Compounds > enkephalin--leucine-2-alanine

enkephalin--leucine-2-alanine and Inflammation

enkephalin--leucine-2-alanine has been researched along with Inflammation* in 2 studies

Other Studies

2 other study(ies) available for enkephalin--leucine-2-alanine and Inflammation

Article	Year
Endosomal signaling of delta opioid receptors is an endogenous mechanism and therapeutic target for relief from inflammatory pain. Proceedings of the National Academy of Sciences of the United States of America, 2020, 06-30, Volume: 117, Issue:26 Topics: Animals; Colon; Enkephalin, Leucine-2-Alanine; HEK293 Cells; Humans; Inflammation; Mice; Nanoparticles; Neurons; Nociceptors; Pain; Receptors, Opioid, delta; Signal Transduction	2020
IL-1 beta-like Freund's adjuvant enhances axonal transport of opiate receptors in sensory neurons. Neuroscience letters, 1994, Aug-15, Volume: 177, Issue:1-2 Chronic pain and inflammation increase substance P in sensory fibres of peripheral nerves in which opiate receptors are known to undergo axonal transport. The aim of the present study was to evaluate a possible modulation of axonal transport of opiate receptors in peripheral nerves during inflammation. After intraplantar injection of Freund's adjuvant to rats, the accumulation of mu and kappa opiate receptors increased on both sides of ligature in sciatic nerves of the injected paw. The contralateral side was unaffected and may serve as control. When IL-1 beta was injected into rat paws, the axonal transport of opiate receptors was increased in a similar way. This suggests that IL-1 beta represents a major mediator to sensitize nociceptors during inflammation through a process requiring retrograde signals. Topics: Animals; Axonal Transport; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Foot; Freund's Adjuvant; Inflammation; Interleukin-1; Ligation; Male; Nerve Tissue Proteins; Neurons, Afferent; Nociceptors; Rats; Rats, Wistar; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sciatic Nerve	1994

Article

Year

Endosomal signaling of delta opioid receptors is an endogenous mechanism and therapeutic target for relief from inflammatory pain.

Proceedings of the National Academy of Sciences of the United States of America, 2020, 06-30, Volume: 117, Issue:26

Topics: Animals; Colon; Enkephalin, Leucine-2-Alanine; HEK293 Cells; Humans; Inflammation; Mice; Nanoparticles; Neurons; Nociceptors; Pain; Receptors, Opioid, delta; Signal Transduction

2020

IL-1 beta-like Freund's adjuvant enhances axonal transport of opiate receptors in sensory neurons.

Neuroscience letters, 1994, Aug-15, Volume: 177, Issue:1-2

Chronic pain and inflammation increase substance P in sensory fibres of peripheral nerves in which opiate receptors are known to undergo axonal transport. The aim of the present study was to evaluate a possible modulation of axonal transport of opiate receptors in peripheral nerves during inflammation. After intraplantar injection of Freund's adjuvant to rats, the accumulation of mu and kappa opiate receptors increased on both sides of ligature in sciatic nerves of the injected paw. The contralateral side was unaffected and may serve as control. When IL-1 beta was injected into rat paws, the axonal transport of opiate receptors was increased in a similar way. This suggests that IL-1 beta represents a major mediator to sensitize nociceptors during inflammation through a process requiring retrograde signals.

Topics: Animals; Axonal Transport; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Foot; Freund's Adjuvant; Inflammation; Interleukin-1; Ligation; Male; Nerve Tissue Proteins; Neurons, Afferent; Nociceptors; Rats; Rats, Wistar; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sciatic Nerve

1994