enkephalin--ala(2)-mephe(4)-gly(5)- has been researched along with Eye-Pain* in 1 studies
1 other study(ies) available for enkephalin--ala(2)-mephe(4)-gly(5)- and Eye-Pain
| Article | Year |
|---|---|
Topical treatment with a mu opioid receptor agonist alleviates corneal allodynia and corneal nerve sensitization in mice.
Corneal pain is considered to be a core symptom of ocular surface disruption and inflammation. The management of this debilitating condition is still a therapeutic challenge. Recent evidence supports a role of the opioid system in the management of corneal nociception. However, the functional involvement of the mu opioid receptor (MOR) underlying this analgesic effect is not known. We first investigated the expression of the MOR in corneal nerve fibers and trigeminal ganglion (TG) neurons in control mice and a mouse model of corneal inflammatory pain. We then evaluated the anti-nociceptive and electrophysiological effects of DAMGO ([D-Ala Topics: Administration, Ophthalmic; Analgesics, Opioid; Animals; Cornea; Corneal Diseases; Disease Models, Animal; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Eye Pain; Inflammation; Male; Mice; Mice, Inbred C57BL; Receptors, Opioid, mu | 2020 |