Page last updated: 2024-08-23

eniluracil and Colorectal Neoplasms

eniluracil has been researched along with Colorectal Neoplasms in 33 studies

Research

Studies (33)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	11 (33.33)	18.2507
2000's	20 (60.61)	29.6817
2010's	2 (6.06)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Chionh, F; Lau, D; Price, T; Tebbutt, N; Yeung, Y	1
Cao, S; Spector, T	1
Fishman, AD; Wadler, S	1
Abbruzzese, JL; Budd, GT; Chansky, K; Doukas, MA; Giguere, JK; Leichman, CG; Macdonald, JS	1
Benson, AB; Catalano, P; Cornfeld, MJ; Graham, DL; Huang, J; Marsh, JC; O'Dwyer, PJ	1
Schilsky, RL	1
Hoff, PM	1
Diasio, RB; Heslin, MJ; Lucas, VS; Owens, J; Shao, L; Weiss, H; Yan, J	1
Geboes, K; Van Cutsem, E	1
Cao, S; Rustum, YM; Spector, T	1
Baccanari, DP; Cao, S; Davis, ST; Joyner, SS; Rustum, YM; Spector, T	1
Punt, CJ	1
Hohneker, JA	1
Meropol, NJ	1
Brito, RA; Hoff, PM; Medgyesy, D; Pazdur, R; Ravandi-Kashani, F; Royce, ME; Zukowski, TH	1
Adjei, AA	1
Abeling, NG; Ahmed, FY; Binnie, N; Cassidy, J; Johnston, SJ; Knight, S; McLeod, HL; Murray, GI; O'Kelly, T; van Gennip, AH	1
Cao, S; Rustum, YM	1
Brito, R; Hoff, PM; Medgyesy, D; Pazdur, R; Royce, M	1
Papamichael, D	1
Bonny, T; Bukowski, R; Burris, H; Hochster, H; Hohneker, J; Levin, J; Mani, S; O'Rourke, M; Schilsky, RL; Wall, JG	1
Damjanov, N; Meropol, NJ	1
Beck, T; Bell, WN; Chevlen, EM; Hochster, H; Hohneker, J; Levin, J; Lokich, J; Mani, S; McGuirt, C; O'Rourke, MA; Schilsky, RL; Weaver, CH; White, R	1
Alauddin, MM; Bading, JR; Conti, PS; Fissekis, JD; Joung, J; Shahinian, AH; Spector, T	1
Peeters, M; Van Cutsem, E	1
Lewis, NL; Meropol, NJ	1
Harboe, K; Lind, A; Ogreid, D; Todnem, K; Zotova, L	1
Dwivedy, S; Hoff, PM; Medgyesy, D; Pazdur, R; Royce, ME; Zukowski, TH	1
Benson, AB	1
Hollis, D; Mayer, RJ; Meropol, NJ; Niedzwiecki, D; Schilsky, RL	1
Beretta, GD; Labianca, R; Mosconi, S; Pessi, MA; Poletti, P	1
Coleman, R; Cunningham, D	1
Ansari, RH; Bell, WN; Colwell, B; Levin, J; McGuirt, PV; Pazdur, R; Schilsky, RL; Thirlwell, MP; West, WH; White, RL; Wong, A; Yates, BB	1

Reviews

20 review(s) available for eniluracil and Colorectal Neoplasms

Article	Year
Oral versus intravenous fluoropyrimidines for colorectal cancer. The Cochrane database of systematic reviews, 2017, Jul-28, Volume: 7 Topics: Administration, Oral; Adult; Antineoplastic Agents; Camptothecin; Capecitabine; Chemotherapy, Adjuvant; Colorectal Neoplasms; Disease-Free Survival; Female; Floxuridine; Fluorouracil; Humans; Injections, Intravenous; Irinotecan; Male; Neoadjuvant Therapy; Organoplatinum Compounds; Palliative Care; Pyridines; Pyrimidines; Randomized Controlled Trials as Topic; Tegafur; Uracil	2017
Advances in the treatment of metastatic colorectal cancer. Clinical colorectal cancer, 2001, Volume: 1, Issue:1 Topics: Administration, Oral; Antibodies, Monoclonal; Antineoplastic Agents; Camptothecin; Cancer Vaccines; Capecitabine; Colorectal Neoplasms; Deoxycytidine; Drug Administration Schedule; Fluorouracil; Humans; Irinotecan; Liver Neoplasms; Neoplasm Metastasis; Organoplatinum Compounds; Oxaliplatin; Prodrugs; Quinazolines; Randomized Controlled Trials as Topic; Thiophenes; Uracil	2001
Practical considerations in the use of oral fluoropyrimidines. Seminars in oncology, 2003, Volume: 30, Issue:3 Suppl 6 Topics: Administration, Oral; Antimetabolites, Antineoplastic; Capecitabine; Clinical Trials as Topic; Colorectal Neoplasms; Deoxycytidine; Drug Combinations; Fluorouracil; Humans; Oxonic Acid; Prodrugs; Pyridines; Tegafur; Uracil	2003
The multidisciplinary management of gastrointestinal cancer. The integration of cytotoxics and biologicals in the treatment of metastatic colorectal cancer. Best practice & research. Clinical gastroenterology, 2007, Volume: 21, Issue:6 Topics: Angiogenesis Inhibitors; Antibodies, Monoclonal; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Cell Death; Cell Survival; Colorectal Neoplasms; Deoxycytidine; Drug Combinations; ErbB Receptors; Fluorouracil; Humans; Leucovorin; Neoplasm Metastasis; Tegafur; Treatment Outcome; Uracil; Vascular Endothelial Growth Factor A	2007
New drugs in the treatment of colorectal carcinoma. Cancer, 1998, Aug-15, Volume: 83, Issue:4 Topics: Antibodies, Monoclonal; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Capecitabine; Clinical Trials as Topic; Colorectal Neoplasms; Deoxycytidine; Fluorouracil; Humans; Irinotecan; Organoplatinum Compounds; Oxaliplatin; Quinazolines; Tegafur; Thiophenes; Topotecan; Trimetrexate; Uracil	1998
Clinical development of eniluracil: current status. Oncology (Williston Park, N.Y.), 1998, Volume: 12, Issue:10 Suppl 7 Topics: Administration, Oral; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; Colorectal Neoplasms; Dihydrouracil Dehydrogenase (NADP); Drug Administration Schedule; Enzyme Inhibitors; Fluorouracil; Humans; Oxidoreductases; Pancreatic Neoplasms; Treatment Outcome; Uracil	1998
Oral fluoropyrimidines in the treatment of colorectal cancer. European journal of cancer (Oxford, England : 1990), 1998, Volume: 34, Issue:10 Topics: Administration, Oral; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Colorectal Neoplasms; Deoxycytidine; Dihydrouracil Dehydrogenase (NADP); Drug Combinations; Enzyme Inhibitors; Fluorouracil; Humans; Oxidoreductases; Pyridines; Tegafur; Uracil	1998
Fluoropyrimidines: a critical evaluation. Oncology, 1999, Volume: 57 Suppl 1 Topics: Administration, Oral; Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Breast Neoplasms; Capecitabine; Colorectal Neoplasms; Deoxycytidine; Drug Combinations; Fluorouracil; Humans; Leucovorin; Oxonic Acid; Pyridines; Tegafur; Uracil	1999
A review of the pharmacology and clinical activity of new chemotherapy agents for the treatment of colorectal cancer. British journal of clinical pharmacology, 1999, Volume: 48, Issue:3 Topics: Antineoplastic Agents; Capecitabine; Colorectal Neoplasms; Deoxycytidine; Fluorouracil; Glutamates; Guanine; Humans; Pemetrexed; Platinum Compounds; Pyridines; Quinazolines; Tegafur; Thiophenes; Uracil	1999
New drugs in therapy of colorectal cancer: preclinical studies. Seminars in oncology, 1999, Volume: 26, Issue:6 Topics: Animals; Antimetabolites, Antineoplastic; Capecitabine; Colorectal Neoplasms; Deoxycytidine; Dihydrouracil Dehydrogenase (NADP); Drug Combinations; Drug Evaluation, Preclinical; Enzyme Inhibitors; Fluorouracil; Folic Acid Antagonists; Humans; Oxidoreductases; Prodrugs; Quinazolines; Tegafur; Thiophenes; Thymidine Phosphorylase; Thymidylate Synthase; Uracil	1999
Oral fluoropoyrimidines. Seminars in oncology, 1999, Volume: 26, Issue:6 Topics: Animals; Antimetabolites, Antineoplastic; Capecitabine; Colorectal Neoplasms; Deoxycytidine; Dihydrouracil Dehydrogenase (NADP); Drug Combinations; Enzyme Inhibitors; Fluorouracil; Folic Acid Antagonists; Humans; Leucovorin; Oxidoreductases; Oxonic Acid; Prodrugs; Pyridines; Tegafur; Uracil	1999
The use of thymidylate synthase inhibitors in the treatment of advanced colorectal cancer: current status. The oncologist, 1999, Volume: 4, Issue:6 Topics: Antineoplastic Agents; Colorectal Neoplasms; Enzyme Inhibitors; Fluorouracil; Humans; Prodrugs; Thymidylate Synthase; Uracil	1999
Oral therapy for colorectal cancer: how to choose. Oncology (Williston Park, N.Y.), 2000, Volume: 14, Issue:6 Topics: Administration, Oral; Antimetabolites, Antineoplastic; Antineoplastic Agents; Biological Availability; Capecitabine; Colorectal Neoplasms; Decision Making; Deoxycytidine; Enzyme Inhibitors; Fluorouracil; Humans; Leucovorin; Tegafur; Uracil	2000
Oral fluoropyrimidines in colorectal cancer. Seminars in oncology, 2000, Volume: 27, Issue:5 Suppl 10 Topics: Administration, Oral; Antimetabolites, Antineoplastic; Capecitabine; Colorectal Neoplasms; Deoxycytidine; Drug Combinations; Fluorouracil; Humans; Leucovorin; Oxonic Acid; Pyridines; Tegafur; Uracil	2000
Oral fluoropyrimidines in cancer treatment. Cancer investigation, 2000, Volume: 18, Issue:8 Topics: Administration, Oral; Animals; Antimetabolites, Antineoplastic; Breast Neoplasms; Capecitabine; Colorectal Neoplasms; Deoxycytidine; Fluorouracil; Head and Neck Neoplasms; Humans; Lung Neoplasms; Neoplasms; Pyridines; Stomach Neoplasms; Tegafur; Uracil	2000
[Fluorinated pyrimidines in oral treatment of advanced colorectal cancer]. Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 2000, Sep-30, Volume: 120, Issue:23 Topics: Administration, Oral; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Colorectal Neoplasms; Deoxycytidine; Dihydrouracil Dehydrogenase (NADP); Drug Combinations; Enzyme Inhibitors; Fluorouracil; Humans; Leucovorin; Oxidoreductases; Prodrugs; Pyrimidines; Tegafur; Uracil	2000
Colorectal cancer: chemotherapy treatment overview. Oncology (Williston Park, N.Y.), 2000, Volume: 14, Issue:12 Suppl 1 Topics: Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Capecitabine; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Colorectal Neoplasms; Deoxycytidine; Fluorouracil; Humans; Irinotecan; Leucovorin; Organoplatinum Compounds; Oxaliplatin; Randomized Controlled Trials as Topic; Tegafur; Treatment Outcome; Uracil	2000
Oral eniluracil/5-FU for advanced colon and breast carcinomas. Oncology (Williston Park, N.Y.), 2001, Volume: 15, Issue:1 Suppl 2 Topics: Administration, Oral; Animals; Antimetabolites, Antineoplastic; Breast Neoplasms; Colorectal Neoplasms; Dihydrouracil Dehydrogenase (NADP); Drug Synergism; Enzyme Inhibitors; Female; Fluorouracil; Forecasting; Humans; Oxidoreductases; Uracil	2001
New drugs and combinations in the palliative treatment of colon and rectal cancer. European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, 2001, Volume: 27, Issue:6 Topics: Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; Colorectal Neoplasms; DNA Topoisomerases, Type I; Female; Humans; Male; Neoplasm Staging; Palliative Care; Platinum Compounds; Prognosis; Sensitivity and Specificity; Survival Analysis; Tegafur; Thymidylate Synthase; Topoisomerase I Inhibitors; Uracil	2001
New options for outpatient chemotherapy--the role of oral fluoropyrimidines. Cancer treatment reviews, 2001, Volume: 27, Issue:4 Topics: Administration, Oral; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Capecitabine; Colorectal Neoplasms; Deoxycytidine; Enzyme Inhibitors; Fluorouracil; Humans; Outpatients; Tegafur; Uracil	2001

Trials

8 trial(s) available for eniluracil and Colorectal Neoplasms

Article	Year
Biochemical modulation of 5-fluorouacil through dihydropyrimidine dehydrogenase inhibition: a Southwest Oncology Group phase II trial of eniluracil and 5-fluorouracil in advanced resistant colorectal cancer. Investigational new drugs, 2002, Volume: 20, Issue:4 Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Antineoplastic Protocols; Colorectal Neoplasms; Confidence Intervals; Dihydrouracil Dehydrogenase (NADP); Enzyme Inhibitors; Female; Fluorouracil; Humans; Male; Middle Aged; Oxidoreductases; Southwestern United States; Survival Rate; Treatment Failure; Uracil	2002
Eastern Cooperative Oncology Group phase II trial (E4296) of oral 5-fluorouracil and eniluracil as a 28-day regimen in metastatic colorectal cancer. Clinical colorectal cancer, 2002, Volume: 2, Issue:1 Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Confidence Intervals; Drug Administration Schedule; Enzyme Inhibitors; Female; Fluorouracil; Humans; Liver Neoplasms; Lung Neoplasms; Male; Middle Aged; Survival Analysis; Uracil	2002
Dihydropyrimidine dehydrogenase (DPD) rapidly regenerates after inactivation by eniluracil (GW776C85) in primary and metastatic colorectal cancer. Cancer chemotherapy and pharmacology, 2003, Volume: 52, Issue:5 Topics: Aged; Colorectal Neoplasms; Dihydrouracil Dehydrogenase (NADP); Enzyme Inhibitors; Female; Humans; Kinetics; Liver; Male; Middle Aged; Monocytes; Neoplasm Metastasis; Uracil	2003
Eniluracil treatment completely inactivates dihydropyrimidine dehydrogenase in colorectal tumors. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1999, Volume: 17, Issue:8 Topics: Adenocarcinoma; Administration, Oral; Aged; Colorectal Neoplasms; Dihydrouracil Dehydrogenase (NADP); Enzyme Inhibitors; Female; Humans; Male; Middle Aged; Oxidoreductases; Preoperative Care; Reverse Transcriptase Polymerase Chain Reaction; Uracil	1999
A multicenter phase II study of a five-day regimen of oral 5-fluorouracil plus eniluracil with or without leucovorin in patients with metastatic colorectal cancer. Annals of oncology : official journal of the European Society for Medical Oncology, 2000, Volume: 11, Issue:4 Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Colorectal Neoplasms; Combined Modality Therapy; Disease-Free Survival; Drug Administration Schedule; Enzyme Inhibitors; Female; Fluorouracil; Humans; Leucovorin; Male; Middle Aged; Treatment Outcome; Uracil	2000
Multicenter phase II study to evaluate a 28-day regimen of oral fluorouracil plus eniluracil in the treatment of patients with previously untreated metastatic colorectal cancer. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2000, Volume: 18, Issue:15 Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Disease Progression; Drug Administration Schedule; Drug Synergism; Female; Fluorouracil; Humans; Male; Middle Aged; Neoplasm Metastasis; Outpatients; Treatment Outcome; Uracil	2000
Phase II study of oral eniluracil, 5-fluorouracil, and leucovorin in patients with advanced colorectal carcinoma. Cancer, 2001, Apr-01, Volume: 91, Issue:7 Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Carcinoma; Colorectal Neoplasms; Dihydrouracil Dehydrogenase (NAD+); Disease Progression; Enzyme Inhibitors; Female; Fluorouracil; Humans; Leucovorin; Male; Middle Aged; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Thymidylate Synthase; Uracil	2001
Randomized, open-label, phase III study of a 28-day oral regimen of eniluracil plus fluorouracil versus intravenous fluorouracil plus leucovorin as first-line therapy in patients with metastatic/advanced colorectal cancer. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2002, Mar-15, Volume: 20, Issue:6 Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Disease Progression; Drug Administration Schedule; Drug Synergism; Female; Fluorouracil; Humans; Infusions, Intravenous; Leucovorin; Male; Middle Aged; Neoplasm Metastasis; Proportional Hazards Models; Survival Analysis; Treatment Outcome; Uracil	2002

Other Studies

5 other study(ies) available for eniluracil and Colorectal Neoplasms

Article	Year
A possible cause and remedy for the clinical failure of 5-fluorouracil plus eniluracil. Clinical colorectal cancer, 2010, Volume: 9, Issue:1 Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Dose-Response Relationship, Drug; Drug Administration Schedule; Fluorouracil; Neoplasms, Experimental; Rats; Rats, Inbred F344; Uracil	2010
Inhibiting 5-fluorouracil breakdown: a broken down approach to 5-fluorouracil modulation. Clinical colorectal cancer, 2002, Volume: 2, Issue:1 Topics: Antimetabolites, Antineoplastic; Colorectal Neoplasms; Dihydrouracil Dehydrogenase (NADP); Drug Synergism; Enzyme Inhibitors; Fluorouracil; Humans; Oxidoreductases; Uracil	2002
5-Ethynyluracil (776C85): modulation of 5-fluorouracil efficacy and therapeutic index in rats bearing advanced colorectal carcinoma. Cancer research, 1994, Mar-15, Volume: 54, Issue:6 Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Colorectal Neoplasms; Drug Synergism; Female; Fluorouracil; Leucovorin; Neoplasm Transplantation; Phosphonoacetic Acid; Rats; Rats, Inbred F344; Uracil	1994
5-Ethynyluracil (776C85): effects on the antitumor activity and pharmacokinetics of tegafur, a prodrug of 5-fluorouracil. Cancer research, 1995, Dec-15, Volume: 55, Issue:24 Topics: Animals; Carcinoma; Colorectal Neoplasms; Dihydrouracil Dehydrogenase (NADP); Drug Synergism; Enzyme Inhibitors; Fluorouracil; Male; Neoplasm Transplantation; Oxidoreductases; Prodrugs; Rats; Tegafur; Uracil	1995
Blocking catabolism with eniluracil enhances PET studies of 5-[18F]fluorouracil pharmacokinetics. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2000, Volume: 41, Issue:10 Topics: Animals; Antimetabolites, Antineoplastic; Colorectal Neoplasms; Enzyme Inhibitors; Female; Fluorine Radioisotopes; Fluorouracil; Radiopharmaceuticals; Rats; Rats, Inbred F344; Tomography, Emission-Computed; Uracil	2000