endothelin-1 and Intestinal-Pseudo-Obstruction

The aim of the present study was to investigate the effect of endothelin-1 on the isolated distal ileum and proximal colon in an experimentally induced ileus in rats. Ileal and colonic contractions by endothelin-1, acetylcholine alone and with endothelin-1 were recorded both in normal and experimentally induced paralytic ileus in rats. In the control group, all the responses to acetylcholine were found to be potentiated significantly when used together with endothelin-1 but in paralytic ileus group, no detectable change was observed in the responses of the amine after administration of acetylcholine together with endothelin-1. This study indicates that endothelin-1 might have an effect on gastrointestinal motility and postoperative paralytic ileus.

Topics: Acetylcholine; Animals; Colon; Drug Synergism; Endothelin-1; Female; Ileum; In Vitro Techniques; Intestinal Pseudo-Obstruction; Male; Muscle Contraction; Muscle, Smooth; Rats; Rats, Wistar; Vasodilator Agents