enhydrin and Uterine-Cervical-Neoplasms

enhydrin has been researched along with Uterine-Cervical-Neoplasms* in 1 studies

Other Studies

1 other study(ies) available for enhydrin and Uterine-Cervical-Neoplasms

Article	Year
Effect of epoxides and α-methylene-γ-lactone skeleton of sesquiterpenes from yacon (Smallanthus sonchifolius) leaves on caspase-dependent apoptosis and NF-κB inhibition in human cercival cancer cells. Fitoterapia, 2011, Volume: 82, Issue:7 The present study investigated the cytotoxicity of enhydrin (1), uvedalin (2) and sonchifolin (3) in cervical cancer cells. We have found that SLs 1-3 in doses in range of 0.22-10 μM inhibited cell proliferation and induced apoptosis in both a dose- and time-dependent fashion. A significant cell death induction was supported by morphological studies. The apoptotic effect is associated with caspase-3/7 activation and NF-кB inhibition. Interestingly, enhydrin possessing two epoxide units was found to be the most cytotoxic compound. Therefore it can be assumed that number of epoxides and existence of α-methylene-γ-lactone moiety are essential for the acceleration of apoptosis. Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Asteraceae; Caspase 3; Caspase 7; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Epoxy Compounds; Female; Humans; Lactones; NF-kappa B; Phytotherapy; Plant Extracts; Plant Leaves; Sesquiterpenes; Uterine Cervical Neoplasms	2011

Article

Year

Effect of epoxides and α-methylene-γ-lactone skeleton of sesquiterpenes from yacon (Smallanthus sonchifolius) leaves on caspase-dependent apoptosis and NF-κB inhibition in human cercival cancer cells.

Fitoterapia, 2011, Volume: 82, Issue:7

The present study investigated the cytotoxicity of enhydrin (1), uvedalin (2) and sonchifolin (3) in cervical cancer cells. We have found that SLs 1-3 in doses in range of 0.22-10 μM inhibited cell proliferation and induced apoptosis in both a dose- and time-dependent fashion. A significant cell death induction was supported by morphological studies. The apoptotic effect is associated with caspase-3/7 activation and NF-кB inhibition. Interestingly, enhydrin possessing two epoxide units was found to be the most cytotoxic compound. Therefore it can be assumed that number of epoxides and existence of α-methylene-γ-lactone moiety are essential for the acceleration of apoptosis.

Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Asteraceae; Caspase 3; Caspase 7; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Epoxy Compounds; Female; Humans; Lactones; NF-kappa B; Phytotherapy; Plant Extracts; Plant Leaves; Sesquiterpenes; Uterine Cervical Neoplasms

2011