endothelin-1 and Duodenal-Diseases

We have found out the clinical presentations and peculiarities of endoscopic and morphologic view of pathologies of mucous membrane of gastroduodenal zone caused by liver cirrhosis. We have examined 74 patients with liver cirrhosis of viral and nonviral etiology using the clinical, endoscopic, morphologic and immunohistochemical methods.We have found that during liver cirrhosis morphometric rates of epithelial cells of mucous coat of stomach that produce somatostatin and endothelin-1 decrease and morphometric rates of epithelial cells that produce nitrogen oxide synthase increase. We have also found out that during liver cirrhosis proliferate activity decrease and apoptosis of epithelial cell of mucous coat of stomach increase.

Topics: Adult; Apoptosis; Cell Proliferation; Duodenal Diseases; Endothelin-1; Enteroendocrine Cells; Female; Gastric Mucosa; Humans; Hypertension, Portal; Intestinal Mucosa; Liver Cirrhosis; Male; Middle Aged; Nitric Oxide Synthase; Severity of Illness Index; Somatostatin; Stomach Diseases

Clinical presentation, endoscopic picture and morphological changes of gastric and duodenal mucosa were evaluated in 75 patients with chronic hepatitis of different (viral and non-viral) etiology. Endoscopic, morphological, and immunohistochemical studies revealed deterioration of morphometric characteristics of somatostatin-immunopositive epitheliocytes in gastric mucosa and their improvement in epitheliocytes producing endothelin-1 and nitric oxide synthase. These changes were associated with decreased proliferative activity and enhanced apoptosis of epitheliocytes in gastric mucosa.

Topics: Adult; Apoptosis; Cell Proliferation; Duodenal Diseases; Endoscopy, Gastrointestinal; Endothelin-1; Female; Hepatitis, Chronic; Humans; Immunohistochemistry; Intestinal Mucosa; Male; Nitric Oxide Synthase; Prognosis; Severity of Illness Index; Stomach Diseases