endothelin-1 and Tuberous-Sclerosis

endothelin-1 has been researched along with Tuberous-Sclerosis* in 1 studies

Other Studies

1 other study(ies) available for endothelin-1 and Tuberous-Sclerosis

ArticleYear
Dysregulation of the endothelin pathway in lymphangioleiomyomatosis with no direct effect on cell proliferation and migration.
    Scientific reports, 2018, 10-02, Volume: 8, Issue:1

    LAM is a rare low-grade metastasizing lung neoplasm. Inhibitors of mTOR improve clinical outcome of LAM patients by preventing loss of lung function. Nevertheless, other cell targets may be of interest for drug development. Therefore, we explored the potential role of EDN1 (endothelin) in LAM. We report an increased endothelin blood level in LAM patients as well as EDN1 overexpression and EDN1 receptor downregulation in LAM-derived primary cells and in TSC2

    Topics: beta-Arrestin 1; Cell Line, Tumor; Cell Movement; Cell Proliferation; Endothelin A Receptor Antagonists; Endothelin-1; Female; Gene Expression Regulation, Neoplastic; Humans; Lung; Lung Neoplasms; Lymphangioleiomyomatosis; Primary Cell Culture; Receptor, Endothelin A; Receptor, Endothelin B; Signal Transduction; Sirolimus; Spheroids, Cellular; Tuberous Sclerosis; Tuberous Sclerosis Complex 2 Protein

2018