enkephalin--leucine-2-alanine and Cardiomyopathies

The effect of a synthetic analogue of encephalin was studied experimentally in 150 rabbits with neoepinephrine-induced myocardial necrosis to whom the drug was administered intravenously at the rate of 100 micrograms/kg, 1 and 6 hours later. Necrotic developments were assessed on the basis of MB CPK and LDH activity and myoglobin levels. Control animals received saline solutions or propranolol in equimolar doses. In encephalin-treated animals, enzyme activity and myoglobin values were significantly lower, an evidence of encephalins' favorable effect on the course of neoepinephrine-induced myocardial necrosis.

Topics: Animals; Cardiomyopathies; Creatine Kinase; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Isoenzymes; Isoproterenol; L-Lactate Dehydrogenase; Male; Myoglobin; Necrosis; Propranolol