enkephalin--leucine-2-alanine and Pancreatic-Diseases

In the experiment on 200 rats with acute pancreatitis, it was revealed that in administration of dalargin at a dose of 10 mg/kg of the mass, the activity of xanthinoxidase and lipid peroxidation in the pancreas was suppressed, at the same time, the activity of trypsin, amylase and transamidinase in the blood serum decreased. In 48 patients, who underwent the intravenous administration of dalargin at a dose of 50 mg/kg at operation on the pancreas and after it, the incidence of acute postoperative pancreatitis development decreased 4.16-fold when compared to the use of protease inhibitors, and 2.4-fold when compared to the use of fluorouracil.

Topics: Acute Disease; Adult; Animals; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Female; Humans; Intraoperative Care; Male; Middle Aged; Pancreatic Diseases; Pancreatitis; Postoperative Complications; Rats; Sympatholytics