endothelin-1 has been researched along with Nevus--Pigmented* in 1 studies
1 other study(ies) available for endothelin-1 and Nevus--Pigmented
| Article | Year |
|---|---|
Keratinocyte Sonic Hedgehog Upregulation Drives the Development of Giant Congenital Nevi via Paracrine Endothelin-1 Secretion.
Giant congenital nevi are associated with clinical complications such as neurocutaneous melanosis and melanoma. Virtually nothing is known about why some individuals develop these lesions. We previously identified the sonic hedgehog (Shh) pathway regulator Cdon as a candidate nevus modifier gene. Here we validate this by studying Cdon knockout mice, and go on to establishing the mechanism by which Shh exacerbates nevogenesis. Cdon knockout mice develop blue nevi without the need for somatic melanocyte oncogenic mutation. In a mouse model carrying melanocyte NRAS Topics: Animals; Endothelin-1; Female; Gene Expression Regulation, Neoplastic; Hedgehog Proteins; Humans; Keratinocytes; Male; Melanocytes; Mice; Mice, Knockout; Neoplasms, Experimental; Nevus, Pigmented; Signal Transduction; Skin Neoplasms; Transcriptional Activation; Tumor Cells, Cultured; Up-Regulation | 2018 |