enkephalin, leucine and Idiopathic Parkinson Disease

enkephalin, leucine has been researched along with Idiopathic Parkinson Disease in 60 studies

Research

Studies (60)

TimeframeStudies, this research(%)All Research%
pre-199023 (38.33)18.7374
1990's7 (11.67)18.2507
2000's21 (35.00)29.6817
2010's7 (11.67)24.3611
2020's2 (3.33)2.80

Authors

AuthorsStudies
Abu-Rumeileh, S; Al Shweiki, MHDR; Barba, L; Barschke, P; Gaetani, L; Halbgebauer, S; Landwehrmeyer, GB; Lewerenz, J; Ludolph, AC; Oeckl, P; Otto, M; Paolini Paoletti, F; Parnetti, L; Steinacker, P1
Chen, H; Chen, L; Chen, XY; Xue, Y1
Ahn, S; Hong, S; Jang, J; Jeon, S; Jung, YR; Kim, J; Oh, JY; Park, HJ; Park, SU; Shin, HS; Song, MA; Song, TJ1
Frau, L; Morelli, M; Simola, N1
Capper-Loup, C; Kaelin-Lang, A; Paganetti, P; Sgroi, S1
Caron, MG; Gainetdinov, RR; Hallett, PJ; Isacson, O; Patterson, M; Reske-Nielsen, C; Sotnikova, TD; Vinuela, A1
Andrén, PE; Fälth, M; Kultima, K; Nilsson, A; Sköld, K; Svenningsson, P; Zhang, X1
Cenci, MA; Crossman, AR; Kobylecki, C; Ravenscroft, P1
Burdett, TC; Cassin, JJ; Chen, JF; Fredholm, BB; Healy, B; Schwarzschild, MA; Xiao, D1
Andersson, M; Bergquist, J; Fälth, M; Hanrieder, J; Ljungdahl, A; Mammo, SE1
Andersson, M; Bergquist, J; Fälth, M; Hanrieder, J; Ljungdahl, A1
Gołembiowska, K; Konieczny, J; Ossowska, K; Pilc, A; Wardas, J; Wolfarth, S1
Bezard, E; Brotchie, JM; Gross, CE1
Konieczny, J; Ossowska, K; Pietraszek, M; Wardas, J; Wolfarth, S1
Damier, P; Drapier, S1
Brotchie, JM; Crossman, AR; Duty, S; Fox, SH; Henry, B1
Ossowska, K; Pietraszek, M; Wardas, J; Wolfarth, S1
Landry, E; Lévesque, D; Rouillard, C; St-Hilaire, M1
Konieczny, J; Kuter, K; Ossowska, K; Pietraszek, M; Pilc, A; Wardas, J; Wolfarth, S1
Bourhis, E; Lévesque, D; Rouillard, C; St-Hilaire, M1
Alba, F; Banegas, I; Barrero, F; Durán, R; Luna, JD; Morales, B; Prieto, I; Ramírez, M; Vives, F1
Bäckman, CM; Hoffer, BJ; Shan, L; Tomac, AC; Zhang, Y1
Cao, X; Chen, Z; Guan, Q; Sun, S; Wang, L; Xu, Y1
Agid, Y; Cesselin, F; Javoy-Agid, F; Taquet, H1
Bouras, C; Constantinidis, J; Richard, J1
Rinne, UK1
Agnoli, A; D'Urso, R; Del Roscio, S; Falaschi, P; Frajese, G; Mearelli, S; Ruggieri, S1
Daniel, SE; Eve, DJ; Foster, OJ; Kingsbury, A; Lees, AJ; Marsden, CD; Nisbet, AP1
de Ceballos, ML; Fernandez, A; Jenner, P; Marsden, CD1
Nagane, Y; Saitoh, K; Tohgi, H; Utsugisawa, K; Yamagata, M; Yoshimura, M1
Brotchie, JM; Crossman, AR; Duty, S; Henry, B1
Dixon, AK; Freeman, TC; Gubitz, AK; Richardson, PJ1
Aubert, I; Bloch, B; Ghorayeb, I; Normand, E1
Damier, P; Féger, J; Hirsch, EC; Tremblay, L1
Schneider, JS; Schroeder, JA1
Andren, PE; Gunne, L; Svenningsson, P1
Blarzino, C; Coccia, R; De Marco, C; Foppoli, C; Rosei, MA1
Bédard, PJ; Birdi, S; Calon, F; Di Paolo, T; Hornykiewicz, O; Rajput, AH1
Forni, C; Kerkerian-Le Goff, L; Manrique, C; Salin, P1
Calne, DB; Chase, TN; Eisler, T; Nutt, JG; Rosin, AJ1
Borison, RL; Diamond, BI1
Sivam, SP1
Tan, MX1
Hunt, SP; Peck, R; Reynolds, GP; Rossor, M; Waters, CM1
Iacono, RP; Sandyk, R1
Agid, Y; Cesselin, F; Giraud, P; Javoy-Agid, F; Legrand, JC; Taquet, H1
Pan, JB1
Holstein, GR; Pasik, P; Pasik, T1
Gerstenbrand, F; Poewe, W1
Luyendijk, W1
Agid, Y; Delay-Goyet, P; Javoy-Agid, F; Roques, BP; Zajac, JM1
Sandyk, R1
Bannon, MJ; Helke, CJ; Jacobowitz, DM; Kopin, IJ; Skofitsch, G; Zamir, N1
Koskinen, V; Laakso, K; Lönnberg, P; Rinne, JK; Rinne, JO; Rinne, UK; Tenovuo, O1
Agid, Y; Cesselin, F; Hamon, M; Javoy-Agid, F; Legrand, JC; Taquet, H1
de Ceballos, ML; Fernandez, A; Jenner, P; Marsden, CD; Rose, S1
Agid, Y; Cesselin, F; Epelbaum, J; Javoy-Agid, F; Taquet, H1
Liu, DK1
Chen, SD; Pan, GB; Xu, DL; Yu, WC1
Sheng, JG; Xu, DL; Yu, HZ1

Reviews

11 review(s) available for enkephalin, leucine and Idiopathic Parkinson Disease

ArticleYear
The globus pallidus as a target for neuropeptides and endocannabinoids participating in central activities.
    Peptides, 2020, Volume: 124

    Topics: Animals; Endocannabinoids; Enkephalins; Globus Pallidus; Humans; Huntington Disease; Neuropeptides; Parkinson Disease; Substance P

2020
The role of striatal metabotropic glutamate receptors in Parkinson's disease.
    Amino acids, 2002, Volume: 23, Issue:1-3

    Topics: Animals; Antiparkinson Agents; Corpus Striatum; Enkephalins; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Humans; Ligands; Parkinson Disease; Protein Isoforms; Protein Precursors; Receptors, Metabotropic Glutamate

2002
Presymptomatic compensation in Parkinson's disease is not dopamine-mediated.
    Trends in neurosciences, 2003, Volume: 26, Issue:4

    Topics: Adaptation, Physiological; Animals; Basal Ganglia; Disease Progression; Dopamine; Enkephalins; Globus Pallidus; Humans; Models, Neurological; Parkinson Disease; Receptors, Dopamine D2; Substantia Nigra

2003
[Continuous subthalamic neurostimulation in Parkinson's disease. Indications and modalities].
    Presse medicale (Paris, France : 1983), 2003, Sep-06, Volume: 32, Issue:28

    Topics: Dopamine; Electric Stimulation Therapy; Electrodes, Implanted; Enkephalins; gamma-Aminobutyric Acid; Glutamic Acid; Humans; Magnetic Resonance Imaging; Parkinson Disease; Patient Selection; Perioperative Care; Referral and Consultation; Risk Factors; Severity of Illness Index; Stereotaxic Techniques; Substance P; Subthalamic Nucleus; Treatment Outcome

2003
An influence of ligands of metabotropic glutamate receptor subtypes on parkinsonian-like symptoms and the striatopallidal pathway in rats.
    Amino acids, 2007, Volume: 32, Issue:2

    Topics: Animals; Benzoates; Catalepsy; Corpus Striatum; Enkephalins; Excitatory Amino Acid Antagonists; Glutamates; Glycine; Haloperidol; Humans; Ligands; Parkinson Disease; Protein Precursors; Rats; Receptors, Metabotropic Glutamate; RNA, Messenger

2007
Putative peptide neurotransmitters in human neuropathology: a review of topography and clinical implications.
    Clinical neuropathology, 1983, Volume: 2, Issue:2

    Topics: Alzheimer Disease; Brain Mapping; Central Nervous System Diseases; Cholecystokinin; Enkephalins; Humans; Huntington Disease; Limbic System; Nerve Tissue Proteins; Neurotransmitter Agents; Parkinson Disease; Schizophrenia; Substance P; Substance-Related Disorders

1983
Adenosine receptor antagonists and Parkinson's disease: actions of the A2A receptor in the striatum.
    Advances in neurology, 1999, Volume: 80

    Topics: Acetylcholine; Animals; Behavior, Animal; Corpus Striatum; Enkephalins; gamma-Aminobutyric Acid; Gene Expression; Humans; Neurotransmitter Agents; Parkinson Disease; Protein Precursors; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Receptors, Purinergic P1; Substance P

1999
[Development of dyskinesias induced by treatment for Parkinson's disease: potential role of first exposure to L-DOPA (or phenomenon of priming)].
    Revue neurologique, 2000, Volume: 156, Issue:3

    Topics: Animals; Antiparkinson Agents; Biological Transport, Active; Corpus Striatum; Disease Models, Animal; Dyskinesia, Drug-Induced; Enkephalins; Haplorhini; Humans; Levodopa; Neural Pathways; Neuronal Plasticity; Neurons, Efferent; Parkinson Disease; Receptors, Dopamine D2; Substance P; Time Factors

2000
[Peptide neurotransmitters and extrapyramidal disorders].
    Zhonghua shen jing jing shen ke za zhi = Chinese journal of neurology and psychiatry, 1985, Volume: 18, Issue:4

    Topics: Animals; Basal Ganglia Diseases; Enkephalins; Humans; Huntington Disease; MSH Release-Inhibiting Hormone; Parkinson Disease; Substance P

1985
Enkephalinergic mechanisms in the "compensated" phase of Parkinson's disease.
    The International journal of neuroscience, 1988, Volume: 42, Issue:3-4

    Topics: Animals; Biomechanical Phenomena; Corpus Striatum; Dopamine; Enkephalins; Humans; Hypothalamus; Parkinson Disease

1988
Neuropeptides and Parkinson's disease.
    Progress in brain research, 1986, Volume: 66

    Topics: Animals; Brain; Enkephalin, Leucine; Enkephalin, Methionine; Hormones; Humans; Neuropeptides; Parkinson Disease; Somatostatin; Substance P

1986

Trials

1 trial(s) available for enkephalin, leucine and Idiopathic Parkinson Disease

ArticleYear
Effect of an opiate antagonist on movement disorders.
    Archives of neurology, 1978, Volume: 35, Issue:12

    Topics: Adult; Aged; Clinical Trials as Topic; Enkephalins; Humans; Huntington Disease; Middle Aged; Naloxone; Naltrexone; Parkinson Disease

1978

Other Studies

48 other study(ies) available for enkephalin, leucine and Idiopathic Parkinson Disease

ArticleYear
Cerebrospinal fluid levels of proenkephalin and prodynorphin are differentially altered in Huntington's and Parkinson's disease.
    Journal of neurology, 2022, Volume: 269, Issue:9

    Topics: Biomarkers; Chromatography, Liquid; Dopamine; Enkephalins; Humans; Huntington Disease; Parkinson Disease; Protein Precursors; Tandem Mass Spectrometry

2022
Effects of a combination treatment of KD5040 and
    BMC complementary and alternative medicine, 2017, Apr-19, Volume: 17, Issue:1

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Brain; Cyclic AMP Response Element-Binding Protein; Disease Models, Animal; Dopamine and cAMP-Regulated Phosphoprotein 32; Dyskinesia, Drug-Induced; Enkephalins; Extracellular Signal-Regulated MAP Kinases; Levodopa; Magnoliopsida; Male; Mice, Inbred C57BL; Movement; Parkinson Disease; Phytotherapy; Plant Extracts; Proto-Oncogene Proteins c-fos; Substance P

2017
Performance of movement in hemiparkinsonian rats influences the modifications induced by dopamine agonists in striatal efferent dynorphinergic neurons.
    Experimental neurology, 2013, Volume: 247

    Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Adrenergic Agents; Analysis of Variance; Animals; Apomorphine; Corpus Striatum; Disease Models, Animal; Dopamine Agonists; Dynorphins; Early Growth Response Protein 1; Enkephalins; Functional Laterality; Gene Expression Regulation; Male; Motor Neurons; Movement; Oxidopamine; Parkinson Disease; Rats; Rats, Sprague-Dawley; RNA, Messenger

2013
Enkephalin and dynorphin neuropeptides are differently correlated with locomotor hypersensitivity and levodopa-induced dyskinesia in parkinsonian rats.
    Experimental neurology, 2016, Volume: 280

    Topics: Analysis of Variance; Animals; Antiparkinson Agents; Disease Models, Animal; Dynorphins; Dyskinesia, Drug-Induced; Enkephalins; Female; Gene Expression Regulation; Levodopa; Oxidopamine; Parkinson Disease; Protein Precursors; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; RNA, Messenger; Statistics as Topic; Sympatholytics; Tyrosine 3-Monooxygenase

2016
Implanted reuptake-deficient or wild-type dopaminergic neurons improve ON L-dopa dyskinesias without OFF-dyskinesias in a rat model of Parkinson's disease.
    Brain : a journal of neurology, 2008, Volume: 131, Issue:Pt 12

    Topics: Animals; Antiparkinson Agents; Brain Tissue Transplantation; Corpus Striatum; Disease Models, Animal; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dyskinesia, Drug-Induced; Enkephalins; Female; Fetal Tissue Transplantation; Gene Expression Regulation; Graft Survival; Levodopa; Mesencephalon; Microdialysis; Neurons; Parkinson Disease; Protein Precursors; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, N-Methyl-D-Aspartate; RNA, Messenger

2008
Striatal alterations of secretogranin-1, somatostatin, prodynorphin, and cholecystokinin peptides in an experimental mouse model of Parkinson disease.
    Molecular & cellular proteomics : MCP, 2009, Volume: 8, Issue:5

    Topics: Amino Acid Sequence; Animals; Cholecystokinin; Chromogranin B; Disease Models, Animal; Enkephalins; Mice; Molecular Sequence Data; Neostriatum; Oxidopamine; Parkinson Disease; Peptides; Postmortem Changes; Protein Precursors; Reproducibility of Results; Somatostatin; Tissue Extracts; Tyrosine 3-Monooxygenase

2009
Calcium-permeable AMPA receptors are involved in the induction and expression of l-DOPA-induced dyskinesia in Parkinson's disease.
    Journal of neurochemistry, 2010, Volume: 114, Issue:2

    Topics: Adamantane; Animals; Antiparkinson Agents; Behavior, Animal; Benserazide; Brain; Calcium; Callithrix; Dyskinesia, Drug-Induced; Enkephalins; Levodopa; Male; Motor Activity; Oxidopamine; Parkinson Disease; Protein Precursors; Rats; Rats, Sprague-Dawley; Receptors, AMPA

2010
Deletion of adenosine A₁ or A(₂A) receptors reduces L-3,4-dihydroxyphenylalanine-induced dyskinesia in a model of Parkinson's disease.
    Brain research, 2011, Jan-07, Volume: 1367

    Topics: Adrenergic Agents; Animals; Antiparkinson Agents; Caffeine; Corpus Striatum; Disease Models, Animal; Dynorphins; Dyskinesia, Drug-Induced; Enkephalins; Gene Expression Regulation; Levodopa; Mice; Mice, Inbred C57BL; Mice, Knockout; Oxidopamine; Parkinson Disease; Protein Precursors; Purinergic P1 Receptor Antagonists; Receptor, Adenosine A1; Receptor, Adenosine A2A; RNA, Messenger; Statistics, Nonparametric; Time Factors

2011
L-DOPA-induced dyskinesia is associated with regional increase of striatal dynorphin peptides as elucidated by imaging mass spectrometry.
    Molecular & cellular proteomics : MCP, 2011, Volume: 10, Issue:10

    Topics: Animals; Antiparkinson Agents; Disease Models, Animal; Dynorphins; Dyskinesia, Drug-Induced; Enkephalins; Female; Humans; Levodopa; Mice; Neostriatum; Parkinson Disease; Protein Precursors; Rats; Rats, Sprague-Dawley; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

2011
Imaging mass spectrometry reveals elevated nigral levels of dynorphin neuropeptides in L-DOPA-induced dyskinesia in rat model of Parkinson's disease.
    PloS one, 2011, Volume: 6, Issue:9

    Topics: Animals; Dynorphins; Dyskinesias; Enkephalins; Female; Immunohistochemistry; Levodopa; Male; Mass Spectrometry; Mice; Mice, Knockout; Parkinson Disease; Protein Precursors; Rats; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

2011
The striopallidal pathway is involved in antiparkinsonian-like effects of the blockade of group I metabotropic glutamate receptors in rats.
    Neuroscience letters, 2003, May-15, Volume: 342, Issue:1-2

    Topics: Animals; Cataplexy; Corpus Striatum; Dopamine Antagonists; Enkephalins; Globus Pallidus; Haloperidol; Male; Neural Pathways; Parkinson Disease; Protein Precursors; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; RNA, Messenger

2003
Increased striatal pre-proenkephalin B expression is associated with dyskinesia in Parkinson's disease.
    Experimental neurology, 2003, Volume: 183, Issue:2

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Aged; Aged, 80 and over; Animals; Antiparkinson Agents; Corpus Striatum; Disease Models, Animal; Dyskinesia, Drug-Induced; Enkephalins; Female; Humans; Macaca mulatta; Male; Parkinson Disease; Parkinsonian Disorders; Protein Precursors; RNA, Messenger

2003
The role of metabotropic glutamate receptors in regulation of striatal proenkephalin expression: implications for the therapy of Parkinson's disease.
    Neuroscience, 2003, Volume: 122, Issue:3

    Topics: Animals; Corpus Striatum; Disease Models, Animal; Dopamine Antagonists; Drug Administration Routes; Drug Interactions; Enkephalins; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Haloperidol; In Situ Hybridization; Male; Parkinson Disease; Protein Precursors; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; RNA, Messenger

2003
Denervation and repeated L-DOPA induce complex regulatory changes in neurochemical phenotypes of striatal neurons: implication of a dopamine D1-dependent mechanism.
    Neurobiology of disease, 2005, Volume: 20, Issue:2

    Topics: Animals; Corpus Striatum; Denervation; Disease Models, Animal; DNA-Binding Proteins; Dopamine; Dopamine Antagonists; Dynorphins; Enkephalins; Excitatory Amino Acid Transporter 2; Gene Expression Regulation; Levodopa; Male; Neurons; Neurotensin; Nuclear Receptor Subfamily 4, Group A, Member 1; Parkinson Disease; Phenotype; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Receptors, Dopamine D1; Receptors, Dopamine D3; Receptors, Steroid; RNA, Messenger; Transcription Factors; Tyrosine 3-Monooxygenase

2005
Impaired behavioural and molecular adaptations to dopamine denervation and repeated L-DOPA treatment in Nur77-knockout mice.
    The European journal of neuroscience, 2006, Volume: 24, Issue:3

    Topics: Adaptation, Physiological; Animals; Antiparkinson Agents; Benserazide; Corpus Striatum; Denervation; Disease Models, Animal; DNA-Binding Proteins; Dopamine; Dopamine Agents; Drug Resistance; Enkephalins; Levodopa; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Neural Pathways; Neurotensin; Nuclear Receptor Subfamily 4, Group A, Member 1; Parkinson Disease; Receptors, Cytoplasmic and Nuclear; Receptors, Dopamine D3; Receptors, Steroid; Transcription Factors

2006
Plasma aminopeptidase activities in Parkinson's disease.
    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 2006, Volume: 38, Issue:11

    Topics: Aged; Aminopeptidases; Angiotensins; Cholecystokinin; Dopamine; Enkephalins; Female; Humans; Male; Middle Aged; Neurotensin; Parkinson Disease; Substance P; Vasopressins

2006
Alterations in prodynorphin, proenkephalin, and GAD67 mRNA levels in the aged human putamen: correlation with Parkinson's disease.
    Journal of neuroscience research, 2007, Volume: 85, Issue:4

    Topics: Adult; Age Factors; Aged; Aged, 80 and over; Enkephalins; Female; Gene Expression Regulation; Glutamate Decarboxylase; Humans; Isoenzymes; Male; Middle Aged; Parkinson Disease; Postmortem Changes; Protein Precursors; Putamen; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger

2007
Effect of antisense FosB and CREB on the expression of prodynorphin gene in rats with levodopa-induced dyskinesias.
    Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban, 2006, Volume: 26, Issue:5

    Topics: Animals; Corpus Striatum; Cyclic AMP Response Element-Binding Protein; Dyskinesia, Drug-Induced; Enkephalins; Female; Levodopa; Neurons; Oligonucleotides, Antisense; Parkinson Disease; Protein Precursors; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; RNA, Messenger

2006
Methionine-enkephalin deficiency in brains of patients with Parkinson's disease.
    Lancet (London, England), 1981, Jun-20, Volume: 1, Issue:8234

    Topics: Aged; Brain Chemistry; Dopamine; Endorphins; Enkephalins; Humans; Methionine; Parkinson Disease

1981
Recent advances in the treatment of Parkinson's disease.
    Acta neurologica Scandinavica. Supplementum, 1980, Volume: 78

    Topics: Brain; Bromocriptine; Drug Therapy, Combination; Endorphins; Enkephalins; Humans; Levodopa; Mental Disorders; Parkinson Disease; Receptors, Dopamine

1980
Are the enkephalins involved in Parkinson's disease? Clinical and neuroendocrine response to naloxone administration.
    Advances in biochemical psychopharmacology, 1980, Volume: 22

    Topics: Aged; Endorphins; Enkephalins; Female; Humans; Male; Middle Aged; Naloxone; Parkinson Disease; Prolactin; Time Factors

1980
Preproenkephalin and preprotachykinin messenger RNA expression in normal human basal ganglia and in Parkinson's disease.
    Neuroscience, 1995, Volume: 66, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Autoradiography; Basal Ganglia; Dopamine Agents; Enkephalins; Female; Gene Expression; Humans; Levodopa; Male; Middle Aged; Neostriatum; Parkinson Disease; Protein Precursors; RNA, Messenger; Sensitivity and Specificity; Tachykinins

1995
Neurotensin, substance P, delta and mu opioid receptors are decreased in basal ganglia of Parkinson's disease patients.
    Neuroscience, 1994, Volume: 61, Issue:1

    Topics: Adult; Aged; Amino Acid Sequence; Analgesics; Basal Ganglia; Biogenic Monoamines; Dopamine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Female; Humans; In Vitro Techniques; Male; Middle Aged; Molecular Sequence Data; Parkinson Disease; Receptors, Neurokinin-1; Receptors, Neurotensin; Receptors, Opioid, delta; Receptors, Opioid, mu

1994
Reduction in the ratio of beta-preprotachykinin to preproenkephalin messenger RNA expression in postmortem human putamen during aging and in patients with status lacunaris. Implications for the susceptibility to parkinsonism.
    Brain research, 1997, Sep-12, Volume: 768, Issue:1-2

    Topics: Adult; Aged; Aged, 80 and over; Aging; Cerebral Infarction; Disease Susceptibility; Enkephalins; Female; Humans; Linear Models; Male; Middle Aged; Parkinson Disease; Polymerase Chain Reaction; Protein Precursors; Putamen; RNA, Messenger; Tachykinins; Transcription, Genetic

1997
Topographical organization of opioid peptide precursor gene expression following repeated apomorphine treatment in the 6-hydroxydopamine-lesioned rat.
    Experimental neurology, 1998, Volume: 150, Issue:2

    Topics: Animals; Apomorphine; Brain; Caudate Nucleus; Disease Models, Animal; Enkephalins; Gene Expression Regulation; In Situ Hybridization; Male; Motor Activity; Nucleus Accumbens; Organ Specificity; Oxidopamine; Parkinson Disease; Protein Precursors; Putamen; Rats; Rats, Sprague-Dawley; Reference Values; Time Factors

1998
Phenotypical characterization of the neurons expressing the D1 and D2 dopamine receptors in the monkey striatum.
    The Journal of comparative neurology, 2000, Feb-28, Volume: 418, Issue:1

    Topics: Animals; Corpus Striatum; Enkephalins; Glutamate Decarboxylase; Isoenzymes; Macaca fascicularis; Neurons; Parkinson Disease; Phenotype; Protein Precursors; Receptors, Dopamine D1; Receptors, Dopamine D2; RNA, Messenger; Substance P

2000
Striatal enkephalin gene expression does not reflect parkinsonian signs.
    Neuroreport, 2000, Jun-26, Volume: 11, Issue:9

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Behavior, Animal; Cats; Caudate Nucleus; Corpus Striatum; Dopamine Agents; Enkephalins; Female; Gene Expression; Male; Motor Activity; Parkinson Disease; Parkinson Disease, Secondary; Protein Precursors; Recovery of Function; RNA, Messenger

2000
L-DOPA produces strong induction of c-fos messenger RNA in dopamine-denervated cortical and striatal areas of the common marmoset.
    Neuroscience, 2000, Volume: 99, Issue:3

    Topics: Animals; Benzazepines; Blotting, Western; Callithrix; Cerebral Cortex; Corpus Striatum; Denervation; Disease Models, Animal; Dopamine; Dopamine Agents; Dopamine Antagonists; Enkephalins; Gene Expression; Genes, Immediate-Early; Levodopa; Nerve Degeneration; Oxidopamine; Parkinson Disease; Protein Precursors; Proto-Oncogene Proteins c-fos; Raclopride; Radioligand Assay; Receptors, Dopamine D1; Receptors, Dopamine D2; RNA, Messenger; Substance P; Substantia Nigra; Sympatholytics; Tritium

2000
Interaction of enkephalin derivatives with reactive oxygen species.
    Biochimica et biophysica acta, 2001, Feb-16, Volume: 1525, Issue:1-2

    Topics: Animals; Enkephalins; Free Radical Scavengers; Humans; Hydroxyl Radical; In Vitro Techniques; Lipid Peroxidation; Melanins; Oxidation-Reduction; Parkinson Disease; Peroxides; Reactive Oxygen Species; Superoxides

2001
Increase of preproenkephalin mRNA levels in the putamen of Parkinson disease patients with levodopa-induced dyskinesias.
    Journal of neuropathology and experimental neurology, 2002, Volume: 61, Issue:2

    Topics: Age Factors; Aged; Aged, 80 and over; Antiparkinson Agents; Caudate Nucleus; Dyskinesia, Drug-Induced; Enkephalins; Humans; In Situ Hybridization; Levodopa; Parkinson Disease; Protein Precursors; Putamen; RNA, Messenger; Statistics as Topic

2002
High-frequency stimulation of the subthalamic nucleus selectively reverses dopamine denervation-induced cellular defects in the output structures of the basal ganglia in the rat.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002, Jun-15, Volume: 22, Issue:12

    Topics: Animals; Basal Ganglia; Behavior, Animal; Corpus Striatum; Dopamine; Electric Stimulation; Electron Transport Complex IV; Enkephalins; Entopeduncular Nucleus; Globus Pallidus; Glutamate Decarboxylase; Isoenzymes; Male; Oxidopamine; Parkinson Disease; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; RNA, Messenger; Substance P; Substantia Nigra; Subthalamic Nucleus

2002
Enkephalins and nigrostriatal function.
    Neurology, 1978, Volume: 28, Issue:11

    Topics: Animals; Apomorphine; Behavior, Animal; Dextroamphetamine; Endorphins; Enkephalins; Hydroxydopamines; Levodopa; Male; Naloxone; Parkinson Disease; Parkinson Disease, Secondary; Phenethylamines; Rats; Receptors, Opioid; Reserpine; Substantia Nigra

1978
Dopamine dependent decrease in enkephalin and substance P levels in basal ganglia regions of postmortem parkinsonian brains.
    Neuropeptides, 1991, Volume: 18, Issue:4

    Topics: Aged; Aged, 80 and over; Animals; Caudate Nucleus; Chromatography, High Pressure Liquid; Dopamine; Dynorphins; Enkephalins; Frontal Lobe; Humans; Male; Middle Aged; Parkinson Disease; Putamen; Radioimmunoassay; Rats; Serotonin; Substance P

1991
Immunocytochemical studies on the basal ganglia and substantia nigra in Parkinson's disease and Huntington's chorea.
    Neuroscience, 1988, Volume: 25, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Basal Ganglia; Catecholamines; Cell Count; Enkephalins; Female; Humans; Huntington Disease; Immunohistochemistry; Male; Middle Aged; Parkinson Disease; Substance P; Substantia Nigra

1988
Non-dopaminergic mechanisms in adrenal medullary transplantation for Parkinson's disease.
    The International journal of neuroscience, 1989, Volume: 45, Issue:3-4

    Topics: Adrenal Medulla; Enkephalins; Humans; Norepinephrine; Parkinson Disease; Pro-Opiomelanocortin

1989
Dynorphin levels in parkinsonian patients: Leu5-enkephalin production from either proenkephalin A or prodynorphin in human brain.
    Brain research, 1985, Aug-26, Volume: 341, Issue:2

    Topics: Aged; Brain; Brain Chemistry; Dynorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Humans; Parkinson Disease; Protein Precursors

1985
[Mechanism of PLG (L-prolyl-L-leucyl-glycinamide) in treating Parkinson's disease].
    Zhonghua shen jing jing shen ke za zhi = Chinese journal of neurology and psychiatry, 1985, Volume: 18, Issue:4

    Topics: Animals; Caudate Nucleus; Drug Synergism; Enkephalins; Levodopa; MSH Release-Inhibiting Hormone; Parkinson Disease; Rats

1985
Ultrastructural chemoanatomy of the basal ganglia: an overview.
    Advances in neurology, 1987, Volume: 45

    Topics: Axons; Basal Ganglia; Corpus Striatum; Dendrites; Dopamine; Enkephalins; gamma-Aminobutyric Acid; Globus Pallidus; Glutamate Decarboxylase; Humans; Immunoenzyme Techniques; Interneurons; Parkinson Disease; Serotonin; Substantia Nigra; Tyrosine 3-Monooxygenase

1987
Dopaminergic-peptidergic interactions in extrapyramidal disorders: a review of the clinical evidence.
    Advances in neurology, 1987, Volume: 45

    Topics: Basal Ganglia; Brain; Dopamine; Enkephalins; Humans; Huntington Disease; MSH Release-Inhibiting Hormone; Neuropeptides; Parkinson Disease

1987
The future role of neurosurgery in medicine.
    Neurosurgical review, 1986, Volume: 9, Issue:1-2

    Topics: Adrenal Medulla; beta-Endorphin; Cerebrovascular Disorders; Corpus Striatum; Electric Stimulation Therapy; Endorphins; Enkephalins; Forecasting; Humans; Microsurgery; Neurosurgery; Otosclerosis; Pain Management; Parkinson Disease; Serotonin; Stapes Mobilization; Stereotaxic Techniques

1986
Regional distribution of mu, delta and kappa opioid receptors in human brains from controls and parkinsonian subjects.
    Brain research, 1987, Jun-23, Volume: 414, Issue:1

    Topics: Aged; Aged, 80 and over; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Etorphine; Humans; Kinetics; Oligopeptides; Parkinson Disease; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu

1987
Primate model of Parkinson's disease: alterations in multiple opioid systems in the basal ganglia.
    Brain research, 1984, Nov-26, Volume: 322, Issue:2

    Topics: Animals; Basal Ganglia; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Female; Macaca mulatta; Male; Nucleus Accumbens; Parkinson Disease; Protein Precursors; Substantia Nigra

1984
Brain enkephalin receptors in Parkinson's disease.
    Journal of neural transmission. Supplementum, 1983, Volume: 19

    Topics: Aged; Brain; Corpus Striatum; Enkephalin, Leucine; Enkephalin, Methionine; Female; Humans; Kinetics; Levodopa; Male; Naloxone; Nucleus Accumbens; Parkinson Disease; Receptors, Dopamine; Receptors, Opioid; Substantia Nigra

1983
Parkinson's disease affects differently Met5- and Leu5-enkephalin in the human brain.
    Brain research, 1983, Dec-05, Volume: 280, Issue:2

    Topics: Brain; Brain Chemistry; Enkephalin, Leucine; Enkephalin, Methionine; Humans; Parkinson Disease; Reference Values; Tissue Distribution

1983
Alterations in peptide levels in Parkinson's disease and incidental Lewy body disease.
    Brain : a journal of neurology, 1996, Volume: 119 ( Pt 3)

    Topics: Aged; Autopsy; Basal Ganglia; Brain Chemistry; Chromatography, High Pressure Liquid; Dopamine; Enkephalin, Leucine; Enkephalin, Methionine; Female; Humans; Male; Middle Aged; Parkinson Disease

1996
[The concentration of homovanillic acid and leucine-enkephalin in the lumbar CSF of patients with Parkinson's disease before and after madopar treatment].
    Zhonghua shen jing jing shen ke za zhi = Chinese journal of neurology and psychiatry, 1989, Volume: 22, Issue:2

    Topics: Adult; Aged; Benserazide; Carboxy-Lyases; Drug Combinations; Enkephalin, Leucine; Female; Homovanillic Acid; Humans; Hydrazines; Levodopa; Male; Middle Aged; Parkinson Disease

1989
Mechanism of action of L-leucyl-glycinamide and its effect on Parkinson's disease.
    Advances in neurology, 1987, Volume: 45

    Topics: Aged; Animals; Antiparkinson Agents; Brain; Enkephalin, Leucine; Female; Humans; Hydroxydopamines; Levodopa; Male; Middle Aged; MSH Release-Inhibiting Hormone; Oxidopamine; Parkinson Disease; Parkinson Disease, Secondary; Rats; Stereotyped Behavior

1987
L-deprenyl in prevention of MPTP induced depletion of striatal enkephalins in mice.
    Chinese medical journal, 1988, Volume: 101, Issue:4

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Corpus Striatum; Disease Models, Animal; Enkephalin, Leucine; Enkephalin, Methionine; Male; Mice; Mice, Inbred C57BL; Parkinson Disease; Phenethylamines; Pyridines; Selegiline; Stereoisomerism

1988