endothelin-1 and Pelvic-Pain

To demonstrate the presence of endothelin-1 (ET-1), atrial natriuretic peptide (ANP) in peritoneal fluid of women and their effects on pathogenesis of pelvic venous congestion syndrome after sterilization (PVCSS).. This randomized controlled study determined the concentrations of ET-1 and ANP in both peritoneal fluid and plasma, counts of macrophage in peritoneal fluid and volumes of peritoneal fluid in 21 cases of PVCSS. 12 normal women after sterilization and 11 normal women as control in early follicular phase by radioimmunoassay.. concentrations of ET-1, ratio of ET-1/ANP and counts of macrophage in peritoneal fluid with PVCSS were lower than those in control (P < 0.005, P < 0.001, P < 0.001) and all had significant negative correlation with scores quantifying the severity of PVCSS (P < 0.05), but volumes of peritoneal fluid in PVCSS were larger than that in control (P < 0.001); counts of macrophage in peritoneal fluid had significant positive correlation with the concentrations of ET-1 of peritoneal fluid in all the three groups (P < 0.05); plasma concentrations of ET-1 and ANP didn't show any significant differences among the three groups (P > 0.05).. ET-1 was present in peritoneal fluid of normal women. Lower concentrations of ET-1 and (or) lower ratio of ET-1/ANP in peritoneal fluid contributed to the pathogenesis of PVCSS.

Topics: Adult; Ascitic Fluid; Atrial Natriuretic Factor; Endothelin-1; Female; Humans; Pelvic Pain; Pelvis; Sterilization, Tubal; Syndrome