enalapril and Venous-Thrombosis

To study effects of two hypotensive drugs--normodipin and spirapril--on intravascular activity of platelets in patients with metabolic syndrome (MS).. Normodipin was given to 25 patients with MS for 3 months, spirapril--to 20 patients for 3 months. The effect was evaluated by changes in lipid peroxidation in plasm and platelets, antioxidant defense of liquid blood and platelets, intravascular activity of platelets.. Administration of normodipin in MS patients had a positive effect on lipid peroxidation and normalized intravascular activity of platelets. Such pronounced positive effects on lipid peroxidation of plasm and platelets as well as on intravascular activity of the latter were not registered after use of spirapril.. Optimization of platelet function in MS patients can be achieved with long-term normodipin treatment.

Topics: Adult; Amlodipine; Antihypertensive Agents; Blood Platelets; Blood Pressure; Enalapril; Female; Humans; Lipid Peroxidation; Male; Metabolic Syndrome; Middle Aged; Platelet Activation; Venous Thrombosis