emodin has been researched along with Sensitivity and Specificity in 17 studies
Emodin: Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as a laxative, but is now used mainly as a tool in toxicity studies.
emodin : A trihydroxyanthraquinone that is 9,10-anthraquinone which is substituted by hydroxy groups at positions 1, 3, and 8 and by a methyl group at position 6. It is present in the roots and barks of numerous plants (particularly rhubarb and buckthorn), moulds, and lichens. It is an active ingredient of various Chinese herbs.
Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "To identify micro-computed tomography (CT) imaging biomarkers for evaluating the effects of emodin, a potential drug to treat osteoporosis, in the mouse model of lipopolysaccharide (LPS)-mediated osteoporosis." | 7.80 | CT imaging biomarker for evaluation of emodin as a potential drug on LPS-mediated osteoporosis mice. ( Juhng, SK; Jung, ST; Kang, DM; Kim, JY; Lee, M; Lee, YH; Oh, JM; Yoon, KH, 2014) |
| "To identify micro-computed tomography (CT) imaging biomarkers for evaluating the effects of emodin, a potential drug to treat osteoporosis, in the mouse model of lipopolysaccharide (LPS)-mediated osteoporosis." | 3.80 | CT imaging biomarker for evaluation of emodin as a potential drug on LPS-mediated osteoporosis mice. ( Juhng, SK; Jung, ST; Kang, DM; Kim, JY; Lee, M; Lee, YH; Oh, JM; Yoon, KH, 2014) |
| " The method was then successfully applied in a pharmacokinetic study of four bioactive components after a single oral administration of DHXD extract to rats." | 1.38 | A novel UPLC-MS/MS method for simultaneous quantification of rhein, emodin, berberine and baicalin in rat plasma and its application in a pharmacokinetic study. ( Gao, JW; Huang, P; Lu, YS; Shi, Z; Yao, MC; Yuan, YM; Zou, JL, 2012) |
| " The absolute bioavailability is about 54." | 1.37 | Development and validation of a highly rapid and sensitive LC-MS/MS method for determination of SZ-685C, an investigational marine anticancer agent, in rat plasma--application to a pharmacokinetic study in rats. ( Chen, JY; Huang, M; Huang, ZY; Li, JL; Li, MF; Qin, XL; Wang, XD; Zhong, GP; Zhu, X, 2011) |
| "Besides cardiovascular diseases, cancer represents the major cause of death in developed countries." | 1.36 | A FRET-based microplate assay for human protein kinase CK2, a target in neoplastic disease. ( Götz, C; Gratz, A; Jose, J, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (35.29) | 29.6817 |
| 2010's | 11 (64.71) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Diamandis, P | 1 |
| Wildenhain, J | 1 |
| Clarke, ID | 1 |
| Sacher, AG | 1 |
| Graham, J | 1 |
| Bellows, DS | 1 |
| Ling, EK | 1 |
| Ward, RJ | 1 |
| Jamieson, LG | 1 |
| Tyers, M | 1 |
| Dirks, PB | 1 |
| Washington, K | 1 |
| Wason, J | 1 |
| Thein, MS | 1 |
| Lavery, LA | 1 |
| Hamblin, MR | 1 |
| Gordon, IL | 1 |
| Nong, F | 1 |
| Zhao, Z | 1 |
| Luo, X | 1 |
| Liu, C | 1 |
| Li, H | 2 |
| Liu, Q | 1 |
| Wen, B | 1 |
| Zhou, L | 1 |
| Buddeberg, BS | 1 |
| Sharma, R | 1 |
| O'Driscoll, JM | 1 |
| Kaelin Agten, A | 1 |
| Khalil, A | 1 |
| Thilaganathan, B | 1 |
| Wakabayashi, H | 1 |
| Osawa, M | 1 |
| Koga, S | 1 |
| Li, K | 1 |
| Sakaue, H | 1 |
| Sengoku, Y | 1 |
| Takagi, H | 1 |
| Kim, SW | 1 |
| Son, Y | 2 |
| Choi, K | 1 |
| Kim, SI | 1 |
| Park, J | 1 |
| Lee, JH | 1 |
| Jang, JH | 1 |
| Brailsford, AD | 1 |
| Majidin, WNM | 1 |
| Wojek, N | 1 |
| Cowan, DA | 1 |
| Walker, C | 1 |
| Kim, JH | 1 |
| Phi, JH | 1 |
| Lee, JY | 1 |
| Kim, KH | 1 |
| Park, SH | 1 |
| Choi, YH | 1 |
| Cho, BK | 1 |
| Kim, SK | 1 |
| Kim, HJ | 1 |
| Pei, M | 1 |
| Ko, JS | 1 |
| Ma, MH | 1 |
| Park, GE | 1 |
| Baek, J | 1 |
| Yang, H | 1 |
| Cho, MJ | 1 |
| Choi, DH | 1 |
| Gundogdu, G | 1 |
| Gundogdu, K | 1 |
| Nalci, KA | 1 |
| Demirkaya, AK | 1 |
| Yılmaz Tascı, S | 1 |
| Demirkaya Miloglu, F | 1 |
| Senol, O | 1 |
| Hacimuftuoglu, A | 1 |
| Kang, DM | 1 |
| Yoon, KH | 1 |
| Kim, JY | 1 |
| Oh, JM | 1 |
| Lee, M | 1 |
| Jung, ST | 1 |
| Juhng, SK | 1 |
| Lee, YH | 1 |
| Wei, L | 1 |
| Wang, X | 1 |
| Mu, S | 1 |
| Sun, L | 1 |
| Yu, Z | 1 |
| Gao, XY | 1 |
| Jiang, Y | 1 |
| Lu, JQ | 1 |
| Tu, PF | 1 |
| Panichayupakaranant, P | 1 |
| Sakunpak, A | 1 |
| Sakunphueak, A | 1 |
| Zhu, M | 1 |
| Gao, Y | 1 |
| Wu, Z | 1 |
| Zhao, Y | 1 |
| Gratz, A | 1 |
| Götz, C | 1 |
| Jose, J | 1 |
| Chen, JY | 1 |
| Wang, XD | 1 |
| Zhong, GP | 1 |
| Qin, XL | 1 |
| Li, JL | 1 |
| Huang, ZY | 1 |
| Zhu, X | 1 |
| Li, MF | 1 |
| Huang, M | 1 |
| Shi, Y | 1 |
| Sun, C | 1 |
| Gao, B | 1 |
| Sun, A | 1 |
| Huang, P | 1 |
| Gao, JW | 1 |
| Shi, Z | 1 |
| Zou, JL | 1 |
| Lu, YS | 1 |
| Yuan, YM | 1 |
| Yao, MC | 1 |
| Ali, NW | 1 |
| Abdelwahab, NS | 1 |
| Abdelkawy, M | 1 |
| Emam, AA | 1 |
| Guo, H | 1 |
| Wu, L | 1 |
| Zhang, Y | 1 |
| Chen, J | 1 |
| Liu, X | 1 |
| Cai, H | 1 |
| Zhang, K | 1 |
| Cai, B | 1 |
| Zaffaroni, M | 1 |
| Mucignat, C | 1 |
| Pecere, T | 1 |
| Zagotto, G | 1 |
| Frapolli, R | 1 |
| D'Incalci, M | 1 |
| Zucchetti, M | 1 |
| Wang, XJ | 1 |
| Yang, J | 1 |
| Cang, H | 1 |
| Zou, YQ | 1 |
| Yi, J | 1 |
| Qiao, C | 1 |
| Bi, S | 1 |
| Sun, Y | 1 |
| Song, D | 1 |
| Zhang, H | 1 |
| Zhou, W | 1 |
17 other studies available for emodin and Sensitivity and Specificity
| Article | Year |
|---|---|
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutic | 2007 |
Topics: Adult; Anabolic Agents; Androgens; Animals; Anthraquinones; Birth Weight; Body Mass Index; Carbon Is | 2018 |
The Effect of Parietin Isolated From Rheum ribes L on In Vitro Wound Model Using Human Dermal Fibroblast Cells.
Topics: Cell Proliferation; Cells, Cultured; Emodin; Fibroblasts; Humans; In Vitro Techniques; Rheum; Ribes; | 2019 |
CT imaging biomarker for evaluation of emodin as a potential drug on LPS-mediated osteoporosis mice.
Topics: Animals; Biomarkers; Bone Remodeling; Bone Resorption; Emodin; Femur; Lipopolysaccharides; Male; Mic | 2014 |
Ultra high performance liquid chromatography with electrospray ionization tandem mass spectrometry coupled with hierarchical cluster analysis to evaluate Wikstroemia indica (L.) C. A. Mey. from different geographical regions.
Topics: Apigenin; Chromatography, High Pressure Liquid; Cluster Analysis; Coumarins; Emodin; Flavones; Furan | 2015 |
One single standard substance for the determination of multiple anthraquinone derivatives in rhubarb using high-performance liquid chromatography-diode array detection.
Topics: Anthraquinones; Calibration; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; Emodin; Li | 2009 |
Quantitative HPLC determination and extraction of anthraquinones in Senna alata leaves.
Topics: Anthraquinones; Chromatography, High Pressure Liquid; Emodin; Plant Leaves; Reproducibility of Resul | 2009 |
A rapid HPLC/ESI-MS/MS method for quantitative analysis of isovalerylshikonin in rat plasma.
Topics: Animals; Boraginaceae; Chromatography, High Pressure Liquid; Drug Stability; Drugs, Chinese Herbal; | 2010 |
A FRET-based microplate assay for human protein kinase CK2, a target in neoplastic disease.
Topics: Casein Kinase II; Emodin; Enzyme Assays; Fluorescence; Fluorescence Resonance Energy Transfer; Human | 2010 |
Development and validation of a highly rapid and sensitive LC-MS/MS method for determination of SZ-685C, an investigational marine anticancer agent, in rat plasma--application to a pharmacokinetic study in rats.
Topics: Animals; Anthraquinones; Antineoplastic Agents; Chromatography, High Pressure Liquid; Drug Stability | 2011 |
Development of a liquid chromatography tandem mass spectrometry method for simultaneous determination of eight adulterants in slimming functional foods.
Topics: Anthraquinones; Chromatography, Liquid; Clopamide; Cyclobutanes; Diet, Reducing; Emodin; Ephedrine; | 2011 |
A novel UPLC-MS/MS method for simultaneous quantification of rhein, emodin, berberine and baicalin in rat plasma and its application in a pharmacokinetic study.
Topics: Animals; Anthraquinones; Berberine; Chromatography, High Pressure Liquid; Colonic Diseases, Function | 2012 |
Validated stability indicating TLC-densitometric method for the determination of diacerein.
Topics: Anthraquinones; Chromatography, Thin Layer; Densitometry; Drug Contamination; Drug Stability; Emodin | 2014 |
Comparative pharmacokinetics study of three anthraquinones in rat plasma after oral administration of Radix et Rhei Rhizoma extract and Dahuang Fuzi Tang by high performance liquid chromatography-mass spectrometry.
Topics: Aconitum; Administration, Oral; Animals; Anthraquinones; Asarum; Calibration; Chromatography, High P | 2013 |
High-performance liquid chromatographic assay for the determination of Aloe Emodin in mouse plasma.
Topics: Animals; Anthraquinones; Chromatography, High Pressure Liquid; Emodin; Mice; Reference Standards; Re | 2003 |
Gene expression alteration during redox-dependent enhancement of arsenic cytotoxicity by emodin in HeLa cells.
Topics: Apoptosis; Arsenic Trioxide; Arsenicals; Cell Survival; Dose-Response Relationship, Drug; Emodin; Ge | 2005 |
Study of interactions of anthraquinones with DNA using ethidium bromide as a fluorescence probe.
Topics: Animals; Anthraquinones; DNA; Dose-Response Relationship, Drug; Emodin; Ethidium; Fishes; Fluorescen | 2008 |