enkephalin, d-penicillamine (2,5)- and Ache

enkephalin, d-penicillamine (2,5)- has been researched along with Ache in 75 studies

Research

Studies (75)

Timeframe	Studies, this research(%)	All Research%
pre-1990	8 (10.67)	18.7374
1990's	47 (62.67)	18.2507
2000's	14 (18.67)	29.6817
2010's	5 (6.67)	24.3611
2020's	1 (1.33)	2.80

Authors

Authors	Studies
Artali, R; Calo, G; Cerlesi, MC; De Marco, R; Gentilucci, L; Janecka, A; Kluczyk, A; Perlikowska, R; Piekielna, J; Tömböly, C	1
Bezawada, P; Coop, A; Cunningham, CW; Devereaux, AL; Griggs, NW; Healy, JR; Matsumoto, RR; Traynor, JR	1
Fu, W; Huang, H; Li, W; Liu, J; Wang, W; Wang, Y; Xu, X; Zhu, C	1
Feeney, C; Kristal, MB; Thompson, AC	1
Kuo, A; Meutermans, W; Smith, MT; Wyse, BD	1
Juma, F; Kanui, TI; Maloiy, GM; Olongida Ole Miaron, J; Towett, PK	1
Bao, G; Deng, H; Friedrich, T; Gu, Q; Li, Y; Schwarz, W; Shen, X; Yang, Z	1
Ansonoff, MA; Pintar, JE; Portoghese, PS	1
Adler, MW; Chen, XH; Howard, OM; Oppenheim, JJ; Rogers, TJ; Szabo, I; Xin, L	1
Narita, M; Nemoto, M; Ohnishi, O; Suzuki, T; Yajima, Y	1
Chen, SR; Pan, HL	1
Chakrabarti, S; Gintzler, AR; Liu, NJ	1
Aono, Y; Cools, AR; Fusa, K; Ikeda, H; Koshikawa, N; Nagase, H; Saigusa, T; Suzuki, T; Takahashi, I; Watanabe, S	1
Adler, MW; Chen, X; Geller, EB; Rogers, TJ	1
Adler, MW; Chen, X; Geller, EB	1
Kohno, T	1
Collins, JG; Harada, Y; Kitahata, LM; Nakatani, K; Nishioka, K	1
Collins, JG; Harada, Y; Kishikawa, K; Kitahata, LM; Nishioka, K	1
Abbott, FV; Hong, Y	1
Almeida, OF; Shippenberg, TS; Spanagel, R	1
Bodnar, RJ; Pasternak, GW; Rossi, GC	1
Garzón, J; Martínez-Peña, Y; Sánchez-Blázquez, P	1
Kim, YH; Lim, JS; Song, DK; Suh, HW; Tseng, LF	1
Crisp, T; Gordon, TL; Hoskins, DL; Perni, VC; Stafinsky, JL; Uram, M	1
Randich, A; Robertson, JD; Willingham, T	1
Han, JS; Ren, MF; Wang, JF; Xue, JC	1
Castro, MA; Garzón, J; Juarros, JL; Sánchez-Blázquez, P	1
Baumeister, AA; Chaney, TM; Curtis, W; Hurry, M; Leoni, RR; Wolf, E	1
Brusa, L; D'Amore, A; Lorenzini, P; Massotti, M	1
Hitosugi, H; Kamei, J; Kasuya, Y; Kawashima, N; Misawa, M; Nagase, H	1
Levine, JD; Miaskowski, C; Taiwo, YO	1
Abood, ME; Pugh, G; Welch, SP	1
Haney, M; Miczek, KA	1
Danzebrink, RM; Gebhart, GF; Green, SA	1
Chaplan, SR; Lee, YW; Yaksh, TL	1
Burks, TF; Hruby, VJ; Roerig, SC; Rosenfeld, GC; Williams, CL	1
Choi, SR; Chung, KM; Kim, YH; Song, DK; Suh, HW	1
Kamei, J; Kawai, K; Mizoguchi, H; Mizusuna, A; Nagase, H; Narita, M; Suzuki, T; Tseng, LF	1
Bandler, R; Christie, MJ; Crowfoot, LJ; Floyd, NS; Henderson, LA; Keay, KA	1
Labuz, D; Machelska, H; Przewłocka, B; Przewłocki, R	1
Bhargava, HN; Cao, YJ	1
Nozaki-Taguchi, N; Yamamoto, T	1
Miczek, KA; Vivian, JA	1
Fujimoto, JM; Gorny, JM; Rady, JJ	1
Holtzman, SG; Waddell, AB	1
DeAntonio, I; DeFelipe, J; García-España, A; Garzón, J; Rodríguez, JR; Sánchez-Blázquez, P	1
Dickenson, A; Fitzgerald, M; Hatch, D; Marsh, D	1
Bian, D; Hruby, VJ; Kovelowski, CJ; Lai, J; Ossipov, MH; Porreca, F	1
Kim, SJ; Lee, DE; Zhuo, M	1
Lohmann, AB; Welch, SP	2
Chung, KM; Huh, SO; Kim, YH; Song, DK; Suh, HW	1
Beslot, F; Ledent, C; Parmentier, M; Roques, BP; Valverde, O	1
Burkey, TH; Hosohata, K; Hruby, VJ; Logan, JK; Porreca, F; Roeske, WR; Vanderah, TW; Varga, E; Yamamura, HI	1
Huh, S; Kim, YH; Song, D; Suh, H	1
Gear, RW; Levine, JD; Schmidt, BL; Tambeli, CH	1
Heller, PH; Levine, JD; Taiwo, YO	1
Aoki, T; Kamei, J; Kasuya, Y; Kawasima, N; Ohhashi, Y	1
Besse, D; Besson, JM; Butler, SH; Lombard, MC; Weil-Fugazza, J	1
Kamei, J; Kasuya, Y; Kawashima, N	1
Collins, JG; Kitahata, LM; Nakatani, K; Omote, K	1
Bennett, GJ; Kajander, KC; Seybold, VS; Stevens, CW	1
Cowan, A; Murray, CW	1
Levine, JD; Miaskowski, C; Sutters, KA; Taiwo, YO	1
Han, JS; Wang, XH; Wang, XJ	1
Fleetwood-Walker, SM; Hope, PJ; Mitchell, R	1
Green, J; Harris, S; Lloyd, P; Lozito, R; Messineo, E; Ossipov, MH	1
Kavaliers, M	1
Amiche, M; Delfour, A; Mor, A; Nicolas, P; Sagan, S	1
Crisp, T; Spanos, LJ; Stafinsky, JL	1
Heyman, JS; Mosberg, HI; Mulvaney, SA; Porreca, F	1
Gulya, K; Kovács, GL; Kriván, M; Nyolczas, N	1
Heyman, JS; Porreca, F	1
Hill, RG; Hughes, J; Leighton, G; Rodriguez, RE	1
Dickenson, AH; Knox, R; Roques, BP; Sullivan, AF; Zajac, JM	1

Reviews

1 review(s) available for enkephalin, d-penicillamine (2,5)- and Ache

Article	Year
[Opioids and spinal analgesia]. Masui. The Japanese journal of anesthesiology, 2007, Volume: 56 Suppl Topics: Analgesia, Epidural; Analgesics, Opioid; Animals; Benzeneacetamides; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Humans; Nerve Fibers; Pain; Posterior Horn Cells; Pyrrolidines; Receptors, Opioid; Synapses; Synaptic Transmission	2007

Other Studies

74 other study(ies) available for enkephalin, d-penicillamine (2,5)- and Ache

Article	Year
Synthesis of mixed MOR/KOR efficacy cyclic opioid peptide analogs with antinociceptive activity after systemic administration. European journal of medicinal chemistry, 2016, Feb-15, Volume: 109 Topics: Amino Acid Sequence; Analgesics, Opioid; Animals; CHO Cells; Cricetulus; Guinea Pigs; Male; Mice; Molecular Docking Simulation; Oligopeptides; Pain; Peptides, Cyclic; Rats, Wistar; Receptors, Opioid, kappa; Receptors, Opioid, mu; Structure-Activity Relationship	2016
Benzylideneoxymorphone: A new lead for development of bifunctional mu/delta opioid receptor ligands. Bioorganic & medicinal chemistry letters, 2017, 02-01, Volume: 27, Issue:3 Topics: Analgesics; Animals; Benzylidene Compounds; Ligands; Mice; Oxymorphone; Pain; Receptors, Opioid, delta; Receptors, Opioid, mu	2017
Discovery of 3-((dimethylamino)methyl)-4-hydroxy-4-(3-methoxyphenyl)-N-phenylpiperidine-1-carboxamide as novel potent analgesic. European journal of medicinal chemistry, 2020, Mar-01, Volume: 189 Topics: Analgesics; Animals; Female; Ligands; Mice; Models, Molecular; Pain; Piperidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Structure-Activity Relationship	2020
Amniotic-fluid ingestion enhances central δ-opioid-induced hypoalgesia in rats in the cold-water tail-flick assay in a repeated-measures design. Brain research, 2018, 10-15, Volume: 1697 Topics: Amniotic Fluid; Analgesics; Analgesics, Opioid; Animals; Cold Temperature; Eating; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Pain; Pain Measurement; Pain Threshold; Pregnancy; Rats; Rats, Long-Evans; Receptors, Opioid, delta; Water	2018
In vivo profiling of seven common opioids for antinociception, constipation and respiratory depression: no two opioids have the same profile. British journal of pharmacology, 2015, Volume: 172, Issue:2 Topics: Analgesics, Opioid; Animals; Benzeneacetamides; Buprenorphine; Castor Oil; Constipation; Diarrhea; Enkephalin, D-Penicillamine (2,5)-; Fentanyl; Hot Temperature; Male; Morphine; Morphine Derivatives; Oxycodone; Pain; Pyrrolidines; Rats, Sprague-Dawley; Respiratory Insufficiency	2015
Activation of micro, delta or kappa opioid receptors by DAMGO, DPDPE, U-50488 or U-69593 respectively causes antinociception in the formalin test in the naked mole-rat (Heterocephalus glaber). Pharmacology, biochemistry, and behavior, 2009, Volume: 91, Issue:4 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Benzeneacetamides; Data Interpretation, Statistical; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Formaldehyde; Injections, Intraperitoneal; Male; Mole Rats; Naloxone; Narcotic Antagonists; Pain; Pain Measurement; Pyrrolidines; Rats; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu	2009
Interactions of Na+,K+-ATPase and co-expressed delta-opioid receptor. Neuroscience research, 2009, Volume: 65, Issue:3 Topics: Analgesics, Opioid; Animals; Cell Membrane; Down-Regulation; Enkephalin, D-Penicillamine (2,5)-; Enzyme Activation; Female; Hippocampus; Membrane Potentials; Neurons; Oocytes; Pain; Patch-Clamp Techniques; Rats; Receptors, Opioid, delta; Sodium; Sodium-Potassium-Exchanging ATPase; Xenopus laevis	2009
Consequences of opioid receptor mutation on actions of univalent and bivalent kappa and delta ligands. Psychopharmacology, 2010, Volume: 210, Issue:2 Topics: Amides; Animals; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Guanidines; Ligands; Male; Mice; Mice, Knockout; Naltrexone; Oligopeptides; Pain; Protein Multimerization; Receptors, Opioid, delta; Receptors, Opioid, kappa	2010
Heterologous desensitization of opioid receptors by chemokines inhibits chemotaxis and enhances the perception of pain. Proceedings of the National Academy of Sciences of the United States of America, 2002, Aug-06, Volume: 99, Issue:16 Topics: Analgesics, Opioid; Animals; Cell Line; Cells, Cultured; Chemokine CCL19; Chemokine CXCL12; Chemokines; Chemokines, CC; Chemokines, CXC; Chemotaxis; Enkephalin, D-Penicillamine (2,5)-; Humans; Interleukin-8; Mice; Monocytes; Pain; Receptors, CCR2; Receptors, CCR5; Receptors, CCR7; Receptors, Chemokine; Receptors, CXCR4; Receptors, Opioid, delta; Receptors, Opioid, mu	2002
Implications of phosphoinositide 3-kinase in the mu- and delta-opioid receptor-mediated supraspinal antinociception in the mouse. Neuroscience, 2002, Volume: 113, Issue:3 Topics: Analgesics, Opioid; Animals; Blotting, Western; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Injections, Intraventricular; Male; Mice; Pain; Phosphatidylinositol 3-Kinases; Receptors, Opioid, delta; Receptors, Opioid, mu; Signal Transduction; Time Factors	2002
Spinal nitric oxide contributes to the analgesic effect of intrathecal [d-pen2,d-pen5]-enkephalin in normal and diabetic rats. Anesthesiology, 2003, Volume: 98, Issue:1 Topics: Analgesics, Opioid; Animals; Behavior, Animal; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enzyme Inhibitors; Injections, Spinal; Male; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; omega-N-Methylarginine; Pain; Pain Measurement; Pain Threshold; Rats; Rats, Sprague-Dawley	2003
Chronic morphine-induced loss of the facilitative interaction between vasoactive intestinal polypeptide and delta-opioid: involvement of protein kinase C and phospholipase Cbetas. Brain research, 2004, Jun-04, Volume: 1010, Issue:1-2 Topics: Analgesics, Opioid; Animals; Calcium Signaling; Central Nervous System; Cyclic AMP; Down-Regulation; Drug Administration Schedule; Drug Tolerance; Enkephalin, D-Penicillamine (2,5)-; Female; Isoenzymes; Morphine; Nociceptors; Pain; Phosphatidylinositols; Phospholipase C beta; Phosphorylation; Protein Isoforms; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Spinal Cord; Type C Phospholipases; Vasoactive Intestinal Peptide; Visceral Afferents	2004
The non-peptidic delta opioid receptor agonist TAN-67 enhances dopamine efflux in the nucleus accumbens of freely moving rats via a mechanism that involves both glutamate and free radicals. Neuroscience, 2005, Volume: 130, Issue:3 Topics: Adrenergic Uptake Inhibitors; alpha-Methyltyrosine; Animals; Dopamine; Enkephalin, D-Penicillamine (2,5)-; Enzyme Inhibitors; Extracellular Space; Free Radicals; Glutamic Acid; Male; Microdialysis; Naloxone; Narcotic Antagonists; Nucleus Accumbens; Oligopeptides; Pain; Quinolines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, Opioid, delta; Reserpine	2005
Rapid heterologous desensitization of antinociceptive activity between mu or delta opioid receptors and chemokine receptors in rats. Drug and alcohol dependence, 2007, Apr-17, Volume: 88, Issue:1 Topics: Analgesics, Opioid; Animals; Chemokine CCL5; Enkephalin, D-Penicillamine (2,5)-; Male; Morphine; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, Chemokine; Receptors, Opioid, delta; Receptors, Opioid, mu	2007
Nociceptin/orphanin FQ blocks the antinociception induced by mu, kappa and delta opioid agonists on the cold water tail-flick test. European journal of pharmacology, 2007, Feb-14, Volume: 557, Issue:1 Topics: Analgesics, Opioid; Animals; Cold Temperature; Dynorphins; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Male; Morphine; Nociceptin; Opioid Peptides; Pain; Pain Measurement; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Tail; Water	2007
Contrasting actions of intrathecal U50,488H, morphine, or [D-Pen2, D-Pen5] enkephalin or intravenous U50,488H on the visceromotor response to colorectal distension in the rat. Anesthesiology, 1995, Volume: 83, Issue:2 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Colon; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intravenous; Injections, Spinal; Male; Morphine; Muscle Contraction; Pain; Pyrrolidines; Rats; Rats, Sprague-Dawley; Rectum	1995
Visceral antinociceptive effects of spinal clonidine combined with morphine, [D-Pen2, D-Pen5] enkephalin, or U50,488H. Anesthesiology, 1995, Volume: 83, Issue:2 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Clonidine; Colon; Drug Synergism; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Spinal; Male; Morphine; Muscle Contraction; Pain; Pyrrolidines; Rats; Rats, Sprague-Dawley; Rectum	1995
Peripheral opioid modulation of pain and inflammation in the formalin test. European journal of pharmacology, 1995, Apr-13, Volume: 277, Issue:1 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Behavior, Animal; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Extravasation of Diagnostic and Therapeutic Materials; Formaldehyde; Inflammation; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Narcotics; Pain; Pyrrolidines; Rats; Receptors, Opioid	1995
Evidence that nor-binaltorphimine can function as an antagonist at multiple opioid receptor subtypes. European journal of pharmacology, 1994, Oct-24, Volume: 264, Issue:2 Topics: Amino Acid Sequence; Analgesics; Animals; Benzeneacetamides; Drug Interactions; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Injections, Intraventricular; Male; Molecular Sequence Data; Naltrexone; Narcotic Antagonists; Pain; Pain Threshold; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Somatostatin	1994
Mu and delta opioid synergy between the periaqueductal gray and the rostro-ventral medulla. Brain research, 1994, Nov-28, Volume: 665, Issue:1 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Amino Acid Sequence; Analgesics; Animals; Drug Synergism; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Medulla Oblongata; Molecular Sequence Data; Oligopeptides; Pain; Periaqueductal Gray; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, mu	1994
Dissimilar efficacy of opioids to produce mu-mediated analgesia: role of Gx/z and Gi2 transducer proteins. Life sciences, 1994, Volume: 55, Issue:11 Topics: Amino Acid Sequence; Analgesia; Analgesics, Opioid; Animals; Cell Membrane; Cerebral Ventricles; Endorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; GTP Phosphohydrolases; GTP-Binding Proteins; Immunoglobulin G; Injections, Intraventricular; Kinetics; Male; Mice; Molecular Sequence Data; Morphine; Naloxone; Pain; Peptide Fragments; Receptors, Opioid, mu; Signal Transduction	1994
The effects of protection by D-Pen2-D-Pen5-enkephalin or D-Ala2-NMePhe4-Gly-ol-enkephalin against beta-chlornaltrexamine in the spinal cord on the antinociception induced by beta-endorphin administered intracerebroventricularly in the mouse. Neuropeptides, 1994, Volume: 27, Issue:2 Topics: Amino Acid Sequence; Analgesics; Animals; beta-Endorphin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Molecular Sequence Data; Naltrexone; Narcotic Antagonists; Pain; Pain Measurement; Spinal Cord	1994
Age-related changes in the spinal antinociceptive effects of DAGO, DPDPE and beta-endorphin in the rat. Brain research, 1994, Apr-18, Volume: 643, Issue:1-2 Topics: Aging; Analgesics; Analysis of Variance; Animals; beta-Endorphin; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Spinal; Male; Pain; Rats; Rats, Inbred F344; Spine	1994
The use of specific opioid agonists and antagonists to delineate the vagally mediated antinociceptive and cardiovascular effects of intravenous morphine. Brain research, 1993, Feb-19, Volume: 603, Issue:2 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analysis of Variance; Animals; Blood Pressure; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Heart Rate; Hexamethonium; Hexamethonium Compounds; Indoles; Injections, Intravenous; Male; Morphinans; Morphine; Naloxone; Naltrexone; Narcotic Antagonists; Narcotics; Pain; Pyrrolidines; Rats; Rats, Sprague-Dawley; Reference Values; Time Factors; Vagotomy; Vagus Nerve	1993
Cyclic AMP mediates mu and delta, but not kappa opioid analgesia in the spinal cord of the rat. Life sciences, 1993, Volume: 52, Issue:24 Topics: Analgesia; Analgesics; Animals; Bucladesine; Cyclic AMP; Dynorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Spinal; Male; Morphine; Pain; Peptide Fragments; Radioimmunoassay; Rats; Rats, Wistar; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord; Time Factors	1993
Antibodies raised against the N-terminal sequence of delta opioid receptors blocked delta-mediated supraspinal antinociception in mice. Life sciences, 1994, Volume: 54, Issue:11 Topics: Amino Acid Sequence; Analysis of Variance; Animals; beta-Endorphin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Enkephalins; GTP-Binding Proteins; Immunoglobulin G; Immunohistochemistry; Male; Mice; Mice, Inbred Strains; Molecular Sequence Data; Morphine; Narcotic Antagonists; Oligopeptides; Pain; Pain Measurement; Protein Binding; Reaction Time; Receptors, Opioid, delta	1994
The antinociceptive and motivational effects of intranigral injection of opioid agonists. Neuropharmacology, 1993, Volume: 32, Issue:12 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Analysis of Variance; Animals; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Microinjections; Morphine; Morphine Derivatives; Motivation; Pain; Periaqueductal Gray; Pyrrolidines; Rats; Rats, Sprague-Dawley; Reward; Stereotaxic Techniques; Substantia Nigra; Time Factors	1993
Area tempestas modulates the behavioural responses to nociceptive stimuli in rats. Annali dell'Istituto superiore di sanita, 1993, Volume: 29, Issue:3 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Anticonvulsants; Azocines; Bicuculline; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Escape Reaction; Foot; Hot Temperature; Male; Morphine; Naltrexone; Narcotic Antagonists; Olfactory Pathways; Pain; Phenazocine; Pressure; Pyrrolidines; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Opioid; Seizures; Tail	1993
Effect of diabetes on the antinociceptive effect of beta-endorphin. Brain research, 1993, Aug-13, Volume: 619, Issue:1-2 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; beta-Endorphin; Cerebral Ventricles; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Naltrexone; Narcotic Antagonists; Pain; Pyrrolidines; Reference Values	1993
Antinociception produced by receptor selective opioids. Modulation of supraspinal antinociceptive effects by spinal opioids. Brain research, 1993, Apr-09, Volume: 608, Issue:1 Topics: Analgesics; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Male; Pain; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Spinal Cord	1993
Antisense oligodeoxynucleotides to the kappa-1 receptor block the antinociceptive effects of delta 9-THC in the spinal cord. Brain research, 1995, Aug-14, Volume: 689, Issue:1 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Base Sequence; Dronabinol; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Mice; Mice, Inbred ICR; Molecular Sequence Data; Oligonucleotides, Antisense; Pain; Psychotropic Drugs; Pyrrolidines; Receptors, Opioid, kappa; Spinal Cord	1995
Delta opioid receptors: reflexive, defensive and vocal affective responses in female rats. Psychopharmacology, 1995, Volume: 121, Issue:2 Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Morphine; Motor Activity; Pain; Rats; Reaction Time; Receptors, Opioid, delta; Vocalization, Animal	1995
Spinal mu and delta, but not kappa, opioid-receptor agonists attenuate responses to noxious colorectal distension in the rat. Pain, 1995, Volume: 63, Issue:1 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Catheterization; Colon; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Spinal; Male; Morphine; Pain; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Rectum	1995
Systemic and supraspinal, but not spinal, opiates suppress allodynia in a rat neuropathic pain model. Neuroscience letters, 1995, Oct-20, Volume: 199, Issue:2 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Analgesics, Opioid; Animals; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraperitoneal; Injections, Intraventricular; Injections, Spinal; Morphine; Motor Activity; Naloxone; Narcotic Antagonists; Pain; Peripheral Nerve Injuries; Pyrrolidines; Rats; Rats, Sprague-Dawley	1995
Inhibition of adenylyl cyclase activity by the cholecystokinin analog SNF 9007 in neuroblastoma x glioma NG108-15 hybrid cells. Regulatory peptides, 1996, Jan-16, Volume: 61, Issue:1 Topics: Adenylyl Cyclase Inhibitors; Amino Acid Sequence; Analgesics; Cholecystokinin; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Enzyme Inhibitors; Glioma; Hybrid Cells; Molecular Sequence Data; Neuroblastoma; Oligopeptides; Pain; Peptide Fragments; Receptors, Opioid, delta	1996
Nicotine enhances morphine- and beta-endorphin-induced antinociception at the supraspinal level in the mouse. Neuropeptides, 1996, Volume: 30, Issue:5 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; beta-Endorphin; Drug Synergism; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Morphine; Nicotine; Nociceptors; Pain; Pain Measurement; Pyrrolidines; Receptors, Opioid, delta; Receptors, Opioid, kappa	1996
Delta-1 opioid receptor-mediated antinociceptive properties of a nonpeptidic delta opioid receptor agonist, (-)TAN-67, in the mouse spinal cord. The Journal of pharmacology and experimental therapeutics, 1997, Volume: 280, Issue:2 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Hyperalgesia; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Pain; Pain Measurement; Pyrrolidines; Quinolines; Reaction Time; Receptors, Opioid, delta; Spinal Cord	1997
Cardiovascular effects of microinjections of opioid agonists into the 'Depressor Region' of the ventrolateral periaqueductal gray region. Brain research, 1997, Jul-11, Volume: 762, Issue:1-2 Topics: Analgesics; Animals; Benzeneacetamides; Blood Pressure; Bradycardia; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Excitatory Amino Acids; Heart Rate; Homocysteine; Hypertension; Hypotension; Male; Microinjections; Neural Inhibition; Pain; Periaqueductal Gray; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu	1997
Inhibition of nitric oxide synthase enhances antinociception mediated by mu, delta and kappa opioid receptors in acute and prolonged pain in the rat spinal cord. The Journal of pharmacology and experimental therapeutics, 1997, Volume: 282, Issue:2 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Enzyme Inhibitors; Formaldehyde; Injections, Spinal; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Pain; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid; Spinal Cord	1997
Interactions of cocaine with morphine, U-50,488H and [D-Pen2, D-Pen5]enkaphalin. Peptides, 1998, Volume: 19, Issue:3 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Cocaine; Drug Interactions; Drug Tolerance; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Hot Temperature; Male; Mice; Morphine; Pain; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu	1998
Involvement of nitric oxide in peripheral antinociception mediated by kappa- and delta-opioid receptors. Anesthesia and analgesia, 1998, Volume: 87, Issue:2 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Benzoates; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Formaldehyde; Imidazoles; Male; Nitric Oxide; Nitro Compounds; Pain; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa	1998
Effects of mu and delta opioid agonists and antagonists on affective vocal and reflexive pain responses during social stress in rats. Psychopharmacology, 1998, Volume: 139, Issue:4 Topics: Aggression; Analgesics; Animals; Behavior, Animal; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Morphine; Narcotic Antagonists; Narcotics; Pain; Pain Threshold; Rats; Rats, Long-Evans; Receptors, Opioid, delta; Receptors, Opioid, mu; Reflex; Social Behavior; Stress, Psychological; Vocalization, Animal	1998
Heroin antinociception changed from mu to delta receptor in streptozotocin-treated mice. Japanese journal of pharmacology, 1998, Volume: 78, Issue:4 Topics: Analgesics, Opioid; Animals; Anti-Bacterial Agents; Benzylidene Compounds; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Drug Interactions; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Heroin; Injections, Intraventricular; Male; Mice; Morphine; Morphine Derivatives; Naloxone; Naltrexone; Narcotic Antagonists; Nociceptors; Pain; Receptors, Opioid, delta; Receptors, Opioid, mu; Streptozocin; Time Factors	1998
Modulation of cocaine-induced antinociception by opioid-receptor agonists. Pharmacology, biochemistry, and behavior, 1999, Volume: 62, Issue:2 Topics: Analgesics; Animals; Benzeneacetamides; Cocaine; Dose-Response Relationship, Drug; Drug Synergism; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Morphine; Pain; Pain Measurement; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, kappa	1999
Transport of CSF antibodies to Galpha subunits across neural membranes requires binding to the target protein and protein kinase C activity. Brain research. Molecular brain research, 1999, Mar-05, Volume: 65, Issue:2 Topics: Analgesics; Analgesics, Opioid; Animals; Autoantibodies; Biological Transport; Brain Chemistry; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Epitopes; GTP-Binding Protein alpha Subunits, Gi-Go; Immunoblotting; Immunoglobulin G; Injections, Intraventricular; Iodine Radioisotopes; Male; Mice; Mice, Inbred Strains; Microscopy, Immunoelectron; Morphine; Neurons; Nociceptors; Oligopeptides; Pain; Protein Kinase C; Signal Transduction	1999
Epidural opioid analgesia in infant rats II: responses to carrageenan and capsaicin. Pain, 1999, Volume: 82, Issue:1 Topics: Analgesia, Epidural; Analgesics, Opioid; Animals; Animals, Newborn; Benzeneacetamides; Capsaicin; Carrageenan; Drug Evaluation, Preclinical; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Injections, Subcutaneous; Male; Morphine; Pain; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu	1999
Selective opioid delta agonists elicit antinociceptive supraspinal/spinal synergy in the rat. Brain research, 1999, Oct-02, Volume: 843, Issue:1-2 Topics: Analgesics; Animals; Drug Synergism; Enkephalin, D-Penicillamine (2,5)-; Hot Temperature; Injections, Spinal; Male; Medulla Oblongata; Microinjections; Oligopeptides; Pain; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Spinal Cord	1999
Comparison of behavioral responses to noxious cold and heat in mice. Brain research, 1999, Oct-16, Volume: 845, Issue:1 Topics: Analgesics, Opioid; Animals; Behavior, Animal; Cold Temperature; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Gyrus Cinguli; Hot Temperature; Injections, Spinal; Male; Mice; Mice, Inbred C57BL; Morphine; Narcotics; Nociceptors; Pain; Reaction Time	1999
ATP-gated K(+) channel openers enhance opioid antinociception: indirect evidence for the release of endogenous opioid peptides. European journal of pharmacology, 1999, Dec-03, Volume: 385, Issue:2-3 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adenosine Triphosphate; Analgesics; Animals; Cromakalim; Diazoxide; Dose-Response Relationship, Drug; Drug Interactions; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Glyburide; Injections, Intraventricular; Ion Channel Gating; Male; Mice; Mice, Inbred ICR; Morphine; Naltrexone; Narcotic Antagonists; Nociceptors; Opioid Peptides; Pain; Potassium Channels; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Somatostatin	1999
Antisenses to opioid receptors attenuate ATP-gated K(+) channel opener-induced antinociception. European journal of pharmacology, 1999, Nov-19, Volume: 384, Issue:2-3 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adenosine Triphosphate; Analgesia; Analgesics; Animals; Cromakalim; Diazoxide; Enkephalin, D-Penicillamine (2,5)-; Male; Mice; Mice, Inbred ICR; Morphine; Nociceptors; Oligodeoxyribonucleotides, Antisense; Pain; Potassium Channels; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu	1999
Effects of histamine receptor antagonists injected intrathecally on antinociception induced by opioids administered intracerebroventricularly in the mouse. Neuropeptides, 1999, Volume: 33, Issue:2 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; beta-Endorphin; Cerebral Ventricles; Cyproheptadine; Enkephalin, D-Penicillamine (2,5)-; Histamine Antagonists; Injections, Intraventricular; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Morphine; Pain; Piperidines; Ranitidine; Receptors, Histamine H1; Receptors, Histamine H2; Receptors, Histamine H3; Receptors, Opioid; Spinal Cord	1999
Reduction of stress-induced analgesia but not of exogenous opioid effects in mice lacking CB1 receptors. The European journal of neuroscience, 2000, Volume: 12, Issue:2 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Opioid; Animals; Dopamine; Electroshock; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Exploratory Behavior; Foot; Habituation, Psychophysiologic; Hot Temperature; Mice; Mice, Knockout; Models, Neurological; Morphine; Motor Activity; Nociceptors; Oligopeptides; Pain; Pain Threshold; Receptors, Cannabinoid; Receptors, Drug; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Stress, Mechanical; Stress, Physiological; Swimming; Tail; Viscera	2000
The role of the G protein gamma(2) subunit in opioid antinociception in mice. European journal of pharmacology, 2000, Mar-31, Volume: 392, Issue:3 Topics: Analgesics, Opioid; Analysis of Variance; Animals; Enkephalin, D-Penicillamine (2,5)-; Heterotrimeric GTP-Binding Proteins; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Mutation; Nociceptors; Oligonucleotides, Antisense; Pain; Pain Measurement; Thionucleotides	2000
Differential potentiative effects of glutamate receptor antagonists in the production of antinociception induced by opioids administered intrathecally in the mouse. Brain research bulletin, 2000, May-15, Volume: 52, Issue:2 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; 6-Cyano-7-nitroquinoxaline-2,3-dione; Analgesics, Opioid; Animals; beta-Endorphin; Dizocilpine Maleate; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Excitatory Amino Acid Antagonists; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Pain; Spinal Cord; Time Factors	2000
mu/delta Cooperativity and opposing kappa-opioid effects in nucleus accumbens-mediated antinociception in the rat. The European journal of neuroscience, 2002, Volume: 15, Issue:5 Topics: Analgesics, Opioid; Animals; Benzeneacetamides; Capsaicin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Male; Narcotic Antagonists; Neurons; Nociceptors; Nucleus Accumbens; Pain; Pyrrolidines; Rats; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Reflex	2002
Mediation of serotonin hyperalgesia by the cAMP second messenger system. Neuroscience, 1992, Volume: 48, Issue:2 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; 8-Hydroxy-2-(di-n-propylamino)tetralin; Adenosine; Analgesics; Animals; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Guanosine 5'-O-(3-Thiotriphosphate); Hyperalgesia; Isomerism; Male; Nociceptors; Pain; Protein Kinase Inhibitors; Pyrrolidines; Pyrrolidinones; Rats; Rats, Inbred Strains; Receptors, Serotonin; Rolipram; Second Messenger Systems; Serotonin; Tetrahydronaphthalenes	1992
Streptozotocin-induced diabetes selectively alters the potency of analgesia produced by mu-opioid agonists, but not by delta- and kappa-opioid agonists. Brain research, 1992, Feb-07, Volume: 571, Issue:2 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Cerebral Ventricles; Diabetes Mellitus, Experimental; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Injections, Spinal; Injections, Subcutaneous; Male; Mice; Mice, Inbred ICR; Morphine; Pain; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord	1992
Monoarthritis induces complex changes in mu-, delta- and kappa-opioid binding sites in the superficial dorsal horn of the rat spinal cord. European journal of pharmacology, 1992, Nov-17, Volume: 223, Issue:2-3 Topics: Animals; Arthritis; Arthritis, Experimental; Autoradiography; Benzeneacetamides; Disease Models, Animal; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Freund's Adjuvant; Male; Pain; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord	1992
Paradoxical analgesia produced by naloxone in diabetic mice is attributable to supersensitivity of delta-opioid receptors. Brain research, 1992, Oct-02, Volume: 592, Issue:1-2 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; Animals; Diabetes Mellitus, Experimental; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Hot Temperature; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Naloxone; Pain; Pain Measurement; Pyrrolidines; Reaction Time; Time Factors	1992
Delta receptor involvement in morphine suppression of noxiously evoked activity of spinal WDR neurons in cats. Brain research, 1991, Jul-19, Volume: 554, Issue:1-2 Topics: Analgesia; Animals; Cats; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Evoked Potentials; Female; Hot Temperature; Injections, Spinal; Male; Morphine; Naltrexone; Narcotic Antagonists; Neurons; Pain; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Spinal Cord	1991
Bilateral and differential changes in spinal mu, delta and kappa opioid binding in rats with a painful, unilateral neuropathy. Pain, 1991, Volume: 46, Issue:3 Topics: Analgesics; Animals; Autoradiography; Behavior, Animal; Benzeneacetamides; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Fentanyl; Ligands; Male; Nervous System Diseases; Pain; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sensory Thresholds; Spinal Cord; Sufentanil	1991
Tonic pain perception in the mouse: differential modulation by three receptor-selective opioid agonists. The Journal of pharmacology and experimental therapeutics, 1991, Volume: 257, Issue:1 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Dose-Response Relationship, Drug; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Fentanyl; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Pain; Pyrrolidines; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sufentanil	1991
Comparison of the antinociceptive and motor effects of intrathecal opioid agonists in the rat. Brain research, 1991, Jul-05, Volume: 553, Issue:1 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Spinal; Male; Narcotic Antagonists; Pain; Postural Balance; Psychomotor Performance; Pyrrolidines; Rats; Rats, Inbred Strains; Sensory Thresholds	1991
Cholecystokinin octapeptide antagonized opioid analgesia mediated by mu- and kappa- but not delta-receptors in the spinal cord of the rat. Brain research, 1990, Jul-16, Volume: 523, Issue:1 Topics: Animals; Dose-Response Relationship, Drug; Dynorphins; Endorphins; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Narcotic Antagonists; Pain; Pain Measurement; Peptide Fragments; Proglumide; Rats; Rats, Inbred Strains; Reaction Time; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Sincalide; Spinal Cord	1990
Distinct antinociceptive actions mediated by different opioid receptors in the region of lamina I and laminae III-V of the dorsal horn of the rat. British journal of pharmacology, 1990, Volume: 101, Issue:2 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Neurons; Pain; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord	1990
Spinal antinociceptive synergy between clonidine and morphine, U69593, and DPDPE: isobolographic analysis. Life sciences, 1990, Volume: 47, Issue:16 Topics: Analgesics; Animals; Benzeneacetamides; Clonidine; Drug Synergism; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Hot Temperature; Injections, Spinal; Male; Morphine; Pain; Pyrrolidines; Rats; Rats, Inbred Strains; Regression Analysis; Spinal Cord	1990
Stimulatory influences of calcium channel antagonists on stress-induced opioid analgesia and locomotor activity. Brain research, 1987, Apr-07, Volume: 408, Issue:1-2 Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium Channel Blockers; Diltiazem; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Immobilization; Mice; Mice, Inbred C57BL; Motor Activity; Naloxone; Nifedipine; Pain; Reaction Time; Stress, Physiological; Verapamil	1987
Dermenkephalin (Tyr-D-Met-Phe-His-Leu-Met-Asp-NH2): a potent and fully specific agonist for the delta opioid receptor. Molecular pharmacology, 1989, Volume: 35, Issue:6 Topics: Amino Acid Sequence; Analgesia; Animals; Binding, Competitive; Brain; Cell Membrane; Cerebral Ventricles; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Kinetics; Male; Mice; Oligopeptides; Opioid Peptides; Pain; Rats; Receptors, Opioid; Receptors, Opioid, delta	1989
A comparative analysis of monoaminergic involvement in the spinal antinociceptive action of DAMPGO and DPDPE. Pain, 1989, Volume: 39, Issue:3 Topics: Anesthetics; Animals; Biogenic Monoamines; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Spinal; Male; Naloxone; Pain; Rats; Rats, Inbred Strains; Receptors, Opioid; Spinal Cord	1989
Opioid delta-receptor involvement in supraspinal and spinal antinociception in mice. Brain research, 1987, Sep-08, Volume: 420, Issue:1 Topics: Animals; Brain; Dose-Response Relationship, Drug; Drug Combinations; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine; Enkephalins; Hot Temperature; Injections, Intraventricular; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Morphine; Naltrexone; Nociceptors; Pain; Receptors, Opioid; Receptors, Opioid, delta; Spinal Cord	1987
Analgesic and tolerance-inducing effects of the highly selective delta opioid agonist [D-Pen2,D-Pen5]enkephalin in mice. European journal of pharmacology, 1988, Jun-10, Volume: 150, Issue:3 Topics: Analgesics; Animals; Drug Tolerance; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Mice; Mice, Inbred Strains; Morphine; Morphine Dependence; Pain; Reaction Time; Receptors, Opioid; Receptors, Opioid, delta; Sensory Thresholds; Substance-Related Disorders	1988
Evidence for opioid receptor interactions in vivo. Proceedings of the Western Pharmacology Society, 1988, Volume: 31 Topics: Animals; Cerebral Ventricles; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; Morphine; Narcotics; Pain; Receptors, Opioid	1988
In vivo evidence for spinal delta-opiate receptor operated antinociception. Neuropeptides, 1986, Volume: 8, Issue:3 Topics: Animals; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Nociceptors; Pain; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Spinal Cord	1986
Opioid receptor subtypes in the rat spinal cord: electrophysiological studies with mu- and delta-opioid receptor agonists in the control of nociception. Brain research, 1987, Jun-09, Volume: 413, Issue:1 Topics: Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Male; Oligopeptides; Pain; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Spinal Cord; Synaptic Transmission	1987