enalaprilat-anhydrous and Intestinal-Pseudo-Obstruction

We report an 11-year-old boy with hypertension and chronic intestinal pseudo-obstruction, which renders him totally dependent on parenteral nutrition and prevents the use of oral medications. Here we report the feasibility of utilizing chronic i.v. enalaprilat and transdermal clonidine on a chronic basis to control hypertension. Over the last 10 months, the patient's hypertension has been well controlled by 1.25 mg i.v. enalaprilat every 8 h and a 0.2-mg clonidine patch every 6 days, with no apparent side-effects. There are no reports of i.v. enalaprilat usage exceeding 3 weeks' duration. Therefore we believe that it is possible to effect reasonable management of chronic hypertension with the use of chronic i.v. enalaprilat and transdermal clonidine therapy.

Topics: Administration, Cutaneous; Adult; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Chronic Disease; Clonidine; Drug Therapy, Combination; Enalaprilat; Feasibility Studies; Humans; Hypertension; Injections, Intravenous; Intestinal Pseudo-Obstruction; Male; Parenteral Nutrition