enerbol and Dementia

With increased life expectancy worldwide, there is an urgent need for improving preventive measures that delay the development of age-related degenerative diseases. Here, we report evidence from mouse and human studies that this goal can be achieved by maintaining optimal hydration throughout life. We demonstrate that restricting the amount of drinking water shortens mouse lifespan with no major warning signs up to 14 months of life, followed by sharp deterioration. Mechanistically, water restriction yields stable metabolism remodeling toward metabolic water production with greater food intake and energy expenditure, an elevation of markers of inflammation and coagulation, accelerated decline of neuromuscular coordination, renal glomerular injury, and the development of cardiac fibrosis. In humans, analysis of data from the Atherosclerosis Risk in Communities (ARIC) study revealed that hydration level, assessed at middle age by serum sodium concentration, is associated with markers of coagulation and inflammation and predicts the development of many age-related degenerative diseases 24 years later. The analysis estimates that improving hydration throughout life may greatly decrease the prevalence of degenerative diseases, with the most profound effect on dementia, heart failure (HF), and chronic lung disease (CLD), translating to the development of these diseases in 3 million fewer people in the United States alone.

Topics: Acute Kidney Injury; Aging; Animals; Atherosclerosis; Biomarkers; Chronic Disease; Dehydration; Dementia; Fibrosis; Heart Failure; Humans; Inflammation; Life; Lung Diseases; Male; Mice; Neurodegenerative Diseases; Organism Hydration Status; Regression Analysis; Risk Factors; Sodium; Water-Electrolyte Balance

Topics: Dementia; Documentation; Humans; Life; Nursing Homes; Professional-Patient Relations; Quality Assurance, Health Care; United States

Topics: Abortion, Induced; Advance Directives; Altruism; Beginning of Human Life; Beneficence; Dementia; Ethics; Euthanasia; Euthanasia, Active; Euthanasia, Passive; Fetus; Freedom; Government Regulation; Human Rights; Humans; Individuality; Jurisprudence; Life; Mental Competency; Morals; Persistent Vegetative State; Personal Autonomy; Personhood; Philosophy; Pregnancy; Pregnant Women; Public Policy; Religion; Right to Die; Social Control, Formal; Suicide, Assisted; Terminally Ill; United States; Value of Life

Topics: Anencephaly; Beginning of Human Life; Brain Death; Cadaver; Catholicism; Death; Dehumanization; Dementia; Heart; Humans; Individuality; Infant, Newborn; Life; Life Support Care; Persistent Vegetative State; Personhood; Reference Standards; Religion; Stress, Psychological; Theology; Tissue and Organ Procurement; Tissue Donors; Ventilators, Mechanical

Topics: Abortion, Induced; Advance Directives; Altruism; Beginning of Human Life; Beneficence; Biomedical Technology; Decision Making; Dementia; Double Effect Principle; Ethics; Euthanasia; Euthanasia, Active; Euthanasia, Passive; Fetus; Freedom; Health Care Rationing; Hospices; Humans; Individuality; Intention; Judaism; Jurisprudence; Life; Life Support Care; Medical Futility; Motivation; Nutritional Support; Pain; Persistent Vegetative State; Personal Autonomy; Personhood; Pharmaceutical Preparations; Public Policy; Quality of Life; Reference Standards; Religion; Resource Allocation; Resuscitation Orders; Right to Die; Risk; Risk Assessment; Terminal Care; Terminally Ill; Theology; Third-Party Consent; Tissue and Organ Procurement; Tissue Donors; Treatment Refusal; Value of Life; Ventilators, Mechanical; Withholding Treatment

Topics: Abortion, Induced; Advance Directives; Beginning of Human Life; Bioethical Issues; Bioethics; Brain Death; Civil Rights; Dementia; Disabled Persons; Embryo, Mammalian; Embryonic and Fetal Development; Euthanasia, Passive; Fetal Tissue Transplantation; Fetal Viability; Fetus; Homicide; Human Experimentation; Humans; Individuality; Jurisprudence; Liability, Legal; Life; Mental Competency; Ownership; Persistent Vegetative State; Personhood; Pregnancy; Pregnant Women; Prenatal Exposure Delayed Effects; Quality of Life; Suicide; Terminally Ill; Third-Party Consent; Treatment Refusal; United States; Withholding Treatment

Topics: Abortion, Induced; Adult; Beginning of Human Life; Bioethical Issues; Bioethics; Brain Death; Brain Diseases; Brain Injuries; Death; Dementia; Ethicists; Ethics; Euthanasia, Passive; Fetus; Human Characteristics; Humans; Individuality; Infant; Infanticide; Life; Moral Obligations; Persistent Vegetative State; Personhood; Philosophy; Reference Standards; Self Concept; Social Responsibility; Value of Life

Topics: Dementia; Humans; Life; Mental Disorders; Psychotic Disorders; Syndrome

Topics: Dementia; Humans; Life; Mental Disorders; Psychotic Disorders

Topics: Alzheimer Disease; Dementia; Humans; Life; Medical Records; Mental Disorders; Psychotic Disorders

Topics: Dementia; Life; Mental Disorders; Psychotic Disorders