enalapril and Water-Intoxication

1. A 21 day prospective placebo controlled double blind cross over trial of enalapril was studied in a normonatremic patient with a known history of SIWI. 2. At the end of each prophylactic treatment, the patient was challenged with a water load of 20 ml/kg. 3. The mean serum sodium of 140.111 mmol/L on prophylactic enalapril was significantly higher than the 137.6 mmol/L on placebo (p = 0.0015). 4. After a water load, the mean serum sodium on enalapril was 137.6 mmol/L, compared to 133.833 mmol/L (p = 0.0015) on placebo.

Topics: Adult; Angiotensin-Converting Enzyme Inhibitors; Double-Blind Method; Enalapril; Humans; Male; Prospective Studies; Schizophrenic Psychology; Sodium; Water Intoxication

Topics: Adult; Captopril; Chronic Disease; Clinical Trials as Topic; Enalapril; Humans; Male; Schizophrenia; Schizophrenic Psychology; Water Intoxication

Topics: Body Weight; Captopril; Enalapril; Humans; Schizophrenia; Schizophrenic Psychology; Water Intoxication