enkephalin--leucine-2-alanine and Digestive-System-Diseases

Topics: Animals; Digestive System Diseases; Digestive System Physiological Phenomena; Dogs; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; Humans; Rats

The authors analyse experience in the use of the synthetic analogue of ++leu enkephalin dalargin in multicomponent balanced anesthesia in operations on the abdominal organs in 36 patients. With the use of the suggested method the intraoperative expenditure of narcotic analgesics is 6 times less but the efficacy of the anesthesia remains the same. Study of the activity of the liver-specific enzymes (histidase and urokinase) in blood plasma and biopsy material taken from the liver and the content of malonic dialdehyde in the hepatic biopsy specimen revealed hepatoprotective properties of dalargin. The decrease of the total peripheral resistance and increase of the elasticity of the arterial reservoir++ in the main group as compared to these values in patients treated by the traditional method were considered by the authors to be the consequence of the autonomic priming effect of the opiopeptide used. It is concluded that the use of synthetic analogues of endogenous opioids (dalargin) in the anesthesiological protection complex in operations on the abdominal organs is expedient.

Topics: Adult; Anesthesia, General; Digestive System Diseases; Enkephalin, Leucine-2-Alanine; Female; Homeostasis; Humans; Intraoperative Care; Intraoperative Complications; Male; Middle Aged; Stress, Physiological