enkephalin--ala(2)-mephe(4)-gly(5)- has been researched along with Lung-Neoplasms* in 2 studies
2 other study(ies) available for enkephalin--ala(2)-mephe(4)-gly(5)- and Lung-Neoplasms
| Article | Year |
|---|---|
Mu3 opiate receptor expression in lung and lung carcinoma: ligand binding and coupling to nitric oxide release.
The mu3 opiate receptor subtype is expressed in human surgical specimens of both normal lung and non-small-cell lung carcinoma. Nitric oxide (NO) release is mediated through the mu3 receptor, and in lung carcinoma, morphine-stimulated NO release is significantly higher and prolonged than in normal lung. Using reverse transcriptase-polymerase chain reaction (RT-PCR) and Southern blot analysis we show that specific mu opioid receptor transcripts are present in lung carcinoma and other cells with the mu3 profile. Our findings identify a unique role for the mu3 opiate receptor in opiate-mediated NO release and suggest that endogenous opiates, through their release of NO, may play a role in cancer progression. Topics: Dihydromorphine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Humans; Lung; Lung Neoplasms; Nitric Oxide; Receptors, Opioid, mu; RNA, Messenger | 1999 |
Activation of opioid receptors inhibits neuronal-like calcium channels, distal steps of secretion, and cell proliferation in human small cell lung carcinoma cells.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Bucladesine; Calcium Channels; Carcinoma, Small Cell; Cell Division; Cyclic AMP; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Humans; Kinetics; Lung Neoplasms; Naloxone; Neurons; Receptors, Opioid, delta; Serotonin; Thapsigargin; Time Factors; Tumor Cells, Cultured | 1998 |