enkephalin, leucine has been researched along with Innate Inflammatory Response in 67 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (4.48) | 18.7374 |
| 1990's | 26 (38.81) | 18.2507 |
| 2000's | 17 (25.37) | 29.6817 |
| 2010's | 18 (26.87) | 24.3611 |
| 2020's | 3 (4.48) | 2.80 |
| Authors | Studies |
|---|---|
| Fichna, J; Giełdoń, A; Kamysz, E; Skowron, P; Sobocińska, M | 1 |
| Abot, A; Aloulou, M; Barreau, F; Battut, L; Blanpied, C; Bories, C; Cenac, N; Dietrich, G; Espinosa, E; Fazilleau, N; Gheziel, N; Knauf, C; Mas-Orea, X; Motta, JP; Mouledous, L; Petitfils, C; Rey, L; Serino, M; Wemelle, E | 1 |
| Makuch, W; Mika, J; Piotrowska, A; Popiolek-Barczyk, K | 1 |
| Hu, M; Li, J; Niyazi, S; Rong, R; Wang, S; Xu, M; Yang, C; Yang, Z; Zeng, Y; Zhang, M; Zhang, W; Zhang, Y; Zheng, L; Zhu, T | 1 |
| Jacobi, CLJ; Stein, C | 1 |
| Baudouin, C; Brignole-Baudouin, F; Labbe, A; Liang, H; Melik-Parsadaniantz, S; Nicolle, P; Rabut, G; Reaux-Le Goazigo, A; Reboussin, E; Warcoin, E | 1 |
| Li, X; Tao, K; Tao, Y; Zhu, J | 1 |
| Jung, JS; Lee, JK; Park, SH; Sim, YB; Suh, HW | 1 |
| Chou, AH; Day, YJ; Lee, CM; Lee, HC; Liao, CC; Lin, YC; Liou, JT; Mao, CC | 1 |
| Fichna, J; Jarmuż, A; Jonakowski, M; Lipkowski, AW; Pilarczyk, A; Sałaga, M; Sobczak, M | 1 |
| Cerda-Cristerna, B; Chavarria-Bolaños, D; Flores-Reyes, H; Lombana-Sanchez, N; Pozos-Guillen, A | 1 |
| Hayama, T; Kamio, N; Matsushima, K; Muromachi, K; Okabe, T | 1 |
| Chen, HD; Chi, XL; Fang, F; Fang, JQ; Liu, YJ; Zhang, JR | 1 |
| Cai, Z; Cheng, X; Guo, Q; Hu, C; Lu, Y; Wu, Z; Zhang, Q | 1 |
| Baddack-Werncke, U; Busch-Dienstfertig, M; González-Rodríguez, S; Grobe, J; Lipp, M; Maddila, SC; Müller, G; Stein, C | 1 |
| Hervera, A; Leánez, S; Pol, O | 1 |
| Furuya, M; Imai, S; Inada, E; Iseki, M; Kobayashi, Y; Kuzumaki, N; Maitani, Y; Narita, M; Niikura, K; Shimizu, T; Suzuki, T; Taketa, Y; Yamazaki, M | 1 |
| Chen, JY; Cheng, YC; Chien, CC; Lin, JY; Lin, SC; Ling, QD; Tsou, TS; Wen, YR | 1 |
| Cabral, L; Lima, D; Martins, I; Pinto, A; Tavares, I; Wilson, SP | 1 |
| Blanpied, C; Boué, J; Dietrich, G; Djata-Cabral, M; Pelletier, L; Vergnolle, N | 1 |
| Gao, X; Huang, YL; Ji, GC; Wu, GC; Zhang, YQ; Zhao, ZQ | 1 |
| Besson, JM; Buritova, J; Catheline, G; Fournié-Zaluski, MC; Le Guen, S; Roques, BP | 1 |
| Besson, JM; Buritova, J; Fournié-Zaluski, MC; Le Guen, S; Roques, BP | 1 |
| Braz, J; Cesselin, F; Hamon, M; Meunier, A; Pohl, M | 1 |
| Cho, HJ; Hwang, SH; Kang, BS; Kim, DS; Lee, HL; Lee, KM; Park, JS; Son, SJ | 1 |
| Arend, A; Aunapuu, M; Bourin, M; Kõks, S; Kurrikoff, K; Matsui, T; Vasar, E | 1 |
| Lin, W; Lu, Y; McNearney, TA; Westlund, KN; Wilson, SP; Yeomans, DC | 1 |
| Chavkin, C; Gendron, L; Pintar, JE | 1 |
| Chu, R; Lu, Y; McNearney, TA; Ren, Y; Westlund, KN; Wilson, SP; Yang, H; Yeomans, DC | 1 |
| Lu, Y; McNearney, TA; Westlund, KN; Wilson, SP; Yeomans, DC | 1 |
| Jeanjean, AP; Laduron, PM; Maloteaux, JM | 1 |
| Imai, Y; Schäfer, M; Stein, C; Uhl, GR | 1 |
| Abbott, FV; Hong, Y | 1 |
| Ableitner, A; Hassan, AH; Herz, A; Stein, C | 1 |
| Ardid, D; Aumaitre, O; Betoin, F; Duchene-Marullaz, P; Eschalier, A; Herbet, A; Kemeny, JL; Lavarenne, J | 1 |
| Fournié-Zaluski, MC; Maldonado, R; Roques, BP; Turcaud, S; Valverde, O | 1 |
| Green, PG; Khasar, SG; Levine, JD | 1 |
| Helyes, Z; Pintér, E; Szolcsányi, J | 1 |
| Beyer, A; Schäfer, M; Stein, C | 1 |
| Brooks, PJ; Holtzman, DA; Pfaff, DW; Schwartz-Giblin, S | 1 |
| Coric, P; Fournié-Zaluski, MC; Maldonado, R; Noble, F; Roques, BP; Smadja, C; Turcaud, S; Valverde, O | 1 |
| Iadarola, MJ; Kim, DJ; Messersmith, DJ | 1 |
| Labuz, D; Mika, J; Przewłocka, B; Przewłocki, R; Toth, G | 1 |
| Franklin, E; MacArthur, L; Pfaffenroth, E; Ren, K; Ruda, MA | 1 |
| Salzet, M; Tasiemski, A | 1 |
| Hammond, DL; Hurley, RW | 1 |
| Blomqvist, A; Engblom, D; Engström, L; Mackerlova, L; Ortegren, U; Paues, J | 1 |
| Befort, K; Brenner, GJ; Ji, RR; Woolf, CJ | 1 |
| Cheng, HY; Crackower, M; Goncalves, J; Ikura, M; Joza, NA; Kockeritz, LK; Laviolette, SR; Oliveira-dos-Santos, AJ; Penninger, JM; Pitcher, GM; Salter, MW; Sarosi, I; Tong, KI; van der Kooy, D; Wada, T; Whishaw, IQ; Woodgett, JR | 1 |
| Günther, B | 1 |
| Green, PG; Levine, JD | 1 |
| Dubner, R; Hylden, JL; Ren, K; Ruda, MA; Williams, GM | 1 |
| Hylden, JL; Noguchi, K; Ruda, MA | 1 |
| Dubner, R; Noguchi, K; Ruda, MA | 1 |
| Jankovic, BD | 1 |
| Dubner, R; Hylden, JL; Iadarola, MJ; Nahin, RL; Thomas, DA | 1 |
| Helme, RD; Khalil, Z | 1 |
| Herz, A; Parsons, CG | 1 |
| Heath, D; Khan, Q; Smith, P | 1 |
| Herz, A; Millan, MJ; Peter, K; Shippenberg, TS; Stein, C | 1 |
| Draisci, G; Iadarola, MJ | 1 |
| Cai, H; Cui, L; Dong, J; Li, J; Qian, C; Qu, Y; Sun, F; Wang, H; Wang, Y | 1 |
| Fournie-Zaluski, MC; Gore, C; Labuz, D; Machelska, H; Roques, BP; Schreiter, A; Stein, C | 1 |
| Carter, L; Schäfer, M; Stein, C | 1 |
| Bianchi, M; Panerai, AE; Sacerdote, P | 1 |
| Adriaensen, D; Bossowska, A; Brouns, I; Gonkowski, S; Majewski, M; Scheuermann, DW; Timmermans, JP; Wojtkiewicz, J | 1 |
| Gramsch, C; Hassan, AH; Herz, A; Parsons, CG; Peter, K; Przewlocki, R; Stein, C | 1 |
3 review(s) available for enkephalin, leucine and Innate Inflammatory Response
| Article | Year |
|---|---|
[From inflammation to pain: experimental gene therapy].
Topics: Animals; Arthritis; Chronic Disease; Cytokines; Disease Models, Animal; Enkephalins; Genetic Therapy; Humans; Inflammation; Pain; Pain Management; Protein Precursors; Rats | 2004 |
Involvement of pro-enkephalin-derived peptides in immunity.
Topics: Animals; Anti-Infective Agents; Enkephalin, Methionine; Enkephalins; Humans; Inflammation; Inflammation Mediators; Invertebrates; Protein Precursors; Vertebrates | 2001 |
Enkephalins and immune inflammatory reactions.
Topics: Anaphylaxis; Animals; Arthus Reaction; Autoimmune Diseases; Enkephalins; Graft Rejection; Humans; Hypersensitivity, Delayed; Immune Tolerance; Inflammation; Neuroimmunomodulation; Rats; Receptors, Opioid | 1991 |
64 other study(ies) available for enkephalin, leucine and Innate Inflammatory Response
| Article | Year |
|---|---|
Topics: Animals; Colitis; Enkephalins; Inflammation; Mice; Neprilysin | 2022 |
Proenkephalin deletion in hematopoietic cells induces intestinal barrier failure resulting in clinical feature similarities with irritable bowel syndrome in mice.
Topics: Analgesics, Opioid; Animals; Enkephalins; Humans; Inflammation; Irritable Bowel Syndrome; Mice; Pain | 2023 |
Biphalin, a Dimeric Enkephalin, Alleviates LPS-Induced Activation in Rat Primary Microglial Cultures in Opioid Receptor-Dependent and Receptor-Independent Manners.
Topics: Animals; Cell Survival; Cells, Cultured; Enkephalins; Inflammation; Inflammation Mediators; Lipopolysaccharides; Male; Microglia; Neuralgia; Nitric Oxide; Nociception; Rats, Wistar; Receptors, Opioid | 2017 |
Protective effects of cyclic helix B peptide on aristolochic acid induced acute kidney injury.
Topics: Acute Kidney Injury; Animals; Aristolochic Acids; bcl-X Protein; Blood Urea Nitrogen; Caspase 3; Caspase 9; Creatinine; Disease Models, Animal; Enkephalins; Inflammation; Kidney; Kidney Function Tests; Male; Mice; Mice, Inbred BALB C; Protective Agents; Protein Precursors; Reperfusion Injury | 2017 |
Inflammatory-linked changes in CpG island methylation of three opioid peptide genes in a rat model for pain.
Topics: Animals; CpG Islands; Disease Models, Animal; DNA Methylation; Enkephalins; Gene Expression Regulation; Inflammation; Male; Pain; Pro-Opiomelanocortin; Protein Precursors; Rats; Rats, Wistar; Real-Time Polymerase Chain Reaction | 2018 |
Proinflammatory Markers, Chemokines, and Enkephalin in Patients Suffering from Dry Eye Disease.
Topics: Adult; Aged; Biomarkers; Cells, Cultured; Chemokines; Conjunctiva; Dry Eye Syndromes; Enkephalins; Female; Gene Expression Regulation; Humans; Inflammation; Male; Middle Aged | 2018 |
Elevated endogenous opioids in obstructive jaundice: The possible skin mechanisms.
Topics: Animals; Cholestasis; Dermis; Endorphins; Enkephalins; Fibroblasts; Heart Diseases; Humans; Inflammation; Jaundice, Obstructive; Keratinocytes; Melanocytes; Merkel Cells; Models, Theoretical; Opioid Peptides; Peptides; Pruritus; Skin; Vascular Diseases | 2018 |
Deficiency of alpha-calcitonin gene-related peptide induces inflammatory responses and lethality in sepsis.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Brain; Calcitonin Gene-Related Peptide; Cecum; Corticosterone; Corticotropin-Releasing Hormone; Cytokines; Enkephalins; Galactosamine; Gene Expression Regulation; Inflammation; Ligation; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Pro-Opiomelanocortin; Protein Precursors; Punctures; RNA, Messenger; Sepsis; Survival Analysis | 2013 |
Lack of interleukin-17 leads to a modulated micro-environment and amelioration of mechanical hypersensitivity after peripheral nerve injury in mice.
Topics: Animals; Behavior, Animal; beta-Endorphin; Central Nervous System Sensitization; Cytokines; Disease Models, Animal; Dynorphins; Enkephalins; Hyperalgesia; Inflammation; Interleukin-10; Interleukin-13; Interleukin-17; Interleukin-1beta; Interleukin-2; Interleukin-6; Macrophages; Mice; Mice, Inbred C57BL; Mice, Knockout; Neuralgia; Neutrophils; Nociception; Peripheral Nerve Injuries; Peroxidase; Sciatic Nerve; T-Lymphocytes; Tumor Necrosis Factor-alpha | 2014 |
Anti-inflammatory and antinociceptive action of the dimeric enkephalin peptide biphalin in the mouse model of colitis: new potential treatment of abdominal pain associated with inflammatory bowel diseases.
Topics: Abdominal Pain; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Colitis; Disease Models, Animal; Enkephalins; Inflammation; Inflammatory Bowel Diseases; Injections, Intraperitoneal; Injections, Intraventricular; Male; Mice; Mice, Inbred BALB C; Mustard Plant; Plant Oils; Trinitrobenzenesulfonic Acid | 2014 |
Sensory Neuropeptides and Endogenous Opioids Expression in Human Dental Pulp with Asymptomatic Inflammation: In Vivo Study.
Topics: Adolescent; Analgesics, Opioid; beta-Endorphin; Calcitonin Gene-Related Peptide; Child; Dental Pulp; Enkephalins; Female; Humans; Inflammation; Male; Methionine; Molar; Neuropeptides; Orthodontics; Pain; Pilot Projects; Radioimmunoassay; Substance P | 2015 |
Kallikrein Promotes Inflammation in Human Dental Pulp Cells Via Protease-Activated Receptor-1.
Topics: Cells, Cultured; Complement C3; Dental Pulp; Enkephalins; Humans; Inflammation; Kallikreins; Prostate-Specific Antigen; Protein Precursors; Pulpitis; Pyrroles; Quinazolines; Receptor, PAR-1; Renin | 2016 |
[Analgesic Effect and Mechanism of Electroacupuncture on Rats with Chronic Inflammatory Pain].
Topics: Analgesia; Animals; Electroacupuncture; Enkephalins; Freund's Adjuvant; Ganglia, Spinal; Inflammation; Male; Pain Management; Peptide Fragments; Posterior Horn Cells; Random Allocation; Rats; Rats, Sprague-Dawley | 2016 |
Nonviral vector plasmid DNA encoding human proenkephalin gene attenuates inflammatory and neuropathic pain-related behaviors in mice.
Topics: Adjuvants, Immunologic; Animals; Behavior, Animal; DNA; Enkephalins; Freund's Adjuvant; Genetic Therapy; Genetic Vectors; Humans; Hyperalgesia; Inflammation; Injections, Intramuscular; Injections, Spinal; Neuralgia; Pain; Pain Management; Plasmids; Protein Precursors; Sciatic Nerve | 2016 |
Cytotoxic T cells modulate inflammation and endogenous opioid analgesia in chronic arthritis.
Topics: Analgesics, Opioid; Animals; Antibodies; Arthritis, Experimental; CD8 Antigens; CD8-Positive T-Lymphocytes; Collagen; Disease Models, Animal; Enkephalins; Female; Freund's Adjuvant; Functional Laterality; Hyperalgesia; Inflammation; Methionine; Mice; Mice, Inbred BALB C; Pain Measurement; Pain Threshold; Time Factors | 2017 |
Peripheral antinociceptive effects of mu- and delta-opioid receptor agonists in NOS2 and NOS1 knockout mice during chronic inflammatory pain.
Topics: Analgesics; Animals; Chronic Disease; Edema; Enkephalins; Freund's Adjuvant; Hyperalgesia; Inflammation; Mice; Mice, Inbred C57BL; Mice, Knockout; Morphine; Neurotransmitter Agents; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Pain; Receptors, Opioid, delta; Receptors, Opioid, mu; Time Factors | 2009 |
Direct evidence for the ongoing brain activation by enhanced dynorphinergic system in the spinal cord under inflammatory noxious stimuli.
Topics: Animals; Behavior, Animal; Brain; Brain Chemistry; Dynorphins; Enkephalins; Freund's Adjuvant; Immunohistochemistry; Inflammation; Injections, Spinal; Magnetic Resonance Imaging; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Pain; Protein Precursors; Receptors, N-Methyl-D-Aspartate; Reverse Transcriptase Polymerase Chain Reaction; RNA; Spinal Cord; Synaptic Transmission | 2010 |
Increased spinal prodynorphin gene expression in reinflammation-associated hyperalgesia after neonatal inflammatory insult.
Topics: Animals; Animals, Newborn; Disease Models, Animal; Enkephalins; Gene Expression Regulation; Hindlimb; Hot Temperature; Hyperalgesia; Inflammation; Physical Stimulation; Protein Precursors; Rats; Rats, Sprague-Dawley; Spinal Cord; Up-Regulation | 2010 |
Reversal of inflammatory pain by HSV-1-mediated overexpression of enkephalin in the caudal ventrolateral medulla.
Topics: Animals; Enkephalins; Gene Expression Regulation, Viral; Genetic Therapy; Genetic Vectors; Herpesvirus 1, Human; Inflammation; Male; Medulla Oblongata; Neuralgia; Neuritis; Pain Management; Rats; Rats, Wistar | 2011 |
Immune conditions associated with CD4+ T effector-induced opioid release and analgesia.
Topics: Adaptive Immunity; Analgesia; Animals; CD4-Positive T-Lymphocytes; Cells, Cultured; Enkephalins; Inflammation; Mice; Mice, Inbred BALB C; Mice, Nude; Opioid Peptides; Pain; Protein Precursors | 2012 |
Expression of 5-HT1A receptor mRNA in rat lumbar spinal dorsal horn neurons after peripheral inflammation.
Topics: Animals; Enkephalins; gamma-Aminobutyric Acid; Inflammation; Lumbosacral Region; Male; Peripheral Nerves; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; RNA, Messenger | 2002 |
Further evidence for the interaction of mu- and delta-opioid receptors in the antinociceptive effects of the dual inhibitor of enkephalin catabolism, RB101(S). A spinal c-Fos protein study in the rat under carrageenin inflammation.
Topics: Analgesics; Animals; Carrageenan; Disulfides; Edema; Enkephalins; Gene Expression Regulation; Inflammation; Male; Phenylalanine; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu; Spinal Cord | 2003 |
Antinociceptive effects of RB101(S), a complete inhibitor of enkephalin-catabolizing enzymes, are enhanced by (+)-HA966, a functional NMDA receptor antagonist: a c-Fos study in the rat spinal cord.
Topics: Analgesics; Animals; Carrageenan; Disulfides; Drug Therapy, Combination; Enkephalins; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Immunohistochemistry; Inflammation; Male; Naloxone; Narcotic Antagonists; Pain; Phenylalanine; Proto-Oncogene Proteins c-fos; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spinal Cord | 2003 |
Spinal NF-kB activation induces COX-2 upregulation and contributes to inflammatory pain hypersensitivity.
Topics: Animals; Cyclooxygenase 2; Enkephalins; Enzyme Inhibitors; Freund's Adjuvant; Gene Expression; Hindlimb; Hyperalgesia; Inflammation; Injections, Spinal; Interleukin 1 Receptor Antagonist Protein; Interleukin-1; Isoenzymes; Male; NF-kappa B; Pain; Prostaglandin-Endoperoxide Synthases; Protein Precursors; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sialoglycoproteins; Spinal Cord; Up-Regulation | 2004 |
Deletion of the CCK2 receptor gene reduces mechanical sensitivity and abolishes the development of hyperalgesia in mononeuropathic mice.
Topics: Animals; Benzodiazepinones; Disease Models, Animal; Dose-Response Relationship, Drug; Dynorphins; Enkephalins; Gene Expression; Hyperalgesia; Inflammation; Ligation; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Naloxone; Narcotic Antagonists; Pain Measurement; Pain Threshold; Phenylurea Compounds; Pro-Opiomelanocortin; Protein Precursors; Receptor, Cholecystokinin B; Receptors, Cholecystokinin; Receptors, Opioid; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sciatic Neuropathy; Time Factors | 2004 |
Treatment of inflamed pancreas with enkephalin encoding HSV-1 recombinant vector reduces inflammatory damage and behavioral sequelae.
Topics: Animals; Behavior, Animal; Enkephalins; Genetic Therapy; Genetic Vectors; Herpesvirus 1, Human; Immunohistochemistry; Inflammation; Pancreas; Pancreatitis; Rats; Spinal Cord | 2007 |
Essential role of mu opioid receptor in the regulation of delta opioid receptor-mediated antihyperalgesia.
Topics: Animals; beta-Endorphin; Dose-Response Relationship, Drug; Dynorphins; Enkephalins; Freund's Adjuvant; Hyperalgesia; Inflammation; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Naltrexone; Narcotic Antagonists; Oligopeptides; Pain Measurement; Protein Precursors; Reaction Time; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Somatostatin | 2007 |
Enkephalin-encoding herpes simplex virus-1 decreases inflammation and hotplate sensitivity in a chronic pancreatitis model.
Topics: Animals; Behavior, Animal; DNA, Complementary; Enkephalins; Genetic Vectors; Herpesvirus 1, Human; Inflammation; Male; Models, Animal; Pancreatitis, Chronic; Protein Precursors; Rats; Rats, Inbred Lew; Receptors, Opioid, mu; Spinal Cord; Time Factors | 2008 |
Joint capsule treatment with enkephalin-encoding HSV-1 recombinant vector reduces inflammatory damage and behavioural sequelae in rat CFA monoarthritis.
Topics: Animals; Arthritis, Experimental; Behavior, Animal; Enkephalins; Freund's Adjuvant; Gene Targeting; Genetic Vectors; Herpesvirus 1, Human; Inflammation; Inflammation Mediators; Joint Capsule; Male; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley | 2008 |
IL-1 beta-like Freund's adjuvant enhances axonal transport of opiate receptors in sensory neurons.
Topics: Animals; Axonal Transport; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Foot; Freund's Adjuvant; Inflammation; Interleukin-1; Ligation; Male; Nerve Tissue Proteins; Neurons, Afferent; Nociceptors; Rats; Rats, Wistar; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sciatic Nerve | 1994 |
Inflammation enhances peripheral mu-opioid receptor-mediated analgesia, but not mu-opioid receptor transcription in dorsal root ganglia.
Topics: Amino Acid Sequence; Analgesia; Analgesics; Animals; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Foot; Ganglia, Spinal; Inflammation; Male; Molecular Sequence Data; Naltrexone; Narcotic Antagonists; Pain Measurement; Rats; Rats, Wistar; Receptors, Opioid, mu; Ribonucleases; RNA, Messenger | 1995 |
Peripheral opioid modulation of pain and inflammation in the formalin test.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Behavior, Animal; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Extravasation of Diagnostic and Therapeutic Materials; Formaldehyde; Inflammation; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Narcotics; Pain; Pyrrolidines; Rats; Receptors, Opioid | 1995 |
Inflammation of the rat paw enhances axonal transport of opioid receptors in the sciatic nerve and increases their density in the inflamed tissue.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Axonal Transport; beta-Endorphin; Biological Transport; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Foot; Freund's Adjuvant; Inflammation; Ligation; Male; Naloxone; Nerve Tissue Proteins; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Sciatic Nerve | 1993 |
Evidence for a central long-lasting antinociceptive effect of vapreotide, an analog of somatostatin, involving an opioidergic mechanism.
Topics: Amino Acid Sequence; Analgesics; Animals; Brain; Disease Models, Animal; Edema; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; In Vitro Techniques; Inflammation; Male; Membranes; Mice; Molecular Sequence Data; Morphine; Motor Activity; Naloxone; Necrosis; Nociceptors; Octreotide; Pain Measurement; Rats; Rats, Sprague-Dawley; Somatostatin; Spinal Cord; Time Factors; Tritium | 1994 |
Antinociceptive response induced by mixed inhibitors of enkephalin catabolism in peripheral inflammation.
Topics: Analgesics; Animals; Disulfides; Enkephalins; Hydroxamic Acids; Inflammation; Injections, Intraventricular; Male; Morphine; Naloxone; Narcotic Antagonists; Neprilysin; Pain; Pain Measurement; Phenylalanine; Quaternary Ammonium Compounds; Rats; Rats, Sprague-Dawley | 1994 |
Comparison of intradermal and subcutaneous hyperalgesic effects of inflammatory mediators in the rat.
Topics: Analgesics; Animals; Bradykinin; Dibenz(b,f)(1,4)oxazepine-10(11H)-carboxylic acid, 8-chloro-, 2-acetylhydrazide; Dinoprostone; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Inflammation; Injections, Intradermal; Injections, Subcutaneous; Male; Pain; Pain Threshold; Rats; Rats, Sprague-Dawley | 1993 |
Neurotransmitter background of the anti-inflammatory effect evoked by activation of sensory nerve fibers.
Topics: Animals; Edema; Enkephalins; Evoked Potentials; Inflammation; Mustard Plant; Naloxone; Nerve Fibers; Neurons, Afferent; Neuropeptides; Neurotransmitter Agents; Paraffin; Plant Extracts; Plant Oils; Plants, Medicinal; Rats; Skin | 1996 |
Antinociceptive effects of dynorphin peptides in a model of inflammatory pain.
Topics: Analgesics; Analgesics, Opioid; Animals; Dynorphins; Edema; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Foot; Inflammation; Male; Nociceptors; Peptide Fragments; Rats; Rats, Wistar | 1997 |
Preproenkephalin mRNA is regulated by an interaction between steroid hormones and nociceptive stimulation.
Topics: Animals; Enkephalins; Female; Hindlimb; In Situ Hybridization; Inflammation; Nociceptors; Ovariectomy; Pain; Protein Precursors; Rats; RNA, Messenger; Spinal Cord; Steroids; Ventromedial Hypothalamic Nucleus | 1997 |
Pain-suppressive effects on various nociceptive stimuli (thermal, chemical, electrical and inflammatory) of the first orally active enkephalin-metabolizing enzyme inhibitor RB 120.
Topics: Administration, Oral; Alanine; Animals; Disulfides; Dose-Response Relationship, Drug; Electric Stimulation; Enkephalins; Enzyme Inhibitors; Hot Temperature; Inflammation; Injections, Intraperitoneal; Injections, Intravenous; Male; Mice; Mice, Inbred Strains; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Stimulation, Chemical | 1997 |
Transcription factor regulation of prodynorphin gene expression following rat hindpaw inflammation.
Topics: Animals; Binding Sites; Cell Nucleus; Cyclic AMP Response Element-Binding Protein; Enkephalins; Gene Expression Regulation; Hindlimb; Inflammation; Male; Models, Neurological; Neurons; PC12 Cells; Phosphorylation; Promoter Regions, Genetic; Protein Precursors; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Spinal Cord; Transcription Factor AP-1; Transcription Factors; Transcription, Genetic; Transfection | 1998 |
Spinal analgesic action of endomorphins in acute, inflammatory and neuropathic pain in rats.
Topics: Acute Disease; Analgesics, Opioid; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Inflammation; Injections, Spinal; Male; Morphine; Pain; Rats; Spinal Cord | 1999 |
Descending modulation of opioid-containing nociceptive neurons in rats with peripheral inflammation and hyperalgesia.
Topics: Animals; Blotting, Northern; Calcitonin Gene-Related Peptide; Colchicine; Denervation; Dynorphins; Enkephalins; Freund's Adjuvant; Ganglia, Spinal; Gene Expression; Hyperalgesia; Inflammation; Male; Neurons, Afferent; Nociceptors; Protein Precursors; Rats; Rats, Sprague-Dawley; RNA, Messenger; Spinal Cord; Tachykinins | 1999 |
Contribution of endogenous enkephalins to the enhanced analgesic effects of supraspinal mu opioid receptor agonists after inflammatory injury.
Topics: Animals; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Inflammation; Male; Microinjections; Naltrexone; Pain; Peptide Fragments; Peptides; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Somatostatin | 2001 |
Preproenkephalin mRNA expression in rat parabrachial neurons: relation to cells activated by systemic immune challenge.
Topics: Animals; Dose-Response Relationship, Drug; Enkephalins; Immune System; Immunohistochemistry; Inflammation; Lipopolysaccharides; Male; Neurons; Pons; Protein Precursors; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; RNA, Messenger; Up-Regulation; Visceral Afferents | 2001 |
ERK MAP kinase activation in superficial spinal cord neurons induces prodynorphin and NK-1 upregulation and contributes to persistent inflammatory pain hypersensitivity.
Topics: Animals; Butadienes; Disease Models, Animal; Enkephalins; Enzyme Activation; Enzyme Inhibitors; Freund's Adjuvant; Hindlimb; Hyperalgesia; Inflammation; Injections, Spinal; Male; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Nitriles; Pain; Posterior Horn Cells; Protein Precursors; Rats; Rats, Sprague-Dawley; RNA, Messenger; Spinal Cord; Substance P; Up-Regulation | 2002 |
DREAM is a critical transcriptional repressor for pain modulation.
Topics: Animals; Base Sequence; Behavior, Animal; Calcium-Binding Proteins; Cells, Cultured; Consensus Sequence; Down-Regulation; Enkephalins; Heart; Hyperalgesia; Inflammation; Kv Channel-Interacting Proteins; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Neuralgia; Neurons; Physical Stimulation; Presenilin-1; Presenilin-2; Protein Precursors; Proto-Oncogene Proteins c-fos; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, kappa; Repressor Proteins; Spinal Cord; Stimulation, Chemical; Transcription, Genetic | 2002 |
[Pathophysiology of acute pain (author's transl)].
Topics: Afferent Pathways; Animals; Endorphins; Enkephalins; Evoked Potentials; Humans; Inflammation; Neural Pathways; Neurons, Afferent; Nociceptors; Pain; Receptors, Opioid | 1978 |
Delta- and kappa-opioid agonists inhibit plasma extravasation induced by bradykinin in the knee joint of the rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Bradykinin; Capsaicin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Inflammation; Joints; Male; Naloxone; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, kappa | 1992 |
The intrathecal administration of excitatory amino acid receptor antagonists selectively attenuated carrageenan-induced behavioral hyperalgesia in rats.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Analgesics; Analysis of Variance; Animals; Behavior, Animal; Carrageenan; Dizocilpine Maleate; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Hyperalgesia; Inflammation; Injections, Spinal; Ketamine; Kynurenic Acid; Male; Piperazines; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Valine | 1992 |
Neonatal capsaicin treatment attenuates spinal Fos activation and dynorphin gene expression following peripheral tissue inflammation and hyperalgesia.
Topics: Animals; Animals, Newborn; Capsaicin; Dynorphins; Enkephalins; Female; Foot Diseases; Gene Expression; Hyperalgesia; Inflammation; Male; Protein Precursors; Proto-Oncogene Proteins c-fos; Rats; Rats, Inbred Strains; Spinal Cord; Substance P | 1992 |
Preproenkephalin mRNA in spinal dorsal horn neurons is induced by peripheral inflammation and is co-localized with Fos and Fos-related proteins.
Topics: Animals; Cell Nucleus; Enkephalins; Gene Expression Regulation; Genes, fos; Inflammation; Male; Neurons; Nucleic Acid Hybridization; Oncogene Proteins v-fos; Protein Precursors; Rats; Rats, Inbred Strains; RNA, Messenger; Spinal Cord | 1992 |
Spinal opioid analgesic effects are enhanced in a model of unilateral inflammation/hyperalgesia: possible involvement of noradrenergic mechanisms.
Topics: Adrenergic alpha-Antagonists; Animals; Carrageenan; Clonidine; Enkephalins; Hyperalgesia; Inflammation; Male; Morphine; Narcotic Antagonists; Nociceptors; Rats; Rats, Inbred Strains; Receptors, Opioid; Spinal Cord | 1991 |
Modulation of a peripheral inflammatory response to substance P by locally administered opioid receptor agonists.
Topics: Administration, Topical; Amino Acid Sequence; Animals; Blister; Capillary Permeability; Capsaicin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Inflammation; Male; Molecular Sequence Data; Naloxone; Oligopeptides; Perfusion; Peripheral Nerves; Rats; Skin; Substance P; Vasodilation | 1990 |
Peripheral opioid receptors mediating antinociception in inflammation. Evidence for activation by enkephalin-like opioid peptides after cold water swim stress.
Topics: Analgesia; Animals; Dioxolanes; Dipeptides; Enkephalins; Inflammation; Leucine; Male; Naloxone; Naltrexone; Neprilysin; Rats; Rats, Inbred Strains; Receptors, Opioid; Stress, Physiological; Swimming; Thiorphan | 1990 |
The distribution of enkephalins in human carotid bodies showing cellular proliferation and chronic glomitis.
Topics: Aged; Aged, 80 and over; Biomarkers; Carotid Body; Cell Count; Cell Division; Chronic Disease; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Female; Humans; Hyperplasia; Immunoenzyme Techniques; Inflammation; Male; Middle Aged | 1990 |
Peripheral opioid receptors mediating antinociception in inflammation. Evidence for involvement of mu, delta and kappa receptors.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Animals; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Inflammation; Male; Naloxone; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sensory Thresholds | 1989 |
Temporal analysis of increases in c-fos, preprodynorphin and preproenkephalin mRNAs in rat spinal cord.
Topics: Animals; Dynorphins; Enkephalins; Gene Expression Regulation; Hyperalgesia; Inflammation; Male; Protein Precursors; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fos; Rats; Rats, Inbred Strains; RNA, Messenger; Spinal Cord | 1989 |
Beta-endorphin inhibits the inflammatory response of bovine endometrial cells through δ opioid receptor in vitro.
Topics: Animal Husbandry; Animals; beta-Endorphin; Cattle; Cells, Cultured; Endometritis; Endometrium; Enkephalin, Leucine; Epithelial Cells; Escherichia coli; Female; Inflammation; Lipopolysaccharides; Naloxone; Narcotic Antagonists; NF-kappa B; Primary Cell Culture; Puerperal Infection; Receptors, Opioid, delta; Signal Transduction | 2021 |
Pain inhibition by blocking leukocytic and neuronal opioid peptidases in peripheral inflamed tissue.
Topics: Alanine; Amino Acid Sequence; Animals; Antibodies; CD13 Antigens; Dose-Response Relationship, Drug; Dynorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enzyme Inhibitors; Flow Cytometry; Hindlimb; Inflammation; Leucine; Leukocytes; Male; Narcotic Antagonists; Neprilysin; Neurons; Opioid Peptides; Pain; Pain Threshold; Phosphinic Acids; Rats; Rats, Wistar; Receptors, Opioid; Thiorphan | 2012 |
Interleukin 1 beta and corticotropin-releasing factor inhibit pain by releasing opioids from immune cells in inflamed tissue.
Topics: Analysis of Variance; Animals; Antibodies; beta-Endorphin; Corticotropin-Releasing Hormone; Cyclosporine; Dose-Response Relationship, Drug; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Humans; Inflammation; Injections; Interleukin-1; Male; Naloxone; Pain; Rats; Rats, Wistar; Recombinant Proteins; Regression Analysis; Somatostatin | 1994 |
Involvement of beta-endorphin in the modulation of paw inflammatory edema in the rat.
Topics: Animals; Antibodies; Benzomorphans; beta-Endorphin; Edema; Enkephalin, Leucine; Foot; Inflammation; Male; Morphine; Naltrexone; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Yeasts | 1996 |
Neither axotomy nor target-tissue inflammation changes the NOS- or VIP-synthesis rate in distal bowel-projecting neurons of the porcine inferior mesenteric ganglion (IMG).
Topics: Animals; Axotomy; Enkephalin, Leucine; Female; Ganglia, Sympathetic; Immunohistochemistry; Inflammation; Interneurons; Intestinal Mucosa; Intestines; Kinetics; Neuropeptides; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Pituitary Adenylate Cyclase-Activating Polypeptide; Swine; Vasoactive Intestinal Peptide | 2002 |
Local opioid receptors mediating antinociception in inflammation: endogenous ligands.
Topics: Animals; Endorphins; Enkephalin, Leucine; Inflammation; Naloxone; Nociceptors; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Somatostatin | 1990 |