enerbol and Heart-Failure

With increased life expectancy worldwide, there is an urgent need for improving preventive measures that delay the development of age-related degenerative diseases. Here, we report evidence from mouse and human studies that this goal can be achieved by maintaining optimal hydration throughout life. We demonstrate that restricting the amount of drinking water shortens mouse lifespan with no major warning signs up to 14 months of life, followed by sharp deterioration. Mechanistically, water restriction yields stable metabolism remodeling toward metabolic water production with greater food intake and energy expenditure, an elevation of markers of inflammation and coagulation, accelerated decline of neuromuscular coordination, renal glomerular injury, and the development of cardiac fibrosis. In humans, analysis of data from the Atherosclerosis Risk in Communities (ARIC) study revealed that hydration level, assessed at middle age by serum sodium concentration, is associated with markers of coagulation and inflammation and predicts the development of many age-related degenerative diseases 24 years later. The analysis estimates that improving hydration throughout life may greatly decrease the prevalence of degenerative diseases, with the most profound effect on dementia, heart failure (HF), and chronic lung disease (CLD), translating to the development of these diseases in 3 million fewer people in the United States alone.

Topics: Acute Kidney Injury; Aging; Animals; Atherosclerosis; Biomarkers; Chronic Disease; Dehydration; Dementia; Fibrosis; Heart Failure; Humans; Inflammation; Life; Lung Diseases; Male; Mice; Neurodegenerative Diseases; Organism Hydration Status; Regression Analysis; Risk Factors; Sodium; Water-Electrolyte Balance

Topics: Aminobutyrates; Biphenyl Compounds; Drug Combinations; Follow-Up Studies; Heart Failure; Humans; Life; Tetrazoles; Valsartan

A total of 18 peritoneal dialyses were performed on 14 patients at the Hamilton Civic Hospital over a period of 11 months. Nine of these patients were in uremia, four had non-nephrotoxic intoxication, and one had hepatic coma. Patients with chronic uremia may present with acute renal failure which may be treated by peritoneal dialysis with resultant significant prolongation of life. A decreased mortality rate might be expected in acute renal failure if dialysis is implemented before the classical picture of uremia develops. Many non-nephrotoxic intoxicating substances are readily dialysable. Considerable benefit to the patient and decreased time in hospital may result from the use of this procedure in cases of intoxication with such substances. Peritoneal dialysis may be of value in treatment of intractable congestive heart failure. This procedure may eventually provide another means of treating hepatic coma.

Topics: Acute Kidney Injury; Dialysis; Fluid Therapy; Heart Failure; Hepatic Encephalopathy; Humans; Kidney Failure, Chronic; Life; Peritoneal Dialysis; Renal Dialysis; Uremia

Topics: Child; Heart Failure; Humans; Infant; Life; Pneumonia

Patent ductus arteriosus and coarctation of the aorta are among the commonest causes of congestive heart failure early in life. When medical therapy fails to control heart failure in these cases, surgical division of the ductus or excision of the coarcted segment can be performed. But the recognition of these anomalies in infancy is more difficult than in childhood or adult life. Retrograde thoracic aortography is a technique which permits positive identification. In the presence of patent ductus arteriosus, opacification of the pulmonary arteries from the descending aorta will be clearly shown; if coarctation is present, its position, severity, and the length of the involved segment can usually be demonstrated. Properly employed, retrograde brachial aortography is a relatively safe and effective diagnostic procedure.

Topics: Adult; Angiography; Aorta, Thoracic; Aortic Coarctation; Aortography; Ductus Arteriosus; Ductus Arteriosus, Patent; Employment; Heart Failure; Humans; Life; Pulmonary Artery

Topics: Biological Products; Chlorides; Heart Failure; Ions; Life

Topics: Constriction, Pathologic; Heart Failure; Life; Mitral Valve; Mitral Valve Stenosis