptors in realizing enkephalin action on the course of hypoxic hypoxia].
Topics: Animals; Drug Evaluation, Preclinical; Enkephalins; Guinea Pigs; Hypoxia; In Vitro Techniques; Male; Mice; Mice, Inbred Strains; Muscle Contraction; Muscle, Smooth; Receptors, Opioid; Structure-Activity Relationship | 1992 |
Tyr-MIF-1 and hemorphin can act as opiate agonists as well as antagonists in the guinea pig ileum.
Topics: Amino Acid Sequence; Animals; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Guinea Pigs; Hemoglobins; Ileum; In Vitro Techniques; Male; Molecular Sequence Data; Morphine; MSH Release-Inhibiting Hormone; Muscle Contraction; Muscle, Smooth; Naloxone; Naltrexone; Narcotic Antagonists; Peptide Fragments; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1992 |
Modulation of peristalsis in the guinea-pig isolated small intestine by exogenous and endogenous opioids.
Topics: Algorithms; Analgesics; Animals; Dynorphins; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Guinea Pigs; In Vitro Techniques; Intestine, Small; Male; Muscle Contraction; Narcotics; Peristalsis; Receptors, Opioid | 1992 |
Dual effect of trimebutine on contractility of the guinea pig ileum via the opioid receptors.
Topics: Acetylcholine; Animals; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Gastrointestinal Motility; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Naloxone; Narcotic Antagonists; Norepinephrine; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Trimebutine | 1991 |
In vitro evaluation of a casomorphin related pentapeptide, a competitive mu opioid receptor antagonist.
Topics: Amino Acid Sequence; Animals; Binding, Competitive; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guinea Pigs; Ileum; In Vitro Techniques; Male; Mice; Mice, Inbred ICR; Molecular Sequence Data; Muscle Contraction; Muscle, Smooth; Narcotic Antagonists; Receptors, Opioid, mu; Vas Deferens | 1991 |
Identification of opioid receptors on gastric muscle cells by selective receptor protection.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Guinea Pigs; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Peptide Fragments; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sincalide; Stomach | 1991 |
Mu and kappa opioid receptor modulation of 5-HT3 and NK-3 receptor-evoked release of acetylcholine from the guinea-pig ileum myenteric plexus.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetylcholine; Analgesics; Animals; Choline; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guinea Pigs; Ileum; Male; Muscle Contraction; Muscle, Smooth; Myenteric Plexus; Peptide Fragments; Pyrrolidines; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Receptors, Serotonin; Receptors, Tachykinin; Serotonin; Substance P; Tritium | 1991 |
Age-related impairment of signal transduction and its correction with antioxidants.
Topics: Adenylyl Cyclases; Aging; Animals; Brain; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Guinea Pigs; Isoproterenol; Male; Muscle Contraction; Muscle, Smooth; Rats; Rats, Inbred Strains; Signal Transduction; Synaptosomes | 1991 |
Proenkephalin A-derived peptide E and its fragments alter opioid contractility in the small intestine.
Topics: Animals; Dogs; Enkephalin, Methionine; Enkephalins; Guinea Pigs; Humans; In Vitro Techniques; Intestine, Small; Male; Mice; Muscle Contraction; Muscle, Smooth; Myenteric Plexus; Peptide Fragments; Peptides; Protein Precursors; Vas Deferens | 1990 |
[D-Pen2,D-Pen5]enkephalin analogues with increased affinity and selectivity for delta opioid receptors.
Topics: Amino Acid Sequence; Animals; Brain; Chemical Phenomena; Chemistry; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guinea Pigs; Ileum; Male; Mice; Molecular Sequence Data; Muscle Contraction; Radioligand Assay; Rats; Receptors, Opioid; Receptors, Opioid, delta; Structure-Activity Relationship; Vas Deferens | 1990 |
An attempt to structurally convert mu-selective morphine toward delta-receptor binding: dimerization based on enkephalin conformation.
Topics: Animals; Binding, Competitive; Brain; Chemical Phenomena; Chemistry, Physical; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; In Vitro Techniques; Male; Mice; Morphine; Morphine Derivatives; Muscle Contraction; Muscle, Smooth; Protein Conformation; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Vas Deferens | 1990 |
Characterization of kappa-opioid receptors in the guinea-pig ileum.
Topics: Animals; Benzeneacetamides; Benzomorphans; Binding, Competitive; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Guinea Pigs; Ileum; In Vitro Techniques; Kinetics; Muscle Contraction; Muscle, Smooth; Naloxone; Pyrroles; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, kappa; Thiophenes | 1990 |
In vivo and in vitro investigation of naltrindole, a delta-opioid antagonist.
Topics: Animals; Dose-Response Relationship, Drug; Electric Stimulation; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; In Vitro Techniques; Indoles; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Morphinans; Morphine; Muscle Contraction; Muscle, Smooth; Naltrexone; Narcotic Antagonists; Reaction Time; Receptors, Opioid; Receptors, Opioid, delta; Vas Deferens | 1990 |
Attenuation of reflex pressor and ventilatory responses to static muscular contraction by intrathecal opioids.
Topics: Animals; Blood Pressure; Cats; Dose-Response Relationship, Drug; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Heart Rate; Injections, Spinal; Muscle Contraction; Respiration; Sciatic Nerve | 1990 |
Central and local actions of opioids upon reticulo-ruminal motility in sheep.
Topics: Animals; Bradykinin; Enkephalins; Gastrointestinal Motility; In Vitro Techniques; Loperamide; Morphine Derivatives; Muscle Contraction; Naloxone; Narcotics; Prostaglandins E; Reticulum; Rumen; Sheep; Substance P | 1985 |
Mu-opioid receptors modulate non-cholinergic constrictor nerves in guinea-pig airways.
Topics: Animals; Autonomic Nervous System; Bronchi; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Guinea Pigs; In Vitro Techniques; Indicators and Reagents; Male; Morphine; Muscle Contraction; Peptide Fragments; Receptors, Opioid; Receptors, Opioid, mu; Substance P; Trachea | 1987 |
Neuropeptides in the human appendix. Distribution and motor effects.
Topics: Appendix; Calcitonin Gene-Related Peptide; Enkephalin, Methionine; Enkephalins; Galanin; Gastrin-Releasing Peptide; Humans; Immunohistochemistry; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Neurokinin A; Neurons; Neuropeptide Y; Neuropeptides; Peptide PHI; Peptides; Protein Precursors; Somatostatin; Substance P; Vasoactive Intestinal Peptide | 1989 |
Deltorphins: a family of naturally occurring peptides with high affinity and selectivity for delta opioid binding sites.
Topics: Amino Acid Sequence; Animals; Anura; Brain; Enkephalins; Guinea Pigs; In Vitro Techniques; Kinetics; Male; Membranes; Molecular Sequence Data; Muscle Contraction; Muscle, Smooth; Oligopeptides; Rats; Receptors, Opioid; Receptors, Opioid, delta; Skin; Vas Deferens | 1989 |
Opioid receptor selectivity of peptide models of beta-endorphin.
Topics: Amino Acid Sequence; Animals; beta-Endorphin; Binding, Competitive; Brain; Cell Membrane; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Guinea Pigs; Ileum; Molecular Sequence Data; Muscle Contraction; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1989 |
Selectivity for opioid receptor subtypes of enkephalin analogues in isolated smooth muscle and in the analgesic effect in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzomorphans; Electric Stimulation; Enkephalins; Guinea Pigs; In Vitro Techniques; Injections, Intraventricular; Male; Mice; Mice, Inbred Strains; Morphine; Muscle Contraction; Muscle, Smooth; Naloxone; Pyrrolidines; Rabbits; Receptors, Opioid | 1989 |
Differential modulation by [D-Pen2, D-Pen5]enkephalin and dynorphin A-(1-17) of the inhibitory bladder motility effects of selected mu agonists in vivo.
Topics: Analgesics; Animals; Drug Synergism; Dynorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Female; Morphine; Muscle Contraction; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reflex; Urinary Bladder | 1989 |
Peripherally acting enkephalin analogues. 2. Polar tri- and tetrapeptides.
Topics: Analgesia; Animals; Enkephalins; Female; Guinea Pigs; In Vitro Techniques; Male; Mice; Muscle Contraction; Oligopeptides; Structure-Activity Relationship | 1989 |
Minimum-structure enkephalin analogues incorporating L-tyrosine, D(or L)-phenylalanine, and a diamine spacer.
Topics: Animals; Chemical Phenomena; Chemistry; Diamines; Enkephalins; Guinea Pigs; Humans; Ileum; In Vitro Techniques; Male; Molecular Conformation; Muscle Contraction; Muscle, Smooth; Phenylalanine; Structure-Activity Relationship; Tyrosine | 1989 |
Conformational studies of diastereomeric cyclic enkephalins by 1H-NMR and computer simulations.
Topics: Animals; Computer Simulation; Enkephalins; Guinea Pigs; In Vitro Techniques; Magnetic Resonance Spectroscopy; Male; Mice; Models, Molecular; Muscle Contraction; Peptides, Cyclic; Protein Conformation; Receptors, Opioid; Stereoisomerism | 1987 |
Differential antagonism of mu agonists by U50,488H in the rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Etorphine; Female; Male; Muscle Contraction; Muscle, Smooth; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Seizures; Urinary Bladder | 1987 |
Pharmacological analysis of the calcium-dependence of mu-receptor agonism.
Topics: Animals; Binding, Competitive; Calcium; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Naloxone; Receptors, Opioid; Receptors, Opioid, mu | 1987 |
Investigation of the structural parameters involved in the mu and delta opioid receptor discrimination of linear enkephalin-related peptides.
Topics: Analgesics; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Guinea Pigs; Mice; Muscle Contraction; Oligopeptides; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Structure-Activity Relationship | 1988 |
Melphalan-containing N,N-dialkylenkephalin analogs as potential irreversible antagonists of the delta opioid receptor.
Topics: Animals; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Melphalan; Morphine; Muscle Contraction; Muscle, Smooth; Receptors, Opioid; Receptors, Opioid, delta; Structure-Activity Relationship | 1986 |
Comparison of the effects of calcium concentration on mu and kappa agonist actions in the guinea pig ileum.
Topics: Animals; Calcium; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Fentanyl; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1986 |
Inhibitory effects of opioids in a circular muscle-myenteric plexus preparation of guinea-pig ileum.
Topics: Animals; Carbachol; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Female; Guinea Pigs; Ileum; In Vitro Techniques; Male; Morphine; Muscle Contraction; Muscle, Smooth; Myenteric Plexus; Narcotics; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1987 |
U50,488H differentially antagonizes the bladder effects of mu agonists at spinal sites.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Morphine; Morphine Derivatives; Muscle Contraction; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Urinary Bladder | 1988 |
Lack of evidence for epsilon-opioid receptors in the rat vas deferens.
Topics: Animals; Calcium; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; In Vitro Techniques; Male; Muscle Contraction; Naloxone; Naltrexone; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Vas Deferens | 1988 |
Solute conformation of enkephalin-like pentapeptides in deuterated dimethylsulphoxide.
Topics: Animals; Deuterium; Dimethyl Sulfoxide; Enkephalins; Guinea Pigs; In Vitro Techniques; Magnetic Resonance Spectroscopy; Male; Mice; Molecular Conformation; Muscle Contraction; Muscle, Smooth; Stereoisomerism; Temperature | 1985 |
The rat urinary bladder. A novel preparation for the investigation of central opioid activity in vivo.
Topics: Animals; Central Nervous System; Enkephalins; Female; Methods; Morphine; Muscle Contraction; Rats; Rats, Inbred Strains; Receptors, Opioid; Urinary Bladder | 1985 |
Central delta-opioid receptor interactions and the inhibition of reflex urinary bladder contractions in the rat.
Topics: Animals; beta-Endorphin; Central Nervous System; Dose-Response Relationship, Drug; Endorphins; Enkephalin, Leucine; Enkephalins; Female; Injections, Intraventricular; Injections, Spinal; Muscle Contraction; Naloxone; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Urinary Bladder | 1985 |
Proenkephalin A fragments exhibit spinal and supraspinal opioid activity in vivo.
Topics: Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Female; Muscle Contraction; Naloxone; Peptide Fragments; Protein Precursors; Rats; Rats, Inbred Strains; Receptors, Opioid; Reflex; Spinal Cord; Urinary Bladder | 1985 |
The opioid receptors in the hamster vas deferens are of the delta-type.
Topics: Animals; Cricetinae; Electric Stimulation; Enkephalins; Gerbillinae; In Vitro Techniques; Male; Mesocricetus; Muscle Contraction; Myenteric Plexus; Narcotics; Protease Inhibitors; Receptors, Opioid; Receptors, Opioid, delta; Vas Deferens | 1985 |
Centrally administered beta-endorphin produces prolonged changes in delta-opioid ligand activity in vivo.
Topics: Animals; beta-Endorphin; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Female; Injections, Intraventricular; Muscle Contraction; Muscle, Smooth; Narcotic Antagonists; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Urinary Bladder | 1986 |
Involvement of different receptor subtypes for the production of in vitro and in vivo effects in a series of synthetic enkephalin analogues.
Topics: Analgesia; Animals; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalins; Guinea Pigs; Ileum; In Vitro Techniques; Male; Morphine; Muscle Contraction; Naloxone; Receptors, Opioid; Time Factors | 1985 |
In vitro activity profiles of cyclic and linear enkephalin pseudopeptide analogs.
Topics: Animals; Biological Assay; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Guinea Pigs; Ileum; Male; Mice; Muscle Contraction; Peptides, Cyclic; Rats; Receptors, Opioid; Structure-Activity Relationship; Vas Deferens | 1986 |
[Synthesis and analysis of des-Met5-[D-Ala2]enkephalinamide analogs].
Topics: Amino Acids; Analgesics; Animals; Circular Dichroism; Electric Stimulation; Enkephalin, Methionine; Enkephalins; Guinea Pigs; Ileum; In Vitro Techniques; Morphine; Muscle Contraction; Muscle, Smooth; Oligopeptides; Rats; Receptors, Opioid; Structure-Activity Relationship | 1986 |
Naloxonazine and opioid-induced inhibition of reflex urinary bladder contractions.
Topics: Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Male; Muscle Contraction; Naloxone; Rats; Receptors, Opioid; Reflex; Urinary Bladder | 1987 |
Interaction of dimers of inactive enkephalin fragments with mu opiate receptors.
Topics: Animals; Enkephalins; Kinetics; Muscle Contraction; Muscle, Smooth; Receptors, Opioid; Receptors, Opioid, mu; Structure-Activity Relationship | 1987 |
Generation of immunoreactive neurotensin(s) and enkephalin(s) by pepsin-treatment of plasma.
Topics: Amino Acid Sequence; Angiotensin I; Animals; Blood Pressure; Capillary Permeability; Enkephalins; Guinea Pigs; Humans; In Vitro Techniques; Muscle Contraction; Neurotensin; Pepsin A; Rats; Skin | 1986 |
Peripherally acting enkephalin analogues. 1. Polar pentapeptides.
Topics: Analgesics; Animals; Chemical Phenomena; Chemistry; Enkephalins; Female; Guinea Pigs; In Vitro Techniques; Male; Mice; Muscle Contraction; Muscle, Smooth; Oligopeptides; Structure-Activity Relationship | 1988 |
Tissue content of opioid peptides in the myenteric plexus-longitudinal muscle of guinea-pig small intestine.
Topics: Animals; Biological Assay; Chromatography, High Pressure Liquid; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Guinea Pigs; Intestine, Small; Male; Mice; Muscle Contraction; Myenteric Plexus; Naloxone; Protein Precursors; Tissue Distribution; Vas Deferens | 1988 |
[D-Met2,Pro5] enkephalin [N1.5-beta-D-glucopyranosyl] amide: a glycosylpeptide with high antinociceptive activity.
Topics: Analgesics; Animals; Enkephalin, Methionine; Enkephalins; Guinea Pigs; In Vitro Techniques; Indicators and Reagents; Male; Mice; Mice, Inbred ICR; Morphine; Muscle Contraction; Muscle, Smooth; Pain; Rats; Rats, Inbred Strains; Structure-Activity Relationship | 1988 |
Mu and delta opioid ligands inhibit reflex contractions of the urinary bladder in the rat by different central mechanisms.
Topics: Animals; Biomechanical Phenomena; Central Nervous System; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Muscle Contraction; Rats; Rats, Inbred Strains; Reflex; Urinary Bladder | 1987 |
The proenkephalin A fragment peptide E is metabolized centrally to a novel peptide with opioid activity.
Topics: Animals; Brain; Enkephalins; Guinea Pigs; In Vitro Techniques; Male; Mice; Muscle Contraction; Muscle, Smooth; Narcotics; Peptide Fragments; Protein Precursors | 1987 |
Studies on peptides. CL. Syntheses of [D-His2]-analogs of enkephalin and adrenorphin and several [D-Arg2]enkephalin analogs.
Topics: Animals; Chemical Phenomena; Chemistry; Enkephalin, Methionine; Enkephalins; Guinea Pigs; Ileum; In Vitro Techniques; Muscle Contraction | 1987 |
Synthesis and biological activity of some glucose-enkephalin conjugates.
Topics: Animals; Biological Assay; Enkephalins; Glucose; Muscle Contraction; Peptides; Structure-Activity Relationship | 1987 |
Action of enkephalinergic neurons on the gastrointestinal motility.
Topics: Animals; Digestive System Physiological Phenomena; Electric Stimulation; Enkephalins; Gastrointestinal Motility; Guinea Pigs; In Vitro Techniques; Intestine, Small; Muscle Contraction; Muscle, Smooth; Myenteric Plexus; Naloxone; Neurons; Peristalsis; Vagus Nerve | 1985 |
Local hormonal control of motility.
Topics: Acetylcholine; Animals; Digestive System Physiological Phenomena; Dogs; Enkephalins; Gastrointestinal Motility; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Nerve Tissue Proteins | 1985 |
Determination of proenkephalin products in brain tissue by high-performance liquid chromatography and a modified bioassay procedure.
Topics: Animals; Biological Assay; Brain Chemistry; Chromatography, High Pressure Liquid; Corpus Striatum; Electric Stimulation; Endorphins; Enkephalins; In Vitro Techniques; Leucine; Male; Mice; Muscle Contraction; Muscle, Smooth; Protein Precursors | 1985 |
2',6'-dimethylphenylalanine (Dmp) can mimic the N-terminal Tyr in opioid peptides.
Topics: Animals; Enkephalin, Leucine; Guinea Pigs; Ileum; In Vitro Techniques; Ligands; Male; Mice; Molecular Mimicry; Muscle Contraction; Muscle, Smooth; Oligopeptides; Opioid Peptides; Phenylalanine; Radioligand Assay; Receptors, Opioid, delta; Tyrosine; Vas Deferens | 2004 |
Great increase in antinociceptive potency of [Leu5]enkephalin after peptidase inhibition.
Topics: Animals; Captopril; Drug Synergism; Enkephalin, Leucine; Glycopeptides; Guinea Pigs; Ileum; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Muscle Contraction; Pain; Peptides; Protease Inhibitors; Rats; Rats, Wistar; Vas Deferens | 2008 |
[Binding sites of opiates and endogenous opioids in the oocytes of the toad Bufo viridis].
Topics: Animals; Benzomorphans; Binding Sites; Bufonidae; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Female; In Vitro Techniques; Kinetics; Male; Morphine; Muscle Contraction; Muscle, Smooth; Naloxone; Oocytes; Rabbits; Receptors, Opioid; Vas Deferens | 1984 |
[Differences in the action of enkephalins, beta-endorphin, and morphine on spontaneous rhythmic movements of the isolated rabbit ileum].
Topics: Animals; beta-Endorphin; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Female; Gastrointestinal Motility; Ileum; In Vitro Techniques; Male; Morphine; Muscle Contraction; Naloxone; Rabbits; Receptors, Opioid | 1984 |
Activation of K-opiate sites by dynorphin in the myenteric plexus.
Topics: Animals; Cyclazocine; Drug Tolerance; Dynorphins; Electric Stimulation; Endorphins; Enkephalin, Leucine; Ethylketocyclazocine; Guinea Pigs; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Myenteric Plexus; Narcotics; Receptors, Opioid; Receptors, Opioid, kappa | 1982 |
Comparison of dynorphin-selective Kappa receptors in mouse vas deferens and guinea pig ileum. Spare receptor fraction as a determinant of potency.
Topics: Animals; Dose-Response Relationship, Drug; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Guinea Pigs; Ileum; Male; Mice; Muscle Contraction; Muscle, Smooth; Naloxone; Naltrexone; Receptors, Opioid; Receptors, Opioid, kappa; Structure-Activity Relationship; Vas Deferens | 1983 |
Opioid receptor selectivity of dynorphin gene products.
Topics: Animals; Dynorphins; Endorphins; Enkephalin, Leucine; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Myenteric Plexus; Naloxone; Naltrexone; Peptide Fragments; Protein Precursors; Receptors, Opioid | 1984 |
Dynorphin-(1-13) restores the potency of morphine on the tolerant guinea pig ileum.
Topics: Animals; beta-Endorphin; Cyclazocine; Drug Interactions; Drug Tolerance; Dynorphins; Endorphins; Enkephalin, Leucine; Ethylketocyclazocine; Guinea Pigs; Ileum; In Vitro Techniques; Male; Morphine; Muscle Contraction; Muscle, Smooth; Naloxone; Peptide Fragments | 1984 |
The effects of leucine-enkephalin on the spontaneous motility of the circular muscle of the cat colon.
Topics: Animals; Atropine; Cats; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Methionine; Female; In Vitro Techniques; Male; Morphine; Muscle Contraction; Muscle, Smooth; Naloxone; Phentolamine; Receptors, Opioid; Tetrodotoxin | 1982 |
Photolabile opioid derivatives of D-Ala2-Leu5-enkephalin and their interactions with the opiate receptor.
Topics: Animals; Biological Assay; Brain; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Male; Mice; Muscle Contraction; Photolysis; Rats; Receptors, Opioid; Vas Deferens | 1983 |
Functional opiate receptor in mouse vas deferens: evidence for a complex interaction.
Topics: Animals; Arylsulfatases; beta-Endorphin; Dose-Response Relationship, Drug; Drug Interactions; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Etorphine; Male; Mice; Mice, Inbred ICR; Morphine; Muscle Contraction; Naloxone; Receptors, Opioid; Sulfatases; Vas Deferens | 1983 |
[Comparative studies of 2 methods for the quantitative measurement of endorphins in the cerebrospinal fluid. The mouse vas deferens and opiate-receptor binding].
Topics: Animals; Dose-Response Relationship, Drug; Endorphins; Enkephalin, Leucine; Humans; Male; Mice; Muscle Contraction; Muscle, Smooth; Receptors, Opioid; Vas Deferens | 1983 |
Unmasking myenteric delta receptors.
Topics: Animals; Biological Assay; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ileum; Morphine; Muscle Contraction; Myenteric Plexus; Receptors, Opioid; Receptors, Opioid, delta | 1983 |
ICI 174864: a highly selective antagonist for the opioid delta-receptor.
Topics: Animals; Enkephalin, Leucine; Male; Mice; Muscle Contraction; Naloxone; Receptors, Opioid; Vas Deferens | 1984 |
[Leu5]enkephalin containing peptides derived from a common precursor: evaluation of opioid activity in in vitro bioassays.
Topics: Animals; Dose-Response Relationship, Drug; Enkephalin, Leucine; Guinea Pigs; Ileum; In Vitro Techniques; Male; Mice; Mice, Inbred ICR; Muscle Contraction; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Structure-Activity Relationship; Vas Deferens | 1984 |
Synthesis and biological activity of (D)Ala2,Leu5-enkephalins containing hydrophilic or hydrophobic moieties.
Topics: Analgesia; Animals; Biological Assay; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Guinea Pigs; Ileum; Muscle Contraction; Structure-Activity Relationship | 1983 |
Effect of enkephalin on the micturition cycle of the cat.
Topics: Animals; Brain Stem; Cats; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; In Vitro Techniques; Male; Muscle Contraction; Naloxone; Spinal Cord; Urinary Bladder; Urination | 1984 |
The synthesis, bioactivity and enzyme stability of D-Ala2, EPhe4, Leu5-enkephalins.
Topics: Animals; Biological Assay; Carboxypeptidases; Enkephalin, Leucine; Guinea Pigs; Ileum; Indicators and Reagents; Male; Mice; Muscle Contraction; Vas Deferens | 1983 |
Synthesis of a newly isolated opioid tridecapeptide, rimorphin, from pituitary using a trifluoroacetic acid-thioanisole deprotection system.
Topics: Amino Acid Sequence; Analgesics; Animals; Dynorphins; Endorphins; Enkephalin, Leucine; Guinea Pigs; In Vitro Techniques; Mice; Muscle Contraction; Muscle, Smooth | 1983 |
Synthesis of N alpha-, and C alpha-derivatives of (D)Ala2, Leu5-enkephalin.
Topics: Analgesics; Animals; Chemical Phenomena; Chemistry, Physical; Enkephalin, Leucine; Guinea Pigs; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Rats | 1983 |
Evidence for an opiate-mediated pyloric sphincter reflex.
Topics: Acid-Base Equilibrium; Animals; Cats; Duodenum; Electromyography; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Gastric Emptying; Gastrointestinal Motility; Manometry; Muscle Contraction; Neural Pathways; Pressure; Pylorus; Reflex | 1984 |
Leucine enkephalin analogues containing a conformationally restrained N-terminal amino acid residue.
Topics: Amino Acids; Analgesics; Animals; Chemical Phenomena; Chemistry; Enkephalin, Leucine; Guinea Pigs; In Vitro Techniques; Injections, Intraventricular; Injections, Subcutaneous; Male; Mice; Molecular Conformation; Muscle Contraction; Muscle, Smooth | 1984 |
Effects of denervation on the sensitizing effect to noradrenaline induced by morphine in the vas deferens of mice treated chronically with morphine.
Topics: Acetylcholine; Animals; Enkephalin, Leucine; Enkephalin, Methionine; Humans; In Vitro Techniques; Male; Mice; Morphine; Morphine Dependence; Muscle Contraction; Muscle Denervation; Muscle, Smooth; Norepinephrine; Vas Deferens | 1982 |
Evidence for functional delta-opiate receptors in the rat intestine.
Topics: Acetylcholine; Animals; Cricetinae; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Female; In Vitro Techniques; Jejunum; Male; Mice; Muscle Contraction; Muscle, Smooth; Naltrexone; Rats; Rats, Wistar; Receptors, Opioid, delta | 1994 |
Participation of opioid receptor types on post-tetanic twitch inhibition in isolated guinea-pig ileal longitudinal muscle.
Topics: Amino Acid Sequence; Animals; Dynorphins; Electric Stimulation; Enkephalin, Leucine; Guinea Pigs; Ileum; In Vitro Techniques; Male; Molecular Sequence Data; Morphine; Muscle Contraction; Muscle, Smooth; Naltrexone; Narcotic Antagonists; Narcotics; Peptide Fragments; Receptors, Opioid | 1994 |
[Distribution, content and action site of leucine-enkephalin in pulmonary artery wall of rat and rabbit].
Topics: Animals; Electric Stimulation; Enkephalin, Leucine; Female; Male; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Pulmonary Artery; Rabbits; Radioimmunoassay; Rats; Rats, Sprague-Dawley | 1994 |
Synthesis and antinociceptive activity of [D-Ala2]Leu-enkephalin derivatives conjugated with the adamantane moiety.
Topics: Adamantane; Analgesics; Animals; Chemical Phenomena; Chemistry, Physical; Electric Stimulation; Enkephalin, Leucine; Guinea Pigs; In Vitro Techniques; Male; Mice; Mice, Inbred Strains; Muscle Contraction; Muscle, Smooth; Pain Measurement; Solubility | 1997 |
Action of FMRFamide-like peptides on porcine gastrointestinal motility in vitro.
Topics: Animals; Calcium Channels; Calcium Channels, L-Type; Enkephalin, Leucine; Enkephalin, Methionine; FMRFamide; Gastrointestinal Motility; Histamine; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Neuropeptides; Nifedipine; Nitroprusside; Oligopeptides; Swine | 1997 |
Characterization of opioid receptors modulating neurogenic contractions of circular muscle from porcine ileum and evidence that delta- and kappa-opioid receptors are coexpressed in myenteric neurons.
Topics: Amino Acid Sequence; Animals; Electric Stimulation; Enkephalin, Leucine; Goats; Ileum; In Vitro Techniques; Molecular Sequence Data; Muscle Contraction; Muscle, Smooth; Myenteric Plexus; Naltrexone; Rabbits; Receptors, Opioid, delta; Receptors, Opioid, kappa; Swine | 2001 |
[The contractile activity of the lymphatic microvessels and the role of opioid peptides in its regulation].
Topics: Animals; Dose-Response Relationship, Drug; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Epinephrine; Lymphatic System; Male; Mesentery; Muscle Contraction; Naloxone; Rats | 1992 |
The opioid activity and receptor selectivity of fluorinated Leu5 enkephalin analogues in vitro and in vivo.
Topics: Analgesics; Animals; Enkephalin, Leucine; Guinea Pigs; Ileum; In Vitro Techniques; Indoles; Male; Mice; Mice, Inbred Strains; Morphinans; Muscle Contraction; Muscle, Smooth; Naloxone; Naltrexone; Narcotic Antagonists; Receptors, Opioid | 1991 |
Opioid receptor activity of GI 87084B, a novel ultra-short acting analgesic, in isolated tissues.
Topics: Alkylation; Animals; Enkephalin, Leucine; Guinea Pigs; Ileum; Kinetics; Male; Mice; Mice, Inbred Strains; Muscle Contraction; Muscle, Smooth; Naloxone; Naltrexone; Narcotic Antagonists; Piperidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Remifentanil; Vas Deferens | 1991 |
Inhibition of peptidases potentiates enkephalin-stimulated contraction of gastric muscle cells.
Topics: Aminopeptidases; Animals; Anti-Bacterial Agents; Carbachol; CD13 Antigens; Enkephalin, Leucine; Enkephalin, Methionine; Glycopeptides; Guinea Pigs; In Vitro Techniques; Kinetics; Male; Muscle Contraction; Muscle, Smooth; Neprilysin; Oligopeptides; Peptides; Protease Inhibitors; Recombinant Proteins; Stomach | 1991 |
Pseudopeptide analogues of substance P and leucine enkephalinamide containing the psi (CH2O) modification: synthesis and biological activity.
Topics: Amino Acid Sequence; Animals; Enkephalin, Leucine; Guinea Pigs; Ileum; Male; Mice; Molecular Sequence Data; Muscle Contraction; Peptide Fragments; Pyrrolidonecarboxylic Acid; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Structure-Activity Relationship; Substance P; Vas Deferens | 1991 |
Evidence that the agonist action of dynorphin A(1-8) in the guinea-pig myenteric-plexus may be mediated partly through conversion to [Leu5]enkephalin.
Topics: Animals; Dynorphins; Enkephalin, Leucine; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Myenteric Plexus; Naltrexone; Narcotic Antagonists; Peptide Fragments; Receptors, Opioid | 1990 |
Activation of delta-type opioid receptors modulates the responses of cat terminal ileum to field electrical stimulation.
Topics: Acetylcholine; Animals; Atropine; Cats; Electric Stimulation; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Guanethidine; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Norepinephrine; Receptors, Opioid; Receptors, Opioid, delta | 1990 |
Preparation and opioid activities of N-methylated analogs of [D-Ala2,Leu5]enkephalin.
Topics: Amino Acid Sequence; Animals; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Guinea Pigs; In Vitro Techniques; Methylation; Molecular Sequence Data; Muscle Contraction; Muscle, Smooth; Rats; Receptors, Opioid | 1990 |
Interaction of newly synthesized N-cyclopropylmethyl derivatives of (-)-6 beta-acetylthionormorphine with opioid receptors.
Topics: Analgesics; Animals; Brain; Enkephalin, Leucine; Guinea Pigs; Ileum; In Vitro Techniques; Male; Mice; Mice, Inbred Strains; Morphine; Morphine Derivatives; Muscle Contraction; Muscle, Smooth; Naloxone; Pain Measurement; Rabbits; Rats; Rats, Inbred Strains; Receptors, Opioid; Synaptosomes; Vas Deferens | 1990 |
Non-cholinergic neurotransmission and the effects of peptides on the urinary bladder of guinea-pigs and rabbits.
Topics: Action Potentials; Animals; Atropine; Chymotrypsin; Electric Stimulation; Enkephalin, Leucine; Guinea Pigs; Muscle Contraction; Neuromuscular Junction; Neurotensin; Peptides; Rabbits; Somatostatin; Substance P; Synaptic Transmission; Urinary Bladder; Vasoactive Intestinal Peptide | 1986 |
Neutral endopeptidase inhibitors potentiate substance P-induced contraction in gut smooth muscle.
Topics: Animals; Drug Synergism; Duodenum; Endopeptidases; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Female; Ferrets; Glycopeptides; Ileum; Intestines; Male; Muscle Contraction; Protease Inhibitors; Rats; Substance P; Thiorphan | 1989 |
Excitatory effect of substance P in parasympathetic ganglia of cat urinary bladder.
Topics: Animals; Atropine; Cats; Enkephalin, Leucine; Evoked Potentials; Female; gamma-Aminobutyric Acid; Ganglia, Parasympathetic; Hexamethonium; Hexamethonium Compounds; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Norepinephrine; Substance P; Synaptic Transmission; Urinary Bladder | 1989 |
Effects of leu-enkephalin on the mechanical activity of longitudinal and circular muscles of the small intestine of the cat.
Topics: Animals; Atropine; Cats; Duodenum; Electric Stimulation; Enkephalin, Leucine; Ileum; In Vitro Techniques; Jejunum; Male; Muscle Contraction; Muscle, Smooth; Naloxone | 1989 |
Biological tests for opiate activity of newly-synthesized compounds--opioid peptides and cyclic beta-diketones.
Topics: Analgesics; Animals; Electric Stimulation; Enkephalin, Leucine; Guinea Pigs; Ileum; In Vitro Techniques; Indans; Indenes; Mice; Muscle Contraction; Muscle, Smooth; Narcotics; Peptides; Rats; Rats, Inbred Strains; Reaction Time | 1989 |
Effects of structurally different (Leu5) enkephalinamides on electrically-evoked contractions of guinea pig ileum.
Topics: Animals; Dose-Response Relationship, Drug; Electric Stimulation; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Evaluation Studies as Topic; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Receptors, Opioid; Structure-Activity Relationship | 1987 |
[Met5]enkephalin acts via delta-opioid receptors to inhibit pelvic nerve-evoked contractions of cat distal colon.
Topics: Animals; Cats; Colon; Electric Stimulation; Enkephalin, Leucine; Enkephalin, Methionine; Female; In Vitro Techniques; Male; Morphine; Muscle Contraction; Muscle Tonus; Muscle, Smooth; Naloxone; Narcotic Antagonists; Receptors, Opioid; Receptors, Opioid, delta | 1987 |
Synthesis and biological activity of [Leu5]enkephalin derivatives containing D-glucose.
Topics: Animals; Enkephalin, Leucine; Glucose; Guinea Pigs; In Vitro Techniques; Indicators and Reagents; Male; Mice; Muscle Contraction; Muscle, Smooth; Receptors, Opioid; Structure-Activity Relationship | 1988 |
Selective presence of opiate receptors on intestinal circular muscle cells.
Topics: Acetylcholine; Animals; Atropine; Benzomorphans; beta-Endorphin; Dose-Response Relationship, Drug; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Guinea Pigs; Humans; Jejunum; Muscle Contraction; Muscle, Smooth; Naloxone; Peptide Fragments; Proglumide; Receptors, Opioid; Sincalide | 1985 |
Evidence for a direct and indirect action of leucine enkephalin at the feline ileocecal sphincter.
Topics: Action Potentials; Animals; Bethanechol; Bethanechol Compounds; Cats; Electric Stimulation; Enkephalin, Leucine; Ileocecal Valve; Muscle Contraction; Pressure; Tetrodotoxin | 1988 |
Characterization of opioid receptors on isolated canine gallbladder smooth muscle cells.
Topics: Animals; Benzomorphans; Dogs; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Gallbladder; Kinetics; Muscle Contraction; Muscle, Smooth; Naloxone; Peptide Fragments; Receptors, Opioid | 1988 |
Modulation of cholinergic neurotransmission in airways by enkephalin.
Topics: Acetylcholine; Animals; Depression, Chemical; Dogs; Electric Stimulation; Enkephalin, Leucine; Enkephalin, Methionine; Muscle Contraction; Muscle, Smooth; Naloxone; Parasympathetic Nervous System; Propranolol; Receptors, Opioid; Synaptic Transmission; Trachea | 1985 |
[Synthesis and biological activity of a lysine-containing cyclic analog of [Leu5]enkephalin].
Topics: Animals; Chemical Phenomena; Chemistry; Enkephalin, Leucine; Guinea Pigs; Ileum; In Vitro Techniques; Male; Mice; Muscle Contraction; Muscle, Smooth; Peptides, Cyclic; Receptors, Opioid; Seminiferous Tubules | 1985 |
Proglumide exhibits delta opioid agonist properties.
Topics: Animals; Binding, Competitive; Electric Stimulation; Enkephalin, Leucine; Enzyme Inhibitors; Glutamine; Guinea Pigs; In Vitro Techniques; Male; Mice; Mice, Inbred ICR; Muscle Contraction; Muscle, Smooth; Naloxone; Norepinephrine; Proglumide; Receptors, Opioid; Receptors, Opioid, delta; Synaptosomes | 1987 |
Opioid peptides. Biological study of [D-MetO2] dermorphin analogues in relation to the plurality of opioid receptors. XI.
Topics: Animals; Brain Chemistry; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Guinea Pigs; In Vitro Techniques; Injections, Intraventricular; Male; Muscle Contraction; Receptors, Opioid | 1987 |
Leucine-enkephalin as a modulator of neurotransmission in cat lower esophageal sphincter.
Topics: Animals; Cats; Electric Stimulation; Enkephalin, Leucine; Esophagogastric Junction; Morphine; Muscle Contraction; Naloxone; Synaptic Transmission | 1987 |
[Influence of captopril on the in vitro and in vivo effects of leu- and met-enkephalins].
Topics: Animals; Captopril; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Synergism; Enkephalin, Leucine; Enkephalin, Methionine; Female; Guinea Pigs; Male; Mice; Muscle Contraction; Muscle, Smooth; Naloxone; Pain; Time Factors | 1987 |
Leucine-enkephalin- and neuropeptide Y-modulation of [3H]noradrenaline release in the oviduct of mature and juvenile rabbits.
Topics: Aging; Animals; Electric Stimulation; Enkephalin, Leucine; Fallopian Tubes; Female; In Vitro Techniques; Muscle Contraction; Neuropeptide Y; Norepinephrine; Rabbits | 1988 |
[Effect of dalargin on blood and lymph microcirculation].
Topics: Animals; Blood Cells; Cell Movement; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Lymph; Lymphatic System; Male; Mesentery; Microcirculation; Muscle Contraction; Muscle, Smooth, Vascular; Rats; Time Factors | 1988 |
[The role of enkephalin in the contraction of the ileum circular muscle of the guinea-pig and rabbit].
Topics: Acetylcholine; Animals; Electric Stimulation; Enkephalin, Leucine; Female; Guinea Pigs; Ileum; Male; Muscle Contraction; Muscle, Smooth; Rabbits | 1988 |
Evidence for Des-Tyr1-D-Ala2-leucine5-enkephalinamide calcium agonist activity in vascular smooth muscle.
Topics: Animals; Calcium; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nitrendipine; Potassium Chloride; Rats; Reserpine; Serotonin; Verapamil | 1987 |
Effects of (D-Ala2,D-Leu5)enkephalinamide on isolated longitudinal muscle guinea pig and rat intestines.
Topics: Animals; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Guinea Pigs; In Vitro Techniques; Intestines; Male; Muscle Contraction; Muscle, Smooth; Rats; Rats, Inbred Strains; Species Specificity | 1987 |
Enkephalin inhibits presynaptically the contractility of urinary tract smooth muscle.
Topics: Animals; Depression, Chemical; Enkephalin, Leucine; Enkephalin, Methionine; Female; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Swine; Urinary Tract | 1987 |
Structure-activity relationships of enkephalins containing serially replaced thiomethylene amide bond surrogates.
Topics: Amides; Animals; Binding, Competitive; Biological Assay; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Enkephalin, Leucine; Etorphine; Guinea Pigs; Ileum; Muscle Contraction; Structure-Activity Relationship; Thioamides | 1986 |
[Effect of enkephalins on the motor function of smooth-muscle cells of the stomach and mesenteric lymphatic vessels].
Topics: Animals; Cattle; Depression, Chemical; Enkephalin, Leucine; Enkephalin, Methionine; Gastrointestinal Motility; In Vitro Techniques; Lymphatic System; Male; Mesentery; Muscle Contraction; Muscle, Smooth; Peristalsis; Rats; Stomach | 1985 |