enkephalin--leucine-2-alanine and Shock--Traumatic

Topics: Animals; Blood Pressure; Drug Evaluation, Preclinical; Enkephalin, Leucine-2-Alanine; Rabbits; Shock, Traumatic

For experimental verification of the authors' hypothesis on the role of the mechanism of adaptative disintegration in pathogenesis of trauma disease the essence of which consists in inadequacy of emergency adaptation of the organism to a critical and middle degree of the injury by the time and amplitude, an investigation on 89 rabbits has been performed with modeling of extensive wound of soft tissues of the femur. The correction of the neuroendocrine response of the organism to trauma by injection of synthetic opiopeptide dalargin++ was made. The use of dalargin changed quantitatively and qualitatively the neuroendocrine reaction to the injury and optimized the wound process and restoration of the homeostasis parameters.

Topics: Adaptation, Physiological; Animals; Disease Models, Animal; Enkephalin, Leucine-2-Alanine; Hindlimb; Homeostasis; Male; Rabbits; Shock, Traumatic; Wounds, Gunshot

The experiments were performed on 86 white male rats, weighing 180-220 g. The animals with traumatic shock revealed a decrease in ATP concentration and a rise in ADP and AMP levels in the brain cortex and hepatic tissue, resulting in the energy charge reduction. The injection of synthetic leu-enkephalin analog D-ala2-arg6-leu-enkephalin to animals with traumatic shock led to energy charge normalization in the brain cortex and increase in hepatic tissue. The mechanisms of enkephalin effect on the energy metabolism during shock are discussed.

Topics: Adenine Nucleotides; Animals; Cerebral Cortex; Energy Metabolism; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Liver; Male; Rats; Shock, Traumatic; Time Factors

Topics: Animals; Crush Syndrome; Drug Evaluation, Preclinical; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Male; Rats; Shock, Traumatic; Stress, Psychological

The experiments on white rats weighing 180-220 g have shown that in traumatic and hemorrhagic shock the initial increase in parathyroid hormone blood concentration is followed by the decrease of functional activity of parathyroid glands. Calcitonin concentration is found to increase during the first hours of shock. The changes in calcium-regulating gland function result in significant disturbances of calcium exchange during shock. The injection of synthetic leu-enkephalin analogs to rats with shock leads to normalization of calcium-regulating endocrine glands function.

Topics: Animals; Calcitonin; Calcium; Drug Evaluation, Preclinical; Endocrine Glands; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Male; Parathyroid Hormone; Rats; Shock, Hemorrhagic; Shock, Traumatic; Time Factors