endothelin-1 and Silicosis

Results of cholecystectomy performance were analyzed in 99 patients with a biliary calculous disease, the course of which have become complicated by cholecystitis occurrence, in 49 of them professional diseases of respiratory organs, including silicosis, antracosis, were registered. Estimating results of laparoscopic and open cholecystectomy, we have established, that carboperitoneum in laparoscopic cholecystectomy impacts negatively the course of early postoperative period, what manifests with hemodynamic and respiratory disorders. The level of fibronectin and endotelin--1 in the blood plasm directly depends on the respiratory disorders severity and may be applied as a test for respiratory dysfunction. The method of cholecystectomy in patients, suffering professional diseases of respiratory organs, must be selected, depending on severity of functional disorders of respiratory organs.

Topics: Blood Pressure; Cholecystectomy; Cholecystectomy, Laparoscopic; Cholecystitis; Cholelithiasis; Endothelin-1; Endothelium, Vascular; Fibronectins; Hemodynamics; Humans; Respiratory Function Tests; Respiratory Insufficiency; Severity of Illness Index; Silicosis; Treatment Outcome