enkephalin, leucine has been researched along with Idiopathic Parkinson Disease in 60 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 23 (38.33) | 18.7374 |
1990's | 7 (11.67) | 18.2507 |
2000's | 21 (35.00) | 29.6817 |
2010's | 7 (11.67) | 24.3611 |
2020's | 2 (3.33) | 2.80 |
Authors | Studies |
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Abu-Rumeileh, S; Al Shweiki, MHDR; Barba, L; Barschke, P; Gaetani, L; Halbgebauer, S; Landwehrmeyer, GB; Lewerenz, J; Ludolph, AC; Oeckl, P; Otto, M; Paolini Paoletti, F; Parnetti, L; Steinacker, P | 1 |
Chen, H; Chen, L; Chen, XY; Xue, Y | 1 |
Ahn, S; Hong, S; Jang, J; Jeon, S; Jung, YR; Kim, J; Oh, JY; Park, HJ; Park, SU; Shin, HS; Song, MA; Song, TJ | 1 |
Frau, L; Morelli, M; Simola, N | 1 |
Capper-Loup, C; Kaelin-Lang, A; Paganetti, P; Sgroi, S | 1 |
Caron, MG; Gainetdinov, RR; Hallett, PJ; Isacson, O; Patterson, M; Reske-Nielsen, C; Sotnikova, TD; Vinuela, A | 1 |
Andrén, PE; Fälth, M; Kultima, K; Nilsson, A; Sköld, K; Svenningsson, P; Zhang, X | 1 |
Cenci, MA; Crossman, AR; Kobylecki, C; Ravenscroft, P | 1 |
Burdett, TC; Cassin, JJ; Chen, JF; Fredholm, BB; Healy, B; Schwarzschild, MA; Xiao, D | 1 |
Andersson, M; Bergquist, J; Fälth, M; Hanrieder, J; Ljungdahl, A; Mammo, SE | 1 |
Andersson, M; Bergquist, J; Fälth, M; Hanrieder, J; Ljungdahl, A | 1 |
Gołembiowska, K; Konieczny, J; Ossowska, K; Pilc, A; Wardas, J; Wolfarth, S | 1 |
Bezard, E; Brotchie, JM; Gross, CE | 1 |
Konieczny, J; Ossowska, K; Pietraszek, M; Wardas, J; Wolfarth, S | 1 |
Damier, P; Drapier, S | 1 |
Brotchie, JM; Crossman, AR; Duty, S; Fox, SH; Henry, B | 1 |
Ossowska, K; Pietraszek, M; Wardas, J; Wolfarth, S | 1 |
Landry, E; Lévesque, D; Rouillard, C; St-Hilaire, M | 1 |
Konieczny, J; Kuter, K; Ossowska, K; Pietraszek, M; Pilc, A; Wardas, J; Wolfarth, S | 1 |
Bourhis, E; Lévesque, D; Rouillard, C; St-Hilaire, M | 1 |
Alba, F; Banegas, I; Barrero, F; Durán, R; Luna, JD; Morales, B; Prieto, I; Ramírez, M; Vives, F | 1 |
Bäckman, CM; Hoffer, BJ; Shan, L; Tomac, AC; Zhang, Y | 1 |
Cao, X; Chen, Z; Guan, Q; Sun, S; Wang, L; Xu, Y | 1 |
Agid, Y; Cesselin, F; Javoy-Agid, F; Taquet, H | 1 |
Bouras, C; Constantinidis, J; Richard, J | 1 |
Rinne, UK | 1 |
Agnoli, A; D'Urso, R; Del Roscio, S; Falaschi, P; Frajese, G; Mearelli, S; Ruggieri, S | 1 |
Daniel, SE; Eve, DJ; Foster, OJ; Kingsbury, A; Lees, AJ; Marsden, CD; Nisbet, AP | 1 |
de Ceballos, ML; Fernandez, A; Jenner, P; Marsden, CD | 1 |
Nagane, Y; Saitoh, K; Tohgi, H; Utsugisawa, K; Yamagata, M; Yoshimura, M | 1 |
Brotchie, JM; Crossman, AR; Duty, S; Henry, B | 1 |
Dixon, AK; Freeman, TC; Gubitz, AK; Richardson, PJ | 1 |
Aubert, I; Bloch, B; Ghorayeb, I; Normand, E | 1 |
Damier, P; Féger, J; Hirsch, EC; Tremblay, L | 1 |
Schneider, JS; Schroeder, JA | 1 |
Andren, PE; Gunne, L; Svenningsson, P | 1 |
Blarzino, C; Coccia, R; De Marco, C; Foppoli, C; Rosei, MA | 1 |
Bédard, PJ; Birdi, S; Calon, F; Di Paolo, T; Hornykiewicz, O; Rajput, AH | 1 |
Forni, C; Kerkerian-Le Goff, L; Manrique, C; Salin, P | 1 |
Calne, DB; Chase, TN; Eisler, T; Nutt, JG; Rosin, AJ | 1 |
Borison, RL; Diamond, BI | 1 |
Sivam, SP | 1 |
Tan, MX | 1 |
Hunt, SP; Peck, R; Reynolds, GP; Rossor, M; Waters, CM | 1 |
Iacono, RP; Sandyk, R | 1 |
Agid, Y; Cesselin, F; Giraud, P; Javoy-Agid, F; Legrand, JC; Taquet, H | 1 |
Pan, JB | 1 |
Holstein, GR; Pasik, P; Pasik, T | 1 |
Gerstenbrand, F; Poewe, W | 1 |
Luyendijk, W | 1 |
Agid, Y; Delay-Goyet, P; Javoy-Agid, F; Roques, BP; Zajac, JM | 1 |
Sandyk, R | 1 |
Bannon, MJ; Helke, CJ; Jacobowitz, DM; Kopin, IJ; Skofitsch, G; Zamir, N | 1 |
Koskinen, V; Laakso, K; Lönnberg, P; Rinne, JK; Rinne, JO; Rinne, UK; Tenovuo, O | 1 |
Agid, Y; Cesselin, F; Hamon, M; Javoy-Agid, F; Legrand, JC; Taquet, H | 1 |
de Ceballos, ML; Fernandez, A; Jenner, P; Marsden, CD; Rose, S | 1 |
Agid, Y; Cesselin, F; Epelbaum, J; Javoy-Agid, F; Taquet, H | 1 |
Liu, DK | 1 |
Chen, SD; Pan, GB; Xu, DL; Yu, WC | 1 |
Sheng, JG; Xu, DL; Yu, HZ | 1 |
11 review(s) available for enkephalin, leucine and Idiopathic Parkinson Disease
Article | Year |
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The globus pallidus as a target for neuropeptides and endocannabinoids participating in central activities.
Topics: Animals; Endocannabinoids; Enkephalins; Globus Pallidus; Humans; Huntington Disease; Neuropeptides; Parkinson Disease; Substance P | 2020 |
The role of striatal metabotropic glutamate receptors in Parkinson's disease.
Topics: Animals; Antiparkinson Agents; Corpus Striatum; Enkephalins; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Humans; Ligands; Parkinson Disease; Protein Isoforms; Protein Precursors; Receptors, Metabotropic Glutamate | 2002 |
Presymptomatic compensation in Parkinson's disease is not dopamine-mediated.
Topics: Adaptation, Physiological; Animals; Basal Ganglia; Disease Progression; Dopamine; Enkephalins; Globus Pallidus; Humans; Models, Neurological; Parkinson Disease; Receptors, Dopamine D2; Substantia Nigra | 2003 |
[Continuous subthalamic neurostimulation in Parkinson's disease. Indications and modalities].
Topics: Dopamine; Electric Stimulation Therapy; Electrodes, Implanted; Enkephalins; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Magnetic Resonance Imaging; Parkinson Disease; Patient Selection; Perioperative Care; Referral and Consultation; Risk Factors; Severity of Illness Index; Stereotaxic Techniques; Substance P; Subthalamic Nucleus; Treatment Outcome | 2003 |
An influence of ligands of metabotropic glutamate receptor subtypes on parkinsonian-like symptoms and the striatopallidal pathway in rats.
Topics: Animals; Benzoates; Catalepsy; Corpus Striatum; Enkephalins; Excitatory Amino Acid Antagonists; Glutamates; Glycine; Haloperidol; Humans; Ligands; Parkinson Disease; Protein Precursors; Rats; Receptors, Metabotropic Glutamate; RNA, Messenger | 2007 |
Putative peptide neurotransmitters in human neuropathology: a review of topography and clinical implications.
Topics: Alzheimer Disease; Brain Mapping; Central Nervous System Diseases; Cholecystokinin; Enkephalins; Humans; Huntington Disease; Limbic System; Nerve Tissue Proteins; Neurotransmitter Agents; Parkinson Disease; Schizophrenia; Substance P; Substance-Related Disorders | 1983 |
Adenosine receptor antagonists and Parkinson's disease: actions of the A2A receptor in the striatum.
Topics: Acetylcholine; Animals; Behavior, Animal; Corpus Striatum; Enkephalins; gamma-Aminobutyric Acid; Gene Expression; Humans; Neurotransmitter Agents; Parkinson Disease; Protein Precursors; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Receptors, Purinergic P1; Substance P | 1999 |
[Development of dyskinesias induced by treatment for Parkinson's disease: potential role of first exposure to L-DOPA (or phenomenon of priming)].
Topics: Animals; Antiparkinson Agents; Biological Transport, Active; Corpus Striatum; Disease Models, Animal; Dyskinesia, Drug-Induced; Enkephalins; Haplorhini; Humans; Levodopa; Neural Pathways; Neuronal Plasticity; Neurons, Efferent; Parkinson Disease; Receptors, Dopamine D2; Substance P; Time Factors | 2000 |
[Peptide neurotransmitters and extrapyramidal disorders].
Topics: Animals; Basal Ganglia Diseases; Enkephalins; Humans; Huntington Disease; MSH Release-Inhibiting Hormone; Parkinson Disease; Substance P | 1985 |
Enkephalinergic mechanisms in the "compensated" phase of Parkinson's disease.
Topics: Animals; Biomechanical Phenomena; Corpus Striatum; Dopamine; Enkephalins; Humans; Hypothalamus; Parkinson Disease | 1988 |
Neuropeptides and Parkinson's disease.
Topics: Animals; Brain; Enkephalin, Leucine; Enkephalin, Methionine; Hormones; Humans; Neuropeptides; Parkinson Disease; Somatostatin; Substance P | 1986 |
1 trial(s) available for enkephalin, leucine and Idiopathic Parkinson Disease
Article | Year |
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Effect of an opiate antagonist on movement disorders.
Topics: Adult; Aged; Clinical Trials as Topic; Enkephalins; Humans; Huntington Disease; Middle Aged; Naloxone; Naltrexone; Parkinson Disease | 1978 |
48 other study(ies) available for enkephalin, leucine and Idiopathic Parkinson Disease
Article | Year |
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Cerebrospinal fluid levels of proenkephalin and prodynorphin are differentially altered in Huntington's and Parkinson's disease.
Topics: Biomarkers; Chromatography, Liquid; Dopamine; Enkephalins; Humans; Huntington Disease; Parkinson Disease; Protein Precursors; Tandem Mass Spectrometry | 2022 |
Effects of a combination treatment of KD5040 and
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Brain; Cyclic AMP Response Element-Binding Protein; Disease Models, Animal; Dopamine and cAMP-Regulated Phosphoprotein 32; Dyskinesia, Drug-Induced; Enkephalins; Extracellular Signal-Regulated MAP Kinases; Levodopa; Magnoliopsida; Male; Mice, Inbred C57BL; Movement; Parkinson Disease; Phytotherapy; Plant Extracts; Proto-Oncogene Proteins c-fos; Substance P | 2017 |
Performance of movement in hemiparkinsonian rats influences the modifications induced by dopamine agonists in striatal efferent dynorphinergic neurons.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Adrenergic Agents; Analysis of Variance; Animals; Apomorphine; Corpus Striatum; Disease Models, Animal; Dopamine Agonists; Dynorphins; Early Growth Response Protein 1; Enkephalins; Functional Laterality; Gene Expression Regulation; Male; Motor Neurons; Movement; Oxidopamine; Parkinson Disease; Rats; Rats, Sprague-Dawley; RNA, Messenger | 2013 |
Enkephalin and dynorphin neuropeptides are differently correlated with locomotor hypersensitivity and levodopa-induced dyskinesia in parkinsonian rats.
Topics: Analysis of Variance; Animals; Antiparkinson Agents; Disease Models, Animal; Dynorphins; Dyskinesia, Drug-Induced; Enkephalins; Female; Gene Expression Regulation; Levodopa; Oxidopamine; Parkinson Disease; Protein Precursors; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; RNA, Messenger; Statistics as Topic; Sympatholytics; Tyrosine 3-Monooxygenase | 2016 |
Implanted reuptake-deficient or wild-type dopaminergic neurons improve ON L-dopa dyskinesias without OFF-dyskinesias in a rat model of Parkinson's disease.
Topics: Animals; Antiparkinson Agents; Brain Tissue Transplantation; Corpus Striatum; Disease Models, Animal; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dyskinesia, Drug-Induced; Enkephalins; Female; Fetal Tissue Transplantation; Gene Expression Regulation; Graft Survival; Levodopa; Mesencephalon; Microdialysis; Neurons; Parkinson Disease; Protein Precursors; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, N-Methyl-D-Aspartate; RNA, Messenger | 2008 |
Striatal alterations of secretogranin-1, somatostatin, prodynorphin, and cholecystokinin peptides in an experimental mouse model of Parkinson disease.
Topics: Amino Acid Sequence; Animals; Cholecystokinin; Chromogranin B; Disease Models, Animal; Enkephalins; Mice; Molecular Sequence Data; Neostriatum; Oxidopamine; Parkinson Disease; Peptides; Postmortem Changes; Protein Precursors; Reproducibility of Results; Somatostatin; Tissue Extracts; Tyrosine 3-Monooxygenase | 2009 |
Calcium-permeable AMPA receptors are involved in the induction and expression of l-DOPA-induced dyskinesia in Parkinson's disease.
Topics: Adamantane; Animals; Antiparkinson Agents; Behavior, Animal; Benserazide; Brain; Calcium; Callithrix; Dyskinesia, Drug-Induced; Enkephalins; Levodopa; Male; Motor Activity; Oxidopamine; Parkinson Disease; Protein Precursors; Rats; Rats, Sprague-Dawley; Receptors, AMPA | 2010 |
Deletion of adenosine A₁ or A(₂A) receptors reduces L-3,4-dihydroxyphenylalanine-induced dyskinesia in a model of Parkinson's disease.
Topics: Adrenergic Agents; Animals; Antiparkinson Agents; Caffeine; Corpus Striatum; Disease Models, Animal; Dynorphins; Dyskinesia, Drug-Induced; Enkephalins; Gene Expression Regulation; Levodopa; Mice; Mice, Inbred C57BL; Mice, Knockout; Oxidopamine; Parkinson Disease; Protein Precursors; Purinergic P1 Receptor Antagonists; Receptor, Adenosine A1; Receptor, Adenosine A2A; RNA, Messenger; Statistics, Nonparametric; Time Factors | 2011 |
L-DOPA-induced dyskinesia is associated with regional increase of striatal dynorphin peptides as elucidated by imaging mass spectrometry.
Topics: Animals; Antiparkinson Agents; Disease Models, Animal; Dynorphins; Dyskinesia, Drug-Induced; Enkephalins; Female; Humans; Levodopa; Mice; Neostriatum; Parkinson Disease; Protein Precursors; Rats; Rats, Sprague-Dawley; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2011 |
Imaging mass spectrometry reveals elevated nigral levels of dynorphin neuropeptides in L-DOPA-induced dyskinesia in rat model of Parkinson's disease.
Topics: Animals; Dynorphins; Dyskinesias; Enkephalins; Female; Immunohistochemistry; Levodopa; Male; Mass Spectrometry; Mice; Mice, Knockout; Parkinson Disease; Protein Precursors; Rats; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2011 |
The striopallidal pathway is involved in antiparkinsonian-like effects of the blockade of group I metabotropic glutamate receptors in rats.
Topics: Animals; Cataplexy; Corpus Striatum; Dopamine Antagonists; Enkephalins; Globus Pallidus; Haloperidol; Male; Neural Pathways; Parkinson Disease; Protein Precursors; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; RNA, Messenger | 2003 |
Increased striatal pre-proenkephalin B expression is associated with dyskinesia in Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Aged; Aged, 80 and over; Animals; Antiparkinson Agents; Corpus Striatum; Disease Models, Animal; Dyskinesia, Drug-Induced; Enkephalins; Female; Humans; Macaca mulatta; Male; Parkinson Disease; Parkinsonian Disorders; Protein Precursors; RNA, Messenger | 2003 |
The role of metabotropic glutamate receptors in regulation of striatal proenkephalin expression: implications for the therapy of Parkinson's disease.
Topics: Animals; Corpus Striatum; Disease Models, Animal; Dopamine Antagonists; Drug Administration Routes; Drug Interactions; Enkephalins; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Haloperidol; In Situ Hybridization; Male; Parkinson Disease; Protein Precursors; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; RNA, Messenger | 2003 |
Denervation and repeated L-DOPA induce complex regulatory changes in neurochemical phenotypes of striatal neurons: implication of a dopamine D1-dependent mechanism.
Topics: Animals; Corpus Striatum; Denervation; Disease Models, Animal; DNA-Binding Proteins; Dopamine; Dopamine Antagonists; Dynorphins; Enkephalins; Excitatory Amino Acid Transporter 2; Gene Expression Regulation; Levodopa; Male; Neurons; Neurotensin; Nuclear Receptor Subfamily 4, Group A, Member 1; Parkinson Disease; Phenotype; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Receptors, Dopamine D1; Receptors, Dopamine D3; Receptors, Steroid; RNA, Messenger; Transcription Factors; Tyrosine 3-Monooxygenase | 2005 |
Impaired behavioural and molecular adaptations to dopamine denervation and repeated L-DOPA treatment in Nur77-knockout mice.
Topics: Adaptation, Physiological; Animals; Antiparkinson Agents; Benserazide; Corpus Striatum; Denervation; Disease Models, Animal; DNA-Binding Proteins; Dopamine; Dopamine Agents; Drug Resistance; Enkephalins; Levodopa; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Neural Pathways; Neurotensin; Nuclear Receptor Subfamily 4, Group A, Member 1; Parkinson Disease; Receptors, Cytoplasmic and Nuclear; Receptors, Dopamine D3; Receptors, Steroid; Transcription Factors | 2006 |
Plasma aminopeptidase activities in Parkinson's disease.
Topics: Aged; Aminopeptidases; Angiotensins; Cholecystokinin; Dopamine; Enkephalins; Female; Humans; Male; Middle Aged; Neurotensin; Parkinson Disease; Substance P; Vasopressins | 2006 |
Alterations in prodynorphin, proenkephalin, and GAD67 mRNA levels in the aged human putamen: correlation with Parkinson's disease.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Enkephalins; Female; Gene Expression Regulation; Glutamate Decarboxylase; Humans; Isoenzymes; Male; Middle Aged; Parkinson Disease; Postmortem Changes; Protein Precursors; Putamen; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2007 |
Effect of antisense FosB and CREB on the expression of prodynorphin gene in rats with levodopa-induced dyskinesias.
Topics: Animals; Corpus Striatum; Cyclic AMP Response Element-Binding Protein; Dyskinesia, Drug-Induced; Enkephalins; Female; Levodopa; Neurons; Oligonucleotides, Antisense; Parkinson Disease; Protein Precursors; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; RNA, Messenger | 2006 |
Methionine-enkephalin deficiency in brains of patients with Parkinson's disease.
Topics: Aged; Brain Chemistry; Dopamine; Endorphins; Enkephalins; Humans; Methionine; Parkinson Disease | 1981 |
Recent advances in the treatment of Parkinson's disease.
Topics: Brain; Bromocriptine; Drug Therapy, Combination; Endorphins; Enkephalins; Humans; Levodopa; Mental Disorders; Parkinson Disease; Receptors, Dopamine | 1980 |
Are the enkephalins involved in Parkinson's disease? Clinical and neuroendocrine response to naloxone administration.
Topics: Aged; Endorphins; Enkephalins; Female; Humans; Male; Middle Aged; Naloxone; Parkinson Disease; Prolactin; Time Factors | 1980 |
Preproenkephalin and preprotachykinin messenger RNA expression in normal human basal ganglia and in Parkinson's disease.
Topics: Adult; Aged; Aged, 80 and over; Autoradiography; Basal Ganglia; Dopamine Agents; Enkephalins; Female; Gene Expression; Humans; Levodopa; Male; Middle Aged; Neostriatum; Parkinson Disease; Protein Precursors; RNA, Messenger; Sensitivity and Specificity; Tachykinins | 1995 |
Neurotensin, substance P, delta and mu opioid receptors are decreased in basal ganglia of Parkinson's disease patients.
Topics: Adult; Aged; Amino Acid Sequence; Analgesics; Basal Ganglia; Biogenic Monoamines; Dopamine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Female; Humans; In Vitro Techniques; Male; Middle Aged; Molecular Sequence Data; Parkinson Disease; Receptors, Neurokinin-1; Receptors, Neurotensin; Receptors, Opioid, delta; Receptors, Opioid, mu | 1994 |
Reduction in the ratio of beta-preprotachykinin to preproenkephalin messenger RNA expression in postmortem human putamen during aging and in patients with status lacunaris. Implications for the susceptibility to parkinsonism.
Topics: Adult; Aged; Aged, 80 and over; Aging; Cerebral Infarction; Disease Susceptibility; Enkephalins; Female; Humans; Linear Models; Male; Middle Aged; Parkinson Disease; Polymerase Chain Reaction; Protein Precursors; Putamen; RNA, Messenger; Tachykinins; Transcription, Genetic | 1997 |
Topographical organization of opioid peptide precursor gene expression following repeated apomorphine treatment in the 6-hydroxydopamine-lesioned rat.
Topics: Animals; Apomorphine; Brain; Caudate Nucleus; Disease Models, Animal; Enkephalins; Gene Expression Regulation; In Situ Hybridization; Male; Motor Activity; Nucleus Accumbens; Organ Specificity; Oxidopamine; Parkinson Disease; Protein Precursors; Putamen; Rats; Rats, Sprague-Dawley; Reference Values; Time Factors | 1998 |
Phenotypical characterization of the neurons expressing the D1 and D2 dopamine receptors in the monkey striatum.
Topics: Animals; Corpus Striatum; Enkephalins; Glutamate Decarboxylase; Isoenzymes; Macaca fascicularis; Neurons; Parkinson Disease; Phenotype; Protein Precursors; Receptors, Dopamine D1; Receptors, Dopamine D2; RNA, Messenger; Substance P | 2000 |
Striatal enkephalin gene expression does not reflect parkinsonian signs.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Behavior, Animal; Cats; Caudate Nucleus; Corpus Striatum; Dopamine Agents; Enkephalins; Female; Gene Expression; Male; Motor Activity; Parkinson Disease; Parkinson Disease, Secondary; Protein Precursors; Recovery of Function; RNA, Messenger | 2000 |
L-DOPA produces strong induction of c-fos messenger RNA in dopamine-denervated cortical and striatal areas of the common marmoset.
Topics: Animals; Benzazepines; Blotting, Western; Callithrix; Cerebral Cortex; Corpus Striatum; Denervation; Disease Models, Animal; Dopamine; Dopamine Agents; Dopamine Antagonists; Enkephalins; Gene Expression; Genes, Immediate-Early; Levodopa; Nerve Degeneration; Oxidopamine; Parkinson Disease; Protein Precursors; Proto-Oncogene Proteins c-fos; Raclopride; Radioligand Assay; Receptors, Dopamine D1; Receptors, Dopamine D2; RNA, Messenger; Substance P; Substantia Nigra; Sympatholytics; Tritium | 2000 |
Interaction of enkephalin derivatives with reactive oxygen species.
Topics: Animals; Enkephalins; Free Radical Scavengers; Humans; Hydroxyl Radical; In Vitro Techniques; Lipid Peroxidation; Melanins; Oxidation-Reduction; Parkinson Disease; Peroxides; Reactive Oxygen Species; Superoxides | 2001 |
Increase of preproenkephalin mRNA levels in the putamen of Parkinson disease patients with levodopa-induced dyskinesias.
Topics: Age Factors; Aged; Aged, 80 and over; Antiparkinson Agents; Caudate Nucleus; Dyskinesia, Drug-Induced; Enkephalins; Humans; In Situ Hybridization; Levodopa; Parkinson Disease; Protein Precursors; Putamen; RNA, Messenger; Statistics as Topic | 2002 |
High-frequency stimulation of the subthalamic nucleus selectively reverses dopamine denervation-induced cellular defects in the output structures of the basal ganglia in the rat.
Topics: Animals; Basal Ganglia; Behavior, Animal; Corpus Striatum; Dopamine; Electric Stimulation; Electron Transport Complex IV; Enkephalins; Entopeduncular Nucleus; Globus Pallidus; Glutamate Decarboxylase; Isoenzymes; Male; Oxidopamine; Parkinson Disease; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; RNA, Messenger; Substance P; Substantia Nigra; Subthalamic Nucleus | 2002 |
Enkephalins and nigrostriatal function.
Topics: Animals; Apomorphine; Behavior, Animal; Dextroamphetamine; Endorphins; Enkephalins; Hydroxydopamines; Levodopa; Male; Naloxone; Parkinson Disease; Parkinson Disease, Secondary; Phenethylamines; Rats; Receptors, Opioid; Reserpine; Substantia Nigra | 1978 |
Dopamine dependent decrease in enkephalin and substance P levels in basal ganglia regions of postmortem parkinsonian brains.
Topics: Aged; Aged, 80 and over; Animals; Caudate Nucleus; Chromatography, High Pressure Liquid; Dopamine; Dynorphins; Enkephalins; Frontal Lobe; Humans; Male; Middle Aged; Parkinson Disease; Putamen; Radioimmunoassay; Rats; Serotonin; Substance P | 1991 |
Immunocytochemical studies on the basal ganglia and substantia nigra in Parkinson's disease and Huntington's chorea.
Topics: Adult; Aged; Aged, 80 and over; Basal Ganglia; Catecholamines; Cell Count; Enkephalins; Female; Humans; Huntington Disease; Immunohistochemistry; Male; Middle Aged; Parkinson Disease; Substance P; Substantia Nigra | 1988 |
Non-dopaminergic mechanisms in adrenal medullary transplantation for Parkinson's disease.
Topics: Adrenal Medulla; Enkephalins; Humans; Norepinephrine; Parkinson Disease; Pro-Opiomelanocortin | 1989 |
Dynorphin levels in parkinsonian patients: Leu5-enkephalin production from either proenkephalin A or prodynorphin in human brain.
Topics: Aged; Brain; Brain Chemistry; Dynorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Humans; Parkinson Disease; Protein Precursors | 1985 |
[Mechanism of PLG (L-prolyl-L-leucyl-glycinamide) in treating Parkinson's disease].
Topics: Animals; Caudate Nucleus; Drug Synergism; Enkephalins; Levodopa; MSH Release-Inhibiting Hormone; Parkinson Disease; Rats | 1985 |
Ultrastructural chemoanatomy of the basal ganglia: an overview.
Topics: Axons; Basal Ganglia; Corpus Striatum; Dendrites; Dopamine; Enkephalins; gamma-Aminobutyric Acid; Globus Pallidus; Glutamate Decarboxylase; Humans; Immunoenzyme Techniques; Interneurons; Parkinson Disease; Serotonin; Substantia Nigra; Tyrosine 3-Monooxygenase | 1987 |
Dopaminergic-peptidergic interactions in extrapyramidal disorders: a review of the clinical evidence.
Topics: Basal Ganglia; Brain; Dopamine; Enkephalins; Humans; Huntington Disease; MSH Release-Inhibiting Hormone; Neuropeptides; Parkinson Disease | 1987 |
The future role of neurosurgery in medicine.
Topics: Adrenal Medulla; beta-Endorphin; Cerebrovascular Disorders; Corpus Striatum; Electric Stimulation Therapy; Endorphins; Enkephalins; Forecasting; Humans; Microsurgery; Neurosurgery; Otosclerosis; Pain Management; Parkinson Disease; Serotonin; Stapes Mobilization; Stereotaxic Techniques | 1986 |
Regional distribution of mu, delta and kappa opioid receptors in human brains from controls and parkinsonian subjects.
Topics: Aged; Aged, 80 and over; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Etorphine; Humans; Kinetics; Oligopeptides; Parkinson Disease; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1987 |
Primate model of Parkinson's disease: alterations in multiple opioid systems in the basal ganglia.
Topics: Animals; Basal Ganglia; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Female; Macaca mulatta; Male; Nucleus Accumbens; Parkinson Disease; Protein Precursors; Substantia Nigra | 1984 |
Brain enkephalin receptors in Parkinson's disease.
Topics: Aged; Brain; Corpus Striatum; Enkephalin, Leucine; Enkephalin, Methionine; Female; Humans; Kinetics; Levodopa; Male; Naloxone; Nucleus Accumbens; Parkinson Disease; Receptors, Dopamine; Receptors, Opioid; Substantia Nigra | 1983 |
Parkinson's disease affects differently Met5- and Leu5-enkephalin in the human brain.
Topics: Brain; Brain Chemistry; Enkephalin, Leucine; Enkephalin, Methionine; Humans; Parkinson Disease; Reference Values; Tissue Distribution | 1983 |
Alterations in peptide levels in Parkinson's disease and incidental Lewy body disease.
Topics: Aged; Autopsy; Basal Ganglia; Brain Chemistry; Chromatography, High Pressure Liquid; Dopamine; Enkephalin, Leucine; Enkephalin, Methionine; Female; Humans; Male; Middle Aged; Parkinson Disease | 1996 |
[The concentration of homovanillic acid and leucine-enkephalin in the lumbar CSF of patients with Parkinson's disease before and after madopar treatment].
Topics: Adult; Aged; Benserazide; Carboxy-Lyases; Drug Combinations; Enkephalin, Leucine; Female; Homovanillic Acid; Humans; Hydrazines; Levodopa; Male; Middle Aged; Parkinson Disease | 1989 |
Mechanism of action of L-leucyl-glycinamide and its effect on Parkinson's disease.
Topics: Aged; Animals; Antiparkinson Agents; Brain; Enkephalin, Leucine; Female; Humans; Hydroxydopamines; Levodopa; Male; Middle Aged; MSH Release-Inhibiting Hormone; Oxidopamine; Parkinson Disease; Parkinson Disease, Secondary; Rats; Stereotyped Behavior | 1987 |
L-deprenyl in prevention of MPTP induced depletion of striatal enkephalins in mice.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Corpus Striatum; Disease Models, Animal; Enkephalin, Leucine; Enkephalin, Methionine; Male; Mice; Mice, Inbred C57BL; Parkinson Disease; Phenethylamines; Pyridines; Selegiline; Stereoisomerism | 1988 |