enkephalin, leucine has been researched along with Glial Cell Tumors in 110 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 66 (60.00) | 18.7374 |
| 1990's | 41 (37.27) | 18.2507 |
| 2000's | 2 (1.82) | 29.6817 |
| 2010's | 1 (0.91) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ammer, H; Eisinger, DA; Heiss, A | 1 |
| An, L; Han, R; Kang, X; Wang, B; Yang, C | 1 |
| Brandt, M; Buchen, C; Hamprecht, B | 1 |
| Hamprecht, B; Propst, F | 1 |
| Kimura, S; Lewis, RV; Rossier, J; Stein, S; Stern, AS; Udenfriend, S | 1 |
| Ferrara, P; Hammonds, RG; Li, CH | 2 |
| Hullihan, J; Jones, BN; Kilpatrick, DL; Kimura, S; Shively, JE; Stein, S; Stern, AS; Taniguchi, T; Udenfriend, S | 1 |
| Brandt, M; Hamprecht, B; Löffler, F; Propst, F; van Calker, D | 1 |
| Glaser, T; Hamprecht, B; Hübner, K | 3 |
| Blume, AJ; Fantozzi, R; Mullikin-Kilpatrick, D | 1 |
| de Castiglione, R; Glaser, T; Hamprecht, B; Hübner, K | 1 |
| Dornay, M; Simantov, R | 1 |
| Koehler, JE; Law, PY; Loh, HH | 1 |
| Costa, T; Krumins, SA; Munson, PJ; Rodbard, D; Shimohigashi, Y | 1 |
| Baram, D; Simantov, R | 1 |
| Costa, T; Krumins, SA; Rodbard, D | 1 |
| Baram, D; Levy, R; Simantov, R | 1 |
| Blume, AJ; Larsen, NE; Mullikin-Kilpatrick, D | 1 |
| Costa, T; Gramsch, C; Wüster, M | 1 |
| Akiyama, K; Burks, TF; Galligan, JJ; Gee, K; Hruby, VJ; Hurst, R; Mosberg, HI; Yamamura, HI | 1 |
| Dawson, G; Lockney, MW; Scheideler, MA | 1 |
| Deslauriers, R; Griffith, DW; Jarrell, HC; McGregor, WH; Smith, IC | 1 |
| Dawson, G; McLawhon, R; Miller, RJ | 1 |
| Fukuda, K; Higashida, H; Kato, S; Mori, K; Morikawa, H | 1 |
| Kushner, L; Tamir, M | 1 |
| Graeser, D; Neubig, RR | 1 |
| Jin, W; Lee, NM; Loh, HH; Thayer, SA | 2 |
| Kondo, Y; Okajima, F; Tomura, H | 2 |
| Han, JS; Ren, MF; Shun, XJ; Wang, JF; Yang, HF | 1 |
| Bachelot, T; Benabid, AL; Berger, FR; Brunet, JF; Gustin, T; Molin, LF; Verna, JM | 1 |
| Cai, Y; Pei, G; Wu, Y; Zhang, Y | 1 |
| Lambert, DG; Smart, D | 1 |
| Burks, TF; Hruby, VJ; Roerig, SC; Rosenfeld, GC; Williams, CL | 1 |
| Feigenbaum, JJ; Simantov, R | 1 |
| Fujimoto, J; Ho, BY; Holmes, BB; Zhao, J | 1 |
| Cai, YC; Cheng, ZJ; Fan, GH; Jiang, LZ; Ma, L; Pei, G | 1 |
| Breivogel, CS; Childers, SR; Selley, DE | 1 |
| Cai, YC; Fan, GH; Jiang, LZ; Ma, L; Pei, G; Zhao, J | 1 |
| Dave, HP; Fu, W; Hilt, DC; Jiang, H; Joshi, JB; Shah, SR | 1 |
| Lou, LG; Pei, G | 1 |
| Akil, H; Clark, MJ; Emmerson, PJ; Mansour, A; Medzihradsky, F; Portoghese, PS; Remmers, AE; Woods, JH | 1 |
| Murphy, J; Schulz, K; Schulz, R; Wehmeyer, A | 1 |
| Clark, MJ; Emmerson, PJ; Medzihradsky, F; Remmers, AE | 1 |
| Gomes, I; Gupta, A; Sharma, SK; Singh, SP | 1 |
| Ma, L; Pei, G; Wu, GX; Xin, SM; Zhang, WB; Zhang, Z | 1 |
| Wand, G; Yang, X | 1 |
| Brandt, M; Glaser, T; Hamprecht, B; Klebensberger, W; Traber, J | 1 |
| Blume, AJ | 1 |
| Gerber, LD; Rubinstein, M; Stein, S; Udenfriend, S; Wideman, J | 1 |
| Chang, KJ; Cuatrecasas, P; Miller, RJ | 1 |
| Blume, AJ; Boone, G; Lichtshtein, D | 1 |
| Fox, CF; Lee, TT; Williams, RE | 1 |
| Howells, RD; Yin, J | 1 |
| Law, PY; Loh, HH; Roerig, SC | 1 |
| Hawkins, PT; Jackson, TR; Poyner, DR | 1 |
| Costa, EM; Hoffman, BB; Loew, GH | 1 |
| Howells, RD; Lee, JA; Yin, J | 1 |
| Casey, G; Gubits, RM; Munell, F; Vitek, MP; Yu, H | 1 |
| Bieck, PR; Eiring, A; Howells, RD; Manier, DH; Sulser, F | 1 |
| Joshi, J; Sabol, SL | 1 |
| Chu, HM; Comb, MJ; Kobierski, LA; Tan, Y | 1 |
| Bykov, V; George, C; Jacobson, AE; Kim, CH; Klee, WA; Long, JB; Mattson, MV; Rice, KC; Rothman, RB; Streaty, RA | 1 |
| Bidlack, JM; Selley, DE | 1 |
| Krumins, SA | 1 |
| Bidlack, JM; O'Malley, WE; Schulz, R | 1 |
| Sabol, SL; Yoshikawa, K | 2 |
| Delay-Goyet, P; Foucaud, B; Rigaudy, P; Roques, BP; Zajac, JM | 1 |
| Akiyama, K; Gee, KW; Hruby, VJ; Mosberg, HI; Yamamura, HI | 1 |
| Kurose, H; Ui, M | 1 |
| Brown, SR; Cote, TE; Cox, BM; Puttfarcken, P; Werling, LL | 1 |
| Schwartz, JP | 1 |
| Aktories, K; Costa, T; Jakobs, KH; Wüster, M | 1 |
| Barg, J; Levy, R; Simantov, R | 1 |
| Griffin, MT; Law, PY; Loh, HH | 1 |
| Costa, T; Wüster, M | 1 |
| Braas, KM; Childers, SR; U'Prichard, DC | 1 |
| Moses, MA; Snell, CR | 2 |
| Hom, DS; Law, PY; Loh, HH | 2 |
| Chueh, SH; Liu, TY; Song, SL | 1 |
| Kozloba, MV; Slepko, NG | 1 |
| Kentroti, S; Kozlova, M; Vernadakis, A | 1 |
| Belardetti, F; Gutowski, S; Sternweis, PC; Wilk-Blaszczak, MA | 1 |
| Armelin, MC; Camargo, AC; Ferro, ES; Gobersztejn, F; Gomes, MD; Kipnis, TL; Sucupira, M; Tambourgi, DV | 1 |
| Dragatsis, I; Georgoussi, Z; Konidakis, G; Megaritis, G; Merkouris, M; Milligan, G; Zioudrou, C | 1 |
| Campana, G; Di Toro, R; Murari, G; Sciarretta, V; Spampinato, S | 1 |
| McKenzie, FR; Milligan, G | 1 |
| Dawson, G; Scheideler, MA | 1 |
| Narahashi, T; Tsunoo, A; Yoshii, M | 1 |
| Hescheler, J; Rosenthal, W; Schultz, G; Tang, M; Trautwein, W; Wulfern, M; Yajima, M | 1 |
| Costa, T; Lang, J | 1 |
| Costa, T; Herz, A | 1 |
| Costa, T; Klinz, FJ | 1 |
| Costa, T; Herz, A; Vachon, L | 1 |
| Law, PY; Loh, HH; Louie, AK; Zhan, JN | 1 |
| Magee, AI; Milligan, G; Mullaney, I; Unson, CG | 1 |
| Krumins, SA; Rodbard, D | 1 |
| Burke, TR; Costa, T; Cruciani, RA; Jacobson, AE; Krumins, SA; Lutz, RA; Rice, KC; Rodbard, D | 1 |
| Costa, T; Gramsch, C; Herz, A; Wüster, M | 1 |
| Grandt, R; Greiner, C; Jakobs, KH; Zubin, P | 1 |
| Charness, ME; Diamond, I; Querimit, LA | 1 |
| Klein, C; Levy, R; Simantov, R | 1 |
| Greenspan, DL; Musacchio, JM | 1 |
2 review(s) available for enkephalin, leucine and Glial Cell Tumors
| Article | Year |
|---|---|
Involvement of sulfhydryl groups in the functional integrity of the opiate receptors of neuroblastoma x glioma hybrid NG108-15.
Topics: Animals; Enkephalins; Ethylmaleimide; Glioma; Hybrid Cells; Kinetics; Mice; Neoplasms, Experimental; Neuroblastoma; Rats; Receptors, Opioid; Sulfhydryl Compounds | 1983 |
The opioid-induced desensitization (tolerance) in neuroblastoma x glioma NG 108-15 hybrid cells: results from receptor uncoupling.
Topics: Animals; Bacterial Toxins; Carbachol; Cell Membrane; Cyclic AMP; Drug Tolerance; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Glioma; Hybrid Cells; Mice; Naloxone; Narcotics; Neuroblastoma; Norepinephrine; Prostaglandins E; Rats; Receptors, Opioid; Virulence Factors, Bordetella | 1984 |
1 trial(s) available for enkephalin, leucine and Glial Cell Tumors
| Article | Year |
|---|---|
Effects of combining electroacupuncture with general anesthesia induced by sevoflurane in patients undergoing supratentorial craniotomy and improvements in their clinical recovery profile & blood enkephalin.
Topics: Acupuncture Points; Adult; Anesthesia, General; Anesthetics, Inhalation; Craniotomy; Electroacupuncture; Enkephalins; Female; Glioma; Humans; Male; Methyl Ethers; Middle Aged; Sevoflurane; Supratentorial Neoplasms | 2012 |
107 other study(ies) available for enkephalin, leucine and Glial Cell Tumors
| Article | Year |
|---|---|
delta-Opioid receptor-stimulated Akt signaling in neuroblastoma x glioma (NG108-15) hybrid cells involves receptor tyrosine kinase-mediated PI3K activation.
Topics: Cell Line, Tumor; Cell Survival; Cytoprotection; Enkephalins; Enzyme Activation; Etorphine; Glioma; Glycogen Synthase Kinase 3; GTP-Binding Protein alpha Subunits, Gi-Go; GTP-Binding Protein beta Subunits; GTP-Binding Protein gamma Subunits; Humans; Hybrid Cells; Insulin-Like Growth Factor I; Neuroblastoma; Nuclear Envelope; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Transport; Proto-Oncogene Proteins c-akt; Receptor Protein-Tyrosine Kinases; Receptors, Nerve Growth Factor; Receptors, Opioid, delta; Signal Transduction; Transcriptional Activation | 2009 |
Relationship between the actions of calcium ions, opiods, and prostaglandin E1 on the level of cyclic AMP in neuroblastoma x glioma hybrid cells.
Topics: Animals; Calcium; Cell Line; Cholera Toxin; Cyclic AMP; Dose-Response Relationship, Drug; Egtazic Acid; Endorphins; Enkephalins; Glioma; Hybrid Cells; Kinetics; Mice; Neuroblastoma; Prostaglandins E | 1980 |
Opioids, noradrenaline and GTP analogs inhibit cholera toxin activated adenylate cyclase in neuroblastoma x glioma hybrid cells.
Topics: Adenylyl Cyclases; Animals; Cell Line; Cholera Toxin; Clone Cells; Diphosphonates; Endorphins; Enkephalin, Methionine; Enkephalins; Glioma; Guanosine Monophosphate; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Hybrid Cells; Kinetics; Mice; Morphine; Neuroblastoma; Norepinephrine; Rats | 1981 |
Opioid hexapeptides and heptapeptides in adrenal medulla and brain possible implications on the biosynthesis of enkephalins.
Topics: Adrenal Medulla; Amino Acids; Animals; Brain Chemistry; Cattle; Cell Line; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Glioma; Hybrid Cells; Neuroblastoma; Receptors, Opioid | 1980 |
beta-Endorphin: characteristics of binding sites in a neuroblastoma--glioma hybrid cell.
Topics: Animals; Cell Line; Endorphins; Enkephalins; Glioma; Kinetics; Ligands; Neoplasms, Experimental; Neuroblastoma; Phospholipids; Rats; Receptors, Opioid; Structure-Activity Relationship | 1981 |
A highly potent 3200-dalton adrenal opioid peptide that contains both a [Met]- and [Leu]enkephalin sequence.
Topics: Adrenal Medulla; Amino Acid Sequence; Animals; Biological Assay; Cattle; Cell Line; Chromaffin Granules; Chromaffin System; Endorphins; Enkephalins; Glioma; Guinea Pigs; Ileum; Mice; Molecular Weight; Muscle Contraction; Neuroblastoma; Receptors, Opioid | 1981 |
Regulation by neurohormones of cyclic AMP concentration in cells derived from the nervous system.
Topics: Acetylcholine; Animals; Brain; Calcium; Cations; Cell Line; Cells, Cultured; Cyclic AMP; Enkephalin, Leucine; Enkephalins; Glioma; Guanine Nucleotides; Hybrid Cells; Mice; Narcotics; Neuroblastoma; Norepinephrine; Rats; Sodium | 1981 |
Glucocorticoids elevate the level of enkephalin-like peptides in neuroblastoma x glioma hybrid cells.
Topics: Alprostadil; Animals; Chromatography, High Pressure Liquid; Cyclic AMP; Dexamethasone; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Glioma; Glucocorticoids; Hybrid Cells; Naloxone; Neuroblastoma; Prostaglandins E | 1981 |
Irreversible inactivation of the opiate receptors in the neuroblastoma x glioma hybrid NG108-15 by chlornaltrexamine.
Topics: Animals; Cyclic AMP; Enkephalin, Methionine; Enkephalins; Glioma; Hybrid Cells; Mice; Naloxone; Naltrexone; Neoplasms, Experimental; Neuroblastoma; Nitrogen Mustard Compounds; Prostaglandins E, Synthetic; Rats; Receptors, Opioid | 1981 |
Dermorphins, opioid peptides from amphibian skin, act on opioid receptors of mouse neuroblastoma x rat glioma hybrid cells.
Topics: Amphibians; Animals; Binding, Competitive; Cell Line; Enkephalin, Leucine; Enkephalins; Glioma; Hybrid Cells; Kinetics; Mice; Neuroblastoma; Oligopeptides; Opioid Peptides; Rats; Receptors, Opioid; Structure-Activity Relationship | 1981 |
Opiate receptors from different tissue sources: solubilization and characterization.
Topics: Animals; Brain; Cell Line; Cerebral Cortex; Enkephalin, Methionine; Enkephalins; Glioma; Hybridomas; Hypothalamus; Male; Mice; Neuroblastoma; Rats; Rats, Inbred Strains; Receptors, Opioid; Solubility; Thalamus | 1982 |
Neuroblastoma X glioma hybrid cells synthesize enkephalin-like opioid peptides.
Topics: Alprostadil; Animals; Cell Line; Cyclic AMP; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Glioma; Hybrid Cells; Mice; Naloxone; Neuroblastoma; Oxidation-Reduction; Prostaglandins E; Rats | 1982 |
Comparison of opiate inhibition of adenylate cyclase activity in neuroblastoma N18tG2 and neuroblastoma x glioma NG108-15 hybrid cell lines.
Topics: Adenylyl Cyclase Inhibitors; Animals; Cell Line; Cyclic AMP; Enkephalins; Glioma; Guanosine Triphosphate; Hybrid Cells; Kinetics; Mice; Narcotics; Neoplasms, Experimental; Neuroblastoma; Rats; Receptors, Opioid | 1982 |
Differential effects of GTP and cations on binding of labeled dimeric and monomeric enkephalins to neuroblastoma-glioma cell delta opiate receptors.
Topics: Animals; Binding, Competitive; Cell Line; Enkephalins; Glioma; Guanosine Triphosphate; Hybrid Cells; Kinetics; Macromolecular Substances; Manganese; Mice; Neuroblastoma; Rats; Receptors, Opioid; Receptors, Opioid, delta; Sodium | 1982 |
Enkephalins and opiate antagonists control calmodulin distribution in neuroblastoma-glioma cells.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Calcium-Binding Proteins; Calmodulin; Cell Line; Enkephalins; Glioma; Hybrid Cells; Kinetics; Mice; Narcotic Antagonists; Neuroblastoma; Rats; Receptors, Opioid; Subcellular Fractions | 1983 |
Enkephalin dimers: regulation of cyclic AMP levels in NG108-15 cells.
Topics: Alprostadil; Animals; Cyclic AMP; Enkephalins; Glioma; Hybrid Cells; Kinetics; Mice; Neuroblastoma; Prostaglandins E; Rats; Structure-Activity Relationship | 1983 |
Down regulation of enkephalin (delta) receptors. Demonstration in membrane-bound and solubilized receptors.
Topics: Alkaloids; Animals; Drug Tolerance; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Etorphine; Glioma; Hybrid Cells; In Vitro Techniques; Morphine; Neuroblastoma; Rats; Receptors, Opioid; Solubility | 1982 |
Uncoupling of receptors is essential for opiate-induced desensitization (tolerance) in neuroblastoma x glioma hybrid cells NG 108-15.
Topics: Animals; Cell Line; Enkephalins; Glioma; Hybrid Cells; Kinetics; Mice; Narcotics; Neuroblastoma; Norepinephrine; Rats; Receptors, Opioid | 1983 |
Cyclic penicillamine containing enkephalin analogs display profound delta receptor selectivities.
Topics: Animals; Brain; Cell Line; Cell Membrane; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Glioma; Guinea Pigs; Hybrid Cells; Ileum; Male; Mice; Muscle Contraction; Neuroblastoma; Rats; Receptors, Opioid; Receptors, Opioid, delta; Structure-Activity Relationship; Vas Deferens | 1983 |
Cell-cycle dependence of a ganglioside glycosyltransferase activity and its inhibition by enkephalin in a neurotumor cell line.
Topics: Animals; Cell Cycle; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; G(M2) Ganglioside; G(M3) Ganglioside; Galactosyltransferases; Gangliosides; Glioma; Hybrid Cells; Kinetics; Mice; N-Acetylgalactosaminyltransferases; Neuroblastoma; Rats | 1984 |
Production and regulation of enkephalin-like peptides in neuroblastoma x glioma cells.
Topics: Cells, Cultured; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Glioma; Humans; Hybrid Cells; Neoplasms, Experimental; Neuroblastoma; Steroids | 1982 |
Degradation of enkephalin and enkephalinamide by neuroblastoma x glioma hybrid cells as studied by 13C n.m.r.
Topics: Cell Membrane; Chromatography, Thin Layer; Endorphins; Enkephalin, Methionine; Enkephalins; Glioma; Humans; Hybrid Cells; Magnetic Resonance Spectroscopy; Neuroblastoma; Puromycin; Trypsin | 1980 |
Inhibition of sialoglycosphingolipid (ganglioside) biosynthesis in mouse clonal lines N4TG1 and NG108-15 by beta-endorphin, enkephalins, and opiates.
Topics: Animals; Cell Line; Endorphins; Enkephalins; Galactosamine; Galactose; Gangliosides; Glioma; Glucosamine; Glycosphingolipids; Hybrid Cells; Kinetics; Mice; Morphine; Naloxone; Narcotics; Neuroblastoma | 1980 |
Coupling of the cloned mu-opioid receptor with the omega-conotoxin-sensitive Ca2+ current in NG108-15 cells.
Topics: Animals; Calcium Channels; Cloning, Molecular; DNA, Complementary; Electric Conductivity; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Gene Expression; Glioma; GTP-Binding Proteins; Hybrid Cells; Neuroblastoma; omega-Conotoxin GVIA; Peptides; Pertussis Toxin; Rats; Receptors, Opioid, mu; Transfection; Tumor Cells, Cultured; Virulence Factors, Bordetella | 1995 |
Expression of functional delta opioid receptors in Xenopus oocytes.
Topics: Adenylyl Cyclases; Analgesics; Analysis of Variance; Animals; Cyclic AMP; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Female; Glioma; Hybrid Cells; Isoproterenol; Mice; Naltrexone; Neuroblastoma; Oocytes; Poly A; Rats; Receptors, Opioid, delta; RNA; RNA, Messenger; Xenopus laevis | 1993 |
Compartmentation of receptors and guanine nucleotide-binding proteins in NG108-15 cells: lack of cross-talk in agonist binding among the alpha 2-adrenergic, muscarinic, and opiate receptors.
Topics: Adrenergic alpha-Agonists; Animals; Binding Sites; Cell Compartmentation; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Glioma; GTP-Binding Proteins; Mathematics; Neuroblastoma; Oxotremorine; Parasympathomimetics; Receptors, Adrenergic, alpha; Receptors, Muscarinic; Receptors, Opioid; Signal Transduction | 1993 |
Opioids mobilize calcium from inositol 1,4,5-trisphosphate-sensitive stores in NG108-15 cells.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Calcium; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Fluorescent Dyes; Fura-2; Glioma; Hybrid Cells; Inositol 1,4,5-Trisphosphate; Kinetics; Mice; Microscopy, Fluorescence; Naloxone; Narcotics; Neuroblastoma; Pyrrolidines; Rats; Tumor Cells, Cultured | 1994 |
Enkephalin activates the phospholipase C/Ca2+ system through cross-talk between opioid receptors and P2-purinergic or bradykinin receptors in NG 108-15 cells. A permissive role for pertussis toxin-sensitive G-proteins.
Topics: Adenosine Triphosphate; Bradykinin; Calcium; Enkephalin, Leucine; Enkephalins; Enzyme Activation; Glioma; GTP-Binding Proteins; Hybrid Cells; Inositol 1,4,5-Trisphosphate; Naloxone; Neuroblastoma; Pertussis Toxin; Receptors, Bradykinin; Receptors, Neurotransmitter; Receptors, Opioid; Receptors, Purinergic; Terpenes; Thapsigargin; Tumor Cells, Cultured; Type C Phospholipases; Virulence Factors, Bordetella | 1993 |
Suppression by [D-Pen2, D-Pen5]enkephalin on cyclic AMP dependent protein kinase-induced, but not protein kinase C-induced increment of intracellular free calcium in NG108-15 cells.
Topics: Analgesics; Animals; Bucladesine; Calcium; Calcium Channels; Colforsin; Depression, Chemical; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Glioma; Hybrid Cells; Intracellular Fluid; Mice; Neuroblastoma; Potassium Chloride; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Rats; Receptors, Opioid, delta; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1993 |
Immunodetection of endogenous opioid peptides in human brain tumors and associated cyst fluids.
Topics: Brain Neoplasms; Cysts; Enkephalin, Methionine; Enkephalins; Glial Fibrillary Acidic Protein; Glioma; Humans; Immunohistochemistry; Protein Precursors; Radioimmunoassay | 1993 |
delta Opioid receptor in neuronal cells undergoes acute and homologous desensitization.
Topics: 1-Methyl-3-isobutylxanthine; Analgesics; Animals; Cerebral Cortex; Cyclic AMP; Dose-Response Relationship, Drug; Embryo, Mammalian; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Glioma; Hybrid Cells; Kinetics; Mice; Neuroblastoma; Neurons; Rats; Receptors, Opioid, delta; Time Factors; Tumor Cells, Cultured | 1996 |
delta-Opioids stimulate inositol 1,4,5-trisphosphate formation, and so mobilize Ca2+ from intracellular stores, in undifferentiated NG108-15 cells.
Topics: Analgesics; Animals; Calcium; Calcium Channel Blockers; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Glioma; Inositol 1,4,5-Trisphosphate; Neuroblastoma; Nickel; Nifedipine; Pertussis Toxin; Receptors, Opioid, delta; Tumor Cells, Cultured; Type C Phospholipases; Virulence Factors, Bordetella | 1996 |
Inhibition of adenylyl cyclase activity by the cholecystokinin analog SNF 9007 in neuroblastoma x glioma NG108-15 hybrid cells.
Topics: Adenylyl Cyclase Inhibitors; Amino Acid Sequence; Analgesics; Cholecystokinin; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Enzyme Inhibitors; Glioma; Hybrid Cells; Molecular Sequence Data; Neuroblastoma; Oligopeptides; Pain; Peptide Fragments; Receptors, Opioid, delta | 1996 |
Lack of effect of gamma-hydroxybutyrate on mu, delta and kappa opioid receptor binding.
Topics: Adjuvants, Anesthesia; Analgesics; Animals; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Etorphine; Glioma; Guinea Pigs; Naloxone; Narcotic Antagonists; Narcotics; Neuroblastoma; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sodium Oxybate; Tritium; Tumor Cells, Cultured | 1996 |
Determination of delta-opioid in NG108-15 cells.
Topics: Animals; Benzylidene Compounds; Cyclic AMP; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Glioma; Mice; Naltrexone; Neuroblastoma; Rats; Receptors, Opioid, delta; Tumor Cells, Cultured | 1997 |
Functional expression, activation and desensitization of opioid receptor-like receptor ORL1 in neuroblastoma x glioma NG108-15 hybrid cells.
Topics: Colforsin; Cyclic AMP; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Glioma; GTP-Binding Proteins; Hybrid Cells; Naltrexone; Narcotic Antagonists; Neuroblastoma; Nociceptin; Nociceptin Receptor; Opioid Peptides; Pertussis Toxin; Receptors, Opioid; Receptors, Opioid, delta; Virulence Factors, Bordetella | 1997 |
Acute and chronic effects of opioids on delta and mu receptor activation of G proteins in NG108-15 and SK-N-SH cell membranes.
Topics: Analgesics; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Glioma; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Hybrid Cells; Membrane Proteins; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Neuroblastoma; Protein Binding; Rats; Receptors, Opioid, delta; Receptors, Opioid, mu; Signal Transduction; Sulfur Radioisotopes; Time Factors | 1997 |
Activation of N-methyl-D-aspartate receptor attenuates acute responsiveness of delta-opioid receptors.
Topics: Analgesics; Animals; CHO Cells; Cricetinae; Cyclic AMP-Dependent Protein Kinases; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Glioma; Ketamine; Mice; N-Methylaspartate; Neuroblastoma; Neurons; Phosphorylation; Protein Kinase C; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, delta; Signal Transduction | 1997 |
Transactivation of proenkephalin gene by HTLV-1 tax1 protein in glial cells: involvement of Fos/Jun complex at an AP-1 element in the proenkephalin gene promoter.
Topics: Animals; Binding Sites; Brain Neoplasms; Cells, Cultured; Enkephalins; Gene Expression Regulation, Viral; Gene Products, tax; Genes, pX; Genes, Reporter; Glioma; Human T-lymphotropic virus 1; Humans; Neuroglia; Promoter Regions, Genetic; Protein Precursors; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Rats; Regulatory Sequences, Nucleic Acid; Transcription Factor AP-1; Transcriptional Activation | 1997 |
Modulation of protein kinase C and cAMP-dependent protein kinase by delta-opioid.
Topics: Calcium; Cyclic AMP-Dependent Protein Kinases; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Enzyme Activation; Glioma; Hybrid Cells; Kinetics; Neuroblastoma; Pertussis Toxin; Protein Kinase C; Receptors, Opioid, delta; Tumor Cells, Cultured; Virulence Factors, Bordetella | 1997 |
Opioid efficacy in a C6 glioma cell line stably expressing the delta opioid receptor.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclase Inhibitors; Animals; Cholera Toxin; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Glioma; Guanosine 5'-O-(3-Thiotriphosphate); Narcotics; Pertussis Toxin; Rats; Receptors, Opioid, delta; Tumor Cells, Cultured; Virulence Factors, Bordetella | 1997 |
Effect of phosducin on opioid receptor function.
Topics: Cyclic AMP; DNA; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Eye Proteins; Flow Cytometry; Glioma; Green Fluorescent Proteins; GTP Phosphohydrolases; GTP-Binding Protein Regulators; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Hybrid Cells; Luminescent Proteins; Microscopy, Confocal; Nerve Tissue Proteins; Neuroblastoma; Phosphoproteins; Radioligand Assay; Receptors, Opioid; Recombinant Fusion Proteins; Transfection; Tumor Cells, Cultured | 1999 |
Membrane microviscosity modulates mu-opioid receptor conformational transitions and agonist efficacy.
Topics: Animals; Cell Line; Cell Membrane; Cholesterol Esters; Diprenorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Glioma; Guanosine 5'-O-(3-Thiotriphosphate); Membrane Fluidity; Nalbuphine; Naltrexone; Narcotic Antagonists; Narcotics; Neuroblastoma; Protein Conformation; Rats; Receptors, Opioid, mu; Sodium Chloride; Sufentanil; Tumor Cells, Cultured; Viscosity | 1999 |
Monoclonal antibody to the delta opioid receptor acts as an agonist in dual regulation of adenylate cyclase in NG108-15 cells.
Topics: Adenylyl Cyclases; Alprostadil; Amino Acid Sequence; Animals; Antibodies, Monoclonal; Blotting, Western; Cyclic AMP; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Epitopes; Fluorescent Antibody Technique; Glioma; Molecular Sequence Data; Neuroblastoma; Precipitin Tests; Receptors, Opioid, delta; Tumor Cells, Cultured | 1999 |
Endogenous delta-opioid and ORL1 receptors couple to phosphorylation and activation of p38 MAPK in NG108-15 cells and this is regulated by protein kinase A and protein kinase C.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cyclic AMP-Dependent Protein Kinases; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Enzyme Activation; Enzyme Inhibitors; Glioma; Hybrid Cells; Imidazoles; Kinetics; Mitogen-Activated Protein Kinases; Neuroblastoma; Nociceptin Receptor; p38 Mitogen-Activated Protein Kinases; Pertussis Toxin; Phosphorylation; Protein Kinase C; Pyridines; Receptors, Opioid; Receptors, Opioid, delta; Recombinant Proteins; Transfection; Virulence Factors, Bordetella | 1999 |
Ethanol uses cAMP-independent signal transduction mechanisms to activate proenkephalin promoter activity in rat C6 glioma cells.
Topics: Adrenergic beta-Agonists; Animals; Central Nervous System Depressants; Choline O-Acetyltransferase; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enkephalins; Enzyme Inhibitors; Ethanol; Glioma; Isoproterenol; Promoter Regions, Genetic; Protein Kinase C; Protein Precursors; Rats; Signal Transduction; Tumor Cells, Cultured | 2000 |
Different receptors for somatostatin and opioids in neuroblastoma X glioma hybrid cells.
Topics: Animals; Binding, Competitive; Cyclic AMP; Enkephalins; Etorphine; Glioma; Hybrid Cells; Naloxone; Neuroblastoma; Neurons; Prostaglandins E; Rats; Receptors, Cell Surface; Receptors, Opioid; Somatostatin | 1977 |
Opiate binding to membrane preparations of neuroblastoma x glioma hybrid cells NG108-15: effects of ions and nucleotides.
Topics: Cell Membrane; Cells, Cultured; Enkephalins; Etorphine; Glioma; Guanylyl Imidodiphosphate; Hybrid Cells; Magnesium; Manganese; Naloxone; Neuroblastoma; Nucleotides; Receptors, Opioid; Sodium | 1978 |
Binding assay for opioid peptides with neuroblastoma x glioma hybrid cells: specificity of the receptor site.
Topics: Animals; beta-Lipotropin; Binding, Competitive; Cell Line; Endorphins; Enkephalins; Glioma; Mice; Neoplasms, Experimental; Neuroblastoma; Radioligand Assay; Receptors, Opioid | 1978 |
Interaction of enkephalin with opiate receptors in intact cultured cells.
Topics: Binding, Competitive; Brain; Cations; Cell Line; Endorphins; Enkephalins; Glioma; Hydrolases; Kinetics; Narcotic Antagonists; Narcotics; Neuroblastoma; Receptors, Opioid | 1978 |
Regulation of the neuroblastoma x glioma hybrid opiate receptors by Na+ and guanine nucleotides.
Topics: Animals; Binding, Competitive; Cell Line; Enkephalins; Glioma; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Hybrid Cells; Kinetics; Neuroblastoma; Receptors, Opioid; Sodium | 1979 |
Photoaffinity inactivation of the enkephalin receptor.
Topics: Affinity Labels; Animals; Cell Line; Cell Membrane; Endorphins; Enkephalins; Glioma; Hybrid Cells; Kinetics; Mice; Neuroblastoma; Photolysis; Rats; Receptors, Opioid; Spectrophotometry, Ultraviolet | 1979 |
Glucocorticoid-mediated down regulation of c-fos mRNA in C6 glioma cells: lack of correlation with proenkephalin mRNA.
Topics: Animals; Base Sequence; Brain; Cell Line; Dexamethasone; Enkephalins; Gene Expression Regulation, Neoplastic; Genes, fos; Glioma; Isoproterenol; Kinetics; Molecular Sequence Data; Protein Precursors; Proto-Oncogene Proteins c-fos; Rats; RNA, Messenger; Tetradecanoylphorbol Acetate | 1992 |
Identification of three separate guanine nucleotide-binding proteins that interact with the delta-opioid receptor in NG108-15 neuroblastoma x glioma hybrid cells.
Topics: Adenosine Diphosphate Ribose; Adenylate Cyclase Toxin; Analgesics; Animals; Autoradiography; Cell Line; Cell Membrane; Cholera Toxin; Electrophoresis, Polyacrylamide Gel; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Glioma; GTP-Binding Proteins; Hybrid Cells; Kinetics; Mice; Molecular Weight; Neuroblastoma; Pertussis Toxin; Phosphorus Radioisotopes; Rats; Receptors, Opioid; Receptors, Opioid, delta; Virulence Factors, Bordetella | 1992 |
Stimulation of phosphatidylinositol-3-kinase by insulin-like growth factor 1 and other agonists.
Topics: Animals; Bradykinin; Cell Line; Enkephalins; Enzyme Activation; Glioma; Insulin-Like Growth Factor I; Interleukin-1; Kinetics; Nerve Growth Factors; Neuroblastoma; Phosphatidylinositol 3-Kinases; Phosphotransferases; Transforming Growth Factor beta; Vasopressins | 1992 |
Assessment of delta-opioid receptor activation by a series of peptides in cultured cells.
Topics: Amino Acid Sequence; Binding, Competitive; Cell Membrane; Cyclic AMP; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Glioma; GTP Phosphohydrolases; Hybrid Cells; Molecular Sequence Data; Neuroblastoma; Protein Conformation; Receptors, Opioid, delta; Structure-Activity Relationship; Tumor Cells, Cultured | 1992 |
Stimulation of c-fos and c-jun gene expression and down-regulation of proenkephalin gene expression in C6 glioma cells by endothelin-1.
Topics: Animals; Cell Line; Dactinomycin; Dose-Response Relationship, Drug; Endothelins; Enkephalins; Gene Expression; Gene Expression Regulation, Neoplastic; Genes, fos; Genes, jun; Glioma; Histones; Kinetics; Plasmids; Protein Precursors; RNA, Messenger; RNA, Neoplasm | 1992 |
Altered genetic response to beta-adrenergic receptor activation in late passage C6 glioma cells.
Topics: Actins; Amyloid beta-Protein Precursor; Animals; Blotting, Northern; Bucladesine; Cell Division; Enkephalins; Gene Expression; Genes, fos; Genes, jun; Glial Fibrillary Acidic Protein; Glioma; Isoproterenol; Kinetics; Nerve Growth Factors; Protein Precursors; Rats; Receptors, Adrenergic, beta; RNA, Messenger; RNA, Neoplasm; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1992 |
Dual excitatory and inhibitory effects of opioids on intracellular calcium in neuroblastoma x glioma hybrid NG108-15 cells.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Bucladesine; Calcium; Calcium Channels; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Glioma; Hybrid Cells; Ion Channel Gating; Narcotics; Neuroblastoma; Phorbol 12,13-Dibutyrate; Pyrrolidines; Receptors, Opioid, delta; Tumor Cells, Cultured | 1992 |
Enkephalin induces Ca2+ mobilization in single cells of bradykinin-sensitized differentiated neuroblastoma hybridoma (NG108-15) cells.
Topics: Animals; Bradykinin; Bucladesine; Calcium; Cell Differentiation; Egtazic Acid; Enkephalins; Fura-2; Glioma; Hybrid Cells; Kinetics; Mice; Microscopy, Fluorescence; Neuroblastoma; Pertussis Toxin; Rats; Time Factors; Video Recording; Virulence Factors, Bordetella | 1992 |
The 'serotonin/norepinephrine link' beyond the beta adrenoceptor.
Topics: Adrenergic beta-Antagonists; Animals; Cyclic AMP; Enkephalins; Gene Expression Regulation; Glioma; Glucocorticoids; Models, Biological; Norepinephrine; Protein Precursors; Rats; Receptors, Adrenergic, beta; RNA, Messenger; Serotonin; Tumor Cells, Cultured | 1992 |
Proenkephalin gene expression in C6 rat glioma cells: potentiation of cyclic adenosine 3',5'-monophosphate-dependent transcription by glucocorticoids.
Topics: Animals; Chloramphenicol O-Acetyltransferase; Cloning, Molecular; Colforsin; Cyclic AMP; Dexamethasone; DNA; Drug Synergism; Enkephalins; Gene Expression; Glioma; Plasmids; Protein Precursors; Rats; RNA, Messenger; Transcription, Genetic; Transfection; Tumor Cells, Cultured | 1991 |
cAMP-dependent regulation of proenkephalin by JunD and JunB: positive and negative effects of AP-1 proteins.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Base Sequence; Cell Line; Colforsin; Cyclic AMP; Enhancer Elements, Genetic; Enkephalins; Gene Expression Regulation; Genes, fos; Glioma; Humans; Mice; Molecular Sequence Data; Oligodeoxyribonucleotides; Protein Biosynthesis; Protein Kinases; Protein Precursors; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Reticulocytes; Second Messenger Systems; Transcriptional Activation; Transfection | 1991 |
Probes for narcotic receptor mediated phenomena. 15. (3S,4S)-(+)-trans-3-methylfentanyl isothiocyanate, a potent site-directed acylating agent for the delta opioid receptors in vitro.
Topics: Acylation; Adenylyl Cyclase Inhibitors; Analgesia; Animals; Brain; Cell Membrane; Chemical Phenomena; Chemistry; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Fentanyl; Glioma; Hybrid Cells; Indicators and Reagents; Ligands; Male; Molecular Structure; Neuroblastoma; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Stereoisomerism; Structure-Activity Relationship; Tumor Cells, Cultured | 1989 |
Guanine nucleotide regulation of [125I]beta-endorphin binding to NG108-15 and SK-N-SH cell membranes: specific cation requirements.
Topics: beta-Endorphin; Cations; Cell Membrane; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Glioma; Guanine Nucleotides; Guanosine Diphosphate; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Humans; Hybrid Cells; Neuroblastoma; Oligopeptides; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Sodium Chloride; Tumor Cells, Cultured | 1989 |
The effects of long-term treatment of NG108-15 cells with penta- and tetrapeptide enkephalin dimers on opioid receptor binding and cyclic AMP (cAMP) levels.
Topics: Alprostadil; Animals; Cell Line; Cyclic AMP; Enkephalins; Glioma; Hybrid Cells; Kinetics; Mice; Neuroblastoma; Rats; Receptors, Opioid; Structure-Activity Relationship | 1987 |
Comparison of [125I]beta-endorphin binding to rat brain and NG108-15 cells using a monoclonal antibody directed against the opioid receptor.
Topics: Animals; Antibodies, Monoclonal; beta-Endorphin; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Glioma; Immunoglobulin M; In Vitro Techniques; Iodine Radioisotopes; Male; Molecular Weight; Neuroblastoma; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Tumor Cells, Cultured | 1988 |
Expression of the enkephalin precursor gene in C6 rat glioma cells: regulation by beta-adrenergic agonists and glucocorticoids.
Topics: Adrenergic beta-Agonists; Animals; Cell Line; Dexamethasone; Drug Synergism; Enkephalin, Methionine; Enkephalins; Gene Expression Regulation; Glioma; Glucocorticoids; Norepinephrine; Nucleic Acid Hybridization; Protein Precursors; Rats; RNA, Messenger; Transcription, Genetic | 1986 |
Comparative binding properties of linear and cyclic delta-selective enkephalin analogues: [3H]-[D-Thr2, Leu5] enkephalyl-Thr6 and [3H]-[D-Pen2, D-Pen5] enkephalin.
Topics: Animals; Brain; Cell Line; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Glioma; Guinea Pigs; Isomerism; Kinetics; Neuroblastoma; Oligopeptides; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta | 1985 |
Characterization of [3H][2-D-penicillamine, 5-D-penicillamine]-enkephalin binding to delta opiate receptors in the rat brain and neuroblastoma--glioma hybrid cell line (NG 108-15).
Topics: Animals; Brain; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Glioma; Hybrid Cells; Kinetics; Membranes; Mice; Neuroblastoma; Rats; Receptors, Opioid; Receptors, Opioid, delta | 1985 |
Dual pathways of receptor-mediated cyclic GMP generation in NG108-15 cells as differentiated by susceptibility to islet-activating protein, pertussis toxin.
Topics: Adenylate Cyclase Toxin; Animals; Bacterial Toxins; Calcimycin; Cyclic AMP; Cyclic GMP; Dinoprost; Enkephalins; Glioma; Hybrid Cells; Melitten; Mice; Neuroblastoma; Pertussis Toxin; Phospholipids; Prostaglandins F; Rats; Receptors, Cell Surface; Virulence Factors, Bordetella | 1985 |
Sodium regulation of agonist binding at opioid receptors. I. Effects of sodium replacement on binding at mu- and delta-type receptors in 7315c and NG108-15 cells and cell membranes.
Topics: Adenylyl Cyclase Inhibitors; Animals; Cell Line; Cell Membrane; Cyclazocine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylketocyclazocine; Etorphine; Glioma; Guinea Pigs; Monensin; Naloxone; Neuroblastoma; Pituitary Neoplasms; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Sodium | 1986 |
Glucocorticoids and cyclic AMP synergistically regulate the abundance of preproenkephalin messenger RNA in neuroblastoma-glioma hybrid cells.
Topics: Base Sequence; Cells, Cultured; Colforsin; Cyclic AMP; Drug Synergism; Enkephalin, Methionine; Enkephalins; Gene Expression Regulation; Glioma; Glucocorticoids; Hybrid Cells; Neuroblastoma; Protein Precursors; RNA, Messenger | 1986 |
Chronic exposure to opiate agonists increases proenkephalin biosynthesis in NG108 cells.
Topics: Animals; Cell Line; Colforsin; Enkephalin, Methionine; Enkephalins; Etorphine; Genes; Glioma; Hybrid Cells; Morphinans; Morphine; Naloxone; Neuroblastoma; Protein Precursors; RNA, Messenger; Transcription, Genetic | 1988 |
Sodium regulation of opioid agonist binding is potentiated by pertussis toxin.
Topics: Animals; Bacterial Toxins; Cell Line; Diprenorphine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Glioma; Guanine Nucleotides; Hybrid Cells; Mice; Morphinans; Neuroblastoma; Pertussis Toxin; Rats; Receptors, Opioid; Sodium; Virulence Factors, Bordetella | 1984 |
Up-regulation of opiate receptors by opiate antagonists in neuroblastoma-glioma cell culture: the possibility of interaction with guanosine triphosphate-binding proteins.
Topics: Animals; Cells, Cultured; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Glioma; GTP-Binding Proteins; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Naloxone; Neuroblastoma; Rats; Receptors, Opioid; Receptors, Opioid, delta | 1984 |
Beta-endorphin. Binding activity of synthetic analogs with various chain lengths in neuroblastoma x glioma NG108-15 cell membranes.
Topics: Animals; beta-Endorphin; Cell Membrane; Endorphins; Enkephalin, Leucine; Glioma; In Vitro Techniques; Kinetics; Neuroblastoma; Rats; Receptors, Opioid; Structure-Activity Relationship | 1984 |
Mechanisms of multiple cellular adaptation processes in clonal cell lines during chronic opiate treatment.
Topics: Adaptation, Physiological; Adenylyl Cyclases; Animals; Cell Line; Clone Cells; Cytosol; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Etorphine; Glioma; Guanylyl Imidodiphosphate; Lanthanum; Mice; Naloxone; Narcotics; Neuroblastoma; Rats; Receptors, Opioid; Sodium; Time Factors | 1984 |
Induction of differentiation increases Met5-enkephalin and Leu5-enkephalin content in NG108-15 hybrid cells: an immunocytochemical and biochemical analysis.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Bucladesine; Cell Differentiation; Culture Media; Cyclic AMP; Enkephalin, Leucine; Enkephalin, Methionine; Glioma; Hybrid Cells; Immunochemistry; Neuroblastoma; Staining and Labeling | 1983 |
The regulation of delta-opiate receptor density on 108CC15 neuroblastoma X glioma hybrid cells.
Topics: Animals; Bucladesine; Cell Differentiation; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Glioma; Hybrid Cells; Mice; Morphine; Neuroblastoma; Rats; Receptors, Opioid; Receptors, Opioid, delta | 1984 |
Down-regulation of opiate receptor in neuroblastoma x glioma NG108-15 hybrid cells. Chloroquine promotes accumulation of tritiated enkephalin in the lysosomes.
Topics: Animals; Cell Line; Chloroquine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Glioma; Hybrid Cells; Kinetics; Lysosomes; Mice; Neuroblastoma; Rats; Receptors, Opioid | 1984 |
Down regulation of opiate receptors on 108CC15 hybrid cells is inhibited by receptor occupancy.
Topics: Animals; Cell Line; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Glioma; Hybrid Cells; Kinetics; Mice; Neuroblastoma; Rats; Receptors, Opioid; Receptors, Opioid, delta | 1983 |
Heterologous desensitization of opioid-stimulated Ca2+ increase by bradykinin or ATP in NG108-15 cells.
Topics: Adenosine Triphosphate; Bradykinin; Calcium; Cyclic AMP; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Glioma; Inositol 1,4,5-Trisphosphate; Neuroblastoma; Receptors, Opioid, delta; Tumor Cells, Cultured | 1995 |
[The effect of opioid peptides on a decreased proliferation and on an increased maturation rate of glioma C-6 cells manifested by enhanced marker enzyme activity].
Topics: 2',3'-Cyclic-Nucleotide Phosphodiesterases; Animals; Biomarkers, Tumor; Cell Division; Cell Transformation, Neoplastic; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Glioma; Glutamate-Ammonia Ligase; Phenotype; Rats; Time Factors; Tumor Cells, Cultured | 1994 |
Maintenance of glial plasticity with aging in C-6 glial cells and normal astrocytes in culture: responsiveness to opioid peptides.
Topics: 2',3'-Cyclic-Nucleotide Phosphodiesterases; Amino Acid Sequence; Animals; Astrocytes; Cellular Senescence; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Glioma; Glutamate-Ammonia Ligase; Mice; Mice, Inbred C3H; Molecular Sequence Data; Nerve Tissue Proteins; Neuroglia; Neuronal Plasticity; Oligodendroglia; Tumor Cells, Cultured | 1993 |
Bradykinin modulates potassium and calcium currents in neuroblastoma hybrid cells via different pertussis toxin-insensitive pathways.
Topics: Animals; Bradykinin; Calcium Channels; Electrophysiology; Enkephalin, Leucine; Glioma; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Hybrid Cells; Kinetics; Models, Biological; Neuroblastoma; Pertussis Toxin; Phosphatidylinositol Diacylglycerol-Lyase; Phosphoinositide Phospholipase C; Phosphoric Diester Hydrolases; Potassium Channels; Tetrodotoxin; Tumor Cells, Cultured; Virulence Factors, Bordetella | 1994 |
Secretion of a neuropeptide-metabolizing enzyme similar to endopeptidase 22.19 by glioma C6 cells.
Topics: Amino Acid Sequence; Animals; Enkephalin, Leucine; Enkephalin, Methionine; Glioma; Kinetics; Metalloendopeptidases; Molecular Sequence Data; Neuropeptides; Rats; Sequence Homology, Amino Acid; Substrate Specificity; Tumor Cells, Cultured | 1993 |
Identification of the critical domains of the delta-opioid receptor involved in G protein coupling using site-specific synthetic peptides.
Topics: Amino Acid Sequence; Analgesics; Animals; Binding Sites; Enkephalin, Leucine; Fibroblasts; Glioma; GTP Phosphohydrolases; GTP-Binding Proteins; Hybrid Cells; Kinetics; Mice; Molecular Sequence Data; Neuroblastoma; Peptide Fragments; Protein Structure, Tertiary; Rats; Receptors, Opioid, delta; Structure-Activity Relationship; Substrate Specificity; Transfection; Tritium; Tumor Cells, Cultured | 1996 |
Regulation of delta opioid receptors by delta9-tetrahydrocannabinol in NG108-15 hybrid cells.
Topics: Animals; Colforsin; Dose-Response Relationship, Drug; Dronabinol; Enkephalin, Leucine; Glioma; Mice; Neuroblastoma; Piperidines; Pyrazoles; Rats; Receptors, Opioid, delta; Rimonabant; RNA, Messenger; Tumor Cells, Cultured | 1998 |
Delta-opioid-receptor-mediated inhibition of adenylate cyclase is transduced specifically by the guanine-nucleotide-binding protein Gi2.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclase Inhibitors; Amino Acid Sequence; Animals; Base Sequence; Cell Line; DNA, Neoplasm; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Glioma; GTP Phosphohydrolases; GTP-Binding Proteins; Guanylyl Imidodiphosphate; Hybrid Cells; Immune Sera; Kinetics; Mice; Molecular Sequence Data; NAD; Neuroblastoma; Oligonucleotide Probes; Pertussis Toxin; Rats; Receptors, Opioid; Receptors, Opioid, delta; RNA, Neoplasm; Signal Transduction; Virulence Factors, Bordetella | 1990 |
Direct demonstration of the activation of UDP-N-acetylgalactosamine: [GM3]N-acetylgalactosaminyltransferase by cyclic AMP.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Brain; Cell Line; Cyclic AMP; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enzyme Activation; Galactosyltransferases; Glioma; Kinetics; Mice; Microsomes; N-Acetylgalactosaminyltransferases; Neuroblastoma; Phosphoproteins; Phosphorylation; Polypeptide N-acetylgalactosaminyltransferase; Protein Kinases; Rats | 1986 |
Block of calcium channels by enkephalin and somatostatin in neuroblastoma-glioma hybrid NG108-15 cells.
Topics: Animals; Calcium; Calcium Channel Blockers; Cell Line; Dose-Response Relationship, Drug; Electric Conductivity; Enkephalin, Leucine; Glioma; Ion Channels; Naloxone; Neuroblastoma; Rats; Somatostatin | 1986 |
Involvement of the guanine nucleotide-binding protein, No, in the inhibitory regulation of neuronal calcium channels.
Topics: Animals; Calcium; Cell Line; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Glioma; GTP-Binding Proteins; Homeostasis; Hybrid Cells; Ion Channels; Neuroblastoma; Neurons | 1988 |
Chronic exposure of NG 108-15 cells to opiate agonists does not alter the amount of the guanine nucleotide-binding proteins Gi and Go.
Topics: Adenosine Diphosphate Ribose; Electrophoresis, Polyacrylamide Gel; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Glioma; GTP-Binding Proteins; Hybrid Cells; Immunoblotting; Morphine; NAD; Neuroblastoma; Pertussis Toxin; Time Factors; Tumor Cells, Cultured; Virulence Factors, Bordetella | 1989 |
Antagonists with negative intrinsic activity at delta opioid receptors coupled to GTP-binding proteins.
Topics: Animals; Benzomorphans; Cell Line; Cell Membrane; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethylmaleimide; Glioma; GTP Phosphohydrolases; GTP-Binding Proteins; Kinetics; Narcotic Antagonists; Neuroblastoma; Pertussis Toxin; Receptors, Opioid; Receptors, Opioid, delta; Virulence Factors, Bordetella | 1989 |
Cholera toxin ADP-ribosylates the receptor-coupled form of pertussis toxin-sensitive G-proteins.
Topics: Adenosine Diphosphate Ribose; Animals; Cell Line; Cell Membrane; Cholera Toxin; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Glioma; GTP Phosphohydrolases; GTP-Binding Proteins; Hybrid Cells; NAD; Neuroblastoma; Pertussis Toxin; Receptors, Opioid; Virulence Factors, Bordetella | 1989 |
Opioid receptor desensitization in NG 108-15 cells. Differential effects of a full and a partial agonist on the opioid-dependent GTPase.
Topics: Adenylyl Cyclase Inhibitors; Cell Line; Cell Membrane; Drug Tolerance; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Glioma; GTP Phosphohydrolases; Hybrid Cells; Morphine; Neuroblastoma; Phosphoric Monoester Hydrolases; Receptors, Opioid | 1987 |
Modification of opioid receptor activity by acid phosphatase in neuroblastoma x glioma NG108-15 hybrid cells.
Topics: Acid Phosphatase; Animals; Chromatography, High Pressure Liquid; Cyclic AMP; Diprenorphine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Etorphine; Glioma; Guanfacine; Guanidines; Hybrid Cells; Neuroblastoma; Phenylacetates; Receptors, Opioid | 1988 |
Differential regulation of amounts of the guanine-nucleotide-binding proteins Gi and Go in neuroblastoma x glioma hybrid cells in response to dibutyryl cyclic AMP.
Topics: Bucladesine; Cell Differentiation; Cell Membrane; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Glioma; GTP-Binding Proteins; Hybrid Cells; Neuroblastoma; Time Factors | 1988 |
Multiple affinity states of opiate receptor in neuroblastoma x glioma NG108-15 hybrid cells. Opiate agonist association rate is a function of receptor occupancy.
Topics: Animals; Binding, Competitive; Cell Line; Diprenorphine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Glioma; Guanylyl Imidodiphosphate; Hybrid Cells; Kinetics; Magnesium; Neuroblastoma; Receptors, Opioid; Sodium | 1985 |
Comparative studies of the binding of dimeric and monomeric enkephalins to neuroblastoma-glioma NG108-15 cells.
Topics: Animals; Cell Line; Cell Membrane; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Glioma; Neuroblastoma; Receptors, Opioid; Tritium | 1985 |
Increased affinity of dimeric enkephalins is not dependent on receptor density.
Topics: Animals; Cell Line; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Glioma; Kinetics; Models, Neurological; Neuroblastoma; Receptors, Opioid; Receptors, Opioid, delta | 1985 |
Multiple states of opioid receptors may modulate adenylate cyclase in intact neuroblastoma X glioma hybrid cells.
Topics: Adenylyl Cyclases; Animals; Cell Line; Cyclic AMP; Diprenorphine; Dose-Response Relationship, Drug; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Etorphine; Glioma; Hybrid Cells; Kinetics; Ligands; Morphine; Naloxone; Neuroblastoma; Neurons; Receptors, Opioid; Receptors, Opioid, delta | 1985 |
Bradykinin stimulates GTP hydrolysis in NG108-15 membranes by a high-affinity, pertussis toxin-insensitive GTPase.
Topics: Bradykinin; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Glioma; GTP Phosphohydrolases; GTP-Binding Proteins; Guanosine Triphosphate; Hybrid Cells; Hydrolysis; Membranes; Neuroblastoma; Pertussis Toxin; Phosphatidylinositols; Phosphoric Monoester Hydrolases; Virulence Factors, Bordetella | 1986 |
Ethanol increases the expression of functional delta-opioid receptors in neuroblastoma x glioma NG108-15 hybrid cells.
Topics: Cell Line; Cyclic AMP; Cycloheximide; Dactinomycin; Diprenorphine; DNA; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Ethanol; Etorphine; Glioma; Hybridomas; Naloxone; Neuroblastoma; Phenylisopropyladenosine; Receptors, Opioid; Receptors, Opioid, delta; Sodium; Transcription, Genetic | 1986 |
Subcellular compartmentation of opioid receptors: modulation by enkephalin and alkaloids.
Topics: Animals; Cell Line; Cell Membrane; Centrifugation, Density Gradient; Chloroquine; Diprenorphine; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Etorphine; Glioma; Golgi Apparatus; Kinetics; Lysosomes; Microsomes; Neuroblastoma; Receptors, Opioid | 1986 |
The adenylate cyclase rebound response to naloxone in the NG108-15 cells. Effects of etorphine and other opiates.
Topics: Adenylyl Cyclases; Alprostadil; Cell Line; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalin, Methionine; Etorphine; Glioma; Morphinans; Morphine; Naloxone; Neuroblastoma; Receptors, Opioid | 1986 |