Compounds > enkephalin--leucine-2-alanine

enkephalin--leucine-2-alanine and Leukemia--Lymphocytic--Chronic--B-Cell

enkephalin--leucine-2-alanine has been researched along with Leukemia--Lymphocytic--Chronic--B-Cell* in 1 studies

Other Studies

1 other study(ies) available for enkephalin--leucine-2-alanine and Leukemia--Lymphocytic--Chronic--B-Cell

Article	Year
Neutral endopeptidase 24.11 and angiotensin converting enzyme like activity in CALLA positive and CALLA negative lymphoid cells. Biochemical and biophysical research communications, 1989, May-15, Volume: 160, Issue:3 Taking advantage of the recently demonstrated identity of common acute lymphoblastic leukemia antigen (CALLA) and neutral endopeptidase EC.24.11 (NEP) the presence of this ectoenzyme on lymphoid cells has been reassessed using highly sensitive assays (cleavage of [3H]-D-Ala2-leucine-enkephalin and binding of the inhibitor [3H]HACBO-Gly. NEP activity was found not only on already classified CALLA + ve cells but also on numerous cells (including mature B and polyclonal T cells) previously considered as CALLA-ve. This suggests that CALLA/NEP is expressed all along the differentiation pathway in B and T cell lineage. Moreover substantial ACE-like activity was also detected in three tested cells, all of the pre-B phenotype. The availability of specific inhibitors for these enzymes should help clarify their role in cell-differentiation. Topics: Animals; Antigens, Differentiation; Antigens, Neoplasm; Antigens, Surface; B-Lymphocytes; Brain; Cell Membrane; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Glycine; Humans; Hydroxylamines; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Lymphoid; Lymphocytes; Mice; Neprilysin; Peptidyl-Dipeptidase A; T-Lymphocytes; Tumor Cells, Cultured	1989

Article

Year

Neutral endopeptidase 24.11 and angiotensin converting enzyme like activity in CALLA positive and CALLA negative lymphoid cells.

Biochemical and biophysical research communications, 1989, May-15, Volume: 160, Issue:3

Taking advantage of the recently demonstrated identity of common acute lymphoblastic leukemia antigen (CALLA) and neutral endopeptidase EC.24.11 (NEP) the presence of this ectoenzyme on lymphoid cells has been reassessed using highly sensitive assays (cleavage of [3H]-D-Ala2-leucine-enkephalin and binding of the inhibitor [3H]HACBO-Gly. NEP activity was found not only on already classified CALLA + ve cells but also on numerous cells (including mature B and polyclonal T cells) previously considered as CALLA-ve. This suggests that CALLA/NEP is expressed all along the differentiation pathway in B and T cell lineage. Moreover substantial ACE-like activity was also detected in three tested cells, all of the pre-B phenotype. The availability of specific inhibitors for these enzymes should help clarify their role in cell-differentiation.

Topics: Animals; Antigens, Differentiation; Antigens, Neoplasm; Antigens, Surface; B-Lymphocytes; Brain; Cell Membrane; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Glycine; Humans; Hydroxylamines; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Lymphoid; Lymphocytes; Mice; Neprilysin; Peptidyl-Dipeptidase A; T-Lymphocytes; Tumor Cells, Cultured

1989