endothelin-1 and Tuberculosis--Pulmonary

81 patients with active pulmonary tuberculosis were investigated. The morpho-functional status of vascular endothelium was evaluated by plasma levels of stable metabolites of nitric oxide, endothelin-1 and von Willebrand factor antigen. Typical increase of endothelin-1 in positive correlation with systemic inflammatory response syndrome (SIRS) expression was established. Nitric oxide level decreased in patients with chronic and severe course of disease. Decrease of nitric oxide level was not associated with SIRS but was consequence of specific intoxication. von Willebrand factor antigen decreased in patients with recent and limited spread of tissue damage but increased progressively with intensity of SIRS. This complex of changes (contrast shifts of nitric oxide and endothelin-1 and von Willebrand factor antigen increase) manifested in endothelium metabolic dysfunction syndrome and developed pre-conditions for microcirculation disturbances.

Topics: Adolescent; Adult; Aged; Endothelin-1; Endothelium, Vascular; Female; Humans; Male; Microcirculation; Middle Aged; Nitric Oxide; Pulmonary Circulation; Tuberculosis, Pulmonary; Vasodilation; von Willebrand Factor; Young Adult