enalaprilat-anhydrous and Liver-Diseases

enalaprilat-anhydrous has been researched along with Liver-Diseases* in 1 studies

Other Studies

1 other study(ies) available for enalaprilat-anhydrous and Liver-Diseases

Article	Year
Enalapril (MK421) activation in man: importance of liver status. British journal of clinical pharmacology, 1985, Volume: 19, Issue:5 The in vitro conversion of enalapril (MK421) to enalaprilic acid (MK422) in human autopsy tissues was examined. MK422 was measured by radioimmunoassay. Human cadaver liver was the only tissue in which significant conversion was demonstrated. The esterase activity was stable after post mortem. Autopsy liver tissues from patients with elevated ante mortem liver function tests were found to have a reduced rate of deesterification. Topics: Angiotensin-Converting Enzyme Inhibitors; Biotransformation; Dipeptides; Enalapril; Enalaprilat; Esterases; Humans; In Vitro Techniques; Liver; Liver Diseases; Liver Function Tests; Proteins; Radioimmunoassay	1985

Article

Year

Enalapril (MK421) activation in man: importance of liver status.

British journal of clinical pharmacology, 1985, Volume: 19, Issue:5

The in vitro conversion of enalapril (MK421) to enalaprilic acid (MK422) in human autopsy tissues was examined. MK422 was measured by radioimmunoassay. Human cadaver liver was the only tissue in which significant conversion was demonstrated. The esterase activity was stable after post mortem. Autopsy liver tissues from patients with elevated ante mortem liver function tests were found to have a reduced rate of deesterification.

Topics: Angiotensin-Converting Enzyme Inhibitors; Biotransformation; Dipeptides; Enalapril; Enalaprilat; Esterases; Humans; In Vitro Techniques; Liver; Liver Diseases; Liver Function Tests; Proteins; Radioimmunoassay

1985