enkephalin, leucine and Morphine Abuse

enkephalin, leucine has been researched along with Morphine Abuse in 71 studies

Research

Studies (71)

Timeframe	Studies, this research(%)	All Research%
pre-1990	41 (57.75)	18.7374
1990's	21 (29.58)	18.2507
2000's	7 (9.86)	29.6817
2010's	2 (2.82)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Fink, DJ; Hao, S; Hu, J	1
Gieryk, A; Kubik, J; Przewlocki, R; Solecki, W; Ziolkowska, B	1
Földes, A; Kovács, KJ; Luisa Laorden, M; Martín, F; Núñez, C; Victoria Milanés, M	1
King, MA; Nitsche, JF; Pasternak, GW; Pintar, JE; Schuller, AG; Zengh, M	1
Christie, MJ; Hack, SP; Vaughan, CW	1
Besson, MJ; Daugé, V; Durand, C; Giros, B; Penit-Soria, J; Vazquez, V	1
Chang, JK; Jen, MF; Lee, NM; Loh, HH; Tulunay, FC	1
Herz, A	2
Ehrenpreis, S	1
Moreton, JE; Tortella, FC	1
Isaacson, RL; Lanthorn, TH	1
Brady, LS; Holtzman, SG	3
Bhargava, HN	2
Chapman, DB; Hu, J; Way, EL	1
Hui, KS; Lajtha, A; Tsai, H; Wang, YJ; Wong, KH	1
Howe, SJ; McCarthy, PS; Metcalf, G	1
Iwamoto, Y; Kamei, J; Kasuya, Y; Misawa, M; Nagase, H; Ohsawa, M; Saitoh, A; Suzuki, T	1
Bhargava, HN; Gudehithlu, KP	1
Il'Ina, AD; Klodt, PM; Maisky, AI; Zaitsev, SV	1
Bhargava, HN; Matwyshyn, GA; Reddy, PL; Thorat, SN	1
Chen, CY; Hwang, CL; Tao, PL	1
Cox, BM; Noble, F	1
Befort, K; Dierich, A; Dollé, P; Hanoune, J; Kieffer, BL; Kitchen, I; Le Meur, M; Maldonado, R; Matthes, HW; Roques, BP; Simonin, F; Slowe, S; Tzavara, E; Valverde, O	1
Kelly, MJ; Lagrange, AH; Rønnekleiv, OK; Wagner, EJ; Zhang, G	1
Contarino, A; Drago, F; Giusti, P; Lipartiti, M; Natolino, F; Zanotti, A	1
Fukunaga, Y; Inoue, N; Kishioka, S; Miyamoto, M; Yamamoto, H	1
Ambrosio, E; Corchero, J; Crespo, JA; Fuentes, JA; García-Lecumberri, C; Manzanares, J; Martín, S	1
Fukunaga, Y; Kishioka, S	1
Lipkowski, AW; Narita, M; Suzuki, T; Yamazaki, M	1
Cupo, A; Nieto, MM; Noble, F; Roques, BP; Wilson, J	1
Chau-Pham, TT	1
Childers, SR; Coyle, JT; Schwarcz, R; Snyder, SH	1
Mashkovskiĭ, MD	1
Khazan, N; Moreton, JE; Tortella, FC	1
DeFeudis, FV	1
Buescher, HH; Hill, RC; Roemer, D	1
Baxter, MG; Follenfant, RL; Miller, AA; Sethna, DM	1
Costa, E; Fratta, W; Hong, J; Yang, HY	1
Malin, DH; Sarantakis, D; Ungar, AL; Ungar, G	1
Childers, SR; Simantov, R; Snyder, SH	1
Herz, A; Höllt, V; Wesche, D	1
Costa, E; Fratta, W; Hong, JS; Yang, HY	1
Ho, WK; Lam, S; Ma, L; Wen, HL	1
Li, CH; Loh, HH; Tseng, LF	1
Takemori, AE; Vaught, JL	1
Bergström, L; Terenius, L	1
Baumeister, AA; Hurry, MJ; Richard, AL; Richmond-Landeche, L; Waguespack, AM	1
Fournié-Zaluski, MC; Maldonado, R; Roques, BP	1
Abdelhamid, EE; Takemori, AE	2
Long, JB; Rothman, RB; Yang, HY	1
Bhargava, HN; Gulati, A	2
Bodnar, RJ; Pasternak, GW; Paul, D	1
Brown, SR; Cox, BM; Werling, LL	1
Gulya, K; Kovács, GL; Kriván, M; Nyolczas, N	1
Dzoljic, MR; Haffmans, J; van Amsterdam, JC; Walsum, MV	1
Holtzman, SG; Locke, KW	1
Costa, E; Mocchetti, I; Snyder, SH; Supattapone, S	1
Hughes, DG; Moses, MA; Snell, CR	1
Buckingham, JC; Cooper, TA	1
Contreras, E; Gaete, S; Juica, S; Tamayo, L	1
Miyamoto, Y; Portoghese, PS; Takemori, AE	1
Olley, JE; Scheer, J; Tiong, GK; von Jenner, NM	1
Tsou, K; Wang, FS	1
Priestley, T; Turnbull, MJ; Wei, E	1
Chichenkov, ON; Petrov, VE; Sergeeva, MG; Varfolomeev, SD; Zaĭtsev, SV	1

Reviews

4 review(s) available for enkephalin, leucine and Morphine Abuse

Article	Year
Enkephalinergic neurons in the periaqueductal gray and morphine withdrawal. Japanese journal of pharmacology, 2000, Volume: 82, Issue:3 Topics: Animals; Cyclic AMP Response Element-Binding Protein; Enkephalins; Humans; Morphine Dependence; Periaqueductal Gray; Protein Precursors; RNA, Messenger; Substance Withdrawal Syndrome	2000
The opiate receptors and the discovery of opioid-like peptides. Drug metabolism reviews, 1978, Volume: 7, Issue:2 Topics: Amino Acids; Analgesics; Animals; Behavior, Animal; Endorphins; Enkephalins; Guinea Pigs; Humans; Hydrogen-Ion Concentration; Ions; Lipids; Mice; Morphine Dependence; Muscle Contraction; Neurotransmitter Agents; Peptide Hydrolases; Peptides; Rats; Receptors, Opioid; Temperature	1978
Environmental theory of drug addiction. General pharmacology, 1978, Volume: 9, Issue:5 Topics: Amphetamine; Animals; Brain Chemistry; Enkephalins; Humans; Learning; Male; Memory; Mice; Morphine Dependence; Rabbits; Rats; Social Environment; Social Isolation; Substance-Related Disorders	1978
Opioid peptide biosynthesis: enzymatic selectivity and regulatory mechanisms. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 1987, Volume: 1, Issue:1 Topics: Animals; Brain; Carboxypeptidase H; Carboxypeptidases; Corpus Striatum; Endopeptidases; Endorphins; Enkephalins; Morphine Dependence; Neuropeptides; Receptors, Dopamine	1987

Other Studies

67 other study(ies) available for enkephalin, leucine and Morphine Abuse

Article	Year
Transgene-mediated enkephalin expression attenuates signs of naloxone-precipitated morphine withdrawal in rats with neuropathic pain. Behavioural brain research, 2009, Jan-30, Volume: 197, Issue:1 Topics: Analgesics, Opioid; Animals; Disease Models, Animal; Enkephalins; Ganglia, Spinal; Gene Transfer Techniques; Genetic Vectors; Ligation; Lumbar Vertebrae; Male; Morphine; Morphine Dependence; Naloxone; Pain Threshold; Peripheral Nervous System Diseases; Protein Precursors; Rats; Rats, Sprague-Dawley; Simplexvirus; Spinal Nerve Roots; Substance Withdrawal Syndrome; Transgenes	2009
Forebrain PENK and PDYN gene expression levels in three inbred strains of mice and their relationship to genotype-dependent morphine reward sensitivity. Psychopharmacology, 2010, Volume: 208, Issue:2 Topics: Animals; Behavior, Addictive; Behavior, Animal; Conditioning, Psychological; Cues; Enkephalins; Gene Expression Regulation; Genotype; In Situ Hybridization; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Morphine Dependence; Naltrexone; Narcotic Antagonists; Nucleus Accumbens; Phenotype; Protein Precursors; Receptors, Opioid, kappa; Reward; RNA, Messenger; Species Specificity	2010
Induction of FosB/DeltaFosB in the brain stress system-related structures during morphine dependence and withdrawal. Journal of neurochemistry, 2010, Volume: 114, Issue:2 Topics: Animals; Brain; Corticotropin-Releasing Hormone; Dynorphins; Enkephalins; Hypothalamo-Hypophyseal System; Male; Morphine; Morphine Dependence; Pituitary-Adrenal System; Protein Precursors; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Stress, Physiological; Substance Withdrawal Syndrome; Tyrosine 3-Monooxygenase	2010
Genetic dissociation of opiate tolerance and physical dependence in delta-opioid receptor-1 and preproenkephalin knock-out mice. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002, Dec-15, Volume: 22, Issue:24 Topics: Analgesics, Opioid; Animals; Drug Tolerance; Enkephalins; Gene Targeting; Mice; Mice, Knockout; Morphine; Morphine Dependence; N-Methylaspartate; Protein Precursors; Receptors, Opioid, delta; Substance Withdrawal Syndrome	2002
Modulation of GABA release during morphine withdrawal in midbrain neurons in vitro. Neuropharmacology, 2003, Volume: 45, Issue:5 Topics: Action Potentials; Adenosine; Affinity Labels; Animals; Colforsin; Cyclic AMP; Dipyridamole; Dose-Response Relationship, Drug; Drug Interactions; Enkephalins; Enzyme Inhibitors; gamma-Aminobutyric Acid; In Vitro Techniques; Isoquinolines; Male; Mesencephalon; Mice; Mice, Inbred C57BL; Morphine; Morphine Dependence; Naloxone; Narcotic Antagonists; Narcotics; Neural Inhibition; Neurons; Patch-Clamp Techniques; Periaqueductal Gray; Probenecid; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Substance Withdrawal Syndrome; Sulfonamides; Synaptic Transmission; Thioinosine; Time Factors; Uricosuric Agents; Vasodilator Agents; Xanthines	2003
Maternal deprivation increases vulnerability to morphine dependence and disturbs the enkephalinergic system in adulthood. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2005, May-04, Volume: 25, Issue:18 Topics: Analysis of Variance; Animals; Animals, Newborn; Autoradiography; Behavior, Animal; Brain; Choice Behavior; Conditioning, Psychological; Dialysis; Dose-Response Relationship, Drug; Drinking Behavior; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Methionine; Enkephalins; Female; In Situ Hybridization; Maternal Deprivation; Morphine; Morphine Dependence; Narcotics; Nucleus Accumbens; Pregnancy; Protein Precursors; Radioimmunoassay; Rats; Rats, Long-Evans; Receptors, Opioid, mu; RNA, Messenger; Self Administration; Sucrose; Time Factors; Tritium	2005
Possible regulatory role of dynorphin on morphine- and beta-endorphin-induced analgesia. The Journal of pharmacology and experimental therapeutics, 1981, Volume: 219, Issue:2 Topics: Analgesics; Animals; beta-Endorphin; Drug Interactions; Drug Tolerance; Dynorphins; Endorphins; Enkephalins; Humans; Male; Mice; Mice, Inbred ICR; Morphine; Morphine Dependence; Substance Withdrawal Syndrome	1981
Role of endorphins in addiction. Modern problems of pharmacopsychiatry, 1981, Volume: 17 Topics: Alcoholism; Animals; beta-Endorphin; Brain; Corpus Striatum; Endorphins; Enkephalins; Heroin Dependence; Humans; Morphine Dependence; Opioid-Related Disorders; Pituitary Gland; Rats; Receptors, Opioid	1981
D-phenylalanine and other enkephalinase inhibitors as pharmacological agents: implications for some important therapeutic application. Substance and alcohol actions/misuse, 1982, Volume: 3, Issue:4 Topics: Acupuncture Therapy; Animals; Drug Tolerance; Enkephalin, Methionine; Enkephalins; Humans; Morphine; Morphine Dependence; Neprilysin; Nociceptors; Pain; Phenylalanine; Protease Inhibitors; Receptors, Opioid	1982
D-ala2-methionine-enkephalinamide self-administration in the morphine-dependent rat. Psychopharmacology, 1980, Volume: 69, Issue:2 Topics: Animals; Drug Administration Schedule; Endorphins; Enkephalin, Methionine; Enkephalins; Female; Humans; Injections, Intraventricular; Morphine Dependence; Rats; Self Administration; Substance Withdrawal Syndrome	1980
Hippocampal involvement in the pharmacologic induction of withdrawal-like behaviors. Federation proceedings, 1981, Volume: 40, Issue:5 Topics: Animals; Cyclazocine; Endorphins; Enkephalin, Methionine; Enkephalins; Escape Reaction; Ethylketocyclazocine; Hippocampus; Humans; Injections, Intraventricular; Kainic Acid; Morphine Dependence; Pyrrolidines; Rats; Serotonin; Shivering; Substance Withdrawal Syndrome; Valproic Acid	1981
Effects of intraventricular morphine and enkephalins on locomotor activity in nondependent, morphine-dependent and postdependent rats. The Journal of pharmacology and experimental therapeutics, 1981, Volume: 218, Issue:3 Topics: Animals; Dose-Response Relationship, Drug; Endorphins; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Humans; Male; Morphine; Morphine Dependence; Motor Activity; Naloxone; Rats; Time Factors	1981
Comparative effects of synthetic enkephalinamides and morphine on abstinence responses in morphine-dependent mice. Pharmacology, biochemistry, and behavior, 1980, Volume: 12, Issue:5 Topics: Amides; Animals; Body Temperature; Endorphins; Enkephalins; Humans; Male; Mice; Morphine; Morphine Dependence; Stereotyped Behavior; Substance Withdrawal Syndrome	1980
Methionine-enkephalin antagonism and endorphin potentiation of narcotic-induced analgesia. European journal of pharmacology, 1980, Aug-08, Volume: 65, Issue:4 Topics: Animals; Drug Interactions; Drug Tolerance; Endorphins; Enkephalin, Methionine; Enkephalins; Guinea Pigs; Humans; In Vitro Techniques; Male; Mice; Mice, Inbred ICR; Morphine; Morphine Dependence; Muscle Contraction; Muscle, Smooth; Reaction Time	1980
The effect of naloxone on enkephalin catabolism. Peptides, 1981, Volume: 2 Suppl 1 Topics: Aminopeptidases; Animals; Biotransformation; Brain; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Humans; Male; Mice; Morphine Dependence; Naloxone; Protease Inhibitors	1981
Effects of intraventricular morphine and enkephalins on schedule-controlled behavior in nondependent, morphine-dependent and postdependent rats. The Journal of pharmacology and experimental therapeutics, 1981, Volume: 219, Issue:2 Topics: Animals; Conditioning, Operant; Dose-Response Relationship, Drug; Endorphins; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Enkephalins; Humans; Injections, Intraventricular; Male; Morphine; Morphine Dependence; Rats; Rats, Inbred Strains; Substance Withdrawal Syndrome	1981
Analgesic effects of intraventricular morphine and enkephalins in nondependent and morphine-dependent rats. The Journal of pharmacology and experimental therapeutics, 1982, Volume: 222, Issue:1 Topics: Analgesics; Animals; Endorphins; Enkephalins; Humans; Injections, Intraventricular; Male; Morphine; Morphine Dependence; Rats; Rats, Inbred Strains; Time Factors	1982
Continuous infusion in rats as a method of assessing morphine-like physical dependence for opiates. Pharmacology, biochemistry, and behavior, 1982, Volume: 16, Issue:5 Topics: Animals; Disease Models, Animal; Enkephalins; Humans; Male; Morphine Dependence; Narcotics; Opioid-Related Disorders; Rats; Rats, Inbred Strains	1982
Modification of mu-opioid agonist-induced locomotor activity and development of morphine dependence by diabetes. The Journal of pharmacology and experimental therapeutics, 1995, Volume: 274, Issue:2 Topics: Animals; Diabetes Mellitus, Experimental; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Mice; Mice, Inbred ICR; Morphine; Morphine Dependence; Motor Activity; Naloxone; Naltrexone; Receptors, Opioid, mu; Streptozocin	1995
Modulation of preproenkephalin mRNA levels in brain regions and spinal cord of rats treated chronically with morphine. Peptides, 1995, Volume: 16, Issue:3 Topics: Animals; Brain; Drug Tolerance; Enkephalins; Male; Morphine; Morphine Dependence; Protein Precursors; Rats; Rats, Sprague-Dawley; Reference Values; RNA, Messenger; Spinal Cord	1995
Opiate withdrawal intensity correlates with the presence of DSLET high-affinity binding. Pharmacology, biochemistry, and behavior, 1994, Volume: 49, Issue:4 Topics: Amino Acid Sequence; Analgesics; Animals; Drug Implants; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Molecular Sequence Data; Morphine; Morphine Dependence; Naloxone; Narcotics; Receptors, Opioid, delta; Receptors, Opioid, mu; Substance Withdrawal Syndrome	1994
Effect of morphine tolerance and abstinence on the binding of [3H]naltrexone to discrete brain regions and spinal cord of the rat. General pharmacology, 1994, Volume: 25, Issue:2 Topics: Analgesics; Animals; Brain; Drug Implants; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Membranes; Morphine; Morphine Dependence; Naltrexone; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, mu; Spinal Cord; Substance Withdrawal Syndrome	1994
U-50,488 blocks the development of morphine tolerance and dependence at a very low dose in guinea pigs. European journal of pharmacology, 1994, May-02, Volume: 256, Issue:3 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Dose-Response Relationship, Drug; Drug Synergism; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Guinea Pigs; Male; Morphine; Morphine Dependence; Nociceptors; Pain; Pyrrolidines; Receptors, Opioid, kappa	1994
Differential desensitization of mu- and delta- opioid receptors in selected neural pathways following chronic morphine treatment. British journal of pharmacology, 1996, Volume: 117, Issue:1 Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adenylyl Cyclases; Aminobutyrates; Analgesics; Animals; Brain; Caudate Nucleus; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Glutamic Acid; Male; Morphine; Morphine Dependence; Naloxone; Narcotic Antagonists; Nucleus Accumbens; Oligopeptides; Periaqueductal Gray; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu; Serotonin Receptor Agonists; Substance Withdrawal Syndrome; Thalamus	1996
Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the mu-opioid-receptor gene. Nature, 1996, Oct-31, Volume: 383, Issue:6603 Topics: Analgesics; Animals; Behavior, Animal; Cell Line; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Gene Deletion; Mice; Mice, Inbred C57BL; Mice, Knockout; Morphine; Morphine Dependence; Narcotics; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reward; Substance Withdrawal Syndrome	1996
Tolerance to mu-opioid receptor agonists but not cross-tolerance to gamma-aminobutyric acid(B) receptor agonists in arcuate A12 dopamine neurons with chronic morphine treatment. The Journal of pharmacology and experimental therapeutics, 1997, Volume: 280, Issue:2 Topics: Animals; Arcuate Nucleus of Hypothalamus; Baclofen; Drug Tolerance; Electrophysiology; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Female; GABA-B Receptor Agonists; Guinea Pigs; Hypothalamus; In Vitro Techniques; Membrane Potentials; Morphine; Morphine Dependence; Neurons; Receptors, Opioid, mu; Tetrodotoxin; Tyrosine 3-Monooxygenase	1997
Conditioned place preference: no tolerance to the rewarding properties of morphine. Naunyn-Schmiedeberg's archives of pharmacology, 1997, Volume: 355, Issue:5 Topics: Analysis of Variance; Animals; Behavior, Animal; Benzeneacetamides; Body Weight; Disease Models, Animal; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Injections, Intraperitoneal; Male; Morphine; Morphine Dependence; Narcotics; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu	1997
Effects of peptidase inhibitors, [D-Ala2, Met5]-enkephalinamide and antiserum to methionine-enkephalin microinjected into the caudal periaqueductal gray on morphine withdrawal in rats. Japanese journal of pharmacology, 1998, Volume: 78, Issue:4 Topics: Animals; Enkephalin, Methionine; Enkephalins; Immune Sera; Male; Microinjections; Morphine; Morphine Dependence; Naloxone; Periaqueductal Gray; Protease Inhibitors; Protein Precursors; Rats; Rats, Sprague-Dawley; RNA, Messenger; Substance Withdrawal Syndrome	1998
Differential basal proenkephalin gene expression in dorsal striatum and nucleus accumbens, and vulnerability to morphine self-administration in Fischer 344 and Lewis rats. Brain research, 1999, Mar-13, Volume: 821, Issue:2 Topics: Animals; Behavior, Animal; Corpus Striatum; Enkephalins; Gene Expression; Male; Morphine; Morphine Dependence; Narcotics; Nucleus Accumbens; Protein Precursors; Rats; Rats, Inbred F344; Rats, Inbred Lew; RNA, Messenger; Self Administration	1999
The opioid peptide analogue biphalin induces less physical dependence than morphine. Life sciences, 2001, Jul-20, Volume: 69, Issue:9 Topics: Analgesics, Opioid; Animals; Behavior, Animal; Enkephalins; Infusions, Intravenous; Male; Morphine; Morphine Dependence; Naloxone; Pentazocine; Rats; Rats, Sprague-Dawley; Substance-Related Disorders; Weight Loss	2001
Chronic morphine treatment modulates the extracellular levels of endogenous enkephalins in rat brain structures involved in opiate dependence: a microdialysis study. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002, Feb-01, Volume: 22, Issue:3 Topics: Animals; Behavior, Animal; Brain; Brain Chemistry; Cholecystokinin; Conditioning, Psychological; Drug Administration Schedule; Enkephalins; Extracellular Space; Hippocampus; Male; Microdialysis; Morphine; Morphine Dependence; Nucleus Accumbens; Opioid Peptides; Periaqueductal Gray; Rats; Rats, Wistar; Reward; Substance Withdrawal Syndrome; Wakefulness	2002
Radioimmunoassay of enkephalins: levels of methionine- and leucine-enkephalin in morphine-dependent and kainic acid-lesioned rat brains. Advances in biochemical psychopharmacology, 1978, Volume: 18 Topics: Animals; Antibody Specificity; Brain Chemistry; Endorphins; Enkephalins; Humans; Kainic Acid; Male; Microwaves; Morphine Dependence; Naloxone; Pyrrolidines; Radioimmunoassay; Rats; Receptors, Opioid	1978
[Enkephalins and endorphins--a new class of biogenic physiologically active substances]. Terapevticheskii arkhiv, 1978, Volume: 50, Issue:5 Topics: Analgesics; Animals; beta-Lipotropin; Brain; Catecholamines; Chemical Phenomena; Chemistry; Cyclic AMP; Drug Tolerance; Endorphins; Enkephalins; Guinea Pigs; Humans; In Vitro Techniques; Mice; Morphine; Morphine Dependence; Naloxone; Rats; Receptors, Opioid	1978
Electroencephalographic and behavioral tolerance to and cross-tolerance between D-Ala2-methionine-enkephalinamide and morphine in the rat. The Journal of pharmacology and experimental therapeutics, 1979, Volume: 210, Issue:2 Topics: Animals; Behavior, Animal; Dose-Response Relationship, Drug; Drug Tolerance; Electroencephalography; Endorphins; Enkephalins; Female; Humans; Morphine; Morphine Dependence; Naloxone; Rats; Sleep, REM; Substance Withdrawal Syndrome; Substance-Related Disorders; Time Factors	1979
Some pharmacological properties of FK 33-824, a stable orally active analogue of methionine enkephalin. Advances in biochemical psychopharmacology, 1978, Volume: 18 Topics: Animals; Endorphins; Enkephalins; Haplorhini; Humans; Injections, Intraventricular; Macaca mulatta; Mice; Morphine; Morphine Dependence; Rabbits; Rats; Reaction Time; Time Factors	1978
[Endorphins: a key to understanding pain, addiction and mental disorders?]. Deutsche medizinische Wochenschrift (1946), 1979, Mar-16, Volume: 104, Issue:11 Topics: Endorphins; Enkephalins; Humans; Mental Disorders; Morphine Dependence; Naloxone; Pain; Substance-Related Disorders	1979
Some morphine-like properties of a potent antinociceptive synthetic pentapeptide in relation to physical dependence in rodents [proceedings]. British journal of pharmacology, 1977, Volume: 59, Issue:3 Topics: Analgesics; Animals; Enkephalins; Humans; Mice; Morphine; Morphine Dependence; Oligopeptides; Rats; Substance Withdrawal Syndrome	1977
Stability of Met-enkephalin content in brain structures of morphine-dependent or foot shock-stressed rats. Nature, 1977, Aug-04, Volume: 268, Issue:5619 Topics: Animals; Brain; Corpus Striatum; Enkephalins; Humans; Hypothalamus; Male; Morphine Dependence; Naltrexone; Oligopeptides; Rats; Stress, Psychological; Substance Withdrawal Syndrome	1977
Brain peptides with opiate antagonist action: their possible role in tolerance and dependence. Psychoneuroendocrinology, 1977, Volume: 2, Issue:1 Topics: Animals; Brain Chemistry; Chemical Phenomena; Chemistry; Dose-Response Relationship, Drug; Drug Tolerance; Enkephalins; Humans; In Vitro Techniques; Male; Morphine; Morphine Dependence; Morphine Derivatives; Peptides; Rats; Tissue Extracts; Vas Deferens	1977
Enkephalin: radioimmunoassay and radioreceptor assay in morphine dependent rats. European journal of pharmacology, 1977, Dec-01, Volume: 46, Issue:3 Topics: Animals; Brain Chemistry; Corpus Striatum; Endorphins; Enkephalins; Humans; Hypothalamus; Morphine Dependence; Radioimmunoassay; Radioligand Assay; Rats	1977
New in vivo evidence for narcotic agonistic property of leucine-enkephalin. Journal of pharmaceutical sciences, 1978, Volume: 67, Issue:1 Topics: Animals; Behavior, Animal; Endorphins; Enkephalins; Humans; Male; Mice; Morphine; Morphine Dependence; Naloxone; Narcotics; Substance Withdrawal Syndrome	1978
Radioimmunoassay of enkephalins. Regional distribution in rat brain after morphine treatment and hypophysectomy. Naunyn-Schmiedeberg's archives of pharmacology, 1977, Volume: 301, Issue:1 Topics: Animals; Brain Chemistry; Endorphins; Enkephalins; Female; Humans; Hypophysectomy; Morphine; Morphine Dependence; Radioimmunoassay; Rats	1977
Rat brain enkephalins: distribution and biosynthesis. Advances in biochemical psychopharmacology, 1978, Volume: 18 Topics: Animals; Antibody Specificity; Brain; Endorphins; Enkephalins; Humans; Morphine Dependence; Radioimmunoassay; Rats	1978
The influence of electro-acupuncture on naloxone-induced morphine withdrawal in mice: elevation of brain opiate-like activity. European journal of pharmacology, 1978, May-15, Volume: 49, Issue:2 Topics: Acupuncture Therapy; Animals; Brain Chemistry; Endorphins; Enkephalins; Female; Humans; Mice; Mice, Inbred Strains; Morphine Dependence; Naloxone; Substance Withdrawal Syndrome	1978
[D-Thr2, Thz5]-enkephalinamide: a potent analgesic by subcutaneous and oral administration. Life sciences, 1978, Nov-13, Volume: 23, Issue:20 Topics: Administration, Oral; Analgesics; Animals; Endorphins; Enkephalins; Humans; Injections, Subcutaneous; Male; Mice; Mice, Inbred ICR; Morphine; Morphine Dependence; Motor Activity; Naloxone; Time Factors	1978
Differential effects of leucine and methionine enkephalin on morphine-induced analgesia, acute tolerance and dependence. The Journal of pharmacology and experimental therapeutics, 1979, Volume: 208, Issue:1 Topics: Analgesia; Animals; Brain; Drug Synergism; Drug Tolerance; Endorphins; Enkephalins; Humans; Male; Mice; Morphine; Morphine Dependence; Reaction Time	1979
Enkephalin levels decrease in rat striatum during morphine abstinence. European journal of pharmacology, 1979, Dec-20, Volume: 60, Issue:4 Topics: Animals; Antibody Formation; Antigen-Antibody Reactions; Corpus Striatum; Endorphins; Enkephalins; Humans; Male; Morphine Dependence; Rabbits; Rats; Substance Withdrawal Syndrome; Time Factors	1979
Further studies of the role of opioid receptors in the nigra in the morphine withdrawal syndrome. Neuropharmacology, 1992, Volume: 31, Issue:9 Topics: Amino Acid Sequence; Analgesics; Animals; Behavior, Animal; Body Temperature; Brain; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Molecular Sequence Data; Morphine; Morphine Dependence; Naloxone; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Somatostatin; Stereotaxic Techniques; Substance Withdrawal Syndrome; Substantia Nigra	1992
Attenuation of the morphine withdrawal syndrome by inhibition of catabolism of endogenous enkephalins in the periaqueductal gray matter. Naunyn-Schmiedeberg's archives of pharmacology, 1992, Volume: 345, Issue:4 Topics: Analgesics; Animals; Behavior, Animal; Body Temperature; Body Weight; Corticosterone; Dipeptides; Enkephalins; Hydroxamic Acids; Male; Morphine; Morphine Dependence; Naloxone; Neprilysin; Periaqueductal Gray; Phenylalanine; Rats; Rats, Inbred Strains; Substance Withdrawal Syndrome; Thiorphan	1992
Characteristics of mu and delta opioid binding sites in striatal slices of morphine-tolerant and -dependent mice. European journal of pharmacology, 1991, Jun-06, Volume: 198, Issue:2-3 Topics: Analgesics; Animals; Binding Sites; Corpus Striatum; Drug Interactions; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Male; Mice; Morphine; Morphine Dependence; Naloxone; Pain; Receptors, Opioid	1991
Upregulation of rat brain opioid receptors by the chronic administration of morphine: possible evidence for an anti-opiate model of tolerance and dependence. NIDA research monograph, 1990, Volume: 105 Topics: Animals; Brain Chemistry; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Immunoglobulin G; Injections, Intraventricular; Ligands; Male; Morphine; Morphine Dependence; Oligopeptides; Rats; Rats, Inbred Strains; Receptors, Opioid; Up-Regulation	1990
The effect of morphine tolerance-dependence and abstinence on mu, delta, and kappa opiate receptors of discrete brain regions and spinal cord of the rat. NIDA research monograph, 1990, Volume: 105 Topics: Animals; Brain Chemistry; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Ethylketocyclazocine; In Vitro Techniques; Male; Morphine; Morphine Dependence; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord; Substance Withdrawal Syndrome	1990
Enhanced affinity of mu-opioid receptors in morphine-dependent mice. Progress in clinical and biological research, 1990, Volume: 328 Topics: Animals; Corpus Striatum; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Kinetics; Male; Mice; Morphine Dependence; Receptors, Opioid; Receptors, Opioid, mu	1990
Proglumide selectively potentiates supraspinal mu 1 opioid analgesia in mice. Neuropharmacology, 1990, Volume: 29, Issue:5 Topics: Animals; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Glutamine; Male; Mice; Morphine; Morphine Dependence; Narcotics; Proglumide; Reaction Time; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu	1990
Down-regulation of brain and spinal cord mu-opiate receptors in morphine tolerant-dependent rats. European journal of pharmacology, 1990, Nov-13, Volume: 190, Issue:3 Topics: Animals; Brain; Down-Regulation; Drug Tolerance; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Membranes; Morphine; Morphine Dependence; Rats; Rats, Inbred Strains; Receptors, Opioid; Spinal Cord	1990
Effects of prior exposure to morphine on the opioid inhibition of the stimulated release of [3H]norepinephrine from guinea pig cortex slices. NIDA research monograph, 1986, Volume: 75 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Cerebral Cortex; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Guinea Pigs; In Vitro Techniques; Male; Morphine; Morphine Dependence; Norepinephrine; Pyrrolidines; Receptors, Opioid	1986
Analgesic and tolerance-inducing effects of the highly selective delta opioid agonist [D-Pen2,D-Pen5]enkephalin in mice. European journal of pharmacology, 1988, Jun-10, Volume: 150, Issue:3 Topics: Analgesics; Animals; Drug Tolerance; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Mice; Mice, Inbred Strains; Morphine; Morphine Dependence; Pain; Reaction Time; Receptors, Opioid; Receptors, Opioid, delta; Sensory Thresholds; Substance-Related Disorders	1988
Phelorphan, an inhibitor of enzymes involved in the biodegradation of enkephalins, affected the withdrawal symptoms in chronic morphine-dependent rats. Neuroscience, 1987, Volume: 22, Issue:1 Topics: Aminopeptidases; Animals; Brain; CD13 Antigens; Dipeptides; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; Endopeptidases; Enkephalins; Male; Morphine Dependence; Naloxone; Neprilysin; Protease Inhibitors; Rats; Rats, Inbred Strains; Receptors, Opioid; Substance Withdrawal Syndrome; Thiorphan; Tiopronin	1987
Behavioral effects of opioid peptides selective for mu or delta receptors. II. Locomotor activity in nondependent and morphine-dependent rats. The Journal of pharmacology and experimental therapeutics, 1986, Volume: 238, Issue:3 Topics: Animals; beta-Endorphin; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Dose-Response Relationship, Drug; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Male; Morphine Dependence; Motor Activity; Naltrexone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu	1986
Tolerance and withdrawal are associated with ligand dependent receptor regulation in vitro and in vivo. Neuropeptides, 1984, Volume: 5, Issue:1-3 Topics: Animals; Drug Tolerance; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Humans; Hybrid Cells; Morphine; Morphine Dependence; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Substance Withdrawal Syndrome	1984
Differences in hypothalamo-pituitary-adrenocortical activity in the rat after acute and prolonged treatment with morphine. Neuroendocrinology, 1984, Volume: 38, Issue:5 Topics: Adrenal Cortex; Adrenocorticotropic Hormone; Animals; Corticosterone; Corticotropin-Releasing Hormone; Culture Techniques; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Methionine; Humans; Hypothalamo-Hypophyseal System; Male; Morphine; Morphine Dependence; Naloxone; Pituitary-Adrenal System; Rats; Rats, Inbred Strains; Stress, Physiological	1984
Effects of denervation on the sensitizing effect to noradrenaline induced by morphine in the vas deferens of mice treated chronically with morphine. Neuropharmacology, 1982, Volume: 21, Issue:8 Topics: Acetylcholine; Animals; Enkephalin, Leucine; Enkephalin, Methionine; Humans; In Vitro Techniques; Male; Mice; Morphine; Morphine Dependence; Muscle Contraction; Muscle Denervation; Muscle, Smooth; Norepinephrine; Vas Deferens	1982
Involvement of delta 2 opioid receptors in the development of morphine dependence in mice. The Journal of pharmacology and experimental therapeutics, 1993, Volume: 264, Issue:3 Topics: Animals; Enkephalin, Leucine; Isothiocyanates; Male; Mice; Morphinans; Morphine Dependence; Naloxone; Naltrexone; Receptors, Opioid, delta; Substance Withdrawal Syndrome; Thiocyanates	1993
Responses of morphine dependent opioid neurones to stressors. Progress in clinical and biological research, 1990, Volume: 328 Topics: Animals; beta-Endorphin; Brain; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Female; Morphine Dependence; Naloxone; Neurons; Pregnancy; Rats; Stress, Physiological; Tissue Distribution	1990
Substance P and [leucine]enkephalin release in guinea pig ileum during naloxone-precipitated morphine withdrawal. The Journal of pharmacology and experimental therapeutics, 1989, Volume: 249, Issue:1 Topics: Animals; Enkephalin, Leucine; Guinea Pigs; Ileum; In Vitro Techniques; Morphine Dependence; Myenteric Plexus; Naloxone; Substance P; Substance Withdrawal Syndrome	1989
In vivo evidence for the selectivity of ICI 154129 for the delta-opioid receptor. Neuropharmacology, 1985, Volume: 24, Issue:2 Topics: Analgesics; Animals; Enkephalin, Leucine; Etorphine; Female; Humans; Mice; Mice, Inbred C57BL; Morphine Dependence; Motor Activity; Rats; Receptors, Opioid; Receptors, Opioid, delta	1985
[Changes in the properties of brain opiate receptors during the development of morphine tolerance in rats]. Biokhimiia (Moscow, Russia), 1986, Volume: 51, Issue:8 Topics: Animals; Brain; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Kinetics; Male; Morphine; Morphine Dependence; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Opioid	1986