endothelin-1 and Aortitis

endothelin-1 has been researched along with Aortitis* in 1 studies

Other Studies

1 other study(ies) available for endothelin-1 and Aortitis

ArticleYear
Plasma endothelin-1 levels and circulating endothelial cells in patients with aortoarteritis.
    Hypertension research : official journal of the Japanese Society of Hypertension, 2000, Volume: 23, Issue:5

    To investigate the correlation between plasma endothelin-1 (ET-1), circulating endothelial cells (CECs), and the disease activity in patients with aortoarteritis. In this study, radioimmunoassay was used to measure plasma levels of ET-1 in 56 patients with aortoarteritis. Circulating endothelial cell counts were also carried out as an indicator of vessel wall lesions. The plasma levels of ET-1 and CECs in the active disease patient group were significantly higher than those in inactive patient group (p<0.001). A significant positive correlation was found between plasma ET-1 levels and erythrocyte sedimentation rates (ESRs) in patients with aortoarteritis (r=0.645, p<0.001), as well as CECs (r=0.876, p<0.001). These results suggested that the ET-1 secreted during the active stages of aortoarteritis may cause constriction and proliferation of vascular smooth muscle cells, thus contributing to the pathogenesis of luminal narrowing. The increased CECs might serve as a marker of disease activity.

    Topics: Adult; Aortitis; Endothelin-1; Endothelium, Vascular; Female; Humans; Male; Predictive Value of Tests; Radioimmunoassay; Regression Analysis; Severity of Illness Index

2000