endothelin-1--ala(1-3-11-15)- and Encephalitis

endothelin-1--ala(1-3-11-15)- has been researched along with Encephalitis* in 1 studies

Other Studies

1 other study(ies) available for endothelin-1--ala(1-3-11-15)- and Encephalitis

Article	Year
Production of monocyte chemoattractant protein-1 and cytokine-induced neutrophil chemoattractant-1 in rat brain is stimulated by intracerebroventricular administration of an endothelin ETB receptor agonist. Neuroreport, 2007, Aug-06, Volume: 18, Issue:12 The role of endothelin (ET)B receptors in chemokine production in the brain of rats was examined. Intracerebroventricular administration of 500 pmol/day of Ala(1,3,11,15)-ET-1, a selective ETB agonist, for 3 or 7 days increased monocyte chemoattractant protein (MCP)-1 and cytokine-induced neutrophil chemoattractant (CINC)-1 mRNA in the caudate-putamen and cerebrum, whereas it had no effects on regulated on activation normal T-cell expressed and secreted (RANTES), fractalkine and stromal cell-derived factor (SDF)-1alpha mRNA expression. Immunoreactive MCP-1 and CINC-1 in the caudate-putamen and the cerebrum were increased by the ETB agonist. Immunohistochemical observations on the Ala(1,3,11,15)-ET-1-infused rats showed that glial fibrillary acidic protein-positive astrocytes had immunoreactivity for MCP-1 and CINC-1. These findings indicate that the activation of brain ETB receptors causes the production of MCP-1 and CINC-1, and suggest a pathophysiological role for brain ETB receptors in nervous system damage. Topics: Animals; Astrocytes; Brain; Chemokine CCL2; Chemokine CXCL1; Chemokines, CXC; Encephalitis; Endothelin-1; Endothelins; Glial Fibrillary Acidic Protein; Gliosis; Immunohistochemistry; Injections, Intraventricular; Male; Neostriatum; Rats; Rats, Wistar; Receptor, Endothelin B; RNA, Messenger; Telencephalon; Up-Regulation	2007

Article

Year

Production of monocyte chemoattractant protein-1 and cytokine-induced neutrophil chemoattractant-1 in rat brain is stimulated by intracerebroventricular administration of an endothelin ETB receptor agonist.

Neuroreport, 2007, Aug-06, Volume: 18, Issue:12

The role of endothelin (ET)B receptors in chemokine production in the brain of rats was examined. Intracerebroventricular administration of 500 pmol/day of Ala(1,3,11,15)-ET-1, a selective ETB agonist, for 3 or 7 days increased monocyte chemoattractant protein (MCP)-1 and cytokine-induced neutrophil chemoattractant (CINC)-1 mRNA in the caudate-putamen and cerebrum, whereas it had no effects on regulated on activation normal T-cell expressed and secreted (RANTES), fractalkine and stromal cell-derived factor (SDF)-1alpha mRNA expression. Immunoreactive MCP-1 and CINC-1 in the caudate-putamen and the cerebrum were increased by the ETB agonist. Immunohistochemical observations on the Ala(1,3,11,15)-ET-1-infused rats showed that glial fibrillary acidic protein-positive astrocytes had immunoreactivity for MCP-1 and CINC-1. These findings indicate that the activation of brain ETB receptors causes the production of MCP-1 and CINC-1, and suggest a pathophysiological role for brain ETB receptors in nervous system damage.

Topics: Animals; Astrocytes; Brain; Chemokine CCL2; Chemokine CXCL1; Chemokines, CXC; Encephalitis; Endothelin-1; Endothelins; Glial Fibrillary Acidic Protein; Gliosis; Immunohistochemistry; Injections, Intraventricular; Male; Neostriatum; Rats; Rats, Wistar; Receptor, Endothelin B; RNA, Messenger; Telencephalon; Up-Regulation

2007