enalapril and Kidney-Tubular-Necrosis--Acute

We report two cases of acute renal failure in renal transplant patients using cyclosporine-A (CsA) after the introduction of angiotensin-converting enzyme inhibitor (ACEI) to control arterial hypertension. They had no renal artery stenosis or acute rejection. Both patients presented severe acute tubular necrosis (ATN), which subsided after discontinuation of the ACEI. Synergistic toxic effect of ACEI and CsA on the renal tubules might explain ATN in these two cases.

Topics: Cyclosporine; Dose-Response Relationship, Drug; Drug Synergism; Enalapril; Female; Humans; Hypertension; Kidney Transplantation; Kidney Tubular Necrosis, Acute; Kidney Tubules; Male; Middle Aged

Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Dogs; Dose-Response Relationship, Drug; Enalapril; Kidney; Kidney Diseases; Kidney Tubular Necrosis, Acute