enkephalin, leucine has been researched along with Aging in 134 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 49 (36.57) | 18.7374 |
| 1990's | 68 (50.75) | 18.2507 |
| 2000's | 11 (8.21) | 29.6817 |
| 2010's | 6 (4.48) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cavanagh, C; Chabot, JG; Herzog, H; Ménard, C; Quirion, R; Schwarzer, C; Tse, YC; Wong, TP | 1 |
| Garcia-Galiano, D; Leon, S; Manfredi-Lozano, M; Navarro, VM; Pinilla, L; Roa, J; Ruiz-Pino, F; Sánchez-Garrido, MA; Tena-Sempere, M | 1 |
| Bing, G; Kim, HC; Liu, M; Nguyen, XV | 1 |
| Daugé, V; Giros, B; Morel, LJ | 1 |
| Eghlidi, DH; Haley, GE; Kohama, SG; Noriega, NC; Urbanski, HF | 1 |
| Ionov, ID; Pushinskaya, II | 1 |
| Chen, J; Han, R; Huang, J; Kaneko, T; Li, YQ; Lin, Y; Wang, W; Wang, YY; Wei, YY; Wu, SX | 1 |
| Bacalini, MG; Capri, M; Castellani, G; Collino, S; Di Blasio, AM; Franceschi, C; Garagnani, P; Gentilini, D; Giuliani, C; Gori, D; Mari, D; Pirazzini, C; Rezzi, S; Salvioli, S; Vitale, G | 1 |
| Angulo, JA; Barr, GA; Noailles, PA; Wiedenmayer, CP | 1 |
| Apte-Deshpande, A; Freund, YR; Kilduff, TS; Morairty, S; Terao, A | 1 |
| Göcze, PM; Környei, JL; Kovács, KA; Vértes, M; Vértes, Z | 1 |
| Chen, Q; Reiner, A; Sun, Z | 1 |
| Bertacchi, I; Gambarelli, A; Mola, L; Pederzoli, A | 1 |
| Bakalkin, G; Bing, G; Choi, DY; Foster, TC; Kulik, C; Kumar, A; Liu, M; Masse, J; Nguyen, XV; Usynin, I; Vijitruth, R | 1 |
| McGeer, EG; McGeer, PL | 1 |
| Beckley, SC; Joh, TH; Miller, RJ; Pickel, VM; Reis, DJ; Sumal, KK | 1 |
| Elde, RP; Graybiel, AM; Ragsdale, CW; Yoneoka, ES | 1 |
| Boissier, JR; Dupont, A; Labrie, F; Mérand, Y; Savard, P | 1 |
| Ng, SC; Tsang, D | 1 |
| Bartke, A; Blum, K; Briggs, A; Dalterio, S; DeLallo, L; Sweeney, C | 1 |
| Herkenham, M; Kent, JL; Pert, CB | 1 |
| Covelli, V; Govoni, S; Riccardi, F; Spano, PF; Trabucchi, M | 1 |
| Ho, KP; Ng, SC; Tsang, D | 1 |
| Coscia, CJ; Roth, BL; Wohltmann, M | 1 |
| Ho, KP; Ho, WK; Ng, SC; Tsang, D | 1 |
| de la Baume, S; Fournié-Zaluski, MC; Gacel, G; Malfroy, B; Patey, G; Perdrisot, R; Roques, BP; Schwartz, JC; Swerts, JP | 1 |
| Barden, N; Cusan, L; Dupont, A; Ferland, L; Labrie, F; Merand, Y | 1 |
| Forman, LJ; Meites, J; Sonntag, WE; Steger, RW; Van Vugt, DA | 1 |
| Fukushima, N; Hayashi, C; Katayama, T; Misu, Y; Miyamae, T; Ueda, H | 1 |
| Dagerlind, A; Hökfelt, T; Holgert, H; Lagercrantz, H | 1 |
| Bakalkin, G; Telkov, M; Terenius, L; Yakovleva, T | 1 |
| Keller, RW; Snyder-Keller, AM | 1 |
| Coenen, A; Lasoń, W; Przewłocka, B; Van Luijtelaar, G | 1 |
| De Vries, TJ; Jonker, AJ; Mulder, AH; Schoffelmeer, AN; Voorn, P | 1 |
| Boone, JB; McMillen, D | 1 |
| Merchenthaler, I | 1 |
| Soghomonian, JJ | 1 |
| Crisp, T; Gordon, TL; Hoskins, DL; Perni, VC; Stafinsky, JL; Uram, M | 1 |
| Barron, BA; Boluyt, MO; Caffrey, JL; Crow, MT; Lakatta, EG; O'Neill, L; Younes, A | 2 |
| Benson, B; Dunn, AM; Rodriguez, RE; Wise, ME | 1 |
| Harlan, RE; Song, DD | 1 |
| Mitsuo, K; Nishiyama, N; Schwartz, JP; Sheng, JG; Shirabe, S | 1 |
| Burke, RE; Franklin, SO; Inturrisi, CE | 1 |
| Isayama, T; McLaughlin, PJ; Zagon, IS | 1 |
| Ase, A; Finkielman, S; Kleid, MC; Nahmod, VE; Rodriguez Vida, MI; Vindrola, O | 1 |
| Schiffmann, SN; Vanderhaeghen, JJ | 1 |
| Fan, LQ; Hiller, JM; Simon, EJ | 1 |
| Hong, JS; Hudson, PM; Hung, GH; Lee, DY; McMillian, MK; Thai, L | 1 |
| Basheer, R; Tempel, A; Yang, J | 1 |
| McLaughlin, PJ | 1 |
| Casis, L; de Gandarias, JM; Echevarría, E; Gil, J; Irazusta, J | 1 |
| Avoli, M; Barbarosie, M; Kurcewicz, I; Louvel, J; Pumain, R | 1 |
| Gallagher, M; Gill, TM; Nagahara, AH; Nicolle, M | 1 |
| Bizon, JL; Gallagher, M; Nicolle, MM | 1 |
| Handa, RJ; Li, Y; McGivern, RF; Nagahara, AH | 1 |
| Nagane, Y; Saitoh, K; Tohgi, H; Utsugisawa, K; Yamagata, M; Yoshimura, M | 1 |
| Fredholm, BB; Johansson, B; Lindström, K; Wahlström, G | 1 |
| Crisp, T; Gordon, TL; Hoskins, DL | 1 |
| Lau, SM; Tang, F | 1 |
| Beasley, J; London, E; Mizuno, TM; Mobbs, CV; Silverstein, JH | 1 |
| Eschenhagen, T; Fleige, G; Mittmann, C; Orthey, E; Scholz, H; Weil, J | 1 |
| Allar, MA; McLaughlin, PJ | 1 |
| Basura, GJ; Walker, PD | 1 |
| Deviche, P; Gulledge, CC | 1 |
| Bose, P; Vacca-Galloway, LL | 1 |
| Hamra, M; Kunze, DL; McNeil, RS; Runciman, M | 1 |
| Cho, GJ; Costa, ME; Hill, DF; Junier, MP; Lee, BJ; Norgren, RB; Ojeda, SR; Tapia, V | 1 |
| Bakalkin, G; Hauser, KF; Itkis, OS; Knapp, PE; Spruce, BA; Zhang, L | 1 |
| Campbell, BM; Gresch, PJ; Walker, PD | 1 |
| Bloom, FE; Guillemin, R; Rogers, J; Rossier, J; Shibasaki, T | 1 |
| Kudo, N; Okado, N; Ozaki, S | 1 |
| Tang, F; Vacca-Galloway, LL; Yung, KK | 1 |
| Halter, JB; Kiritsy-Roy, JA; Smith, MJ; Terry, LC | 1 |
| Dondi, D; Limonta, P; Maggi, R; Martini, L; Piva, F | 1 |
| Marini, AM; Schwartz, JP; Shinoda, H | 1 |
| Espinoza, K; Tempel, A | 1 |
| Arai, Y; Ghoda, K; Kajita, T; Liu, XF; Matsumiya, T; Ohgiya, N; Oka, T; Taniguchi, T | 1 |
| Borgundvaag, B; George, SR; Kudlow, JE; Mueller, SG | 1 |
| Barg, J; Belcheva, M; Bem, WT; Coscia, CJ; Yeung, SJ | 1 |
| Barg, J; Simantov, R | 1 |
| Barr, GA; Carden, SE; Hofer, MA | 1 |
| Olson, L; Stieg, P; Strömberg, I | 1 |
| Cimino, M; Weiss, B; Zoli, M | 1 |
| Khokhlov, AP; Yarygin, KN | 1 |
| Brakier-Gingras, L; Dumont, M; Lemaire, S; Ouellette, M | 1 |
| Attali, B; Saya, D; Vogel, Z | 1 |
| De Vries, TJ; Hogenboom, F; Mulder, AH; Schoffelmeer, AN | 1 |
| Landymore, KM; Wilkinson, M | 1 |
| Biegon, A; Dillon, KA; Gross-Isseroff, R; Israeli, M | 1 |
| Polakiewicz, RD; Rosen, H | 1 |
| Hironaka, T; Kiyama, H; Morita, Y; Noguchi, K; Sato, M; Tateno, E; Tohyama, M; Zhang, JH | 1 |
| McLaughlin, PJ; Zagon, IS | 1 |
| Hoegler, DB; Liew, CC; Sole, MJ | 1 |
| Jackson, HC; Kitchen, I | 2 |
| Bardo, MT; Neisewander, JL; Nonneman, AJ; Rowlett, JK | 1 |
| Gallagher, M; Hong, JS; Jiang, HK; Owyang, VV | 1 |
| Ali, SF; Hong, JS; Hudson, PM; Mason, GA; Yoshikawa, K | 1 |
| Aumüller, G; Jungblut, T; Malek, B; Melchior, H | 1 |
| Polakiewicz, R; Rosen, H | 1 |
| Hamill, RW; Newton, BW; Pierre, AH; Romagnano, MA | 1 |
| King, JS; Walker, JJ | 1 |
| Senba, E; Tohyama, M; Yanaihara, C; Yanaihara, N | 1 |
| Kitchen, I; McDowell, J | 1 |
| Barr, GA; Habas, J; Paredes, W; Tempel, A | 1 |
| Pasternak, GW; Wood, PJ | 1 |
| Breese, GR; Hong, JS; Krause, JE; Mueller, RA; Napier, TC; Sivam, SP | 1 |
| Abrous, N; Dulluc, J; Herman, JP; Le Moal, M; Vigny, A | 1 |
| Altschuler, RA; Hoffman, DW; Jones-King, KL | 1 |
| Recant, L; Timmers, K; Voyles, NR; Wilkins, S; Zalenski, C | 1 |
| Quirion, R; Segal, M; Zamir, N | 1 |
| Finch, CE; Morgan, DG; Rogers, J; Shoemaker, WJ | 1 |
| Helen, P; Hervonen, A; Järvi, R; Pelto-Huikko, M; Rapoport, SI | 1 |
| Aizawa, T; Yoshikawa, K | 1 |
| Schwartz, JP; Simantov, R | 1 |
| Aloyz, R; Ase, A; Finkielman, S; Nahmod, VE; Vindrola, O | 1 |
| Boyce, S; De Ceballos, ML; Jenner, P; Marsden, CD; Taylor, M | 1 |
| Laorden, ML; Miralles, FS; Olaso, MJ; Puig, MM | 1 |
| Alessi, NE; Khachaturian, H; Munfakh, N; Watson, SJ | 1 |
| Hara, Y; Inagaki, S; Kawai, Y; Sakanaka, M; Senba, E; Shiosaka, S; Takatsuki, K; Tohyama, M | 1 |
| Snead, OC; Stephens, H | 1 |
| Brecha, N; Chang, KJ; Gall, C; Karten, HJ | 1 |
| Lönnberg, P; Marjamäki, P; Rinne, JO | 1 |
| Aĭzman, RI; Dushina, EN; Mikhaĭlova, NN; Slepushkin, VD | 1 |
| Babst, R; Bongiorno, L; Marini, M; Marzano, M; Roda, LG; Spagnoli, G; Urbani, A | 1 |
| Kawano, H; Masuko, S; Niwa, H; Takeichi, M | 1 |
| Cheung, A; Tang, F; Vacca-Galloway, LL | 1 |
| Bijlani, V; Jotwani, G; Rath, S; Wadhwa, S | 1 |
| Chong, PN; de Ceballos, ML; Jenner, P; Marsden, CD; Rose, S; Taylor, MD | 1 |
| Chiaia, NL; Hess, PR; Miller, MW; Rhoades, RW | 1 |
| Christ, GJ; Dunlap, CE; Rose, JC | 1 |
| Charakchieva, S; Chernaeva, L | 1 |
| Adler, JE; La Gamma, EF | 1 |
3 review(s) available for enkephalin, leucine and Aging
| Article | Year |
|---|---|
Properties variations and possible synaptic functions of "enkephalinase": a newly characterised dipeptidyl carboxypeptidase.
Topics: Aging; Animals; Brain; Endopeptidases; Enkephalins; Humans; Morphine; Neprilysin; Peptides; Synapses | 1980 |
Physiological role of endorphins in neuroendocrinology.
Topics: Aging; Animals; Endorphins; Enkephalin, Methionine; Enkephalins; Estrus; Female; Growth Hormone; Hypothalamus; Male; Pregnancy; Prolactin; Rats; Serotonin; Stimulation, Chemical | 1981 |
Multiple mu opiate receptors.
Topics: Aging; Analgesia; Animals; Autoradiography; Binding, Competitive; Brain; Dihydromorphine; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Ethylmaleimide; Morphine; Naloxone; Neurotransmitter Agents; Phylogeny; Receptors, Opioid; Receptors, Opioid, mu; Respiration; Substance-Related Disorders; Tissue Distribution | 1986 |
131 other study(ies) available for enkephalin, leucine and Aging
| Article | Year |
|---|---|
Knockdown of prodynorphin gene prevents cognitive decline, reduces anxiety, and rescues loss of group 1 metabotropic glutamate receptor function in aging.
Topics: Aging; Animals; Anxiety; Benzamides; Benzphetamine; Central Nervous System Stimulants; Cerebral Cortex; Cognition Disorders; Disease Models, Animal; Enkephalins; Excitatory Amino Acid Antagonists; Exploratory Behavior; Gene Expression Regulation; Hippocampus; In Vitro Techniques; Long-Term Synaptic Depression; Memory Disorders; Mice; Mice, Inbred C57BL; Mice, Knockout; Protein Precursors; Pyrazoles; Pyridines; Receptors, Metabotropic Glutamate; Recognition, Psychology | 2013 |
Effects and interactions of tachykinins and dynorphin on FSH and LH secretion in developing and adult rats.
Topics: Aging; Animals; Dynorphins; Enkephalins; Female; Follicle Stimulating Hormone; Hypothalamus; Kisspeptins; Luteinizing Hormone; Male; Neurokinin B; Peptide Fragments; Protein Precursors; Rats, Wistar; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Substance P | 2015 |
Effects of prodynorphin deletion on striatal dopamine in mice during normal aging and in response to MPTP.
Topics: Aging; Amino Acid Sequence; Animals; Corpus Striatum; Disease Models, Animal; Dopamine; Enkephalins; Female; Immunohistochemistry; Male; Mice; Mice, Knockout; Neural Pathways; Parkinsonian Disorders; Phosphorylation; Protein Precursors; Serine; Substantia Nigra; Tyrosine 3-Monooxygenase; Up-Regulation | 2009 |
Adolescent exposure to chronic delta-9-tetrahydrocannabinol blocks opiate dependence in maternally deprived rats.
Topics: Aging; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Brain; Conditioning, Classical; Dronabinol; Enkephalins; Male; Maternal Deprivation; Morphine; Opioid-Related Disorders; Protein Precursors; Rats; Rats, Long-Evans; Receptor, Cannabinoid, CB1; Receptors, Opioid, mu; RNA, Messenger; Self Administration; Space Perception; Time Factors | 2009 |
Influence of age and 17beta-estradiol on kisspeptin, neurokinin B, and prodynorphin gene expression in the arcuate-median eminence of female rhesus macaques.
Topics: Age Factors; Aging; Animals; Arcuate Nucleus of Hypothalamus; Enkephalins; Estradiol; Female; Gene Expression; Genes, Tumor Suppressor; Macaca mulatta; Median Eminence; Neurokinin B; Ovariectomy; Protein Precursors; Receptors, G-Protein-Coupled; Time Factors | 2010 |
Amyloid-beta production in aged guinea pigs: atropine-induced enhancement is reversed by naloxone.
Topics: Aging; Amyloid beta-Peptides; Animals; Atropine; Cerebral Cortex; Enkephalins; Guinea Pigs; Male; Muscarinic Antagonists; Naloxone; Narcotic Antagonists | 2010 |
Spatial and temporal distribution patterns of enkephalinergic neurons in adult and developing retinas of the preproenkephalin-green fluorescent protein transgenic mouse.
Topics: Aging; Animals; Enkephalins; gamma-Aminobutyric Acid; Glycine Plasma Membrane Transport Proteins; Green Fluorescent Proteins; Mice; Mice, Transgenic; Neurons; Phosphopyruvate Hydratase; Protein Precursors; Qa-SNARE Proteins; Retina; Stilbamidines; Time Factors | 2012 |
Methylation of ELOVL2 gene as a new epigenetic marker of age.
Topics: Acetyltransferases; Adolescent; Adult; Aged; Aged, 80 and over; Aging; Child; CpG Islands; DNA Methylation; Enkephalins; Epigenesis, Genetic; Fatty Acid Elongases; Female; Fetal Blood; Genetic Markers; Genome, Human; Humans; LIM-Homeodomain Proteins; Male; Middle Aged; Muscle Proteins; Oligonucleotide Array Sequence Analysis; Protein Precursors; Transcription Factors | 2012 |
Stress-induced preproenkephalin mRNA expression in the amygdala changes during early ontogeny in the rat.
Topics: Aging; Amygdala; Animals; Animals, Newborn; Enkephalins; Male; Neural Pathways; Neurons; Pain; Periaqueductal Gray; Protein Precursors; Rats; Rats, Long-Evans; RNA, Messenger; Sex Factors; Social Behavior; Stress, Psychological | 2002 |
Age-related decline in hypocretin (orexin) receptor 2 messenger RNA levels in the mouse brain.
Topics: Aging; Animals; Brain; Brain Chemistry; Enkephalins; Gene Expression Regulation; Male; Mice; Mice, Inbred C57BL; Orexin Receptors; Protein Precursors; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; RNA, Messenger | 2002 |
Developmental changes in the inhibition of cultured rat uterine cell proliferation by opioid peptides.
Topics: Aging; Animals; Cell Division; Cells, Cultured; Dose-Response Relationship, Drug; Dynorphins; Endorphins; Enkephalin, Methionine; Enkephalins; Epidermal Growth Factor; Estradiol; Female; Inhibitory Concentration 50; Naloxone; Narcotic Antagonists; Opioid Peptides; Ovariectomy; Rats; Rats, Inbred Strains; Rats, Wistar; Uterus | 2003 |
Enkephalinergic striatal projection neurons become less affected by quinolinic acid than substance P-containing striatal projection neurons as rats age.
Topics: Aging; Animals; Cell Survival; Corpus Striatum; Efferent Pathways; Enkephalins; In Situ Hybridization; Injections, Intraventricular; Male; Neurons; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Substance P | 2003 |
Occurrence of ACTH- and enkephalin-like peptides in the developing gut of Dicentrarchus labrax L.
Topics: Adrenocorticotropic Hormone; Aging; alpha-MSH; Animals; Bass; beta-Endorphin; Digestive System; Enkephalins; Immunohistochemistry; Larva; Pro-Opiomelanocortin | 2004 |
Prodynorphin knockout mice demonstrate diminished age-associated impairment in spatial water maze performance.
Topics: Age Factors; Aging; Analysis of Variance; Animals; Behavior, Animal; Brain Chemistry; Dynorphins; Enkephalins; Frontal Lobe; Gene Expression Regulation; Genotype; Hippocampus; Maze Learning; Mice; Mice, Knockout; Protein Precursors; Radioimmunoassay; Reaction Time; Retention, Psychology; Space Perception; Spatial Behavior; Swimming; Time Factors | 2005 |
Chemistry of mood and emotion.
Topics: Acetylcholine; Aging; Brain; Dopamine; Emotions; Enkephalins; Epinephrine; gamma-Aminobutyric Acid; Humans; Neurotransmitter Agents; Norepinephrine; Receptors, Neurotransmitter; Serotonin | 1980 |
Light and electron microscopic localization of enkephalin and tyrosine hydroxylase in neostriatum of fetal and adult rat brain.
Topics: Aging; Animals; Corpus Striatum; Endorphins; Enkephalins; Female; Fetus; Fluorescent Antibody Technique; Immunoenzyme Techniques; Microscopy, Electron; Pregnancy; Rats; Tyrosine 3-Monooxygenase | 1981 |
An immunohistochemical study of enkephalins and other neuropeptides in the striatum of the cat with evidence that the opiate peptides are arranged to form mosaic patterns in register with the striosomal compartments visible by acetylcholinesterase stainin
Topics: Acetylcholinesterase; Aging; Animals; Animals, Newborn; Cats; Caudate Nucleus; Corpus Striatum; Endorphins; Enkephalins; Immunoenzyme Techniques; Microscopy, Fluorescence; Nucleus Accumbens; Putamen; Substance P | 1981 |
Age-related changes in central nervous system enkephalins and substance P.
Topics: Aging; Animals; beta-Endorphin; Brain; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Hypothalamus; Male; Rats; Rats, Inbred Strains; Substance P | 1981 |
Effect of antenatal exposure to opiates on the development of opiate receptors in rat brain.
Topics: Aging; Animals; Animals, Newborn; Brain; Enkephalin, Methionine; Enkephalins; Female; Fetus; Maternal-Fetal Exchange; Morphine; Naloxone; Pregnancy; Rats; Receptors, Opioid | 1980 |
Perinatal exposure to delta 9-THC in mice: altered enkephalin and norepinephrine sensitivity in vas deferens.
Topics: Aging; Animals; Dronabinol; Endorphins; Enkephalin, Methionine; Enkephalins; Female; Male; Mice; Muscle, Smooth; Norepinephrine; Pregnancy; Prenatal Exposure Delayed Effects; Vas Deferens | 1980 |
Ontogeny of opiate receptors in rat forebrain: visualization by in vitro autoradiography.
Topics: Aging; Animals; Autoradiography; Cerebral Cortex; Corpus Striatum; Enkephalin, Leucine-2-Alanine; Enkephalins; Female; Naloxone; Neurons; Olfactory Pathways; Pregnancy; Rats; Receptors, Opioid; Septum Pellucidum; Telencephalon | 1981 |
Rat dopaminergic function in the retina during aging.
Topics: 3,4-Dihydroxyphenylacetic Acid; Aging; Animals; Binding Sites; Corpus Striatum; Enkephalins; Male; Phenylacetates; Rats; Receptors, Dopamine; Receptors, Opioid; Retina | 1981 |
Development of methionine-enkephalin and naloxone binding sites in regions of rat brain.
Topics: Aging; Animals; Binding, Competitive; Brain; Brain Stem; Cerebellum; Endorphins; Enkephalin, Methionine; Enkephalins; Female; Kinetics; Male; Naloxone; Rats; Rats, Inbred Strains; Receptors, Opioid; Tissue Distribution | 1982 |
Differential postnatal development of mu and delta opiate receptors.
Topics: Aging; Animals; Brain; Endorphins; Enkephalin, Leucine-2-Alanine; Enkephalins; Kinetics; Naloxone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu | 1982 |
Ontogenesis of opiate binding sites and radioimmunoassayable beta-endorphin and enkephalin in regions of rat brain.
Topics: Aging; Animals; Animals, Newborn; beta-Endorphin; Brain; Endorphins; Enkephalins; Female; Kinetics; Male; Naloxone; Rats; Rats, Inbred Strains; Receptors, Opioid | 1982 |
Reduced ability of naloxone to stimulate LH and testosterone release in aging male rats; possible relation to increase in hypothalamic met5-enkephalin.
Topics: Aging; Animals; Endorphins; Enkephalin, Methionine; Enkephalins; Hypothalamus; Luteinizing Hormone; Male; Morphine; Naloxone; Rats; Testosterone | 1980 |
Species and age-dependent differences of functional coupling between opioid delta-receptor and G-proteins and possible involvement of protein kinase C in striatal membranes.
Topics: Aging; Analgesics; Animals; Carbazoles; Cell Membrane; Corpus Striatum; Cyclic AMP-Dependent Protein Kinases; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; GTP Phosphohydrolases; GTP-Binding Proteins; Guinea Pigs; Indoles; Kinetics; Male; Naltrexone; Naphthalenes; Polycyclic Compounds; Protein Kinase C; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Species Specificity | 1994 |
Neuronal markers, peptides and enzymes in nerves and chromaffin cells in the rat adrenal medulla during postnatal development.
Topics: Acetylcholinesterase; Adrenal Medulla; Aging; Animals; Animals, Newborn; Biomarkers; Calcitonin Gene-Related Peptide; Enkephalins; Female; Fluorescent Antibody Technique; Galanin; GAP-43 Protein; Gene Expression; Immunohistochemistry; In Situ Hybridization; Male; Membrane Glycoproteins; Nerve Fibers; Nerve Tissue Proteins; Neurofilament Proteins; Neurons; Neuropeptide Y; Neuropeptides; Peptide Biosynthesis; Peptides; Rats; Rats, Sprague-Dawley; RNA, Messenger | 1994 |
[Leu5]enkephalin-encoding sequences are targets for a specific DNA-binding factor.
Topics: Aging; Amino Acid Sequence; Animals; Animals, Newborn; Base Sequence; beta-Galactosidase; Binding Sites; Cell Nucleus; DNA-Binding Proteins; Embryo, Mammalian; Enkephalin, Leucine; Enkephalins; Methylation; Mice; Mice, Inbred Strains; Molecular Sequence Data; Oligodeoxyribonucleotides; Protein Precursors; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Substrate Specificity; Transfection | 1995 |
Prenatal cocaine increases striatal serotonin innervation without altering the patch/matrix organization of intrinsic cell types.
Topics: Acetylcholinesterase; Aging; Animals; Calbindins; Cocaine; Corpus Striatum; Enkephalins; Female; Immunohistochemistry; Male; NADPH Dehydrogenase; Neurons, Afferent; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; S100 Calcium Binding Protein G; Serotonin; Substance P; Substantia Nigra | 1993 |
Proenkephalin and prodynorphin mRNA level in brain of rats with absence epilepsy.
Topics: Aging; Animals; Brain; Cerebral Cortex; Corpus Striatum; Enkephalins; Epilepsy, Absence; Hippocampus; In Situ Hybridization; Male; Protein Precursors; Rats; RNA, Messenger | 1994 |
Adaptive changes in rat striatal preproenkephalin expression and dopamine-opioid interactions upon chronic haloperidol treatment during different developmental stages.
Topics: Aging; Animals; Corpus Striatum; Dopamine; Embryonic and Fetal Development; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Fetus; Gene Expression; Guanylate Cyclase; Haloperidol; In Situ Hybridization; Maternal-Fetal Exchange; Pregnancy; Protein Precursors; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, mu; RNA, Messenger | 1994 |
Proenkephalin gene expression is altered in the brain of spontaneously hypertensive rats during the development of hypertension.
Topics: Aging; Animals; Blood Pressure; Body Weight; Brain; Enkephalins; Female; Gene Expression; Hypertension; In Situ Hybridization; Oligonucleotide Probes; Organ Specificity; Protein Precursors; Rats; Rats, Inbred SHR; Rats, Inbred WKY; RNA, Messenger; Systole | 1994 |
Induction of enkephalin in tuberoinfundibular dopaminergic neurons of pregnant, pseudopregnant, lactating and aged female rats.
Topics: Aging; Animals; Dopamine; Enkephalins; Estrus; Female; Fluorescent Dyes; Hypothalamus; Immunohistochemistry; In Situ Hybridization; Lactation; Neurons; Ovariectomy; Pregnancy; Pregnancy, Animal; Protein Precursors; Pseudopregnancy; Rats; RNA, Messenger; Stilbamidines; Tyrosine 3-Monooxygenase | 1994 |
Differential regulation of glutamate decarboxylase and preproenkephalin mRNA levels in the rat striatum.
Topics: Aging; Animals; Animals, Newborn; Autoradiography; Dopamine; Enkephalins; Female; Glutamate Decarboxylase; Haloperidol; In Situ Hybridization; Neostriatum; Neurons; Oxidopamine; Pertussis Toxin; Pregnancy; Protein Precursors; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sulpiride; Virulence Factors, Bordetella | 1994 |
Age-related changes in the spinal antinociceptive effects of DAGO, DPDPE and beta-endorphin in the rat.
Topics: Aging; Analgesics; Analysis of Variance; Animals; beta-Endorphin; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Spinal; Male; Pain; Rats; Rats, Inbred F344; Spine | 1994 |
Aging, cardiac proenkephalin mRNA and enkephalin peptides in the Fisher 344 rat.
Topics: Aging; Animals; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Male; Myocardium; Protein Precursors; Rats; Rats, Inbred F344; RNA, Messenger; Sympathectomy, Chemical | 1994 |
Age-related changes in biogenic amines, opiate, and steroid receptors in the prepubertal bull calf.
Topics: Aging; alpha-Methyltyrosine; Analysis of Variance; Animals; Biogenic Amines; Cattle; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Hypothalamus; Luteinizing Hormone; Male; Methyltyrosines; Naloxone; Pituitary Gland; Radioimmunoassay; Receptors, Opioid; Receptors, Steroid; Tyrosine 3-Monooxygenase | 1993 |
Ontogeny of the proenkephalin system in the rat corpus striatum: its relationship to dopaminergic innervation and transient compartmental expression.
Topics: Aging; Animals; Corpus Striatum; DNA Probes; Dopamine; Embryo, Mammalian; Embryonic and Fetal Development; Enkephalin, Methionine; Enkephalins; Gene Expression Regulation; Gestational Age; Immunohistochemistry; In Situ Hybridization; Neurons; Protein Precursors; Rats; Rats, Sprague-Dawley; Tyrosine 3-Monooxygenase | 1993 |
Trophic factor production by reactive astrocytes in injured brain.
Topics: Aging; Animals; Astrocytes; Biomarkers; Cells, Cultured; Cerebellum; Enkephalin, Methionine; Enkephalins; Fetus; Glial Fibrillary Acidic Protein; Male; Mice; Mice, Inbred C57BL; MPTP Poisoning; Nerve Growth Factors; Neuropeptides; Neurotoxins; Oxidopamine; Protein Precursors; Rats; Rats, Sprague-Dawley; RNA, Messenger; Somatostatin | 1993 |
Acute and persistent suppression of preproenkephalin mRNA expression in the striatum following developmental hypoxic-ischemic injury.
Topics: Aging; Animals; Autoradiography; Brain Ischemia; Corpus Striatum; Enkephalins; Female; Hypoxia, Brain; In Situ Hybridization; NADPH Dehydrogenase; Neurons; Phosphorus Radioisotopes; Protein Precursors; Rats; Rats, Sprague-Dawley; RNA, Messenger; Suppression, Genetic | 1994 |
Preproenkephalin mRNA expression in the developing and adult rat brain.
Topics: Aging; Animals; Blotting, Northern; Brain; Cerebellum; Embryonic and Fetal Development; Enkephalin, Methionine; Enkephalins; Female; Gene Expression; Gestational Age; In Situ Hybridization; Male; Organ Specificity; Protein Precursors; Rats; Rats, Sprague-Dawley; RNA, Messenger | 1994 |
Synenkephalin processing in embryonic rat brain.
Topics: Aging; Animals; Antibodies, Monoclonal; Brain; Brain Chemistry; Cell Division; Chromatography, Affinity; Chromatography, Gel; Chromatography, High Pressure Liquid; Enkephalins; Female; Neostriatum; Pregnancy; Protein Precursors; Radioimmunoassay; Rats; Rats, Wistar | 1994 |
Age-related loss of mRNA encoding adenosine A2 receptor in the rat striatum.
Topics: Adenosine; Aging; Animals; Autoradiography; Biomarkers; Corpus Striatum; Enkephalins; Histocytochemistry; Image Processing, Computer-Assisted; In Situ Hybridization; Male; Oligonucleotide Probes; Phenethylamines; Rats; Rats, Wistar; Receptors, Purinergic P1; RNA, Messenger | 1993 |
Age-associated increase in rat cardiac opioid production.
Topics: Aging; Animals; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Heart Conduction System; Hypertrophy, Left Ventricular; Male; Myocardium; Osmolar Concentration; Protein Precursors; Rats; Rats, Wistar; RNA, Messenger; Sympathectomy, Chemical | 1993 |
Alterations in delta opioid receptor levels in discrete areas of the neocortex and in the globus pallidus of the aging guinea pig: a quantitative autoradiographic study.
Topics: Aging; Analgesics; Animals; Autoradiography; Cerebral Cortex; Corpus Striatum; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalins; Globus Pallidus; Guinea Pigs; In Vitro Techniques; Male; Radioligand Assay; Receptors, Opioid, delta | 1993 |
Developmental changes in rat adrenal enkephalin precursor: peptide ratio.
Topics: Adrenal Glands; Aging; Animals; Carboxypeptidase H; Carboxypeptidases; Enkephalin, Methionine; Enkephalins; Nicotine; Protein Precursors; Rats; Rats, Inbred F344 | 1993 |
Prenatal morphine exposure differentially alters expression of opioid peptides in striatum of newborns.
Topics: Aging; Animals; Animals, Newborn; Blotting, Northern; Brain; Corpus Striatum; Dynorphins; Enkephalin, Methionine; Enkephalins; Female; Frontal Lobe; Gene Expression; Hippocampus; Hypothalamus; Morphine; Multivariate Analysis; Organ Specificity; Pregnancy; Prenatal Exposure Delayed Effects; Protein Biosynthesis; Protein Precursors; Rats; Rats, Sprague-Dawley; RNA, Messenger | 1995 |
Regulation of DNA synthesis of myocardial and epicardial cells in developing rat heart by [Met5]enkephalin.
Topics: Aging; Animals; Animals, Newborn; Cells, Cultured; DNA; Enkephalin, Methionine; Enkephalins; Female; Male; Myocardium; Pericardium; Protein Precursors; Rats; Rats, Sprague-Dawley; Receptors, Opioid; RNA, Messenger; Tissue Distribution | 1996 |
Age-related changes in the soluble and the membrane-bound Tyr-aminopeptidase activities in several areas of the male and female rat brain.
Topics: Aging; Aminopeptidases; Analysis of Variance; Animals; Brain; Enkephalins; Female; Male; Membranes; Rats; Rats, Sprague-Dawley; Sex Characteristics; Solubility | 1996 |
Extracellular free potassium and calcium during synchronous activity induced by 4-aminopyridine in the juvenile rat hippocampus.
Topics: 4-Aminopyridine; 6-Cyano-7-nitroquinoxaline-2,3-dione; Aging; Analgesics; Animals; Calcium; Electrophysiology; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Excitatory Amino Acid Antagonists; Extracellular Space; Hippocampus; Membrane Potentials; Patch-Clamp Techniques; Piperazines; Potassium; Rats; Receptors, Opioid, mu | 1996 |
Alterations in opiate receptor binding in the hippocampus of aged Long-Evans rats.
Topics: Age Factors; Aging; Animals; Autoradiography; Binding, Competitive; Diprenorphine; Enkephalins; Hippocampus; Male; Rats; Receptors, Opioid | 1996 |
In vitro autoradiography of ionotropic glutamate receptors in hippocampus and striatum of aged Long-Evans rats: relationship to spatial learning.
Topics: Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Autoradiography; Corpus Striatum; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Hippocampus; Kainic Acid; Male; Maze Learning; N-Methylaspartate; Organ Specificity; Prosencephalon; Rats; Receptors, AMPA; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Regression Analysis; Tritium | 1996 |
Alterations in the estrogen sensitivity of hypothalamic proenkephalin mRNA expression with age and prenatal exposure to alcohol.
Topics: Age Factors; Aging; Animals; Enkephalins; Estrogens; Ethanol; Female; Hypothalamus; In Situ Hybridization; Maternal Exposure; Protein Precursors; Rats; Rats, Sprague-Dawley; RNA, Messenger | 1997 |
Reduction in the ratio of beta-preprotachykinin to preproenkephalin messenger RNA expression in postmortem human putamen during aging and in patients with status lacunaris. Implications for the susceptibility to parkinsonism.
Topics: Adult; Aged; Aged, 80 and over; Aging; Cerebral Infarction; Disease Susceptibility; Enkephalins; Female; Humans; Linear Models; Male; Middle Aged; Parkinson Disease; Polymerase Chain Reaction; Protein Precursors; Putamen; RNA, Messenger; Tachykinins; Transcription, Genetic | 1997 |
Age-dependent changes in adenosine receptors are not modified by life-long intermittent alcohol administration.
Topics: Aging; Alcoholism; Animals; Autoradiography; Brain; Disease Models, Animal; Enkephalins; Male; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Receptors, Purinergic P1; RNA, Messenger | 1998 |
The effects of aging on mu and delta opioid receptors in the spinal cord of Fischer-344 rats.
Topics: Aging; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Naltrexone; Narcotic Antagonists; Radioligand Assay; Rats; Rats, Inbred F344; Receptors, Opioid, delta; Receptors, Opioid, mu; Spinal Cord | 1998 |
The effect of aging on the response of striatal preproenkephalin and preprotachykinin mRNA contents to chronic haloperidol treatment in rats: measurement by solution-hybridization RNase protection assay.
Topics: Aging; Animals; Corpus Striatum; Enkephalins; Haloperidol; Male; Protein Precursors; Rats; Rats, Sprague-Dawley; RNA, Messenger; Tachykinins | 1998 |
Adrenal neuropeptide Y mRNA but not preproenkephalin mRNA induction by stress is impaired by aging in Fischer 344 rats.
Topics: Adrenal Glands; Aging; Animals; Enkephalins; Gene Expression Regulation; Male; Neuropeptide Y; Protein Precursors; Rats; Rats, Inbred F344; RNA, Messenger; Stress, Physiological | 1998 |
Localization of preproenkephalin mRNA in rat heart: selective gene expression in left ventricular myocardium.
Topics: Aging; Animals; Animals, Newborn; Blotting, Northern; Body Weight; Enkephalins; Female; Gene Expression Regulation, Developmental; Heart; Heart Ventricles; In Situ Hybridization; Male; Myocardium; Organ Size; Protein Precursors; Rats; Rats, Wistar; RNA, Messenger; Transcription, Genetic | 1998 |
Preproenkephalin gene expression and [Met5]-enkephalin levels in the developing rat heart.
Topics: Aging; Animals; Caudate Nucleus; DNA Probes; Embryonic and Fetal Development; Enkephalin, Methionine; Enkephalins; Female; Fetal Heart; Gene Expression Regulation, Developmental; Gestational Age; Heart; Liver; Male; Myocardium; Pro-Opiomelanocortin; Protein Precursors; Rats; Rats, Sprague-Dawley; RNA, Messenger; Transcription, Genetic | 1998 |
Differential sensitivity of tachykinin vs. enkephalin gene expression in the posterior striatum in response to acute p-chloroamphetamine treatment during postnatal development.
Topics: Aging; Animals; Animals, Newborn; Corpus Striatum; Enkephalins; Gene Expression; p-Chloroamphetamine; Protein Precursors; Rats; Rats, Sprague-Dawley; RNA, Messenger; Serotonin Agents; Tachykinins; Tissue Distribution | 1999 |
Age- and sex-related differences in opioid receptor densities in the songbird vocal control system.
Topics: Aging; Analgesics, Opioid; Animals; Autoradiography; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Image Processing, Computer-Assisted; Male; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Reproduction; Sex Characteristics; Songbirds; Vocalization, Animal | 1999 |
Increase in fiber density for immunoreactive serotonin, substance P, enkephalin and thyrotropin-releasing hormone occurs during the early presymptomatic period of motoneuron disease in Wobbler mouse spinal cord ventral horn.
Topics: Aging; Animals; Behavior, Animal; Cell Count; Enkephalins; Female; Immunohistochemistry; Male; Mice; Mice, Neurologic Mutants; Motor Neuron Disease; Nerve Fibers; Serotonin; Spinal Cord; Substance P; Thyrotropin-Releasing Hormone | 1999 |
Opioid modulation of calcium current in cultured sensory neurons: mu-modulation of baroreceptor input.
Topics: Aging; Analgesics, Opioid; Animals; Animals, Newborn; Calcium; Calcium Channels; Cells, Cultured; Electric Conductivity; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; GTP-Binding Proteins; Naloxone; Narcotic Antagonists; Narcotics; Neurons, Afferent; Nodose Ganglion; Pressoreceptors; Rats; Receptors, Opioid, mu | 1999 |
TTF-1, a homeodomain gene required for diencephalic morphogenesis, is postnatally expressed in the neuroendocrine brain in a developmentally regulated and cell-specific fashion.
Topics: Aging; Animals; Astrocytes; Cell Line; Diencephalon; Enkephalins; Ependyma; Female; Gene Expression Regulation, Developmental; Gene Silencing; Gonadotropin-Releasing Hormone; Hypothalamus; Median Eminence; Neurons; Neurosecretory Systems; Nuclear Proteins; Promoter Regions, Genetic; Protein Precursors; Rats; Rats, Sprague-Dawley; Receptor, ErbB-2; RNA, Messenger; Thyroid Gland; Thyroid Nuclear Factor 1; Transcription Factors; Transcriptional Activation | 2001 |
Endogenous opioids and oligodendroglial function: possible autocrine/paracrine effects on cell survival and development.
Topics: Aging; Animals; Animals, Newborn; Autocrine Communication; Brain; Cell Differentiation; Cell Survival; Cells, Cultured; Dynorphins; Enkephalins; Immunohistochemistry; Mice; Narcotic Antagonists; Narcotics; Oligodendroglia; Opioid Peptides; Paracrine Communication; Protein Precursors; Receptors, Opioid, kappa; Stem Cells | 2001 |
Neonatal dopamine depletion reveals a synergistic mechanism of mRNA regulation that is mediated by dopamine(D1) and serotonin(2) receptors and is targeted to tachykinin neurons of the dorsomedial striatum.
Topics: 3,4-Dihydroxyphenylacetic Acid; Aging; Animals; Animals, Newborn; Dopamine; Dopamine Agonists; Dopamine Antagonists; Drug Synergism; Enkephalins; Gene Expression Regulation, Developmental; Male; Movement Disorders; Neostriatum; Neurons; Oxidopamine; Protein Precursors; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Serotonin; RNA, Messenger; Serotonin Antagonists; Serotonin Receptor Agonists; Tachykinins | 2001 |
Opioid peptides and alpha-melanocyte-stimulating hormone in genetically obese (ob/ob) mice during development.
Topics: Aging; Animals; Body Weight; Brain; Endorphins; Enkephalins; Melanocyte-Stimulating Hormones; Mice; Mice, Obese; Organ Size; Pituitary Gland | 1979 |
Immunohistochemical study on development of serotonin-, substance P-, and enkephalin-positive fibers in the rat spinal motor nucleus.
Topics: Aging; Animals; Enkephalins; Female; Immunohistochemistry; Medulla Oblongata; Nerve Fibers; Neural Pathways; Pregnancy; Raphe Nuclei; Rats; Rats, Wistar; Serotonin; Spinal Cord; Substance P | 1992 |
Decrease of enkephalins in cerebellum during Wobbler mouse motoneuron disease.
Topics: Aging; Animals; Cerebellum; Corpus Striatum; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Mice; Mice, Neurologic Mutants; Motor Neuron Disease; Substance P; Thyrotropin-Releasing Hormone | 1992 |
Selective impairment of neuroendocrine and hemodynamic responses to a mu-opioid peptide in aged rats.
Topics: Adrenocorticotropic Hormone; Aging; Animals; Corticotropin-Releasing Hormone; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Epinephrine; Hemodynamics; Hormones; Naloxone; Norepinephrine; Prolactin; Rats; Rats, Inbred F344 | 1992 |
Binding characteristics of delta opioid receptors in different regions of the brain of young and old male rats as studied with the highly selective ligand [D-Pen2-D-Pen5] enkephalin.
Topics: Aging; Animals; Binding, Competitive; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; In Vitro Techniques; Kinetics; Male; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Tissue Distribution | 1992 |
Developmental expression of the proenkephalin and prosomatostatin genes in cultured cortical and cerebellar astrocytes.
Topics: Aging; Animals; Astrocytes; Cells, Cultured; Cerebellum; Cerebral Cortex; DNA Probes; Enkephalin, Methionine; Enkephalins; Fetus; Gene Expression; Protein Precursors; Radioimmunoassay; Rats; Rats, Inbred Strains; RNA, Messenger; Somatostatin | 1992 |
Morphine-induced downregulation of mu-opioid receptors and peptide synthesis in neonatal rat brain.
Topics: Aging; Animals; Animals, Newborn; Blotting, Northern; Brain; Down-Regulation; Enkephalins; Female; Maternal-Fetal Exchange; Morphine; Pregnancy; Protein Precursors; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu; RNA; RNA, Messenger | 1992 |
Effects of the subcutaneous administration of enkephalins on tail-flick response and righting reflex of developing rats.
Topics: Aging; Animals; Anti-Bacterial Agents; Captopril; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Methionine; Enkephalins; Female; Glycopeptides; Injections, Subcutaneous; Male; Oligopeptides; Pain; Peptides; Posture; Protease Inhibitors; Rats; Rats, Wistar; Reflex | 1992 |
Dopamine receptor activation inhibits estrogen-stimulated transforming growth factor-alpha gene expression and growth in anterior pituitary, but not in uterus.
Topics: Aging; Animals; beta-N-Acetylhexosaminidases; Blotting, Northern; Bromocriptine; Cell Division; Enkephalins; Estradiol; Female; Gene Expression Regulation; Hexosaminidase A; Kinetics; Ovariectomy; Pituitary Gland, Anterior; Prolactin; Protein Precursors; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D2; RNA, Messenger; Silicone Elastomers; Time Factors; Transforming Growth Factor alpha; Uterus | 1992 |
Age-dependent changes in the subcellular distribution of rat brain mu-opioid receptors and GTP binding regulatory proteins.
Topics: Aging; Animals; Animals, Newborn; Blotting, Western; Cell Fractionation; Cell Membrane; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; GTP-Binding Proteins; Guanylyl Imidodiphosphate; Male; Prosencephalon; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu; Subcellular Fractions | 1991 |
Transient expression of opioid receptors in defined regions of developing brain: are embryonic receptors selective?
Topics: Aging; Animals; Animals, Newborn; Brain; Corpus Striatum; Dithiothreitol; Embryo, Mammalian; Embryonic and Fetal Development; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Guinea Pigs; Hippocampus; Rats; Receptors, Opioid; Time Factors; Tissue Distribution | 1991 |
Differential effects of specific opioid receptor agonists on rat pup isolation calls.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Aging; Animals; Behavior, Animal; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Social Isolation; Ultrasonics; Vocalization, Animal | 1991 |
Effects of donor age on superior cervical ganglion transplants: evaluation of Falck-Hillarp histochemistry and immunocytochemistry.
Topics: Aging; Animals; Animals, Newborn; Calcitonin Gene-Related Peptide; Enkephalins; Female; Ganglia, Sympathetic; Histocytochemistry; Immunohistochemistry; Nerve Tissue; Neuropeptide Y; Neuropeptides; Rats; Rats, Inbred Strains; Transplantation, Homologous; Tyrosine 3-Monooxygenase | 1991 |
Differential ontogenetic expression and regulation of proenkephalin and preprosomatostatin mRNAs in rat caudate-putamen as studied by in situ hybridization histochemistry.
Topics: Aging; Animals; Caudate Nucleus; Enkephalins; Gestational Age; Nucleic Acid Hybridization; Oligonucleotide Probes; Protein Precursors; Putamen; Rats; Rats, Inbred Strains; RNA, Messenger; Somatostatin | 1991 |
Age-related impairment of signal transduction and its correction with antioxidants.
Topics: Adenylyl Cyclases; Aging; Animals; Brain; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Guinea Pigs; Isoproterenol; Male; Muscle Contraction; Muscle, Smooth; Rats; Rats, Inbred Strains; Signal Transduction; Synaptosomes | 1991 |
Expression of the preproenkephalin A gene in the heart of cardiomyopathic hamsters.
Topics: Aging; Amino Acid Sequence; Animals; Blotting, Northern; Cardiomyopathies; Cricetinae; Enkephalin, Methionine; Enkephalins; Gene Expression; Glyceraldehyde-3-Phosphate Dehydrogenases; Heart Atria; Heart Ventricles; Male; Molecular Sequence Data; Protein Precursors; Radioimmunoassay; RNA, Messenger | 1991 |
Pre- and postnatal development of opiate receptor subtypes in rat spinal cord.
Topics: Aging; Animals; Binding, Competitive; Diprenorphine; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Rats; Rats, Inbred Strains; Receptors, Opioid; Spinal Cord | 1990 |
Ontogeny of mu-, delta- and kappa-opioid receptors mediating inhibition of neurotransmitter release and adenylate cyclase activity in rat brain.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetylcholine; Adenylyl Cyclases; Aging; Animals; Brain; Catecholamines; Electric Stimulation; Embryonic and Fetal Development; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; In Vitro Techniques; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid | 1990 |
Ontogenesis of cell surface mu-opioid ([3H]DAGO) binding sites in rat hypothalamus and ex vivo determination of blood-brain barrier penetration by opioid peptide FK 33-824.
Topics: Aging; Animals; Binding, Competitive; Blood-Brain Barrier; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Hypothalamus; Naloxone; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu | 1990 |
Regionally selective increases in mu opioid receptor density in the brains of suicide victims.
Topics: Adult; Aging; Autoradiography; Brain; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Female; Humans; Kinetics; Male; Middle Aged; Receptors, Opioid; Receptors, Opioid, mu; Suicide | 1990 |
Regulated expression of proenkephalin A during ontogenic development of mesenchymal derivative tissues.
Topics: Aging; Animals; Embryonic and Fetal Development; Enkephalins; Female; Gene Expression Regulation; Genes; Kidney; Muscle Development; Muscles; Nucleic Acid Hybridization; Organ Specificity; Pregnancy; Protein Precursors; Rats; Rats, Inbred Strains; RNA, Messenger; Skin; Transcription, Genetic | 1990 |
Postnatal development of preproenkephalin mRNA containing neurons in the rat lower brainstem.
Topics: Aging; Animals; Brain Stem; Enkephalins; Gene Expression Regulation; Male; Nucleic Acid Hybridization; Protein Precursors; Rats; Rats, Inbred Strains; RNA, Messenger | 1990 |
Ultrastructural localization of enkephalin-like immunoreactivity in developing rat cerebellum.
Topics: Aging; Animals; Cerebellum; Enkephalins; Immunohistochemistry; Microscopy, Electron; Rats; Rats, Inbred Strains | 1990 |
Rat brain regional preproenkephalin A messenger RNA levels are altered in genetic hypertension.
Topics: Aging; Animals; Blotting, Northern; Brain; Enkephalins; Hybridization, Genetic; Hypertension; In Vitro Techniques; Male; Myelin Basic Protein; Protein Precursors; Rats; Rats, Inbred SHR; Rats, Inbred WKY; RNA, Messenger | 1989 |
Behavioural effects of selective mu-, kappa-, and delta-opioid agonists in neonatal rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Aging; Analgesics; Animals; Animals, Newborn; Behavior, Animal; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Male; Morphine; Narcotics; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 1989 |
Up-regulation of opiate receptors following chronic naltrexone treatment in mature and aged male and female rats.
Topics: Aging; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Female; Male; Naltrexone; Rats; Rats, Inbred F344; Receptors, Opioid | 1989 |
Elevated dynorphin in the hippocampal formation of aged rats: relation to cognitive impairment on a spatial learning task.
Topics: Aging; Animals; Blotting, Northern; Cognition; Dynorphins; Enkephalins; Hippocampus; Learning; Protein Precursors; Rats; RNA, Messenger | 1989 |
Effects of chlordecone administration on brain and pituitary peptide systems.
Topics: Aging; Animals; Animals, Newborn; beta-Endorphin; Brain; Castration; Chlordecone; Diet; Diethylstilbestrol; Dose-Response Relationship, Drug; Endorphins; Enkephalin, Methionine; Enkephalins; Estrogens; Female; Insecticides; Luteinizing Hormone; Male; Nerve Tissue Proteins; Pituitary Gland, Anterior; Prolactin; Rats; Time Factors | 1985 |
Age-dependency and regional distribution of enkephalinergic nerves in human prostate.
Topics: Adolescent; Adult; Aged; Aging; Autonomic Nervous System; Child, Preschool; Enkephalins; Humans; Infant; Male; Middle Aged; Neurons; Prostate | 1989 |
Postnatal expression of opioid genes in rat brain.
Topics: Aging; Animals; Brain; Enkephalins; Gene Expression Regulation; Nucleic Acid Hybridization; Protein Precursors; Rats; RNA, Messenger | 1989 |
Postnatal ontogeny of enkephalin fibers in spinal sympathetic nuclei.
Topics: Adrenergic Fibers; Aging; Animals; Enkephalins; Rats; Rats, Inbred Strains; Spinal Cord | 1989 |
Ontogenesis of enkephalinergic afferent systems in the opossum cerebellum.
Topics: Aging; Animals; Cerebellum; Enkephalins; Immunohistochemistry; Opossums | 1989 |
Proenkephalin opioid peptide product in the sensory ganglia of the rat: a developmental immunohistochemical study.
Topics: Aging; Animals; Cell Count; Embryonic and Fetal Development; Enkephalin, Methionine; Enkephalins; Ganglia, Spinal; Gestational Age; Immunohistochemistry; Neurons, Afferent; Protein Precursors; Rats; Trigeminal Nerve | 1989 |
Development of delta-opioid receptors in rat brain characterised by [3H]-[D-Pen2,D-Pen5] enkephalin binding.
Topics: Aging; Animals; Brain; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Kinetics; Male; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta | 1986 |
Morphine-induced downregulation of mu-opioid receptors in neonatal rat brain.
Topics: Aging; Animals; Brain; Delayed-Action Preparations; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Kinetics; Morphine; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, mu | 1988 |
Neonatal and adult 6-hydroxydopamine-induced lesions differentially alter tachykinin and enkephalin gene expression.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Aging; Animals; Animals, Newborn; Benzazepines; Corpus Striatum; Dopamine; Dynorphins; Enkephalin, Methionine; Enkephalins; Ergolines; Female; Gene Expression Regulation; Hippocampus; Hydroxydopamines; Male; Motor Activity; Neuropeptides; Oxidopamine; Peptide Fragments; Protein Precursors; Quinpirole; Rats; Rats, Inbred Strains; RNA, Messenger; Substantia Nigra; Tachykinins | 1987 |
Distorted development of intracerebral grafts: long-term maintenance of tyrosine hydroxylase-containing neurons in grafts of cortical tissue.
Topics: Aging; Animals; Brain; Dopamine; Enkephalins; Frontal Lobe; Graft Survival; Hydroxydopamines; Immunohistochemistry; Male; Neuronal Plasticity; Neuropeptide Y; Oxidopamine; Rats; Rats, Inbred Strains; Tyrosine 3-Monooxygenase | 1988 |
Putative neurotransmitters in the rat cochlea at several ages.
Topics: Acetylcholine; Aging; Animals; Chromatography, High Pressure Liquid; Cochlea; Dynorphins; Enkephalins; Neurotransmitter Agents; Radioimmunoassay; Rats; Rats, Inbred F344; Reference Values | 1988 |
Altered beta-endorphin, Met- and Leu-enkephalins, and enkephalin-containing peptides in pancreas and pituitary of genetically obese diabetic (db/db) mice during development of diabetic syndrome.
Topics: Aging; Animals; beta-Endorphin; Body Weight; Diabetes Mellitus, Experimental; Endorphins; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Insulin; Islets of Langerhans; Mice; Mice, Obese; Pituitary Gland | 1986 |
Ontogeny and regional distribution of proenkephalin- and prodynorphin-derived peptides and opioid receptors in rat hippocampus.
Topics: Aging; Animals; Animals, Newborn; Embryo, Mammalian; Enkephalins; Hippocampus; Male; Protein Precursors; Rats; Rats, Inbred Strains; Receptors, Opioid | 1985 |
Senescent change in tissue weight and immunoreactive beta-endorphin, enkephalin, and vasopressin in eight regions of C57BL/6J mouse brain and pituitary.
Topics: Aging; Animals; beta-Endorphin; Brain Chemistry; Brain Stem; Cerebral Cortex; Corpus Striatum; Endorphins; Enkephalins; Hippocampus; Hypothalamus; Male; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Organ Size; Pituitary Gland; Vasopressins | 1985 |
Age-related changes of enkephalinergic innervation of human sympathetic neurons.
Topics: Adult; Aged; Aged, 80 and over; Aging; Enkephalins; Ganglia, Sympathetic; Humans; Immunohistochemistry; Middle Aged; Neurons; Reference Values; Sympathetic Nervous System | 1988 |
Transient increases and individual variations in preprocholecystokinin gene expression in rat telencephalic regions during postnatal development: a quantitative comparison between preprocholecystokinin mRNA and preproenkephalin mRNA.
Topics: Aging; Animals; Animals, Newborn; Cerebral Cortex; Cholecystokinin; Corpus Striatum; Enkephalins; Genes; Hippocampus; Organ Specificity; Protein Precursors; Rats; Rats, Inbred Strains; Reference Values; RNA, Messenger; Telencephalon; Transcription, Genetic | 1988 |
Developmental expression of proenkephalin mRNA in rat striatum and in striatal cultures.
Topics: Age Factors; Aging; Animals; Cells, Cultured; Corpus Striatum; Enkephalins; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Neuroglia; Nucleic Acid Hybridization; Protein Precursors; Rats; Rats, Inbred Strains; RNA, Messenger | 1988 |
Adrenal proenkephalin-derived peptides during postnatal development in spontaneously hypertensive rats.
Topics: Adrenal Glands; Aging; Animals; Chlorisondamine; Chromatography, Gel; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Hypertension; Male; Molecular Weight; Protein Precursors; Rats; Rats, Inbred SHR; Rats, Inbred WKY | 1988 |
Age-related decreases in the concentration of Met- and Leu-enkephalin and neurotensin in the basal ganglia of rats.
Topics: Aging; Animals; Basal Ganglia; Chromatography, High Pressure Liquid; Enkephalin, Leucine; Enkephalin, Methionine; Enkephalins; Male; Neurotensin; Radioimmunoassay; Rats; Rats, Inbred Strains | 1987 |
Cerebrospinal fluid leucine-enkephalin-like levels in febrile convulsions.
Topics: Adolescent; Adult; Age Factors; Aged; Aging; Brain Chemistry; Child; Child, Preschool; Enkephalin, Leucine; Enkephalins; Female; Humans; Male; Middle Aged; Narcotics; Seizures; Seizures, Febrile | 1985 |
Ontogeny of opioid and related peptides in the rat cns and pituitary: an immunocytochemical study.
Topics: Aging; Animals; Brain; Dynorphins; Embryo, Mammalian; Endorphins; Enkephalin, Leucine; Female; Peptide Fragments; Pituitary Gland; Pituitary Hormones, Anterior; Pregnancy; Pro-Opiomelanocortin; Protein Precursors; Rats; Rats, Inbred Strains | 1983 |
Ontogeny of the peptidergic system in the rat spinal cord: immunohistochemical analysis.
Topics: Aging; Animals; Enkephalin, Leucine; Female; Fluorescent Antibody Technique; Ganglia, Spinal; Gestational Age; Male; Neural Pathways; Neurons; Neurotensin; Pregnancy; Rats; Somatostatin; Spinal Cord; Substance P; Synaptic Transmission | 1982 |
The ontogeny of seizures induced by leucine-enkephalin and beta-endorphin.
Topics: Aging; Animals; beta-Endorphin; Brain; Electroencephalography; Endorphins; Enkephalin, Leucine; Evoked Potentials; Male; Naloxone; Rats; Rats, Inbred Strains; Seizures | 1984 |
Ontogeny of enkephalin-like immunoreactivity in the rat hippocampus.
Topics: Aging; Animals; Animals, Newborn; Axons; Enkephalin, Leucine; Female; Fluorescent Antibody Technique; Hippocampus; Immune Sera; Immunoenzyme Techniques; Male; Rats; Rats, Inbred Strains | 1984 |
Human brain methionine- and leucine-enkephalins and their receptors during ageing.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Brain; Child; Child, Preschool; Enkephalin, Leucine; Enkephalin, Methionine; Female; Humans; Male; Middle Aged; Radioimmunoassay; Receptors, Opioid | 1993 |
[The effects of enkephalins on the water-salt metabolism of rats in ontogeny].
Topics: Aging; Animals; Diuresis; Enkephalin, Leucine; Natriuresis; Potassium; Rats; Rats, Wistar; Sodium; Time Factors; Water-Electrolyte Balance | 1993 |
Age-induced increase of leucine enkephalin enzyme degradation in human plasma.
Topics: Adult; Aged; Aged, 80 and over; Aging; Aminopeptidases; Analysis of Variance; Chromatography, Gel; Chromatography, Thin Layer; Enkephalin, Leucine; Female; Glycine; Humans; Hydrolysis; Kinetics; Male; Molecular Weight; Peptide Hydrolases; Protease Inhibitors; Tyrosine | 1998 |
Postnatal changes in development of serotonin-, neuropeptide Y-, Leu-enkephalin- and substance P- terminals in the rat locus coeruleus; a quantitative immunohistochemical study.
Topics: Aging; Animals; Animals, Newborn; Enkephalin, Leucine; Female; Immunoenzyme Techniques; Immunohistochemistry; Locus Coeruleus; Male; Microscopy, Electron; Nerve Endings; Neurons, Afferent; Neuropeptide Y; Rats; Rats, Sprague-Dawley; Serotonin; Substance P | 1992 |
Measurement of neuropeptides in the brain and spinal cord of Wobbler mouse: a model for motoneuron disease.
Topics: Aging; Animals; Brain; Brain Chemistry; Disease Models, Animal; Enkephalin, Leucine; Enkephalin, Methionine; Mice; Mice, Neurologic Mutants; Motor Neurons; Neuromuscular Diseases; Neuropeptides; Somatostatin; Spinal Cord; Substance P; Thyrotropin-Releasing Hormone | 1990 |
Development of substance P, Leu-enkephalin and serotonin profiles in the lateral geniculate nuclear complex of albino rat.
Topics: Aging; Animals; Enkephalin, Leucine; Fetus; Geniculate Bodies; Rats; Rats, Inbred Strains; Serotonin; Substance P | 1990 |
Neuropeptide levels in the basal ganglia of aged common marmosets following prolonged treatment with MPTP.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 3,4-Dihydroxyphenylacetic Acid; Aging; Animals; Basal Ganglia; Biogenic Monoamines; Callithrix; Caudate Nucleus; Dopamine; Enkephalin, Leucine; Enkephalin, Methionine; Female; Globus Pallidus; Homovanillic Acid; Male; Neuropeptides; Neurotensin; Putamen; Reference Values; Sincalide; Substance P | 1991 |
Effect of neonatal infraorbital nerve transection on substance P- and leucine enkephalin-like immunoreactivities in trigeminal subnucleus caudalis of the rat.
Topics: Aging; Animals; Animals, Newborn; Brain Stem; Denervation; Enkephalin, Leucine; Immunohistochemistry; Nervous System Physiological Phenomena; Orbit; Rats; Rats, Inbred Strains; Substance P; Tissue Distribution; Trigeminal Caudal Nucleus; Trigeminal Nucleus, Spinal | 1988 |
Swim-stress-induced antinociception in young rats.
Topics: Aging; Animals; Animals, Newborn; Enkephalin, Leucine; Female; Male; Naloxone; Narcotic Antagonists; Nociceptors; Rats; Rats, Inbred Strains; Stress, Psychological; Swimming | 1989 |
Characterization of opioid receptor binding in adult and fetal sheep brain regions.
Topics: Aging; Animals; Brain Chemistry; Cerebellum; Dihydromorphine; Embryonic and Fetal Development; Enkephalin, Leucine; Female; Frontal Lobe; Hippocampus; Kinetics; Receptors, Opioid; Sheep | 1986 |
Leucine-enkephalin- and neuropeptide Y-modulation of [3H]noradrenaline release in the oviduct of mature and juvenile rabbits.
Topics: Aging; Animals; Electric Stimulation; Enkephalin, Leucine; Fallopian Tubes; Female; In Vitro Techniques; Muscle Contraction; Neuropeptide Y; Norepinephrine; Rabbits | 1988 |
Development of transsynaptic regulation of adrenal enkephalin.
Topics: Adrenal Medulla; Aging; Animals; Animals, Newborn; Denervation; Enkephalin, Leucine; Rats; Rats, Inbred Strains; Synapses | 1988 |